TNFSF10 | ENSG00000121858 | NCBI 8743

Details for: TNFSF10

Gene ID: 8743

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TNFSF10

Ensembl ID: ENSG00000121858

Description: TNF superfamily member 10

Cell Significance Landscape

Display Count:

Associated with

Apoptosis
(R-HSA-109581)
Casp8 activity is inhibited
(R-HSA-5218900)
Caspase activation via death receptors in the presence of ligand
(R-HSA-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-HSA-5357769)
Death receptor signaling
(R-HSA-73887)
Dimerization of procaspase-8
(R-HSA-69416)
Programmed cell death
(R-HSA-5357801)
Regulated necrosis
(R-HSA-5218859)
Regulation by c-flip
(R-HSA-3371378)
Regulation of necroptotic cell death
(R-HSA-5675482)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Trail signaling
(R-HSA-75158)
Apoptotic process
(GO:0006915)
Cell-cell signaling
(GO:0007267)
Cell surface receptor signaling pathway
(GO:0007166)
Cytokine activity
(GO:0005125)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Male gonad development
(GO:0008584)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of extrinsic apoptotic signaling pathway
(GO:2001238)
Positive regulation of release of cytochrome c from mitochondria
(GO:0090200)
Protein binding
(GO:0005515)
Response to insulin
(GO:0032868)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Trail-activated apoptotic signaling pathway
(GO:0036462)
Trail binding
(GO:0045569)
Tumor necrosis factor receptor binding
(GO:0005164)
Zinc ion binding
(GO:0008270)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD14-low, CD16-positive monocyte CL0002396

