Details for: GBF1

Gene ID: 8729

Symbol: GBF1

Ensembl ID: ENSG00000107862

Description: golgi brefeldin A resistant guanine nucleotide exchange factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 303.3201
    Cell Significance Index: -47.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.3747
    Cell Significance Index: -47.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.1467
    Cell Significance Index: -49.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 98.2998
    Cell Significance Index: -39.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 91.0602
    Cell Significance Index: -46.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.8071
    Cell Significance Index: -39.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.2228
    Cell Significance Index: -48.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.1155
    Cell Significance Index: -45.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.6027
    Cell Significance Index: -41.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.8530
    Cell Significance Index: -28.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.3288
    Cell Significance Index: -48.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.1784
    Cell Significance Index: 81.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.9520
    Cell Significance Index: 226.5400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.1416
    Cell Significance Index: 35.2900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.1226
    Cell Significance Index: 51.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1020
    Cell Significance Index: 421.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0775
    Cell Significance Index: 412.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.8654
    Cell Significance Index: 46.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4603
    Cell Significance Index: 40.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4423
    Cell Significance Index: 517.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4260
    Cell Significance Index: 80.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3552
    Cell Significance Index: 220.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2937
    Cell Significance Index: 25.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2586
    Cell Significance Index: 1136.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1829
    Cell Significance Index: 818.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1600
    Cell Significance Index: 24.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0430
    Cell Significance Index: 14.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7704
    Cell Significance Index: 34.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6932
    Cell Significance Index: 30.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6929
    Cell Significance Index: 19.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6459
    Cell Significance Index: 39.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5754
    Cell Significance Index: 21.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5417
    Cell Significance Index: 14.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5397
    Cell Significance Index: 32.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5376
    Cell Significance Index: 36.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4975
    Cell Significance Index: 676.5100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4714
    Cell Significance Index: 6.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4240
    Cell Significance Index: 652.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4221
    Cell Significance Index: 76.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3568
    Cell Significance Index: 657.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3286
    Cell Significance Index: 40.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3189
    Cell Significance Index: 9.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2677
    Cell Significance Index: 6.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2665
    Cell Significance Index: 18.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2331
    Cell Significance Index: 5.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2283
    Cell Significance Index: 22.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1879
    Cell Significance Index: 85.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1725
    Cell Significance Index: 94.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1669
    Cell Significance Index: 106.0100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1649
    Cell Significance Index: 2.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1606
    Cell Significance Index: 302.3800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.1363
    Cell Significance Index: 2.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1251
    Cell Significance Index: 2.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1175
    Cell Significance Index: 5.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1097
    Cell Significance Index: 6.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1039
    Cell Significance Index: 1.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0965
    Cell Significance Index: 42.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0832
    Cell Significance Index: 15.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0163
    Cell Significance Index: 2.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0104
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0184
    Cell Significance Index: -11.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0196
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0236
    Cell Significance Index: -17.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0431
    Cell Significance Index: -31.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0473
    Cell Significance Index: -8.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0532
    Cell Significance Index: -40.2600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0536
    Cell Significance Index: -0.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0536
    Cell Significance Index: -30.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0686
    Cell Significance Index: -2.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0718
    Cell Significance Index: -8.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0816
    Cell Significance Index: -4.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1145
    Cell Significance Index: -5.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1418
    Cell Significance Index: -29.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1468
    Cell Significance Index: -42.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1497
    Cell Significance Index: -21.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1555
    Cell Significance Index: -19.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2111
    Cell Significance Index: -21.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2399
    Cell Significance Index: -12.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2452
    Cell Significance Index: -28.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2675
    Cell Significance Index: -34.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3195
    Cell Significance Index: -36.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3578
    Cell Significance Index: -37.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4029
    Cell Significance Index: -8.5800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.4058
    Cell Significance Index: -5.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4102
    Cell Significance Index: -4.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4262
    Cell Significance Index: -27.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4306
    Cell Significance Index: -32.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4400
    Cell Significance Index: -50.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4421
    Cell Significance Index: -31.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4932
    Cell Significance Index: -7.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5413
    Cell Significance Index: -42.8700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.5432
    Cell Significance Index: -5.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6080
    Cell Significance Index: -31.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6428
    Cell Significance Index: -39.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6646
    Cell Significance Index: -6.1200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7017
    Cell Significance Index: -8.7500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.8424
    Cell Significance Index: -8.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8902
    Cell Significance Index: -29.1500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9017
    Cell Significance Index: -11.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GBF1 is a guanine nucleotide exchange factor (GEF) that is resistant to the inhibitory effects of brefeldin A (BFA), a Golgi apparatus inhibitor. This characteristic allows GBF1 to maintain its activity and facilitate the proper functioning of the Golgi apparatus. GBF1 is highly expressed in various cell types, including immune cells, and is involved in the regulation of several cellular processes, including: 1. Cargo trafficking: GBF1 regulates the transport of proteins and lipids between the endoplasmic reticulum (ER) and the Golgi apparatus. 2. Protein modification: GBF1 is involved in the regulation of post-translational protein modification, including glycosylation and phosphorylation. 3. Vesicle-mediated transport: GBF1 regulates the formation and transport of vesicles between the ER and the Golgi apparatus. **Pathways and Functions:** GBF1 is involved in several cellular pathways, including: 1. Asparagine n-linked glycosylation: GBF1 regulates the transport of glycosylated proteins from the ER to the Golgi apparatus. 2. Cargo trafficking to the periciliary membrane: GBF1 is involved in the transport of proteins and lipids to the periciliary membrane, where they play a crucial role in the regulation of ciliary function. 3. Cell activation involved in immune response: GBF1 regulates the activation of immune cells, including neutrophils, and is involved in the regulation of reactive oxygen species biosynthesis. 4. Cilium assembly: GBF1 is involved in the assembly and maintenance of cilia, which are essential for sensory perception and immune function. **Clinical Significance:** Altered GBF1 expression and function have been implicated in various diseases, including: 1. Cancer: GBF1 is overexpressed in several types of cancer, including lung, breast, and colon cancer, where it promotes tumor growth and metastasis. 2. Neurodegenerative disorders: GBF1 is involved in the regulation of protein aggregation and clearance in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. Immune-related disorders: GBF1 is involved in the regulation of immune responses, including neutrophil chemotaxis and reactive oxygen species biosynthesis, where altered GBF1 expression and function have been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, GBF1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell activation, cargo trafficking, and protein modification. Its altered expression and function have been implicated in various diseases, highlighting the importance of GBF1 in maintaining normal cellular function and preventing disease.

