Details for: TNFSF10

Gene ID: 8743

Symbol: TNFSF10

Ensembl ID: ENSG00000121858

Description: TNF superfamily member 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 227.0079
    Cell Significance Index: -35.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.7922
    Cell Significance Index: -32.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.8322
    Cell Significance Index: -35.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.0695
    Cell Significance Index: -29.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.4506
    Cell Significance Index: -35.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 52.5914
    Cell Significance Index: -35.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.9618
    Cell Significance Index: -31.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.8129
    Cell Significance Index: -35.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.5222
    Cell Significance Index: -35.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3444
    Cell Significance Index: -30.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 10.1168
    Cell Significance Index: 526.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9469
    Cell Significance Index: -35.3100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.4314
    Cell Significance Index: 39.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.2912
    Cell Significance Index: 60.8300
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 3.1742
    Cell Significance Index: 11.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.1601
    Cell Significance Index: 35.9000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.6938
    Cell Significance Index: 16.6200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.2367
    Cell Significance Index: 39.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1088
    Cell Significance Index: 99.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9446
    Cell Significance Index: 90.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9356
    Cell Significance Index: 100.5500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.6404
    Cell Significance Index: 10.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.5396
    Cell Significance Index: 23.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1738
    Cell Significance Index: 31.9500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0691
    Cell Significance Index: 16.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9983
    Cell Significance Index: 441.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8817
    Cell Significance Index: 62.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8246
    Cell Significance Index: 19.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8111
    Cell Significance Index: 60.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8015
    Cell Significance Index: 23.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7164
    Cell Significance Index: 20.0200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7157
    Cell Significance Index: 6.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6977
    Cell Significance Index: 17.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5836
    Cell Significance Index: 63.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.5247
    Cell Significance Index: 60.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5090
    Cell Significance Index: 65.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5025
    Cell Significance Index: 90.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4189
    Cell Significance Index: 12.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3982
    Cell Significance Index: 359.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3552
    Cell Significance Index: 43.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3023
    Cell Significance Index: 13.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2752
    Cell Significance Index: 37.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2680
    Cell Significance Index: 146.3700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2433
    Cell Significance Index: 2.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2323
    Cell Significance Index: 22.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2103
    Cell Significance Index: 41.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2035
    Cell Significance Index: 38.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1098
    Cell Significance Index: 18.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1081
    Cell Significance Index: 2.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0410
    Cell Significance Index: 4.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0275
    Cell Significance Index: 0.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0159
    Cell Significance Index: 11.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0115
    Cell Significance Index: 8.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0042
    Cell Significance Index: 0.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0050
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0104
    Cell Significance Index: -7.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0142
    Cell Significance Index: -0.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0179
    Cell Significance Index: -33.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0214
    Cell Significance Index: -2.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0233
    Cell Significance Index: -42.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0248
    Cell Significance Index: -15.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0278
    Cell Significance Index: -42.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0317
    Cell Significance Index: -20.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0318
    Cell Significance Index: -43.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0329
    Cell Significance Index: -18.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0506
    Cell Significance Index: -5.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0778
    Cell Significance Index: -35.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0999
    Cell Significance Index: -35.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1004
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1079
    Cell Significance Index: -22.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1101
    Cell Significance Index: -12.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1185
    Cell Significance Index: -34.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1254
    Cell Significance Index: -2.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1802
    Cell Significance Index: -36.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1936
    Cell Significance Index: -24.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2168
    Cell Significance Index: -31.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2305
    Cell Significance Index: -6.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2427
    Cell Significance Index: -2.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2951
    Cell Significance Index: -7.5400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3144
    Cell Significance Index: -3.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3439
    Cell Significance Index: -35.8100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3487
    Cell Significance Index: -4.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3530
    Cell Significance Index: -22.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3542
    Cell Significance Index: -28.0500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4227
    Cell Significance Index: -7.1100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.4376
    Cell Significance Index: -3.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4454
    Cell Significance Index: -34.1800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4509
    Cell Significance Index: -7.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4808
    Cell Significance Index: -12.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5489
    Cell Significance Index: -36.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5756
    Cell Significance Index: -35.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6003
    Cell Significance Index: -37.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6015
    Cell Significance Index: -36.9700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.6153
    Cell Significance Index: -8.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6318
    Cell Significance Index: -18.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6913
    Cell Significance Index: -38.7900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.7139
    Cell Significance Index: -4.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7626
    Cell Significance Index: -40.0400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.7707
    Cell Significance Index: -7.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNFSF10 is a small, secreted protein that belongs to the TNF ligand superfamily. It is a member of the TNF-alpha family, which is characterized by its ability to induce apoptosis in sensitive cells. The protein is highly conserved across species and has a high degree of sequence similarity to other TNF ligands. TNFSF10 is primarily expressed in cells of the immune system, including endothelial cells, monocytes, and goblet cells, and is also found in other tissues, such as the lung and prostate. **Pathways and Functions** TNFSF10 plays a crucial role in regulating immune responses and cell death through its interaction with the death receptor, TNFR1. Upon binding to TNFR1, TNFSF10 activates caspase-8, which in turn activates downstream caspases, leading to apoptosis. TNFSF10 also regulates the activity of other signaling pathways, including the NF-kappaB pathway, which is involved in inflammation and immune responses. Additionally, TNFSF10 has been shown to regulate the activity of other proteins, including c-flip and RIPK1, which are involved in necroptotic cell death. TNFSF10 has been implicated in various physiological and pathological processes, including: * Immune response: TNFSF10 plays a crucial role in regulating immune responses, including the activation of T cells and the production of cytokines. * Cell death: TNFSF10 induces apoptosis in sensitive cells, which is essential for maintaining tissue homeostasis and preventing cancer. * Inflammation: TNFSF10 regulates the activity of other signaling pathways, including the NF-kappaB pathway, which is involved in inflammation and immune responses. * Development: TNFSF10 is involved in the development of male gonads and the regulation of cell proliferation and differentiation. **Clinical Significance** TNFSF10 has been implicated in various diseases and disorders, including: * Cancer: TNFSF10 is overexpressed in certain types of cancer, including lung and prostate cancer, and has been shown to promote tumor growth and survival. * Autoimmune diseases: TNFSF10 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it regulates the activity of immune cells and promotes inflammation. * Inflammatory disorders: TNFSF10 is involved in inflammatory disorders, such as asthma and chronic obstructive pulmonary disease (COPD), where it regulates the activity of immune cells and promotes inflammation. * Infectious diseases: TNFSF10 has been implicated in infectious diseases, such as HIV and tuberculosis, where it regulates the activity of immune cells and promotes inflammation. Overall, TNFSF10 is a critical regulator of immune responses and cell death, and its dysregulation has been implicated in various diseases and disorders. Further research is needed to fully understand the role of TNFSF10 in human disease and to develop therapeutic strategies to modulate its activity.