CSI 78.3

rCSI 60.32%

PRS 16.11
extravillous trophoblast CL0008036

CSI 65.16

rCSI 80.6%

PRS 15.3
fallopian tube secretory epithelial cell CL4030006

CSI 61.82

rCSI 59.51%

PRS 18.09
nasal mucosa goblet cell CL0002480

CSI 58.4

rCSI 67.72%

PRS 25.53
pulmonary artery endothelial cell CL1001568

CSI 52.8

rCSI 71.84%

PRS 26.34
tracheal goblet cell CL1000329

CSI 38.66

rCSI 84.39%

PRS 34.29
pulmonary capillary endothelial cell CL4028001

CSI 36.51

rCSI 69.62%

PRS 27.68
epithelial cell of lower respiratory tract CL0002632

CSI 33.78

rCSI 26.19%

PRS 16.7
intestinal epithelial cell CL0002563

CSI 31.91

rCSI 33.36%

PRS 18.26
club cell CL0000158

CSI 31.1

rCSI 45.55%

PRS 20.2
pancreatic ductal cell CL0002079

CSI 30.85

rCSI 60%

PRS 17.85
pancreatic acinar cell CL0002064

CSI 26.87

rCSI 35.72%

PRS 19.11
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 24.78

rCSI 35.12%

PRS 16.2
multi-ciliated epithelial cell CL0005012

CSI 23.7

rCSI 23.65%

PRS 14.92
luminal epithelial cell of mammary gland CL0002326

CSI 23.22

rCSI 42.18%

PRS 26.61
bronchial goblet cell CL1000312

CSI 19.26

rCSI 76.97%

PRS 37.04
keratinocyte CL0000312

CSI 18.25

rCSI 15.3%

PRS 20.84
enterocyte CL0000584

CSI 17.37

rCSI 28.01%

PRS 27.24
glandular epithelial cell CL0000150

CSI 16.42

rCSI 43.23%

PRS 33.84
colon epithelial cell CL0011108

CSI 15.43

rCSI 16.16%

PRS 16.28
granulocyte CL0000094

CSI 14.74

rCSI 22.52%

PRS 22.44
mammary gland epithelial cell CL0002327

CSI 14.33

rCSI 50.29%

PRS 30.81
vein endothelial cell of respiratory system CL4033008

CSI 13.36

rCSI 91.74%

PRS 33.73
epithelial cell of proximal tubule CL0002306

CSI 13.21

rCSI 32.26%

PRS 17.22
cerebral cortex endothelial cell CL1001602

CSI 13.08

rCSI 22.63%

PRS 13.3
epithelial cell of lung CL0000082

CSI 12.87

rCSI 10.67%

PRS 16.51
duct epithelial cell CL0000068

CSI 12.41

rCSI 18.16%

PRS 18.46
respiratory basal cell CL0002633

CSI 12.06

rCSI 12.49%

PRS 20.53
endothelial cell of artery CL1000413

CSI 11.71

rCSI 17.16%

PRS 66.12
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 11.04

rCSI 66.78%

PRS 38.64
respiratory suprabasal cell CL4033048

CSI 10.01

rCSI 12.84%

PRS 20.16
colonocyte CL1000347

CSI 9.56

rCSI 13.7%

PRS 23.84
endothelial cell of uterus CL0009095

CSI 9.48

rCSI 69.34%

PRS 45.69
basal cell of epithelium of trachea CL1000348

CSI 9.27

rCSI 65.44%

PRS 49.37
mucous neck cell CL0000651

CSI 8.45

rCSI 12.17%

PRS 27.71
myoepithelial cell CL0000185

CSI 8.39

rCSI 21.23%

PRS 21.58
capillary endothelial cell CL0002144

CSI 8.16

rCSI 14.96%

PRS 57.14
group 2 innate lymphoid cell CL0001069

CSI 8.14

rCSI 44.04%

PRS 55.22
respiratory hillock cell CL4030023

CSI 8

rCSI 14.26%

PRS 29.27
respiratory goblet cell CL0002370

CSI 7.71

rCSI 83.92%

PRS 33.19
M cell of gut CL0000682

CSI 7.62

rCSI 8.1%

PRS 30.24
endothelial cell of venule CL1000414

CSI 7.6

rCSI 67.41%

PRS 58.56
retinal blood vessel endothelial cell CL0002585

CSI 7.32

rCSI 11.69%

PRS 19.12
vein endothelial cell CL0002543

CSI 6.38

rCSI 17.41%

PRS 59.13
endothelial cell of placenta CL0009092

CSI 5.51

rCSI 27.18%

PRS 23.64
lung microvascular endothelial cell CL2000016

CSI 5.21

rCSI 100%

PRS 49.97
interstitial cell of Cajal CL0002088

CSI 5.13

rCSI 6.53%

PRS 20.31
non-classical monocyte CL0000875

CSI 5.03

rCSI 8.07%

PRS 49.42
tracheobronchial serous cell CL0019001

CSI 5

rCSI 21.6%

PRS 32.41
secretory cell CL0000151

