Details for: GADD45A

Gene ID: 1647

Symbol: GADD45A

Ensembl ID: ENSG00000116717

Description: growth arrest and DNA damage inducible alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.57
    Marker Score: 8723
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.09
    Marker Score: 2436
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.9
    Marker Score: 7128
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.87
    Marker Score: 97545
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.82
    Marker Score: 2404
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.5
    Marker Score: 847
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.35
    Marker Score: 11555
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.35
    Marker Score: 3461
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.33
    Marker Score: 3038
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.19
    Marker Score: 778
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.18
    Marker Score: 3689.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.05
    Marker Score: 852
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.03
    Marker Score: 1591
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2
    Marker Score: 3544
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.97
    Marker Score: 12559
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.9
    Marker Score: 2026
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.86
    Marker Score: 930
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.81
    Marker Score: 6692
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.8
    Marker Score: 2951
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.8
    Marker Score: 926
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.79
    Marker Score: 443
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.78
    Marker Score: 1876
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.71
    Marker Score: 1139
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.7
    Marker Score: 3857
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.57
    Marker Score: 6764
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.55
    Marker Score: 396
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.55
    Marker Score: 1322
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.55
    Marker Score: 3097
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.52
    Marker Score: 17064
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.5
    Marker Score: 2821
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.5
    Marker Score: 4268
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.49
    Marker Score: 2463
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.47
    Marker Score: 1001
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167083.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.43
    Marker Score: 5503
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.42
    Marker Score: 3710
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.41
    Marker Score: 820
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.4
    Marker Score: 1483
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.4
    Marker Score: 544
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4
    Marker Score: 401
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.39
    Marker Score: 47977
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.38
    Marker Score: 351
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.37
    Marker Score: 6573
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.37
    Marker Score: 340
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.36
    Marker Score: 587
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.36
    Marker Score: 4263
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.36
    Marker Score: 1750
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.35
    Marker Score: 340
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.35
    Marker Score: 1343
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.3
    Marker Score: 820
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.27
    Marker Score: 4526
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.27
    Marker Score: 3395
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.27
    Marker Score: 2310
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.26
    Marker Score: 901
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.25
    Marker Score: 2187
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.25
    Marker Score: 504
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.24
    Marker Score: 1808
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.22
    Marker Score: 287
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.22
    Marker Score: 3378
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.22
    Marker Score: 601
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.21
    Marker Score: 1306
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.21
    Marker Score: 524
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.18
    Marker Score: 283
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.18
    Marker Score: 429
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.17
    Marker Score: 1106
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.17
    Marker Score: 772
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.17
    Marker Score: 974
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.16
    Marker Score: 9072
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.15
    Marker Score: 429
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 17939
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.14
    Marker Score: 962
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.14
    Marker Score: 341
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.13
    Marker Score: 2358
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.12
    Marker Score: 513
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.12
    Marker Score: 1134
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.1
    Marker Score: 571
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.09
    Marker Score: 246
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.07
    Marker Score: 1036
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.07
    Marker Score: 1265
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.07
    Marker Score: 246
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.06
    Marker Score: 208
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.06
    Marker Score: 270
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.06
    Marker Score: 607
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.06
    Marker Score: 1305
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.06
    Marker Score: 1451
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.05
    Marker Score: 616
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.02
    Marker Score: 8804
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.02
    Marker Score: 914
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1
    Marker Score: 346
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1
    Marker Score: 3864
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71632
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47857
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.99
    Marker Score: 281
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.99
    Marker Score: 634
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.99
    Marker Score: 1152
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.98
    Marker Score: 1154
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.98
    Marker Score: 441
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.98
    Marker Score: 564
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30376
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.98
    Marker Score: 442

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Other Information

**Key characteristics:** * GADD45A is a protein of the GADD family of proteins, which are characterized by their ability to bind to DNA and regulate gene expression. * GADD45A is a key regulator of the cell cycle, as it is involved in the regulation of cell cycle checkpoints and DNA damage repair mechanisms. * GADD45A is also involved in the regulation of apoptosis and cell growth. **Pathways and functions:** * GADD45A is involved in the regulation of cell cycle checkpoints, as it is a key regulator of the G1/S boundary. * GADD45A is also involved in the regulation of DNA damage repair mechanisms, as it is a key regulator of the repair of DNA damage caused by a variety of agents, including ionizing radiation, chemicals, and viruses. * GADD45A is also involved in the regulation of apoptosis, as it is a key regulator of the decision of cells to undergo apoptosis or to survive. * GADD45A is also involved in the regulation of cell growth, as it is a key regulator of cell cycle entry. **Clinical significance:** GADD45A is a gene that is frequently mutated in human cancer, as it is involved in the regulation of cell cycle checkpoints and DNA damage repair mechanisms. Mutations in GADD45A have been linked to the development of a number of human cancers, including prostate cancer, breast cancer, and colon cancer. **Conclusion:** GADD45A is a critical regulator of cell cycle progression and DNA damage repair mechanisms in mammalian cells. Its mutations have been linked to the development of a number of human cancers, making it a promising target for the development of new cancer therapies.

Genular Protein ID: 2133474875

Symbol: GA45A_HUMAN

Name: Growth arrest and DNA damage-inducible protein GADD45 alpha

UniProtKB Accession Codes:

P24522 Q5TCA7 Q5TCA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1990262

Title: Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.

PubMed ID: 1990262

DOI: 10.1128/mcb.11.2.1009-1016.1991

PubMed ID: 8226988

Title: Analysis of the mammalian gadd45 gene and its response to DNA damage.

PubMed ID: 8226988

DOI: 10.1016/s0021-9258(20)80537-7

PubMed ID: 16421274

Title: Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA.

PubMed ID: 16421274

DOI: 10.1093/nar/gkj459

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12716909

Title: CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.

PubMed ID: 12716909

DOI: 10.1074/jbc.m212835200

PubMed ID: 7973727

Title: Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.

PubMed ID: 7973727

DOI: 10.1126/science.7973727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 20460379

Title: Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase.

PubMed ID: 20460379

DOI: 10.1074/jbc.m109.069344

Sequence Information:

  • Length: 165
  • Mass: 18336
  • Checksum: F2ADC183F6C0F064
  • Sequence:
    • MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVD PDNVVLCLLA 
ADEDDDRDVA LQIHFTLIQA FCCENDINIL RVSNPGRLAE LLLLETDAGP AASEGAEQPP 
DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPER

Genular Protein ID: 1369907362

Symbol: A5JUZ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5JUZ3

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 60
  • Mass: 6665
  • Checksum: 3A92527071682B30
  • Sequence:
    • MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVI HIHLNGRILP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.