Genular Protein ID: 2994719115

Symbol: TNF10_HUMAN

Name: Tumor necrosis factor ligand superfamily member 10

UniProtKB Accession Codes:

P50591 A1Y9B3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8777713

Title: Identification and characterization of a new member of the TNF family that induces apoptosis.

PubMed ID: 8777713

DOI: 10.1016/1074-7613(95)90057-8

PubMed ID: 8663110

Title: Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.

PubMed ID: 8663110

DOI: 10.1074/jbc.271.22.12687

PubMed ID: 21859711

Title: Isolation of a TRAIL antagonist from the serum of HIV-infected patients.

PubMed ID: 21859711

DOI: 10.1074/jbc.m111.274639

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14609566

Title: Regulation of soluble and surface-bound TRAIL in human T cells, B cells, and monocytes.

PubMed ID: 14609566

DOI: 10.1016/s1043-4666(03)00094-2

PubMed ID: 25171405

Title: A secreted tyrosine kinase acts in the extracellular environment.

PubMed ID: 25171405

DOI: 10.1016/j.cell.2014.06.048

PubMed ID: 10549288

Title: Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.

PubMed ID: 10549288

DOI: 10.1016/s1097-2765(00)80207-5

PubMed ID: 10542098

Title: Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.

PubMed ID: 10542098

DOI: 10.1038/14935

PubMed ID: 10485660

Title: 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.

PubMed ID: 10485660

DOI: 10.1016/s1074-7613(00)80100-4

PubMed ID: 26457518

Title: The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.

PubMed ID: 26457518

DOI: 10.1107/s2053230x15016416

Sequence Information:

  • Length: 281
  • Mass: 32509
  • Checksum: DDAAAF78DAAB2F6D
  • Sequence:
    • MAMMEVQGGP SLGQTCVLIV IFTVLLQSLC VAVTYVYFTN ELKQMQDKYS KSGIACFLKE 
DDSYWDPNDE ESMNSPCWQV KWQLRQLVRK MILRTSEETI STVQEKQQNI SPLVRERGPQ 
RVAAHITGTR GRSNTLSSPN SKNEKALGRK INSWESSRSG HSFLSNLHLR NGELVIHEKG 
FYYIYSQTYF RFQEEIKENT KNDKQMVQYI YKYTSYPDPI LLMKSARNSC WSKDAEYGLY 
SIYQGGIFEL KENDRIFVSV TNEHLIDMDH EASFFGAFLV G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.