Details for: GBF1
Gene ID: 8729
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: GBF1
Ensembl ID: ENSG00000107862
Description: golgi brefeldin A resistant guanine nucleotide exchange factor 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 32.25rCSI 46.28%PRS 28.85
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CSI 19.84rCSI 34.97%PRS 34.94
-
CSI 19.64rCSI 32.96%PRS 23.05
-
CSI 17.07rCSI 27.47%PRS 28.21
-
CSI 16.73rCSI 44.4%PRS 49.39
-
CSI 16.08rCSI 39.08%PRS 22.39
-
CSI 15.42rCSI 55.49%PRS 22.08
-
CSI 15.3rCSI 47.8%PRS 24.03
-
CSI 14.66rCSI 20.36%PRS 35.9
-
CSI 14.6rCSI 31.97%PRS 45.71
-
CSI 13.04rCSI 22.3%PRS 56.99
-
CSI 12.54rCSI 18.35%PRS 38.3
-
CSI 12.34rCSI 24.5%PRS 36.05
-
CSI 12.1rCSI 24.98%PRS 44.57
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CSI 11.28rCSI 42.61%PRS 23.89
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CSI 10.71rCSI 17.04%PRS 30.47
-
CSI 9.69rCSI 12.05%PRS 38.32
-
CSI 9.45rCSI 41.51%PRS 33.95
-
CSI 9.41rCSI 17.62%PRS 27.49
-
CSI 9.21rCSI 8.01%PRS 44.2
-
CSI 9.18rCSI 7.42%PRS 47.74
-
CSI 9.15rCSI 36.91%PRS 34.89
-
CSI 8.81rCSI 27.56%PRS 26.01
-
CSI 8.52rCSI 12.61%PRS 40.23
-
CSI 8.4rCSI 49.45%PRS 24.21
-
CSI 8.24rCSI 13.14%PRS 30.88
-
CSI 7.55rCSI 12.36%PRS 28.32
-
CSI 7.48rCSI 6.97%PRS 35.73
-
CSI 7.45rCSI 8.6%PRS 31.39
-
CSI 7.08rCSI 18.38%PRS 42.11
-
CSI 7.07rCSI 8.79%PRS 21.76
-
CSI 6.79rCSI 14.95%PRS 39.84
-
CSI 6.65rCSI 10.69%PRS 24.91
-
CSI 5.3rCSI 10.99%PRS 34.88
-
CSI 5.22rCSI 6.13%PRS 39.6
-
CSI 5.15rCSI 9.09%PRS 22.22
-
CSI 5.06rCSI 3.63%PRS 47.56
-
CSI 5.01rCSI 12.95%PRS 33
-
CSI 4.91rCSI 10.85%PRS 26.45
-
CSI 4.89rCSI 6.68%PRS 40.04
-
CSI 4.81rCSI 10.98%PRS 31.04
-
CSI 4.74rCSI 11.72%PRS 34.18
-
CSI 4.69rCSI 6.02%PRS 34.23
-
CSI 4.65rCSI 5.45%PRS 49.59
-
CSI 4.64rCSI 26.23%PRS 24.48
-
CSI 4.63rCSI 14.81%PRS 33.04
-
CSI 4.53rCSI 4.18%PRS 37.04
-
CSI 4.48rCSI 7.85%PRS 29.31
-
CSI 4.41rCSI 3.27%PRS 30.93
-
CSI 4.4rCSI 17.21%PRS 15.98
-
CSI 4.31rCSI 5.53%PRS 33.5
-
CSI 4.27rCSI 7.03%PRS 40.85
-
CSI 4.15rCSI 7.46%PRS 30.44
-
CSI 4.15rCSI 30.48%PRS 25.77
-
CSI 4.14rCSI 8.4%PRS 21.69
-
CSI 4.07rCSI 9.09%PRS 41.59
-
CSI 3.98rCSI 17.74%PRS 62.57
-
