Details for: DCN

Gene ID: 1634

Symbol: DCN

Ensembl ID: ENSG00000011465

Description: decorin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 112.5143
    Cell Significance Index: -46.3500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.6159
    Cell Significance Index: -35.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.1895
    Cell Significance Index: -30.1400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 47.5760
    Cell Significance Index: 279.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 37.2400
    Cell Significance Index: 252.3200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.6211
    Cell Significance Index: -30.1900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 23.5194
    Cell Significance Index: 301.2100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 19.1515
    Cell Significance Index: 118.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 16.6488
    Cell Significance Index: 477.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 15.7262
    Cell Significance Index: 306.9300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 14.8688
    Cell Significance Index: 44.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.4503
    Cell Significance Index: -25.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.7011
    Cell Significance Index: 203.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.5498
    Cell Significance Index: 1174.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.6609
    Cell Significance Index: -23.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.4130
    Cell Significance Index: 822.1100
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 5.9837
    Cell Significance Index: 60.3900
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 5.4554
    Cell Significance Index: 25.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 5.0466
    Cell Significance Index: 255.0400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 4.3649
    Cell Significance Index: 93.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.0786
    Cell Significance Index: 44.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 3.5800
    Cell Significance Index: 51.4100
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.8583
    Cell Significance Index: 6.6000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.7605
    Cell Significance Index: 17.3600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.5990
    Cell Significance Index: 12.0000
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.0048
    Cell Significance Index: 21.4700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.9220
    Cell Significance Index: 21.2300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 1.3985
    Cell Significance Index: 6.6900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.1479
    Cell Significance Index: 12.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7175
    Cell Significance Index: 55.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3642
    Cell Significance Index: 2.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3471
    Cell Significance Index: 9.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3125
    Cell Significance Index: 5.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2973
    Cell Significance Index: 4.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2893
    Cell Significance Index: 103.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1224
    Cell Significance Index: 54.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0929
    Cell Significance Index: 6.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0893
    Cell Significance Index: 14.5300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.0514
    Cell Significance Index: 0.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0384
    Cell Significance Index: 7.3200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0361
    Cell Significance Index: 0.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0305
    Cell Significance Index: 57.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0072
    Cell Significance Index: 0.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0189
    Cell Significance Index: -14.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0195
    Cell Significance Index: -36.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0213
    Cell Significance Index: -16.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0229
    Cell Significance Index: -1.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0233
    Cell Significance Index: -35.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0245
    Cell Significance Index: -15.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0266
    Cell Significance Index: -16.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0266
    Cell Significance Index: -36.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0337
    Cell Significance Index: -15.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0355
    Cell Significance Index: -6.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0468
    Cell Significance Index: -34.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0513
    Cell Significance Index: -28.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0741
    Cell Significance Index: -40.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0775
    Cell Significance Index: -2.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0983
    Cell Significance Index: -16.7900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1006
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1073
    Cell Significance Index: -22.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1124
    Cell Significance Index: -32.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1175
    Cell Significance Index: -3.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1193
    Cell Significance Index: -14.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1252
    Cell Significance Index: -18.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1288
    Cell Significance Index: -25.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1370
    Cell Significance Index: -13.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1699
    Cell Significance Index: -34.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1795
    Cell Significance Index: -8.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1893
    Cell Significance Index: -1.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1979
    Cell Significance Index: -2.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2070
    Cell Significance Index: -21.1400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2091
    Cell Significance Index: -3.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2225
    Cell Significance Index: -5.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2303
    Cell Significance Index: -25.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2708
    Cell Significance Index: -6.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2816
    Cell Significance Index: -32.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2959
    Cell Significance Index: -34.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2969
    Cell Significance Index: -33.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3051
    Cell Significance Index: -31.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3172
    Cell Significance Index: -19.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3247
    Cell Significance Index: -37.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3546
    Cell Significance Index: -18.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3558
    Cell Significance Index: -10.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3645
    Cell Significance Index: -25.2100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3933
    Cell Significance Index: -6.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4069
    Cell Significance Index: -14.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4118
    Cell Significance Index: -18.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4328
    Cell Significance Index: -30.6100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.5128
    Cell Significance Index: -3.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5420
    Cell Significance Index: -17.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5634
    Cell Significance Index: -26.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5642
    Cell Significance Index: -37.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5788
    Cell Significance Index: -12.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6048
    Cell Significance Index: -38.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6121
    Cell Significance Index: -37.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6337
    Cell Significance Index: -33.2700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.6722
    Cell Significance Index: -7.9900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.7098
    Cell Significance Index: -8.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7315
    Cell Significance Index: -8.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7424
    Cell Significance Index: -41.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Features:** Decorin is a small leucine-rich proteoglycan consisting of a core protein and a covalently attached glycosaminoglycan (GAG) chain. 2. **ECM Binding:** Decorin exhibits a high affinity for collagen, as well as other ECM components, such as fibronectin and laminin. 3. **Regulatory Functions:** Decorin plays a crucial role in regulating ECM organization, cell migration, and angiogenesis. 4. **Expression Patterns:** Decorin is highly expressed in various tissues, including skeletal muscle, connective tissue, and cancerous cells. **Pathways and Functions:** 1. **Glycosaminoglycan Metabolism:** Decorin is involved in the regulation of glycosaminoglycan synthesis and degradation, which affects ECM organization and cell migration. 2. **Extracellular Matrix Organization:** Decorin binds to collagen and other ECM components, modulating their interactions and organization. 3. **Cell Migration and Angiogenesis:** Decorin regulates cell migration and angiogenesis by modulating the interactions between cells and the ECM. 4. **Signaling Pathways:** Decorin is involved in various signaling pathways, including those involved in cell growth, differentiation, and apoptosis. **Clinical Significance:** 1. **Disease Association:** Decorin has been associated with various diseases, including osteoarthritis, cancer, and cardiovascular disease. 2. **Therapeutic Potential:** Decorin has been investigated as a potential therapeutic agent for the treatment of diseases associated with ECM dysregulation. 3. **Cancer Research:** Decorin has been shown to play a role in cancer progression and metastasis, highlighting its potential as a therapeutic target. 4. **Regenerative Medicine:** Decorin has been explored as a potential tool for tissue engineering and regenerative medicine, due to its ability to regulate ECM organization and cell migration. In conclusion, decorin is a critical component of the ECM, playing a pivotal role in regulating ECM organization, cell migration, and angiogenesis. Its dysregulation has been implicated in various diseases, making it an attractive target for therapeutic intervention. Further research is needed to fully elucidate the mechanisms underlying decorin's functions and to explore its potential as a therapeutic agent.