CSI 4.89

rCSI 5.1%

PRS 17.88
acinar cell CL0000622

CSI 4.78

rCSI 7.01%

PRS 22.89
vasa recta descending limb cell CL1001285

CSI 4.76

rCSI 38%

PRS 60.7
tracheobronchial goblet cell CL0019003

CSI 4.6

rCSI 73.87%

PRS 81.03
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 4.42

rCSI 11.43%

PRS 16.26
conjunctival epithelial cell CL1000432

CSI 4.37

rCSI 6.68%

PRS 17.56
P/D1 enteroendocrine cell CL0002268

CSI 4.27

rCSI 23.27%

PRS 41.41
BEST4+ enteroycte CL4030026

CSI 4.24

rCSI 5.27%

PRS 18.5
professional antigen presenting cell CL0000145

CSI 4.22

rCSI 14.53%

PRS 57
foveolar cell of stomach CL0002179

CSI 4.06

rCSI 8.65%

PRS 27.81
CD14-positive, CD16-positive monocyte CL0002397

CSI 3.96

rCSI 5.19%

PRS 24.8
acinar cell of salivary gland CL0002623

CSI 3.32

rCSI 77.33%

PRS 32.36
goblet cell CL0000160

CSI 3.28

rCSI 3.1%

PRS 18.27
group 3 innate lymphoid cell CL0001071

CSI 3.22

rCSI 2.42%

PRS 18.44
mucus secreting cell CL0000319

CSI 3.19

rCSI 5.07%

PRS 22.5
blood vessel endothelial cell CL0000071

CSI 3.07

rCSI 6.36%

PRS 17.39
bronchus fibroblast of lung CL2000093

CSI 3.01

rCSI 2.45%

PRS 18.45
mature NK T cell CL0000814

CSI 2.91

rCSI 3.73%

PRS 61.34
pulmonary ionocyte CL0017000

CSI 2.81

rCSI 3.42%

PRS 21.99
endothelial cell of arteriole CL1000412

CSI 2.73

rCSI 15.13%

PRS 46.71
skin fibroblast CL0002620

CSI 2.69

rCSI 2.32%

PRS 27.55
common myeloid progenitor CL0000049

CSI 2.66

rCSI 2.15%

PRS 17.48
fibroblast of breast CL4006000

CSI 2.6

rCSI 10.91%

PRS 42.83
endothelial cell of vascular tree CL0002139

CSI 2.56

rCSI 13.97%

PRS 28.04
squamous epithelial cell CL0000076

CSI 2.4

rCSI 5.7%

PRS 21.63
glial cell CL0000125

CSI 2.38

rCSI 9.05%

PRS 17.14
naive T cell CL0000898

CSI 2.37

rCSI 1.65%

PRS 24.84
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 2.28

rCSI 4.56%

PRS 29.41
monocyte CL0000576

CSI 2.25

rCSI 4.07%

PRS 44.94
basal cell CL0000646

CSI 2.18

rCSI 2.92%

PRS 19.11
cardiac endothelial cell CL0010008

CSI 2.15

rCSI 8.67%

PRS 15.63
CD14-positive monocyte CL0001054

CSI 2.12

rCSI 2.64%

PRS 24.75
renal alpha-intercalated cell CL0005011

CSI 2.07

rCSI 2.77%

PRS 22.97
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.04

rCSI 1.55%

PRS 23.04
intestine goblet cell CL0019031

CSI 1.98

rCSI 1.76%

PRS 17.53
plasmacytoid dendritic cell, human CL0001058

CSI 1.98

rCSI 1.38%

PRS 18.55
unswitched memory B cell CL0000970

CSI 1.96

rCSI 1.65%

PRS 27.94
ciliated epithelial cell CL0000067

CSI 1.81

rCSI 1.59%

PRS 12.68
intestinal crypt stem cell of small intestine CL0009017

CSI 1.71

rCSI 4.6%

PRS 22.57
alternatively activated macrophage CL0000890

CSI 1.66

rCSI 2.09%

PRS 26.89
lung secretory cell CL1000272

CSI 1.66

rCSI 4.11%

PRS 16.11
hair follicular keratinocyte CL2000092

CSI 1.62

rCSI 28.25%

PRS 61.05
mast cell CL0000097

CSI 1.59

rCSI 3.44%

PRS 62.83
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 1.59

rCSI 0.94%

PRS 24.27
colon goblet cell CL0009039

CSI 1.58

rCSI 3.76%

PRS 26.15
ciliated cell CL0000064

CSI 1.57

rCSI 2.55%

PRS 17.7
alpha-beta T cell CL0000789

CSI 1.54

rCSI 1.81%

PRS 23.57
T-helper 17 cell CL0000899

CSI 1.52

rCSI 1.21%

PRS 30.98
hematopoietic stem cell CL0000037

CSI 1.49

rCSI 0.99%

PRS 21.06
transit amplifying cell of colon CL0009011

CSI 1.43

rCSI 1.67%

PRS 20.39
plasmablast CL0000980

CSI 1.41

rCSI 1.11%

PRS 21.09

CD4-positive, alpha-beta thymocyte CL0000810