Genular Protein ID: 2442077177

Symbol: GBF1_HUMAN

Name: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

UniProtKB Accession Codes:

Q92538 A0A7P0RGV0 Q149P0 Q149P1 Q5VXX3 Q96CK6 Q96HZ3 Q9H473

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 5 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9828135

Title: Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24.

PubMed ID: 9828135

DOI: 10.1006/geno.1998.5563

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12047556

Title: GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat.

PubMed ID: 12047556

DOI: 10.1034/j.1600-0854.2002.30705.x

PubMed ID: 12634853

Title: The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor.

PubMed ID: 12634853

DOI: 10.1038/sj.embor.embor762

PubMed ID: 12808027

Title: ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1.

PubMed ID: 12808027

DOI: 10.1091/mbc.e02-11-0730

PubMed ID: 15616190

Title: Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi.

PubMed ID: 15616190

DOI: 10.1091/mbc.e04-07-0599

PubMed ID: 15813748

Title: Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1.

PubMed ID: 15813748

DOI: 10.1111/j.1600-0854.2005.00282.x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16926190

Title: GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic.

PubMed ID: 16926190

DOI: 10.1242/jcs.03173

PubMed ID: 17005635

Title: Effects of picornavirus 3A Proteins on Protein Transport and GBF1-dependent COP-I recruitment.

PubMed ID: 17005635

DOI: 10.1128/jvi.01225-06

PubMed ID: 17640864

Title: Interactions between conserved domains within homodimers in the BIG1, BIG2, and GBF1 Arf guanine nucleotide exchange factors.

PubMed ID: 17640864

DOI: 10.1074/jbc.m705525200

PubMed ID: 17956946

Title: Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking.

PubMed ID: 17956946

DOI: 10.1242/jcs.010769

PubMed ID: 17429068

Title: Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association.

PubMed ID: 17429068

DOI: 10.1091/mbc.e06-11-1005

PubMed ID: 17666033

Title: The Arf GEF GBF1 is required for GGA recruitment to Golgi membranes.

PubMed ID: 17666033

DOI: 10.1111/j.1600-0854.2007.00623.x

PubMed ID: 18063581

Title: AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus.

PubMed ID: 18063581

DOI: 10.1074/jbc.m708296200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18003980

Title: Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.

PubMed ID: 18003980

DOI: 10.1091/mbc.e07-04-0394

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19039328

Title: A COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factor.

PubMed ID: 19039328

DOI: 10.1038/embor.2008.221

PubMed ID: 19461073

Title: Coatomer-dependent protein delivery to lipid droplets.

PubMed ID: 19461073

DOI: 10.1242/jcs.045849

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22185782

Title: GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis.

PubMed ID: 22185782

DOI: 10.1247/csf.11035

PubMed ID: 21789191

Title: Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1.

PubMed ID: 21789191

DOI: 10.1371/journal.pone.0021889

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22573891

Title: GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kgamma activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production.

PubMed ID: 22573891

DOI: 10.1091/mbc.e12-01-0062

PubMed ID: 23386609

Title: The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).

PubMed ID: 23386609

DOI: 10.1074/jbc.m112.438481

PubMed ID: 23418352

Title: AMPK phosphorylates GBF1 for mitotic Golgi disassembly.

PubMed ID: 23418352

DOI: 10.1242/jcs.121954

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25190516

Title: The small GTPase Arf1 modulates mitochondrial morphology and function.

PubMed ID: 25190516

DOI: 10.15252/embj.201489039

PubMed ID: 24213530

Title: Arf activation at the Golgi is modulated by feed-forward stimulation of the exchange factor GBF1.

