Details for: DGKA

Gene ID: 1606

Symbol: DGKA

Ensembl ID: ENSG00000065357

Description: diacylglycerol kinase alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.3485
    Cell Significance Index: -13.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.7656
    Cell Significance Index: -13.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.3469
    Cell Significance Index: -15.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.0304
    Cell Significance Index: -13.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7110
    Cell Significance Index: -12.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6102
    Cell Significance Index: -14.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5656
    Cell Significance Index: -14.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.0234
    Cell Significance Index: 41.2500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.6872
    Cell Significance Index: 16.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2367
    Cell Significance Index: 36.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1110
    Cell Significance Index: 31.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0060
    Cell Significance Index: 28.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9994
    Cell Significance Index: 51.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6789
    Cell Significance Index: 122.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6168
    Cell Significance Index: 37.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5910
    Cell Significance Index: 15.8400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.5766
    Cell Significance Index: 1.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5758
    Cell Significance Index: 115.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5329
    Cell Significance Index: 65.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5289
    Cell Significance Index: 477.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5207
    Cell Significance Index: 56.6400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5055
    Cell Significance Index: 10.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4736
    Cell Significance Index: 10.2600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.4495
    Cell Significance Index: 1.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4481
    Cell Significance Index: 20.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4091
    Cell Significance Index: 66.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3356
    Cell Significance Index: 8.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3211
    Cell Significance Index: 22.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2599
    Cell Significance Index: 16.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2454
    Cell Significance Index: 11.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2384
    Cell Significance Index: 85.5100
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.2158
    Cell Significance Index: 2.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1827
    Cell Significance Index: 21.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1564
    Cell Significance Index: 15.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1529
    Cell Significance Index: 67.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1262
    Cell Significance Index: 5.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1096
    Cell Significance Index: 2.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1012
    Cell Significance Index: 19.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0764
    Cell Significance Index: 2.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0666
    Cell Significance Index: 13.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0655
    Cell Significance Index: 2.4800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0642
    Cell Significance Index: 0.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0617
    Cell Significance Index: 8.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0600
    Cell Significance Index: 2.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0499
    Cell Significance Index: 0.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0191
    Cell Significance Index: 10.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0088
    Cell Significance Index: 16.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0082
    Cell Significance Index: 12.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0069
    Cell Significance Index: 12.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0046
    Cell Significance Index: -0.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0134
    Cell Significance Index: -6.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0161
    Cell Significance Index: -12.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0164
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0178
    Cell Significance Index: -13.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0201
    Cell Significance Index: -14.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0203
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0231
    Cell Significance Index: -14.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0319
    Cell Significance Index: -5.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0380
    Cell Significance Index: -0.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0447
    Cell Significance Index: -12.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0498
    Cell Significance Index: -1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0512
    Cell Significance Index: -7.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0512
    Cell Significance Index: -3.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0557
    Cell Significance Index: -6.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0666
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0696
    Cell Significance Index: -14.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0697
    Cell Significance Index: -9.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0803
    Cell Significance Index: -9.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0840
    Cell Significance Index: -5.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0846
    Cell Significance Index: -8.6400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0854
    Cell Significance Index: -1.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0863
    Cell Significance Index: -6.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0868
    Cell Significance Index: -1.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0884
    Cell Significance Index: -2.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1006
    Cell Significance Index: -5.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1121
    Cell Significance Index: -6.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1174
    Cell Significance Index: -2.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1207
    Cell Significance Index: -12.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1355
    Cell Significance Index: -10.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1585
    Cell Significance Index: -1.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1929
    Cell Significance Index: -15.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1956
    Cell Significance Index: -12.3300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2309
    Cell Significance Index: -2.0200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.2316
    Cell Significance Index: -1.9900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2338
    Cell Significance Index: -4.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2373
    Cell Significance Index: -12.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2467
    Cell Significance Index: -7.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2501
    Cell Significance Index: -4.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2581
    Cell Significance Index: -3.8900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2628
    Cell Significance Index: -4.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2693
    Cell Significance Index: -7.7200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2709
    Cell Significance Index: -3.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2846
    Cell Significance Index: -14.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2956
    Cell Significance Index: -5.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3027
    Cell Significance Index: -6.5400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3188
    Cell Significance Index: -3.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DGKA is a member of the diacylglycerol kinase family, characterized by its ability to phosphorylate DAG to produce phosphatidic acid. This enzyme is specifically expressed in various cell types, including mature alpha-beta T cells, corneal epithelial cells, and platelets. DGKA is also known to interact with other signaling molecules, such as G-proteins and protein kinase C, to regulate downstream signaling events. **Pathways and Functions:** DGKA is involved in several critical signaling pathways, including: 1. **G-protein coupled receptor (GPCR) signaling**: DGKA modulates the GPCR downstream signaling pathway, which is essential for platelet activation and aggregation. 2. **Protein kinase C (PKC) activation**: DGKA phosphorylates DAG to produce phosphatidic acid, which activates PKC, a key regulator of various cellular processes, including immune response and cell proliferation. 3. **Intracellular signal transduction**: DGKA participates in the regulation of intracellular signaling events, including calcium ion binding and ATP-dependent diacylglycerol kinase activity. 4. **Lipid metabolism**: DGKA is involved in the metabolic process of glycerolipids, including diacylglycerol and phosphatidic acid. **Clinical Significance:** DGKA has been implicated in various immune-related disorders, including: 1. **Platelet activation and thrombosis**: Dysregulation of DGKA activity has been linked to platelet activation and thrombotic events, such as acute coronary syndromes and stroke. 2. **Autoimmune diseases**: DGKA has been shown to play a role in the regulation of immune responses, including those involved in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: DGKA has been implicated in the development and progression of various cancers, including breast cancer and lung cancer, through its regulation of cell proliferation and survival pathways. In conclusion, DGKA is a critical enzyme involved in the regulation of cellular signaling pathways, particularly in the context of immune response and platelet activation. Further research is necessary to fully elucidate the role of DGKA in human diseases and to explore its potential as a therapeutic target for the treatment of immune-related disorders.