CSI -6.8

rCSI -5.5%

PRS 31.3%
megakaryocyte-erythroid progenitor cell CL0000050

CSI -4.6

rCSI -4.1%

PRS 15.7%
effector CD4-positive, alpha-beta T cell CL0001044

CSI -3.3

rCSI -9.4%

PRS 25.8%
lung macrophage CL1001603

CSI -2.9

rCSI -6.4%

PRS 20.2%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI -2.6

rCSI -1.7%

PRS 21.2%
basal cell of epidermis CL0002187

CSI -2.1

rCSI -3.7%

PRS 15.1%
CD4-positive, alpha-beta memory T cell CL0000897

CSI -1.7

rCSI -1.2%

PRS 23.9%
myeloid leukocyte CL0000766

CSI -0.6

rCSI -0.6%

PRS 18.0%
pancreatic stellate cell CL0002410

CSI -0.3

rCSI -2.0%

PRS 26.1%
promyelocyte CL0000836

CSI -0.1

rCSI -0.2%

PRS 24.5%
kidney interstitial alternatively activated macrophage CL1000695

CSI -0.1

rCSI -0.3%

PRS 16.0%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI -0.1

rCSI -0.5%

PRS 56.1%
exhausted T cell CL0011025

CSI 0.0

rCSI -0.5%

PRS 58.3%
transit amplifying cell CL0009010

CSI 0.1

rCSI 0.2%

PRS 28.3%
kidney connecting tubule epithelial cell CL1000768

CSI 0.1

rCSI 0.3%

PRS 13.2%
epithelial cell of esophagus CL0002252

CSI 0.1

rCSI 1.2%

PRS 53.9%
large pre-B-II cell CL0000957

CSI 0.2

rCSI 0.4%

PRS 30.1%
basal cell of prostate epithelium CL0002341

CSI 0.2

rCSI 0.5%

PRS 37.5%
collagen secreting cell CL0000667

CSI 0.2

rCSI 1.1%

PRS 53.4%
myeloid dendritic cell CL0000782

CSI 0.2

rCSI 0.3%

PRS 26.1%
common dendritic progenitor CL0001029

CSI 0.2

rCSI 0.2%

PRS 22.6%
intestinal crypt stem cell of colon CL0009043

CSI 0.2

rCSI 1.8%

PRS 31.7%
alveolar adventitial fibroblast CL4028006

CSI 0.3

rCSI 0.4%

PRS 17.5%
mature T cell CL0002419

CSI 0.3

rCSI 0.2%

PRS 25.5%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.3

rCSI 1.1%

PRS 28.7%
ionocyte CL0005006

CSI 0.3

rCSI 0.3%

PRS 16.1%
cytotoxic T cell CL0000910

CSI 0.3

rCSI 1.7%

PRS 25.6%
keratocyte CL0002363

CSI 0.3

rCSI 0.7%

PRS 25.9%
enterocyte of epithelium of small intestine CL1000334

CSI 0.3

rCSI 4.9%

PRS 42.2%
basal-myoepithelial cell of mammary gland CL0002324

CSI 0.3

rCSI 0.6%

PRS 37.1%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.3

rCSI 1.8%

PRS 34.0%
corneal epithelial cell CL0000575

CSI 0.4

rCSI 1.0%

PRS 30.6%
innate lymphoid cell CL0001065

CSI 0.4

rCSI 0.8%

PRS 26.2%
T follicular helper cell CL0002038

CSI 0.4

rCSI 0.3%

PRS 28.0%
adipocyte CL0000136

CSI 0.4

rCSI 0.5%

PRS 17.0%
enteroendocrine cell CL0000164

CSI 0.4

rCSI 0.5%

PRS 19.3%
paneth cell of epithelium of small intestine CL1000343

CSI 0.4

rCSI 1.2%

PRS 27.0%
paneth cell CL0000510

CSI 0.4

rCSI 0.6%

PRS 27.3%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 0.4

rCSI 0.5%

PRS 30.5%
luminal cell of prostate epithelium CL0002340

CSI 0.4

rCSI 2.3%

PRS 31.1%
transit amplifying cell of small intestine CL0009012

CSI 0.4

rCSI 2.0%

PRS 32.4%
intermediate monocyte CL0002393

CSI 0.5

rCSI 0.7%

PRS 17.6%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.5

rCSI 1.1%

PRS 18.0%
Merkel cell CL0000242

CSI 0.5

rCSI 11.8%

PRS 83.0%
granulocyte monocyte progenitor cell CL0000557

CSI 0.5

rCSI 0.4%

PRS 19.6%
CD1c-positive myeloid dendritic cell CL0002399

CSI 0.5

rCSI 0.6%

PRS 20.9%
cardiac neuron CL0010022

CSI 0.5

rCSI 1.7%

PRS 13.3%
lung ciliated cell CL1000271

CSI 0.5

rCSI 0.6%

PRS 12.8%
Kupffer cell CL0000091

CSI 0.6

rCSI 1.3%

PRS 16.9%
intrahepatic cholangiocyte CL0002538

CSI 0.6

rCSI 1.4%

PRS 31.1%
dendritic cell, human CL0001056