CSI 3.88rCSI 10.12%PRS 46.25
-
CSI 3.83rCSI 7.68%PRS 27.45
-
CSI 3.78rCSI 2.23%PRS 49.09
-
CSI 3.73rCSI 5.28%PRS 33.68
-
CSI 3.72rCSI 4.46%PRS 34.39
-
CSI 3.69rCSI 20.19%PRS 42.34
-
CSI 3.67rCSI 2.9%PRS 25.6
-
CSI 3.65rCSI 3.2%PRS 45.24
-
CSI 3.65rCSI 4.87%PRS 37.76
-
CSI 3.48rCSI 14.19%PRS 35.15
-
CSI 3.44rCSI 7.95%PRS 29.71
-
CSI 3.35rCSI 4.92%PRS 33.17
-
CSI 3.28rCSI 7.81%PRS 38.94
-
CSI 3.28rCSI 9.22%PRS 38.61
-
CSI 3.27rCSI 12.26%PRS 30.67
-
CSI 3.27rCSI 2.54%PRS 50.94
-
CSI 3.24rCSI 3.76%PRS 46.82
-
CSI 3.21rCSI 7.85%PRS 33.44
-
CSI 3.21rCSI 16.87%PRS 46.34
-
CSI 3.17rCSI 8.48%PRS 30.59
-
CSI 3.17rCSI 8.26%PRS 35.2
-
CSI 3.14rCSI 2.42%PRS 34.32
-
CSI 3.13rCSI 10.08%PRS 36.27
-
CSI 3.06rCSI 2.13%PRS 47.73
-
CSI 3.05rCSI 3.94%PRS 23.82
-
CSI 2.99rCSI 3.58%PRS 22.99
-
CSI 2.95rCSI 7%PRS 41.85
-
CSI 2.93rCSI 3.07%PRS 33.6
-
CSI 2.87rCSI 8.86%PRS 48.29
-
CSI 2.82rCSI 2.66%PRS 37.07
-
CSI 2.78rCSI 66.49%PRS 22.51
-
CSI 2.78rCSI 14.21%PRS 38.86
-
CSI 2.77rCSI 2.89%PRS 36.51
-
CSI 2.73rCSI 8.11%PRS 46.94
-
CSI 2.73rCSI 65.77%PRS 23.31
-
CSI 2.72rCSI 6.38%PRS 46.03
-
CSI 2.7rCSI 4.37%PRS 35.07
-
CSI 2.68rCSI 10.43%PRS 45.64
-
CSI 2.65rCSI 1.85%PRS 43.16
-
CSI 2.64rCSI 3.99%PRS 37.16
-
CSI 2.61rCSI 2.86%PRS 39.69
-
CSI 2.61rCSI 2.32%PRS 35.41
-
CSI 2.58rCSI 3.73%PRS 51.22
-
CSI 0.3rCSI 0.6%PRS 33.4%
-
CSI 0.3rCSI 3.3%PRS 39.3%
-
CSI 0.4rCSI 1.9%PRS 46.4%
-
CSI 0.5rCSI 1.3%PRS 29.0%
-
CSI 0.5rCSI 3.6%PRS 35.5%
-
CSI 0.5rCSI 3.7%PRS 33.8%
-
CSI 0.5rCSI 4.6%PRS 40.2%
-
CSI 0.6rCSI 1.5%PRS 40.3%
-
CSI 0.6rCSI 1.1%PRS 37.4%
-
CSI 0.6rCSI 3.5%PRS 35.0%
-
CSI 0.6rCSI 2.8%PRS 34.6%
-
CSI 0.7rCSI 4.3%PRS 44.2%
-
CSI 0.7rCSI 1.3%PRS 44.9%
-
CSI 0.7rCSI 3.6%PRS 51.9%
-
CSI 0.8rCSI 1.7%PRS 32.8%
-
CSI 0.8rCSI 1.9%PRS 35.2%
-
CSI 0.9rCSI 5.8%PRS 34.8%
-
CSI 0.9rCSI 1.2%PRS 43.9%
-
CSI 0.9rCSI 4.6%PRS 35.9%
-
CSI 1.0rCSI 4.6%PRS 35.0%
-
CSI 1.0rCSI 4.0%PRS 58.4%
-
CSI 1.0rCSI 3.3%PRS 26.9%
-
CSI 1.0rCSI 4.0%PRS 56.1%
-
CSI 1.0rCSI 2.2%PRS 57.8%
-
CSI 1.0rCSI 1.6%PRS 33.3%
-
CSI 1.0rCSI 6.9%PRS 35.7%
-
CSI 1.0rCSI 9.2%PRS 26.8%
-
CSI 1.1rCSI 0.9%PRS 26.9%
-
CSI 1.1rCSI 2.5%PRS 55.9%
-
CSI 1.1rCSI 6.8%PRS 24.5%
-
CSI 1.1rCSI 2.7%PRS 46.8%