Genular Protein ID: 428048908

Symbol: DGKA_HUMAN

Name: Diacylglycerol kinase alpha

UniProtKB Accession Codes:

P23743 O75481 O75482 O75483 O95217 Q3ZE25 Q8IZ56 Q8N5Q2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 74 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 9 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 Rhea 26 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2175712

Title: Purification, cDNA-cloning and expression of human diacylglycerol kinase.

PubMed ID: 2175712

DOI: 10.1016/0014-5793(90)81461-v

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8180475

Title: Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12.

PubMed ID: 8180475

DOI: 10.1007/bf00292343

PubMed ID: 7959783

Title: Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis.

PubMed ID: 7959783

DOI: 10.1006/geno.1994.1376

PubMed ID: 15544348

Title: The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol.

PubMed ID: 15544348

DOI: 10.1021/bi0484724

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22627129

Title: Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.

PubMed ID: 22627129

DOI: 10.1016/j.bbrc.2012.05.077

PubMed ID: 30653270

Title: Crystal structure and calcium-induced conformational changes of diacylglycerol kinase alpha EF-hand domains.

PubMed ID: 30653270

DOI: 10.1002/pro.3572

Sequence Information:

  • Length: 735
  • Mass: 82630
  • Checksum: ACAA0AD186EE64A0
  • Sequence:
    • MAKERGLISP SDFAQLQKYM EYSTKKVSDV LKLFEDGEMA KYVQGDAIGY EGFQQFLKIY 
LEVDNVPRHL SLALFQSFET GHCLNETNVT KDVVCLNDVS CYFSLLEGGR PEDKLEFTFK 
LYDTDRNGIL DSSEVDKIIL QMMRVAEYLD WDVSELRPIL QEMMKEIDYD GSGSVSQAEW 
VRAGATTVPL LVLLGLEMTL KDDGQHMWRP KRFPRPVYCN LCESSIGLGK QGLSCNLCKY 
TVHDQCAMKA LPCEVSTYAK SRKDIGVQSH VWVRGGCESG RCDRCQKKIR IYHSLTGLHC 
VWCHLEIHDD CLQAVGHECD CGLLRDHILP PSSIYPSVLA SGPDRKNSKT SQKTMDDLNL 
STSEALRIDP VPNTHPLLVF VNPKSGGKQG QRVLWKFQYI LNPRQVFNLL KDGPEIGLRL 
FKDVPDSRIL VCGGDGTVGW ILETIDKANL PVLPPVAVLP LGTGNDLARC LRWGGGYEGQ 
NLAKILKDLE MSKVVHMDRW SVEVIPQQTE EKSDPVPFQI INNYFSIGVD ASIAHRFHIM 
REKYPEKFNS RMKNKLWYFE FATSESIFST CKKLEESLTV EICGKPLDLS NLSLEGIAVL 
NIPSMHGGSN LWGDTRRPHG DIYGINQALG ATAKVITDPD ILKTCVPDLS DKRLEVVGLE 
GAIEMGQIYT KLKNAGRRLA KCSEITFHTT KTLPMQIDGE PWMQTPCTIK ITHKNQMPML 
MGPPPRSTNF FGFLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.