CSI 0.6

rCSI 0.9%

PRS 20.8%
common lymphoid progenitor CL0000051

CSI 0.6

rCSI 0.8%

PRS 33.2%
helper T cell CL0000912

CSI 0.6

rCSI 0.9%

PRS 24.1%
epithelial cell of proximal tubule segment 3 CL4030011

CSI 0.6

rCSI 4.9%

PRS 59.9%
tuft cell of colon CL0009041

CSI 0.7

rCSI 1.5%

PRS 35.1%
stratified epithelial cell CL0000079

CSI 0.7

rCSI 4.2%

PRS 57.8%
periportal region hepatocyte CL0019026

CSI 0.7

rCSI 2.7%

PRS 23.8%
type L enteroendocrine cell CL0002279

CSI 0.7

rCSI 1.3%

PRS 34.1%
promonocyte CL0000559

CSI 0.7

rCSI 1.2%

PRS 23.7%
renal interstitial pericyte CL1001318

CSI 0.7

rCSI 2.0%

PRS 16.1%
CD4-positive helper T cell CL0000492

CSI 0.7

rCSI 0.6%

PRS 24.0%
lung goblet cell CL1000143

CSI 0.7

rCSI 8.3%

PRS 53.1%
pancreatic A cell CL0000171

CSI 0.8

rCSI 0.8%

PRS 18.7%
adventitial cell CL0002503

CSI 0.8

rCSI 1.9%

PRS 26.7%
Langerhans cell CL0000453

CSI 0.8

rCSI 1.2%

PRS 30.8%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 0.8

rCSI 2.0%

PRS 71.1%
type EC enteroendocrine cell CL0000577

CSI 0.8

rCSI 3.0%

PRS 28.4%
stromal cell of ovary CL0002132

CSI 0.9

rCSI 2.3%

PRS 28.7%
stromal cell CL0000499

CSI 0.9

rCSI 2.4%

PRS 23.7%
deuterosomal cell CL4033044

CSI 0.9

rCSI 2.9%

PRS 28.3%
small intestine goblet cell CL1000495

CSI 0.9

rCSI 1.9%

PRS 23.4%
hepatocyte CL0000182

CSI 0.9

rCSI 1.6%

PRS 16.1%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 0.9

rCSI 1.5%

PRS 34.5%
alveolar macrophage CL0000583

CSI 0.9

rCSI 1.5%

PRS 20.6%
myofibroblast cell CL0000186

CSI 1.0

rCSI 1.3%

PRS 24.9%
basophil CL0000767

CSI 1.0

rCSI 2.1%

PRS 34.8%
vasa recta ascending limb cell CL1001131

CSI 1.0

rCSI 4.5%

PRS 54.8%
mature alpha-beta T cell CL0000791

CSI 1.0

rCSI 3.6%

PRS 29.9%
intestinal tuft cell CL0019032

CSI 1.0

rCSI 1.5%

PRS 20.0%
elicited macrophage CL0000861

CSI 1.0

rCSI 0.9%

PRS 20.3%
immature B cell CL0000816

CSI 1.0

rCSI 0.8%

PRS 25.9%
brush cell CL0002204

CSI 1.1

rCSI 2.1%

PRS 42.8%
prostate gland microvascular endothelial cell CL2000059

CSI 1.2

rCSI 27.5%

PRS 53.3%
enterocyte of epithelium of large intestine CL0002071

CSI 1.2

rCSI 6.3%

PRS 30.2%
pancreatic D cell CL0000173

CSI 1.2

rCSI 1.2%

PRS 19.0%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 1.3

rCSI 1.2%

PRS 27.4%
early lymphoid progenitor CL0000936

CSI 1.3

rCSI 1.1%

PRS 20.0%
stem cell CL0000034

CSI 1.3

rCSI 1.2%

PRS 12.5%
fibroblast of lung CL0002553

CSI 1.3

rCSI 1.2%

PRS 17.5%
activated type II NK T cell CL0000931

CSI 1.3

rCSI 1.5%

PRS 28.1%
brush cell of tracheobronchial tree CL0002075

CSI 1.3

rCSI 3.8%

PRS 24.6%
parietal epithelial cell CL1000452

CSI 1.4

rCSI 3.6%

PRS 14.5%
mononuclear phagocyte CL0000113

CSI 1.4

rCSI 3.1%

PRS 19.6%
plasmablast CL0000980

CSI 1.4

rCSI 1.1%

PRS 21.1%
transit amplifying cell of colon CL0009011

CSI 1.4

rCSI 1.7%

PRS 20.4%
hematopoietic stem cell CL0000037

CSI 1.5

rCSI 1.0%

PRS 21.1%
T-helper 17 cell CL0000899

CSI 1.5

rCSI 1.2%

PRS 31.0%
alpha-beta T cell CL0000789

CSI 1.5

rCSI 1.8%

PRS 23.6%
ciliated cell CL0000064

CSI 1.6

rCSI 2.6%

PRS 17.7%
colon goblet cell CL0009039

CSI 1.6

rCSI 3.8%