-
CSI 1.1rCSI 1.8%PRS 34.1%
-
CSI 1.2rCSI 5.4%PRS 56.8%
-
CSI 1.2rCSI 4.5%PRS 31.9%
-
CSI 1.2rCSI 1.4%PRS 27.5%
-
CSI 1.2rCSI 3.4%PRS 51.8%
-
CSI 1.2rCSI 3.4%PRS 50.9%
-
CSI 1.3rCSI 3.0%PRS 47.5%
-
CSI 1.3rCSI 3.3%PRS 62.7%
-
CSI 1.3rCSI 3.2%PRS 43.3%
-
CSI 1.3rCSI 9.7%PRS 56.5%
-
CSI 1.4rCSI 0.9%PRS 44.6%
-
CSI 1.4rCSI 3.7%PRS 44.6%
-
CSI 1.4rCSI 4.7%PRS 30.2%
-
CSI 1.4rCSI 2.1%PRS 42.0%
-
CSI 1.4rCSI 1.4%PRS 31.0%
-
CSI 1.4rCSI 4.2%PRS 35.0%
-
CSI 1.4rCSI 9.0%PRS 29.8%
-
CSI 1.5rCSI 2.3%PRS 45.2%
-
CSI 1.5rCSI 2.1%PRS 34.0%
-
CSI 1.5rCSI 1.6%PRS 38.0%
-
CSI 1.5rCSI 3.3%PRS 50.3%
-
CSI 1.6rCSI 1.9%PRS 42.5%
-
CSI 1.6rCSI 1.6%PRS 41.4%
-
CSI 1.6rCSI 7.0%PRS 31.0%
-
CSI 1.6rCSI 1.5%PRS 42.3%
-
CSI 1.6rCSI 2.5%PRS 46.5%
-
CSI 1.6rCSI 2.4%PRS 40.2%
-
CSI 1.6rCSI 7.9%PRS 36.7%
-
CSI 1.6rCSI 2.1%PRS 40.6%
-
CSI 1.6rCSI 4.6%PRS 36.9%
-
CSI 1.6rCSI 1.7%PRS 54.8%
-
CSI 1.7rCSI 5.4%PRS 39.1%
-
CSI 1.7rCSI 4.8%PRS 53.9%
-
CSI 1.7rCSI 2.1%PRS 32.3%
-
CSI 1.7rCSI 5.5%PRS 26.8%
-
CSI 1.7rCSI 3.0%PRS 28.2%
-
CSI 1.8rCSI 3.2%PRS 31.3%
-
CSI 1.8rCSI 2.1%PRS 54.7%
-
CSI 1.8rCSI 1.4%PRS 35.7%
-
CSI 1.8rCSI 1.5%PRS 36.3%
-
CSI 1.8rCSI 2.9%PRS 39.0%
-
CSI 1.8rCSI 10.4%PRS 39.5%
-
CSI 1.8rCSI 2.3%PRS 40.5%
-
CSI 1.8rCSI 25.9%PRS 30.1%
-
CSI 1.9rCSI 29.5%PRS 38.9%
-
CSI 1.9rCSI 5.0%PRS 30.3%
-
CSI 1.9rCSI 3.0%PRS 36.6%
-
CSI 1.9rCSI 9.1%PRS 38.9%
-
CSI 2.0rCSI 2.5%PRS 46.9%
-
CSI 2.0rCSI 8.6%PRS 35.7%
-
CSI 2.1rCSI 9.8%PRS 34.2%
-
CSI 2.1rCSI 1.7%PRS 36.8%
-
CSI 2.1rCSI 4.7%PRS 23.6%
-
CSI 2.1rCSI 2.2%PRS 47.8%
-
CSI 2.2rCSI 17.5%PRS 32.3%
-
CSI 2.2rCSI 6.3%PRS 69.5%
-
CSI 2.2rCSI 18.7%PRS 24.8%
-
CSI 2.2rCSI 5.8%PRS 42.4%
-
CSI 2.2rCSI 1.7%PRS 41.7%
-
CSI 2.2rCSI 3.0%PRS 48.7%
-
CSI 2.3rCSI 46.1%PRS 31.6%
-
CSI 2.3rCSI 4.1%PRS 51.6%
-
CSI 2.3rCSI 3.0%PRS 39.7%
-
CSI 2.3rCSI 5.9%PRS 28.3%
-
CSI 2.3rCSI 6.1%PRS 36.2%
-
CSI 2.3rCSI 2.1%PRS 50.5%
-
CSI 2.3rCSI 3.6%PRS 36.2%
-
CSI 2.4rCSI 2.5%PRS 33.7%
-
CSI 2.4rCSI 2.0%PRS 46.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2442077177
Symbol: GBF1_HUMAN
Name: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9828135
Title: Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24.
