Details for: CYP51A1

Gene ID: 1595

Symbol: CYP51A1

Ensembl ID: ENSG00000001630

Description: cytochrome P450 family 51 subfamily A member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.96
    Marker Score: 52548
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.94
    Marker Score: 11530
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.92
    Marker Score: 1352
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.76
    Marker Score: 3082
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.69
    Marker Score: 1824
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.63
    Marker Score: 656
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.57
    Marker Score: 5151.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.33
    Marker Score: 45352
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.31
    Marker Score: 889
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.23
    Marker Score: 1897
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.22
    Marker Score: 7923
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.19
    Marker Score: 73207
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.16
    Marker Score: 9960
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.14
    Marker Score: 1207
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.13
    Marker Score: 4381
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.12
    Marker Score: 3504
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.1
    Marker Score: 281
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.1
    Marker Score: 41620
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.09
    Marker Score: 10294
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.09
    Marker Score: 768
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.07
    Marker Score: 4346
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.07
    Marker Score: 6819
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.07
    Marker Score: 654
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.06
    Marker Score: 39137
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.06
    Marker Score: 444
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.06
    Marker Score: 15802
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.03
    Marker Score: 9823
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.01
    Marker Score: 3923
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71766
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47991
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1
    Marker Score: 19812
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.97
    Marker Score: 4787
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14733
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.93
    Marker Score: 933.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.93
    Marker Score: 1758
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.92
    Marker Score: 251
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.91
    Marker Score: 2181
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2725
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5181
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.91
    Marker Score: 6943
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.9
    Marker Score: 497
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.9
    Marker Score: 3712
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.89
    Marker Score: 1113
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5265
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.86
    Marker Score: 1140
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1391
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.84
    Marker Score: 8493
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.83
    Marker Score: 1003
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.81
    Marker Score: 1146
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.79
    Marker Score: 676
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.79
    Marker Score: 608
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 602
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.78
    Marker Score: 5090
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.78
    Marker Score: 279
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.77
    Marker Score: 1100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.75
    Marker Score: 3946
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.75
    Marker Score: 648
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 472
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.73
    Marker Score: 531
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 664
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3021
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.72
    Marker Score: 299
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.7
    Marker Score: 224
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.69
    Marker Score: 331
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.67
    Marker Score: 1811
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.65
    Marker Score: 3441
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.65
    Marker Score: 393
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1327.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.65
    Marker Score: 228
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.65
    Marker Score: 13856
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.63
    Marker Score: 286
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.63
    Marker Score: 525
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.63
    Marker Score: 201
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.61
    Marker Score: 284
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.61
    Marker Score: 1494
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.59
    Marker Score: 592
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.59
    Marker Score: 542
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.59
    Marker Score: 686
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.59
    Marker Score: 344
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.58
    Marker Score: 588
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1357
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.57
    Marker Score: 4274
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.57
    Marker Score: 685
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.57
    Marker Score: 298
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.56
    Marker Score: 19002
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.56
    Marker Score: 1574
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.56
    Marker Score: 383
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.56
    Marker Score: 250
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.55
    Marker Score: 764
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.55
    Marker Score: 399

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Other Information

**Key characteristics:** - The CYP51A1 gene is located on chromosome 15q21.1. - It is a large gene with a length of approximately 2.6 kilobases. - The protein encoded by CYP51A1 is a transmembrane protein with a molecular weight of approximately 570 kDa. - It is expressed in a variety of cell types, including cortical cell of the adrenal gland, Sertoli cell, acinar cell, germ cell, Leydig cell, type A enteroendocrine cell, hepatoblast, fibroblast of mammary gland, proerythroblast, and L5 extratelencephalic projecting glutamatergic cortical neuron. **Pathways and functions:** - CYP51A1 is involved in a variety of cellular processes, including activation of gene expression, oxidation, and metabolism. - Activation of gene expression by srebp (srebp): CYP51A1 is a key regulator of gene expression in response to stress and inflammation. - Biological oxidations: CYP51A1 is involved in the biological oxidation of various substrates, including cholesterol, bile acids, and xenobiochemicals. - Cholesterol biosynthesis: CYP51A1 is involved in the biosynthesis of cholesterol, which is essential for the maintenance of cell membranes and the production of hormones. - Cytochrome p450 - arranged by substrate type: CYP51A1 is one of the most highly expressed cytochrome P450 enzymes in the human body. It is involved in the metabolism of a wide variety of substrates, including cholesterol, bile acids, xenobiochemicals, and hormones. - Developmental biology: CYP51A1 is involved in the development of the nervous system. It is expressed in cells of the developing brain and spinal cord, and it is required for the myelination of neurons. - Endogenous sterols: CYP51A1 is involved in the metabolism of endogenous sterols, which are cholesterol derivatives produced by the liver. - Heme binding: CYP51A1 is a heme-containing protein that is involved in the production of heme, a protein involved in oxygen transport. - Iron ion binding: CYP51A1 is a metal ion transporter that is involved in the transport of iron ions into cells. - Metabolism: CYP51A1 is involved in a variety of metabolic pathways, including the metabolism of lipids, steroids, and xenobiochemicals. **Clinical significance:** - CYP51A1 mutations are associated with a number of human diseases, including atherosclerosis, cancer, and liver disease. - CYP51A1 inhibitors are being investigated as potential therapeutic agents for these diseases.