PRS 26.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [TNFSF10](/details-gene/8743), also known as Tumor Necrosis Factor Ligand Superfamily Member 10 (TRAIL), is a protein-coding gene located on chromosome 3. It functions as a type II transmembrane protein and a potent cytokine that plays a central role in inducing programmed cell death, or apoptosis. Its expression is particularly significant in specific immune subsets, such as [CD14-low, CD16-positive monocyte](/details-cell/CL0002396), as well as in various specialized epithelial and secretory cells, including [extravillous trophoblast](/details-cell/CL0008036) and [fallopian tube secretory epithelial cell](/details-cell/CL4030006). This expression pattern suggests key roles in immune surveillance, maternal-fetal tolerance, and the maintenance of mucosal barrier integrity. ## Cellular Roles and Expression Landscape The expression profile of [TNFSF10](/details-gene/8743) highlights its importance in both the immune system and at epithelial interfaces. **Overall**, the gene shows the highest significance in [CD14-low, CD16-positive monocyte](/details-cell/CL0002396), a subset of monocytes known for their pro-inflammatory and patrolling functions, suggesting a role for [TNFSF10](/details-gene/8743) in innate immune responses. Beyond the hematopoietic system, [TNFSF10](/details-gene/8743) is a prominent marker in several specialized secretory and epithelial tissues. Its high significance in [extravillous trophoblast](/details-cell/CL0008036) points towards a potential function in placental development and immune regulation at the maternal-fetal interface. Furthermore, strong expression is observed across multiple mucosal surfaces, including in [fallopian tube secretory epithelial cell](/details-cell/CL4030006), [nasal mucosa goblet cell](/details-cell/CL0002480), and [tracheal goblet cell](/details-cell/CL1000329), as well as in endothelial cells such as [pulmonary artery endothelial cell](/details-cell/CL1001568). This widespread expression in barrier tissues suggests a role in host defense by eliminating infected or damaged cells. Conversely, the expression of [TNFSF10](/details-gene/8743) is notably low or absent in several key cell types, defining its specificity. It shows negative significance in T cell developmental stages, such as [CD4-positive, alpha-beta thymocyte](/details-cell/CL0000810), and in hematopoietic progenitors like [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050). Its low relevance in various mature T cell subsets, including [effector CD4-positive, alpha-beta T cell](/details-cell/CL0001044) and [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907), suggests that while it is a crucial effector molecule, it is not a defining lineage marker for the adaptive T cell compartment. ## Pathways and Molecular Function Functionally, [TNFSF10](/details-gene/8743) is intrinsically linked to the regulation of cell death. As a ligand, it exhibits [cytokine activity](/details-go/GO:0005125) and binds to its cognate death receptors, including TNFRSF10A (DR4) and TNFRSF10B (DR5) ([Link](https://doi.org/10.1016/s1097-2765(00)80207-5), [Link](https://doi.org/10.1038/14935)). This interaction initiates the [Trail signaling](/details-reactome/R-HSA-75158) pathway, a critical component of the extrinsic [apoptotic process](/details-go/GO:0006915). The gene's involvement is central to multiple Reactome pathways related to programmed cell death, including [Apoptosis](/details-reactome/R-HSA-109581), [Death receptor signaling](/details-reactome/R-HSA-73887), and [Caspase activation via extrinsic apoptotic signalling pathway](/details-reactome/R-HSA-5357769). The binding of [TNFSF10](/details-gene/8743) leads to