PubMed ID: 9828135
PubMed ID: 9039502
Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
PubMed ID: 9039502
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12047556
Title: GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat.
PubMed ID: 12047556
PubMed ID: 12634853
Title: The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor.
PubMed ID: 12634853
PubMed ID: 12808027
Title: ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1.
PubMed ID: 12808027
PubMed ID: 15616190
Title: Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi.
PubMed ID: 15616190
PubMed ID: 15813748
Title: Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1.
PubMed ID: 15813748
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16926190
Title: GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic.
PubMed ID: 16926190
DOI: 10.1242/jcs.03173
PubMed ID: 17005635
Title: Effects of picornavirus 3A Proteins on Protein Transport and GBF1-dependent COP-I recruitment.
PubMed ID: 17005635
DOI: 10.1128/jvi.01225-06
PubMed ID: 17640864
Title: Interactions between conserved domains within homodimers in the BIG1, BIG2, and GBF1 Arf guanine nucleotide exchange factors.
PubMed ID: 17640864
PubMed ID: 17956946
Title: Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking.
PubMed ID: 17956946
DOI: 10.1242/jcs.010769
PubMed ID: 17429068
Title: Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association.
PubMed ID: 17429068
PubMed ID: 17666033
Title: The Arf GEF GBF1 is required for GGA recruitment to Golgi membranes.
PubMed ID: 17666033
PubMed ID: 18063581
Title: AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus.
PubMed ID: 18063581
PubMed ID: 18088087
PubMed ID: 18003980
Title: Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.
PubMed ID: 18003980
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19039328
Title: A COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factor.
PubMed ID: 19039328
PubMed ID: 19461073
Title: Coatomer-dependent protein delivery to lipid droplets.
PubMed ID: 19461073
DOI: 10.1242/jcs.045849
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22185782
Title: GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis.
PubMed ID: 22185782
DOI: 10.1247/csf.11035
PubMed ID: 21789191
Title: Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1.
PubMed ID: 21789191
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22573891
Title: GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kgamma activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production.
PubMed ID: 22573891
PubMed ID: 23386609
Title: The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).
PubMed ID: 23386609
PubMed ID: 23418352
Title: AMPK phosphorylates GBF1 for mitotic Golgi disassembly.
PubMed ID: 23418352
DOI: 10.1242/jcs.121954
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25190516
Title: The small GTPase Arf1 modulates mitochondrial morphology and function.
PubMed ID: 25190516
PubMed ID: 24213530
Title: Arf activation at the Golgi is modulated by feed-forward stimulation of the exchange factor GBF1.
PubMed ID: 24213530
DOI: 10.1242/jcs.130591
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 31519766
Title: BioID performed on Golgi enriched fractions identify C10orf76 as aGBF1 Binding Protein essential for Golgi maintenance and secretion.
PubMed ID: 31519766
PubMed ID: 32937143
Title: De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation.