Genular Protein ID: 1634872140

Symbol: CP51A_HUMAN

Name: CYPLI

UniProtKB Accession Codes:

Q16850 A0A0C4DFL7 A4D1F8 B2RAI4 B4DJ55 O00770 O00772 Q16784 Q8N1A8 Q99868

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 93 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 18 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 8 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 Rhea 48 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8619637

Title: The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols.

PubMed ID: 8619637

DOI: 10.1006/abbi.1996.0193

PubMed ID: 8797093

Title: Sterol 14-demethylase P450 (P45014DM*) is one of the most ancient and conserved P450 species.

PubMed ID: 8797093

DOI: 10.1093/oxfordjournals.jbchem.a021331

PubMed ID: 8809088

Title: The three human cytochrome P450 lanosterol 14 alpha-demethylase (CYP51) genes reside on chromosomes 3, 7, and 13: structure of the two retrotransposed pseudogenes, association with a line-1 element, and evolution of the human CYP51 family.

PubMed ID: 8809088

DOI: 10.1006/abbi.1996.0416

PubMed ID: 8975714

Title: Structure and mapping of the human lanosterol 14alpha-demethylase gene (CYP51) encoding the cytochrome P450 involved in cholesterol biosynthesis; comparison of exon/intron organization with other mammalian and fungal CYP genes.

PubMed ID: 8975714

DOI: 10.1006/geno.1996.0640

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9559662

Title: Molecular diversity of sterol 14alpha-demethylase substrates in plants, fungi and humans.

PubMed ID: 9559662

DOI: 10.1016/s0014-5793(98)00247-6

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 20149798

Title: Structural basis of human CYP51 inhibition by antifungal azoles.

PubMed ID: 20149798

DOI: 10.1016/j.jmb.2010.01.075

Sequence Information:

  • Length: 509
  • Mass: 57278
  • Checksum: F9145DDB65F94091
  • Sequence:
    • MAAAAGMLLL GLLQAGGSVL GQAMEKVTGG NLLSMLLIAC AFTLSLVYLI RLAAGHLVQL 
PAGVKSPPYI FSPIPFLGHA IAFGKSPIEF LENAYEKYGP VFSFTMVGKT FTYLLGSDAA 
ALLFNSKNED LNAEDVYSRL TTPVFGKGVA YDVPNPVFLE QKKMLKSGLN IAHFKQHVSI 
IEKETKEYFE SWGESGEKNV FEALSELIIL TASHCLHGKE IRSQLNEKVA QLYADLDGGF 
SHAAWLLPGW LPLPSFRRRD RAHREIKDIF YKAIQKRRQS QEKIDDILQT LLDATYKDGR 
PLTDDEVAGM LIGLLLAGQH TSSTTSAWMG FFLARDKTLQ KKCYLEQKTV CGENLPPLTY 
DQLKDLNLLD RCIKETLRLR PPIMIMMRMA RTPQTVAGYT IPPGHQVCVS PTVNQRLKDS 
WVERLDFNPD RYLQDNPASG EKFAYVPFGA GRHRCIGENF AYVQIKTIWS TMLRLYEFDL 
IDGYFPTVNY TTMIHTPENP VIRYKRRSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.