Gene DGKA - ENSG00000065357 | NCBI Gene ID: 1606

Details for: DGKA

Gene ID: 1606

Symbol: DGKA

Ensembl ID: ENSG00000065357

Description: diacylglycerol kinase alpha

Associated with

Effects of pip2 hydrolysis
(R-HSA-114508)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Alkylglycerol kinase activity
(GO:0047649)
Atp-dependent diacylglycerol kinase activity
(GO:0004143)
Atp binding
(GO:0005524)
Calcium ion binding
(GO:0005509)
Cytosol
(GO:0005829)
Diacylglycerol metabolic process
(GO:0046339)
Glycerolipid metabolic process
(GO:0046486)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Lipid binding
(GO:0008289)
Lipid phosphorylation
(GO:0046834)
Membrane
(GO:0016020)
Phosphatidic acid biosynthetic process
(GO:0006654)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.89
Marker Score: 99948
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.76
Marker Score: 1945
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.64
Marker Score: 820
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 1.63
Marker Score: 6998.5
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.63
Marker Score: 2306
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.58
Marker Score: 1661
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.57
Marker Score: 478
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 1.49
Marker Score: 2564
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.49
Marker Score: 1088
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.44
Marker Score: 2813
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.4
Marker Score: 3418
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.33
Marker Score: 2379
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 1.33
Marker Score: 463
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.28
Marker Score: 9501
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 1.25
Marker Score: 570
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.2
Marker Score: 1773
Cell Name: blood cell (CL0000081)
Fold Change: 1.18
Marker Score: 13728
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.17
Marker Score: 1126.5
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.15
Marker Score: 769
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.12
Marker Score: 1045
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.1
Marker Score: 7045
Cell Name: regulatory T cell (CL0000815)
Fold Change: 1.03
Marker Score: 1137
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 1.01
Marker Score: 842
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1
Marker Score: 310
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71728
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47953
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.99
Marker Score: 2774
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30397
Cell Name: basal cell (CL0000646)
Fold Change: 0.97
Marker Score: 1255
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2403
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 482
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 438
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2711
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.9
Marker Score: 7793.5
Cell Name: naive T cell (CL0000898)
Fold Change: 0.88
Marker Score: 567
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.87
Marker Score: 942
Cell Name: Unknown (CL0000548)
Fold Change: 0.87
Marker Score: 631.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5242
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.86
Marker Score: 515
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.86
Marker Score: 686
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.85
Marker Score: 4845
Cell Name: thymocyte (CL0000893)
Fold Change: 0.85
Marker Score: 889
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.85
Marker Score: 958
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.84
Marker Score: 13167
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.84
Marker Score: 604
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.84
Marker Score: 269
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.83
Marker Score: 513
Cell Name: mature T cell (CL0002419)
Fold Change: 0.82
Marker Score: 8119
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.81
Marker Score: 474
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.8
Marker Score: 668
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.8
Marker Score: 2505
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.8
Marker Score: 1390
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.78
Marker Score: 1780
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 306
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.76
Marker Score: 219
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.76
Marker Score: 2064.5
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.76
Marker Score: 820
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.75
Marker Score: 670
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.75
Marker Score: 1216
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 568
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.73
Marker Score: 498
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.73
Marker Score: 168
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 376
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.73
Marker Score: 569.5
Cell Name: enterocyte (CL0000584)
Fold Change: 0.72
Marker Score: 3464
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.72
Marker Score: 546
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.71
Marker Score: 770
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.7
Marker Score: 186
Cell Name: memory B cell (CL0000787)
Fold Change: 0.69
Marker Score: 522
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.69
Marker Score: 42250
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.68
Marker Score: 1702
Cell Name: brush cell (CL0002204)
Fold Change: 0.68
Marker Score: 618
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.68
Marker Score: 334
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.68
Marker Score: 635
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.67
Marker Score: 2828.5
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172.5
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.66
Marker Score: 326
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.65
Marker Score: 9725
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.65
Marker Score: 3895.5
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.65
Marker Score: 24538
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.64
Marker Score: 654
Cell Name: memory T cell (CL0000813)
Fold Change: 0.62
Marker Score: 265
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.62
Marker Score: 193
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.61
Marker Score: 948
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.61
Marker Score: 517
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.6
Marker Score: 398
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.6
Marker Score: 710
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.6
Marker Score: 404
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.59
Marker Score: 4597
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.58
Marker Score: 1373
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.58
Marker Score: 325
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.58
Marker Score: 2375.5
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.58
Marker Score: 391
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.58
Marker Score: 530
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.58
Marker Score: 251
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.58
Marker Score: 484
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.57
Marker Score: 1802
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.57
Marker Score: 573
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.57
Marker Score: 321

