Details for: GMPS

Gene ID: 8833

Symbol: GMPS

Ensembl ID: ENSG00000163655

Description: guanine monophosphate synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 171.6543
    Cell Significance Index: -26.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 131.3261
    Cell Significance Index: -33.3100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 104.0424
    Cell Significance Index: -42.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 88.9388
    Cell Significance Index: -41.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.6416
    Cell Significance Index: -33.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.0932
    Cell Significance Index: -40.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 62.6507
    Cell Significance Index: -42.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.0725
    Cell Significance Index: -34.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.6070
    Cell Significance Index: -38.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.4703
    Cell Significance Index: -36.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3813
    Cell Significance Index: -40.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.7250
    Cell Significance Index: -29.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.9725
    Cell Significance Index: -15.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.0854
    Cell Significance Index: 144.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3189
    Cell Significance Index: 143.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3077
    Cell Significance Index: 78.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2925
    Cell Significance Index: 72.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2896
    Cell Significance Index: 258.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1494
    Cell Significance Index: 228.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0716
    Cell Significance Index: 967.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8891
    Cell Significance Index: 24.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7545
    Cell Significance Index: 270.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6479
    Cell Significance Index: 88.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6121
    Cell Significance Index: 99.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5544
    Cell Significance Index: 68.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5008
    Cell Significance Index: 90.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4805
    Cell Significance Index: 56.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4596
    Cell Significance Index: 250.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4365
    Cell Significance Index: 192.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4067
    Cell Significance Index: 10.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3928
    Cell Significance Index: 18.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3263
    Cell Significance Index: 15.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3263
    Cell Significance Index: 225.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3160
    Cell Significance Index: 20.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2925
    Cell Significance Index: 20.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2469
    Cell Significance Index: 6.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2314
    Cell Significance Index: 29.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2137
    Cell Significance Index: 11.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2136
    Cell Significance Index: 8.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1984
    Cell Significance Index: 8.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1844
    Cell Significance Index: 14.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1770
    Cell Significance Index: 10.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1326
    Cell Significance Index: 25.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1106
    Cell Significance Index: 7.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1033
    Cell Significance Index: 1.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1009
    Cell Significance Index: 5.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0988
    Cell Significance Index: 186.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0890
    Cell Significance Index: 2.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0642
    Cell Significance Index: 8.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0635
    Cell Significance Index: 1.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0549
    Cell Significance Index: 101.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0541
    Cell Significance Index: 34.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0522
    Cell Significance Index: 80.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0369
    Cell Significance Index: 0.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0367
    Cell Significance Index: 6.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0217
    Cell Significance Index: 9.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0131
    Cell Significance Index: 17.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0108
    Cell Significance Index: 0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0200
    Cell Significance Index: -14.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0270
    Cell Significance Index: -3.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0279
    Cell Significance Index: -0.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0282
    Cell Significance Index: -0.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0366
    Cell Significance Index: -27.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0431
    Cell Significance Index: -31.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0502
    Cell Significance Index: -4.9700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0658
    Cell Significance Index: -1.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0682
    Cell Significance Index: -38.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0689
    Cell Significance Index: -7.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0743
    Cell Significance Index: -46.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0792
    Cell Significance Index: -5.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0940
    Cell Significance Index: -2.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1210
    Cell Significance Index: -34.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1243
    Cell Significance Index: -14.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1291
    Cell Significance Index: -2.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1453
    Cell Significance Index: -1.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1644
    Cell Significance Index: -8.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1778
    Cell Significance Index: -6.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2152
    Cell Significance Index: -45.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2351
    Cell Significance Index: -26.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2735
    Cell Significance Index: -8.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2806
    Cell Significance Index: -7.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2939
    Cell Significance Index: -6.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2939
    Cell Significance Index: -4.0100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3273
    Cell Significance Index: -7.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3331
    Cell Significance Index: -34.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3680
    Cell Significance Index: -9.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4042
    Cell Significance Index: -10.1100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4063
    Cell Significance Index: -5.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4177
    Cell Significance Index: -33.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4195
    Cell Significance Index: -26.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4245
    Cell Significance Index: -12.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4347
    Cell Significance Index: -11.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4492
    Cell Significance Index: -27.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5043
    Cell Significance Index: -11.6500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5559
    Cell Significance Index: -10.8500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6438
    Cell Significance Index: -3.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7313
    Cell Significance Index: -20.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7338
    Cell Significance Index: -19.6300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7468
    Cell Significance Index: -6.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7764
    Cell Significance Index: -25.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GMPS is a bifunctional enzyme that exhibits glutamine-hydrolyzing and GMP synthase activities. The glutamine-hydrolyzing activity involves the hydrolysis of glutamine to glutamate and ammonia, while the GMP synthase activity involves the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) and glutamine to GMP. This dual activity allows GMPS to play a central role in both the glutamine metabolism and the purine nucleotide biosynthesis pathways. **Pathways and Functions:** GMPS is involved in several key pathways, including: 1. **Guanine nucleotide biosynthesis:** GMPS catalyzes the conversion of PRPP and glutamine to GMP, a critical step in the production of guanine nucleotides. 2. **Glutamine metabolism:** GMPS exhibits glutamine-hydrolyzing activity, which involves the hydrolysis of glutamine to glutamate and ammonia. 3. **Purine nucleobase biosynthesis:** GMPS is involved in the production of purine nucleobases, including guanine, which is essential for DNA and RNA synthesis. 4. **Metabolism of nucleotides:** GMPS plays a role in the metabolism of nucleotides, including the conversion of nucleotides to nucleosides and vice versa. **Clinical Significance:** Dysregulation of GMPS has been implicated in several diseases, including: 1. **Immunodeficiency disorders:** Mutations in the GMPS gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer:** Elevated GMPS activity has been observed in certain types of cancer, including leukemia and lymphoma. 3. **Neurological disorders:** GMPS has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, GMPS is a critical enzyme involved in the biosynthesis of guanine nucleotides and glutamine metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining normal cellular function and overall health. Further research is needed to fully elucidate the role of GMPS in human disease and to explore potential therapeutic strategies for targeting this enzyme in the treatment of disease.

