Gene DCN - ENSG00000011465 | NCBI Gene ID: 1634

Details for: DCN

Gene ID: 1634

Symbol: DCN

Ensembl ID: ENSG00000011465

Description: decorin

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-HSA-1971475)
Chondroitin sulfate/dermatan sulfate metabolism
(R-HSA-1793185)
Chondroitin sulfate biosynthesis
(R-HSA-2022870)
Cs/ds degradation
(R-HSA-2024101)
Defective b3galt6 causes edsp2 and semdjl1
(R-HSA-4420332)
Defective b3gat3 causes jdssdhd
(R-HSA-3560801)
Defective b4galt7 causes eds, progeroid type
(R-HSA-3560783)
Defective chst3 causes sedcjd
(R-HSA-3595172)
Defective chst14 causes eds, musculocontractural type
(R-HSA-3595174)
Defective chsy1 causes tpbs
(R-HSA-3595177)
Degradation of the extracellular matrix
(R-HSA-1474228)
Dermatan sulfate biosynthesis
(R-HSA-2022923)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Ecm proteoglycans
(R-HSA-3000178)
Extracellular matrix organization
(R-HSA-1474244)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Animal organ morphogenesis
(GO:0009887)
Collagen-containing extracellular matrix
(GO:0062023)
Extracellular matrix binding
(GO:0050840)
Extracellular matrix structural constituent conferring compression resistance
(GO:0030021)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glycosaminoglycan binding
(GO:0005539)
Golgi lumen
(GO:0005796)
Lysosomal lumen
(GO:0043202)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of endothelial cell migration
(GO:0010596)
Negative regulation of vascular endothelial growth factor signaling pathway
(GO:1900747)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of macroautophagy
(GO:0016239)
Positive regulation of mitochondrial depolarization
(GO:0051901)
Positive regulation of mitochondrial fission
(GO:0090141)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 8.38
Marker Score: 5515.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 5.36
Marker Score: 8250.5
Cell Name: theca cell (CL0000503)
Fold Change: 4.91
Marker Score: 3518
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.44
Marker Score: 151113
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.21
Marker Score: 3592
Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.97
Marker Score: 1706.5
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.93
Marker Score: 5402
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.89
Marker Score: 10191
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.67
Marker Score: 23869
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.55
Marker Score: 1477
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.38
Marker Score: 3894
Cell Name: skin fibroblast (CL0002620)
Fold Change: 3.36
Marker Score: 872
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.15
Marker Score: 35531
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.09
Marker Score: 40733
Cell Name: fibroblast (CL0000057)
Fold Change: 3
Marker Score: 2896
Cell Name: decidual cell (CL2000002)
Fold Change: 2.98
Marker Score: 12839
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.86
Marker Score: 1631.5
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.86
Marker Score: 5501.5
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.84
Marker Score: 1579
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.62
Marker Score: 652
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 2.6
Marker Score: 585
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.6
Marker Score: 652
Cell Name: keratocyte (CL0002363)
Fold Change: 2.41
Marker Score: 554
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.37
Marker Score: 804
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.31
Marker Score: 2850
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.16
Marker Score: 611
Cell Name: adipose microvascular endothelial cell (CL2000072)
Fold Change: 2.03
Marker Score: 603.5
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.98
Marker Score: 636
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.95
Marker Score: 1230
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.94
Marker Score: 731
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.92
Marker Score: 2068.5
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.86
Marker Score: 2317
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.84
Marker Score: 907
Cell Name: supporting cell (CL0000630)
Fold Change: 1.82
Marker Score: 3411
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.72
Marker Score: 425
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.72
Marker Score: 885
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.63
Marker Score: 477
Cell Name: Unknown (CL0002371)
Fold Change: 1.62
Marker Score: 1721.5
Cell Name: chondrocyte (CL0000138)
Fold Change: 1.61
Marker Score: 726.5
Cell Name: muscle cell (CL0000187)
Fold Change: 1.6
Marker Score: 454
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.57
Marker Score: 1142
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.54
Marker Score: 1011
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.5
Marker Score: 2462
Cell Name: fat cell (CL0000136)
Fold Change: 1.47
Marker Score: 824
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168414
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.47
Marker Score: 1909
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.45
Marker Score: 324
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.44
Marker Score: 379
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.38
Marker Score: 5104
Cell Name: pericyte (CL0000669)
Fold Change: 1.33
Marker Score: 776
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.3
Marker Score: 451
Cell Name: contractile cell (CL0000183)
Fold Change: 1.22
Marker Score: 662
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.16
Marker Score: 11642
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4765
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.12
Marker Score: 938
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 1.12
Marker Score: 852
Cell Name: reticular cell (CL0000432)
Fold Change: 1.07
Marker Score: 390
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 1.03
Marker Score: 253
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71758
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47983
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1
Marker Score: 22271
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30403
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.98
Marker Score: 5867
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 496
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 451
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.94
Marker Score: 239
Cell Name: podocyte (CL0000653)
Fold Change: 0.92
Marker Score: 340
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.91
Marker Score: 18198
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 366
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2727
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.91
Marker Score: 1996.5
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.89
Marker Score: 936
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.89
Marker Score: 356
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: tendon cell (CL0000388)
Fold Change: 0.88
Marker Score: 217
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.88
Marker Score: 1212
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.88
Marker Score: 2382
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4967
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5270
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.86
Marker Score: 2115
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.82
Marker Score: 213
Cell Name: lactocyte (CL0002325)
Fold Change: 0.81
Marker Score: 13004
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 610.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1260
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.77
Marker Score: 2134.5
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.77
Marker Score: 274
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.76
Marker Score: 1527
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 388
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.74
Marker Score: 338
Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 666
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.71
Marker Score: 1452
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.71
Marker Score: 2800
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.7
Marker Score: 421
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.7
Marker Score: 290.5
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.7
Marker Score: 197
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.69
Marker Score: 5322
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: osteoblast (CL0000062)
Fold Change: 0.68
Marker Score: 367.5
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.67
Marker Score: 2368