receptor trimerization, recruitment of adaptor proteins like FADD, and subsequent activation of initiator caspases (caspase-8), thereby triggering a proteolytic cascade that culminates in cell dismantling. This function is consistent with its initial discovery as a novel member of the TNF family that induces apoptosis ([Link](https://doi.org/10.1016/1074-7613(95)90057-8), [Link](https://doi.org/10.1074/jbc.271.22.12687)). The protein itself is found in the [extracellular region](/details-go/GO:0005576) and on the [plasma membrane](/details-go/GO:0005886), enabling it to mediate [cell-cell signaling](/details-go/GO:0007267). ## Research Directions The diverse expression pattern of [TNFSF10](/details-gene/8743) across immune and non-immune cells presents several avenues for future research, particularly regarding its roles in tissue homeostasis and pathology. **Proposed Hypotheses:** 1. The high significance of [TNFSF10](/details-gene/8743) in [extravillous trophoblast](/details-cell/CL0008036) suggests a critical, non-redundant role in establishing maternal immune tolerance. It may function by selectively inducing apoptosis in activated maternal lymphocytes that approach the feto-maternal interface, thereby preventing immune rejection of the semi-allogeneic fetus. 2. Given its consistent high expression in secretory and goblet cells of the respiratory ([tracheal goblet cell](/details-cell/CL1000329)) and reproductive ([fallopian tube secretory epithelial cell](/details-cell/CL4030006)) tracts, [TNFSF10](/details-gene/8743) may function as a first line of defense in mucosal immunity. It could be constitutively expressed or rapidly upregulated upon pathogen sensing to eliminate infected epithelial cells before viral or bacterial replication spreads. **Key Experimental Approach:** To test the second hypothesis, one could utilize an air-liquid interface (ALI) culture model of human tracheal epithelial cells. [TNFSF10](/details-gene/8743) expression would be knocked down using shRNA or knocked out using CRISPR-Cas9. These modified cultures, alongside wild-type controls, would then be infected with a common respiratory pathogen like Respiratory Syncytial Virus (RSV). The rate of infected cell clearance, viral titer, and maintenance of epithelial barrier integrity (measured by transepithelial electrical resistance) would be quantified over time to determine if loss of [TNFSF10](/details-gene/8743) impairs the ability of the mucosal epithelium to control infection. **Therapeutic Potential:** [TNFSF10](/details-gene/8743) (TRAIL) is a well-established candidate for cancer therapy due to its ability to preferentially induce apoptosis in transformed cells while sparing most normal tissues. Its therapeutic potential lies in *activation*, not inhibition. Strategies include the development of recombinant soluble TRAIL or agonistic antibodies that target its death receptors (DR4 and DR5). These approaches aim to trigger the extrinsic apoptosis pathway specifically in tumor cells. While promising, challenges such as resistance mechanisms in some cancers and potential for hepatotoxicity require further investigation. The specificity of its expression in certain immune and epithelial cells suggests that targeted delivery or combination therapies may be necessary to maximize efficacy and minimize off-target effects.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tumor necrosis factor ligand superfamily member 10