Genular Protein ID: 1004333475

Symbol: GUAA_HUMAN

Name: GMP synthase [glutamine-hydrolyzing]

UniProtKB Accession Codes:

P49915 A8K639 B4DXV7 F8W720

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8089153

Title: Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA.

PubMed ID: 8089153

DOI: 10.1016/s0021-9258(17)31590-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11110714

Title: t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (guanosine 5-prime monophosphate synthetase) gene.

PubMed ID: 11110714

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23816837

Title: Substrate specificity and oligomerization of human GMP synthetase.

PubMed ID: 23816837

DOI: 10.1016/j.jmb.2013.06.032

Sequence Information:

  • Length: 693
  • Mass: 76715
  • Checksum: 1CDA0DD3B244728D
  • Sequence:
    • MALCNGDSKL ENAGGDLKDG HHHYEGAVVI LDAGAQYGKV IDRRVRELFV QSEIFPLETP 
AFAIKEQGFR AIIISGGPNS VYAEDAPWFD PAIFTIGKPV LGICYGMQMM NKVFGGTVHK 
KSVREDGVFN ISVDNTCSLF RGLQKEEVVL LTHGDSVDKV ADGFKVVARS GNIVAGIANE 
SKKLYGAQFH PEVGLTENGK VILKNFLYDI AGCSGTFTVQ NRELECIREI KERVGTSKVL 
VLLSGGVDST VCTALLNRAL NQEQVIAVHI DNGFMRKRES QSVEEALKKL GIQVKVINAA 
HSFYNGTTTL PISDEDRTPR KRISKTLNMT TSPEEKRKII GDTFVKIANE VIGEMNLKPE 
EVFLAQGTLR PDLIESASLV ASGKAELIKT HHNDTELIRK LREEGKVIEP LKDFHKDEVR 
ILGRELGLPE ELVSRHPFPG PGLAIRVICA EEPYICKDFP ETNNILKIVA DFSASVKKPH 
TLLQRVKACT TEEDQEKLMQ ITSLHSLNAF LLPIKTVGVQ GDCRSYSYVC GISSKDEPDW 
ESLIFLARLI PRMCHNVNRV VYIFGPPVKE PPTDVTPTFL TTGVLSTLRQ ADFEAHNILR 
ESGYAGKISQ MPVILTPLHF DRDPLQKQPS CQRSVVIRTF ITSDFMTGIP ATPGNEIPVE 
VVLKMVTEIK KIPGISRIMY DLTSKPPGTT EWE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.