PubMed ID: 32937143
Sequence Information:
- Length: 1860
- Mass: 206574
- Checksum: E93C245039065E40
- Sequence:
MVDKNIYIIQ GEINIVVGAI KRNARWSTHT PLDEERDPLL HSFGHLKEVL NSITELSEIE PNVFLRPFLE VIRSEDTTGP ITGLALTSVN KFLSYALIDP THEGTAEGME NMADAVTHAR FVGTDPASDE VVLMKILQVL RTLLLTPVGA HLTNESVCEI MQSCFRICFE MRLSELLRKS AEHTLVDMVQ LLFTRLPQFK EEPKNYVGTN MKKLKMRAGG MSDSSKWKKQ KRSPRPPRHM TKVTPGSELP TPNGTTLSSN LTGGMPFIDV PTPISSASSE AASAVVSPST DSGLEFSSQT TSKEDLTDLE QPGSPGYSTA TEPGSSELGV PEQPDLQQEG THVEKSQSAS VESIPEVLEE CTSPADHSDS ASVHDMDYVN PRGVRFTQSS QKEGTALVPY GLPCIRELFR FLISLTNPHD RHNSEVMIHM GLHLLTVALE SAPVAQCQTL LGLIKDEMCR HLFQLLSIER LNLYAASLRV CFLLFESMRE HLKFQMEMYI KKLMEIITVE NPKMPYEMKE MALEAIVQLW RIPSFVTELY INYDCDYYCS NLFEELTKLL SKNAFPVSGQ LYTTHLLSLD ALLTVIDSTE AHCQAKVLNS LTQQEKKETA RPSCEIVDGT REASNTERTA SDGKAVGMAS DIPGLHLPGG GRLPPEHGKS GCSDLEEAVD SGADKKFARK PPRFSCLLPD PRELIEIKNK KKLLITGTEQ FNQKPKKGIQ FLQEKGLLTI PMDNTEVAQW LRENPRLDKK MIGEFVSDRK NIDLLESFVS TFSFQGLRLD EALRLYLEAF RLPGEAPVIQ RLLEAFTERW MNCNGSPFAN SDACFSLAYA VIMLNTDQHN HNVRKQNAPM TLEEFRKNLK GVNGGKDFEQ DILEDMYHAI KNEEIVMPEE QTGLVRENYV WNVLLHRGAT PEGIFLRVPT ASYDLDLFTM TWGPTIAALS YVFDKSLEET IIQKAISGFR KCAMISAHYG LSDVFDNLII SLCKFTALSS ESIENLPSVF GSNPKAHIAA KTVFHLAHRH GDILREGWKN IMEAMLQLFR AQLLPKAMIE VEDFVDPNGK ISLQREETPS NRGESTVLSF VSWLTLSGPE QSSVRGPSTE NQEAKRVALE CIKQCDPEKM ITESKFLQLE SLQELMKALV SVTPDEETYD EEDAAFCLEM LLRIVLENRD RVGCVWQTVR DHLYHLCVQA QDFCFLVERA VVGLLRLAIR LLRREEISAQ VLLSLRILLL MKPSVLSRVS HQVAYGLHEL LKTNAANIHS GDDWATLFTL LECIGSGVKP PAALQATARA DAPDAGAQSD SELPSYHQND VSLDRGYTSD SEVYTDHGRP GKIHRSATDA DVVNSGWLVV GKDDVDNSKP GPSRPGPSPL INQYSLTVGL DLGPHDTKSL LKCVESLSFI VRDAAHITPD NFELCVKTLR IFVEASLNGG CKSQEKRGKS HKYDSKGNRF KKKSKEGSML RRPRTSSQHA SRGGQSDDDE DEGVPASYHT VSLQVSQDLL DLMHTLHTRA ASIYSSWAEE QRHLETGGQK IEADSRTLWA HCWCPLLQGI ACLCCDARRQ VRMQALTYLQ RALLVHDLQK LDALEWESCF NKVLFPLLTK LLENISPADV GGMEETRMRA STLLSKVFLQ HLSPLLSLST FAALWLTILD FMDKYMHAGS SDLLSEAIPE SLKNMLLVMD TAEIFHSADA RGGGPSALWE ITWERIDCFL PHLRDELFKQ TVIQDPMPME PQGQKPLASA HLTSAAGDTR TPGHPPPPEI PSELGACDFE KPESPRAASS SSPGSPVASS PSRLSPTPDG PPPLAQPPLI LQPLASPLQV GVPPMTLPII LNPALIEATS PVPLLATPRP TDPIPTSEVN