Genular Protein ID: 234587089

Symbol: PGS2_HUMAN

Name: Decorin

UniProtKB Accession Codes:

P07585 Q9P0Z0 Q9P0Z1 Q9Y5N8 Q9Y5N9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 7 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 12 RefSeq 9 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3484330

Title: Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA.

PubMed ID: 3484330

DOI: 10.1073/pnas.83.20.7683

PubMed ID: 8432527

Title: Human decorin gene: intron-exon junctions and chromosomal localization.

PubMed ID: 8432527

DOI: 10.1006/geno.1993.1023

PubMed ID: 8432526

Title: The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23.

PubMed ID: 8432526

DOI: 10.1006/geno.1993.1022

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2590169

Title: Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II.

PubMed ID: 2590169

DOI: 10.1042/bj2620823

PubMed ID: 3597437

Title: Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone.

PubMed ID: 3597437

DOI: 10.1016/s0021-9258(18)47991-4

PubMed ID: 15671264

Title: Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene.

PubMed ID: 15671264

DOI: 10.1167/iovs.04-0804

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

Sequence Information:

  • Length: 359
  • Mass: 39747
  • Checksum: FF511E871A1A52DD
  • Sequence:
    • MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL GPVCPFRCQC 
HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV 
SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE 
LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS 
LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH 
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.