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**Key characteristics:** * DGKA is a serine/threonine kinase that is highly expressed in immune cells. * It is a key regulator of inflammation and cell signaling. * It is involved in the regulation of platelet activation and aggregation. * It is also involved in the regulation of cell migration and proliferation. **Pathways and functions:** * DGKA is involved in the regulation of inflammation. It is expressed in inflammatory cells, such as macrophages and dendritic cells, and is activated by inflammatory signals. DGKA phosphorylates a number of substrates that are involved in inflammation, including p38 MAPK, STAT3, and COX-1. These phosphorylations help to promote inflammation. * DGKA is also involved in cell signaling. It is a key regulator of cell migration and proliferation. DGKA is expressed in a variety of cell types, including epithelial cells and immune cells. It is thought to play a role in the regulation of cell migration by binding to specific proteins and promoting their phosphorylation. * DGKA is also involved in the regulation of platelet activation and aggregation. It is expressed in platelets, and its activity is increased in response to injury or infection. DGKA phosphorylates a number of proteins involved in platelet activation, including GPCRs and integrins. These phosphorylations help to promote platelet activation and aggregation. **Clinical significance:** DGKA is a potential target for the treatment of inflammatory diseases. Inhibition of DGKA has been shown to reduce inflammation and cell proliferation in animal models of disease. This suggests that DGKA is a potential therapeutic target for a variety of inflammatory diseases, including rheumatoid arthritis, asthma, and cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Diacylglycerol kinase alpha

Genular Protein ID: 428048908

Symbol: DGKA_HUMAN

Name: Diacylglycerol kinase alpha

UniProtKB Accession Codes:

P23743 O75481 O75482 O75483 O95217 Q3ZE25 Q8IZ56 Q8N5Q2

Database IDs:

Citations:

PubMed ID: 2175712

Title: Purification, cDNA-cloning and expression of human diacylglycerol kinase.

PubMed ID: 2175712

DOI: 10.1016/0014-5793(90)81461-v

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8180475

Title: Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12.

PubMed ID: 8180475

DOI: 10.1007/bf00292343

PubMed ID: 7959783

Title: Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis.

PubMed ID: 7959783

DOI: 10.1006/geno.1994.1376

PubMed ID: 15544348

Title: The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol.

PubMed ID: 15544348

DOI: 10.1021/bi0484724

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22627129

Title: Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.

PubMed ID: 22627129

DOI: 10.1016/j.bbrc.2012.05.077

PubMed ID: 30653270

Title: Crystal structure and calcium-induced conformational changes of diacylglycerol kinase alpha EF-hand domains.

PubMed ID: 30653270

DOI: 10.1002/pro.3572

Sequence Information:

Length: 735
Mass: 82630
Checksum: ACAA0AD186EE64A0
Sequence:

MAKERGLISP SDFAQLQKYM EYSTKKVSDV LKLFEDGEMA KYVQGDAIGY EGFQQFLKIY 
LEVDNVPRHL SLALFQSFET GHCLNETNVT KDVVCLNDVS CYFSLLEGGR PEDKLEFTFK 
LYDTDRNGIL DSSEVDKIIL QMMRVAEYLD WDVSELRPIL QEMMKEIDYD GSGSVSQAEW 
VRAGATTVPL LVLLGLEMTL KDDGQHMWRP KRFPRPVYCN LCESSIGLGK QGLSCNLCKY 
TVHDQCAMKA LPCEVSTYAK SRKDIGVQSH VWVRGGCESG RCDRCQKKIR IYHSLTGLHC 
VWCHLEIHDD CLQAVGHECD CGLLRDHILP PSSIYPSVLA SGPDRKNSKT SQKTMDDLNL 
STSEALRIDP VPNTHPLLVF VNPKSGGKQG QRVLWKFQYI LNPRQVFNLL KDGPEIGLRL 
FKDVPDSRIL VCGGDGTVGW ILETIDKANL PVLPPVAVLP LGTGNDLARC LRWGGGYEGQ 
NLAKILKDLE MSKVVHMDRW SVEVIPQQTE EKSDPVPFQI INNYFSIGVD ASIAHRFHIM 
REKYPEKFNS RMKNKLWYFE FATSESIFST CKKLEESLTV EICGKPLDLS NLSLEGIAVL 
NIPSMHGGSN LWGDTRRPHG DIYGINQALG ATAKVITDPD ILKTCVPDLS DKRLEVVGLE 
GAIEMGQIYT KLKNAGRRLA KCSEITFHTT KTLPMQIDGE PWMQTPCTIK ITHKNQMPML 
MGPPPRSTNF FGFLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DGKA

Associated with

Cells (max top 100)

Other Information

Purification, cDNA-cloning and expression of human diacylglycerol kinase. PubMed ID: 2175712

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12. PubMed ID: 8180475

Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis. PubMed ID: 7959783

The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol. PubMed ID: 15544348

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases. PubMed ID: 22627129

Crystal structure and calcium-induced conformational changes of diacylglycerol kinase alpha EF-hand domains. PubMed ID: 30653270