Hover over a box to see details here...

**Key characteristics:** * Decorin is a large protein (100 kDa) that is secreted by cells of the extracellular matrix. * It is a type of glycoprotein that is involved in the organization and stability of the extracellular matrix. * Decorin has been shown to play a role in cell migration, adhesion, and signaling. **Pathways and functions:** * Decorin is involved in the regulation of cell migration and adhesion. * It is a key component of the extracellular matrix, which is a complex network of proteins and polysaccharides that provides structural support and allows cells to interact with their environment. * Decorin is also involved in cell signaling, as it is a ligand for the integrin family of cell adhesion molecules. * Dysregulation of decorin has been linked to a number of diseases, including cancer and cardiovascular disease. **Clinical significance:** * Mutations in the DCN gene have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. * Decorin is a potential target for therapy in these diseases, as it is a key component of the extracellular matrix that is involved in cell migration and adhesion. * Developing drugs that target decorin could provide a new treatment for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Decorin

Genular Protein ID: 234587089

Symbol: PGS2_HUMAN

Name: Decorin

UniProtKB Accession Codes:

P07585 Q9P0Z0 Q9P0Z1 Q9Y5N8 Q9Y5N9

Database IDs:

Citations:

PubMed ID: 3484330

Title: Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA.

PubMed ID: 3484330

DOI: 10.1073/pnas.83.20.7683

PubMed ID: 8432527

Title: Human decorin gene: intron-exon junctions and chromosomal localization.

PubMed ID: 8432527

DOI: 10.1006/geno.1993.1023

PubMed ID: 8432526

Title: The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23.

PubMed ID: 8432526

DOI: 10.1006/geno.1993.1022

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2590169

Title: Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II.

PubMed ID: 2590169

DOI: 10.1042/bj2620823

PubMed ID: 3597437

Title: Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone.

PubMed ID: 3597437

DOI: 10.1016/s0021-9258(18)47991-4

PubMed ID: 15671264

Title: Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene.

PubMed ID: 15671264

DOI: 10.1167/iovs.04-0804

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

Sequence Information:

Length: 359
Mass: 39747
Checksum: FF511E871A1A52DD
Sequence:

MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL GPVCPFRCQC 
HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV 
SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE 
LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS 
LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH 
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DCN

Associated with

Cells (max top 100)

Other Information

Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA. PubMed ID: 3484330

Human decorin gene: intron-exon junctions and chromosomal localization. PubMed ID: 8432527

The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. PubMed ID: 8432526

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II. PubMed ID: 2590169

Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. PubMed ID: 3597437

Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene. PubMed ID: 15671264

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans. PubMed ID: 25326458

An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer. PubMed ID: 32337544

Mass spectrometric analysis of chondroitin sulfate-linked peptides. PubMed ID: 36213313

Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics. PubMed ID: 37453717