Details for: DCN

Gene ID: 1634

Symbol: DCN

Ensembl ID: ENSG00000011465

Description: decorin

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 8.38
    Marker Score: 5,516
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.36
    Marker Score: 8,251
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.91
    Marker Score: 3,518
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.44
    Marker Score: 151,113
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.21
    Marker Score: 3,592
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.97
    Marker Score: 1,707
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.93
    Marker Score: 5,402
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.89
    Marker Score: 10,191
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.67
    Marker Score: 23,869
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.55
    Marker Score: 1,477
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.38
    Marker Score: 3,894
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.36
    Marker Score: 872
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.15
    Marker Score: 35,531
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.09
    Marker Score: 40,733
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3
    Marker Score: 2,896
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.98
    Marker Score: 12,839
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.86
    Marker Score: 1,632
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.86
    Marker Score: 5,502
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.84
    Marker Score: 1,579
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.62
    Marker Score: 652
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.6
    Marker Score: 585
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.6
    Marker Score: 652
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.41
    Marker Score: 554
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.37
    Marker Score: 804
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.31
    Marker Score: 2,850
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.16
    Marker Score: 611
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 2.03
    Marker Score: 604
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.98
    Marker Score: 636
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.95
    Marker Score: 1,230
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.94
    Marker Score: 731
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.92
    Marker Score: 2,069
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.86
    Marker Score: 2,317
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.84
    Marker Score: 907
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.82
    Marker Score: 3,411
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.72
    Marker Score: 425
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.72
    Marker Score: 885
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.63
    Marker Score: 477
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.62
    Marker Score: 1,722
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.61
    Marker Score: 727
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.6
    Marker Score: 454
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.57
    Marker Score: 1,142
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.54
    Marker Score: 1,011
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.5
    Marker Score: 2,462
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.47
    Marker Score: 824
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,414
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.47
    Marker Score: 1,909
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.45
    Marker Score: 324
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.44
    Marker Score: 379
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.38
    Marker Score: 5,104
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.33
    Marker Score: 776
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.3
    Marker Score: 451
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.22
    Marker Score: 662
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.16
    Marker Score: 11,642
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,765
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.12
    Marker Score: 938
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.12
    Marker Score: 852
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.07
    Marker Score: 390
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.03
    Marker Score: 253
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,758
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,983
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1
    Marker Score: 22,271
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.98
    Marker Score: 5,867
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.94
    Marker Score: 239
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.92
    Marker Score: 340
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.91
    Marker Score: 18,198
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,727
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.91
    Marker Score: 1,997
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.89
    Marker Score: 936
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.89
    Marker Score: 356
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.88
    Marker Score: 217
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.88
    Marker Score: 1,212
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.88
    Marker Score: 2,382
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,967
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,270
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.86
    Marker Score: 2,115
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.82
    Marker Score: 213
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.81
    Marker Score: 13,004
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.77
    Marker Score: 2,135
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.77
    Marker Score: 274
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.76
    Marker Score: 1,527
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.74
    Marker Score: 338
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 666
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1,452
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.71
    Marker Score: 2,800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 421
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.7
    Marker Score: 291
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.7
    Marker Score: 197
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.69
    Marker Score: 5,322
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.68
    Marker Score: 368
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.67
    Marker Score: 2,368

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Features:** Decorin is a small leucine-rich proteoglycan consisting of a core protein and a covalently attached glycosaminoglycan (GAG) chain. 2. **ECM Binding:** Decorin exhibits a high affinity for collagen, as well as other ECM components, such as fibronectin and laminin. 3. **Regulatory Functions:** Decorin plays a crucial role in regulating ECM organization, cell migration, and angiogenesis. 4. **Expression Patterns:** Decorin is highly expressed in various tissues, including skeletal muscle, connective tissue, and cancerous cells. **Pathways and Functions:** 1. **Glycosaminoglycan Metabolism:** Decorin is involved in the regulation of glycosaminoglycan synthesis and degradation, which affects ECM organization and cell migration. 2. **Extracellular Matrix Organization:** Decorin binds to collagen and other ECM components, modulating their interactions and organization. 3. **Cell Migration and Angiogenesis:** Decorin regulates cell migration and angiogenesis by modulating the interactions between cells and the ECM. 4. **Signaling Pathways:** Decorin is involved in various signaling pathways, including those involved in cell growth, differentiation, and apoptosis. **Clinical Significance:** 1. **Disease Association:** Decorin has been associated with various diseases, including osteoarthritis, cancer, and cardiovascular disease. 2. **Therapeutic Potential:** Decorin has been investigated as a potential therapeutic agent for the treatment of diseases associated with ECM dysregulation. 3. **Cancer Research:** Decorin has been shown to play a role in cancer progression and metastasis, highlighting its potential as a therapeutic target. 4. **Regenerative Medicine:** Decorin has been explored as a potential tool for tissue engineering and regenerative medicine, due to its ability to regulate ECM organization and cell migration. In conclusion, decorin is a critical component of the ECM, playing a pivotal role in regulating ECM organization, cell migration, and angiogenesis. Its dysregulation has been implicated in various diseases, making it an attractive target for therapeutic intervention. Further research is needed to fully elucidate the mechanisms underlying decorin's functions and to explore its potential as a therapeutic agent.

Genular Protein ID: 234587089

Symbol: PGS2_HUMAN

Name: Decorin

UniProtKB Accession Codes:

P07585 Q9P0Z0 Q9P0Z1 Q9Y5N8 Q9Y5N9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 12 RefSeq 9 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3484330

Title: Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA.

PubMed ID: 3484330

DOI: 10.1073/pnas.83.20.7683

PubMed ID: 8432527

Title: Human decorin gene: intron-exon junctions and chromosomal localization.

PubMed ID: 8432527

DOI: 10.1006/geno.1993.1023

PubMed ID: 8432526

Title: The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23.

PubMed ID: 8432526

DOI: 10.1006/geno.1993.1022

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2590169

Title: Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II.

PubMed ID: 2590169

DOI: 10.1042/bj2620823

PubMed ID: 3597437

Title: Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone.

PubMed ID: 3597437

DOI: 10.1016/s0021-9258(18)47991-4

PubMed ID: 15671264

Title: Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene.

PubMed ID: 15671264

DOI: 10.1167/iovs.04-0804

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

Sequence Information:

  • Length: 359
  • Mass: 39747
  • Checksum: FF511E871A1A52DD
  • Sequence:
    • MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL GPVCPFRCQC 
HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV 
SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE 
LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS 
LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH 
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.