PubMed ID: 24213530

DOI: 10.1242/jcs.130591

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31519766

Title: BioID performed on Golgi enriched fractions identify C10orf76 as aGBF1 Binding Protein essential for Golgi maintenance and secretion.

PubMed ID: 31519766

DOI: 10.1074/mcp.ra119.001645

PubMed ID: 32937143

Title: De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation.

PubMed ID: 32937143

DOI: 10.1016/j.ajhg.2020.08.018

Sequence Information:

  • Length: 1860
  • Mass: 206574
  • Checksum: E93C245039065E40
  • Sequence:
    • MVDKNIYIIQ GEINIVVGAI KRNARWSTHT PLDEERDPLL HSFGHLKEVL NSITELSEIE 
PNVFLRPFLE VIRSEDTTGP ITGLALTSVN KFLSYALIDP THEGTAEGME NMADAVTHAR 
FVGTDPASDE VVLMKILQVL RTLLLTPVGA HLTNESVCEI MQSCFRICFE MRLSELLRKS 
AEHTLVDMVQ LLFTRLPQFK EEPKNYVGTN MKKLKMRAGG MSDSSKWKKQ KRSPRPPRHM 
TKVTPGSELP TPNGTTLSSN LTGGMPFIDV PTPISSASSE AASAVVSPST DSGLEFSSQT 
TSKEDLTDLE QPGSPGYSTA TEPGSSELGV PEQPDLQQEG THVEKSQSAS VESIPEVLEE 
CTSPADHSDS ASVHDMDYVN PRGVRFTQSS QKEGTALVPY GLPCIRELFR FLISLTNPHD 
RHNSEVMIHM GLHLLTVALE SAPVAQCQTL LGLIKDEMCR HLFQLLSIER LNLYAASLRV 
CFLLFESMRE HLKFQMEMYI KKLMEIITVE NPKMPYEMKE MALEAIVQLW RIPSFVTELY 
INYDCDYYCS NLFEELTKLL SKNAFPVSGQ LYTTHLLSLD ALLTVIDSTE AHCQAKVLNS 
LTQQEKKETA RPSCEIVDGT REASNTERTA SDGKAVGMAS DIPGLHLPGG GRLPPEHGKS 
GCSDLEEAVD SGADKKFARK PPRFSCLLPD PRELIEIKNK KKLLITGTEQ FNQKPKKGIQ 
FLQEKGLLTI PMDNTEVAQW LRENPRLDKK MIGEFVSDRK NIDLLESFVS TFSFQGLRLD 
EALRLYLEAF RLPGEAPVIQ RLLEAFTERW MNCNGSPFAN SDACFSLAYA VIMLNTDQHN 
HNVRKQNAPM TLEEFRKNLK GVNGGKDFEQ DILEDMYHAI KNEEIVMPEE QTGLVRENYV 
WNVLLHRGAT PEGIFLRVPT ASYDLDLFTM TWGPTIAALS YVFDKSLEET IIQKAISGFR 
KCAMISAHYG LSDVFDNLII SLCKFTALSS ESIENLPSVF GSNPKAHIAA KTVFHLAHRH 
GDILREGWKN IMEAMLQLFR AQLLPKAMIE VEDFVDPNGK ISLQREETPS NRGESTVLSF 
VSWLTLSGPE QSSVRGPSTE NQEAKRVALE CIKQCDPEKM ITESKFLQLE SLQELMKALV 
SVTPDEETYD EEDAAFCLEM LLRIVLENRD RVGCVWQTVR DHLYHLCVQA QDFCFLVERA 
VVGLLRLAIR LLRREEISAQ VLLSLRILLL MKPSVLSRVS HQVAYGLHEL LKTNAANIHS 
GDDWATLFTL LECIGSGVKP PAALQATARA DAPDAGAQSD SELPSYHQND VSLDRGYTSD 
SEVYTDHGRP GKIHRSATDA DVVNSGWLVV GKDDVDNSKP GPSRPGPSPL INQYSLTVGL 
DLGPHDTKSL LKCVESLSFI VRDAAHITPD NFELCVKTLR IFVEASLNGG CKSQEKRGKS 
HKYDSKGNRF KKKSKEGSML RRPRTSSQHA SRGGQSDDDE DEGVPASYHT VSLQVSQDLL 
DLMHTLHTRA ASIYSSWAEE QRHLETGGQK IEADSRTLWA HCWCPLLQGI ACLCCDARRQ 
VRMQALTYLQ RALLVHDLQK LDALEWESCF NKVLFPLLTK LLENISPADV GGMEETRMRA 
STLLSKVFLQ HLSPLLSLST FAALWLTILD FMDKYMHAGS SDLLSEAIPE SLKNMLLVMD 
TAEIFHSADA RGGGPSALWE ITWERIDCFL PHLRDELFKQ TVIQDPMPME PQGQKPLASA 
HLTSAAGDTR TPGHPPPPEI PSELGACDFE KPESPRAASS SSPGSPVASS PSRLSPTPDG 
PPPLAQPPLI LQPLASPLQV GVPPMTLPII LNPALIEATS PVPLLATPRP TDPIPTSEVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.