Genular Protein ID: 2994719115

Symbol: TNF10_HUMAN

Name: Tumor necrosis factor ligand superfamily member 10

UniProtKB Accession Codes:

P50591 A1Y9B3

Database IDs:

Citations:

PubMed ID: 8777713

Title: Identification and characterization of a new member of the TNF family that induces apoptosis.

PubMed ID: 8777713

DOI: 10.1016/1074-7613(95)90057-8

PubMed ID: 8663110

Title: Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.

PubMed ID: 8663110

DOI: 10.1074/jbc.271.22.12687

PubMed ID: 21859711

Title: Isolation of a TRAIL antagonist from the serum of HIV-infected patients.

PubMed ID: 21859711

DOI: 10.1074/jbc.m111.274639

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14609566

Title: Regulation of soluble and surface-bound TRAIL in human T cells, B cells, and monocytes.

PubMed ID: 14609566

DOI: 10.1016/s1043-4666(03)00094-2

PubMed ID: 25171405

Title: A secreted tyrosine kinase acts in the extracellular environment.

PubMed ID: 25171405

DOI: 10.1016/j.cell.2014.06.048

PubMed ID: 10549288

Title: Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.

PubMed ID: 10549288

DOI: 10.1016/s1097-2765(00)80207-5

PubMed ID: 10542098

Title: Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.

PubMed ID: 10542098

DOI: 10.1038/14935

PubMed ID: 10485660

Title: 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.

PubMed ID: 10485660

DOI: 10.1016/s1074-7613(00)80100-4

PubMed ID: 26457518

Title: The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.

PubMed ID: 26457518

DOI: 10.1107/s2053230x15016416

Sequence Information:

Length: 281
Mass: 32509
Checksum: DDAAAF78DAAB2F6D
Sequence:

MAMMEVQGGP SLGQTCVLIV IFTVLLQSLC VAVTYVYFTN ELKQMQDKYS KSGIACFLKE 
DDSYWDPNDE ESMNSPCWQV KWQLRQLVRK MILRTSEETI STVQEKQQNI SPLVRERGPQ 
RVAAHITGTR GRSNTLSSPN SKNEKALGRK INSWESSRSG HSFLSNLHLR NGELVIHEKG 
FYYIYSQTYF RFQEEIKENT KNDKQMVQYI YKYTSYPDPI LLMKSARNSC WSKDAEYGLY 
SIYQGGIFEL KENDRIFVSV TNEHLIDMDH EASFFGAFLV G

Details for: TNFSF10

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification and characterization of a new member of the TNF family that induces apoptosis. PubMed ID: 8777713

Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. PubMed ID: 8663110

Isolation of a TRAIL antagonist from the serum of HIV-infected patients. PubMed ID: 21859711

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of soluble and surface-bound TRAIL in human T cells, B cells, and monocytes. PubMed ID: 14609566

A secreted tyrosine kinase acts in the extracellular environment. PubMed ID: 25171405

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. PubMed ID: 10549288

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation. PubMed ID: 10542098

2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity. PubMed ID: 10485660

The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex. PubMed ID: 26457518