Details for: DDIT3

Gene ID: 1649

Symbol: DDIT3

Ensembl ID: ENSG00000175197

Description: DNA damage inducible transcript 3

Associated with

  • Atf4 activates genes in response to endoplasmic reticulum stress
    (R-HSA-380994)
  • Atf6 (atf6-alpha) activates chaperone genes
    (R-HSA-381183)
  • Atf6 (atf6-alpha) activates chaperones
    (R-HSA-381033)
  • Cellular responses to stimuli
    (R-HSA-8953897)
  • Cellular responses to stress
    (R-HSA-2262752)
  • Cellular response to starvation
    (R-HSA-9711097)
  • Foxo-mediated transcription
    (R-HSA-9614085)
  • Foxo-mediated transcription of cell death genes
    (R-HSA-9614657)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Perk regulates gene expression
    (R-HSA-381042)
  • Response of eif2ak1 (hri) to heme deficiency
    (R-HSA-9648895)
  • Response of eif2ak4 (gcn2) to amino acid deficiency
    (R-HSA-9633012)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Unfolded protein response (upr)
    (R-HSA-381119)
  • Anterior/posterior axis specification
    (GO:0009948)
  • Artery development
    (GO:0060840)
  • Atf6-mediated unfolded protein response
    (GO:0036500)
  • Blood vessel maturation
    (GO:0001955)
  • Camp response element binding protein binding
    (GO:0008140)
  • Cell redox homeostasis
    (GO:0045454)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dna damage response
    (GO:0006974)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Er overload response
    (GO:0006983)
  • Establishment of protein localization to mitochondrion
    (GO:0072655)
  • Gene expression
    (GO:0010467)
  • Hri-mediated signaling
    (GO:0140468)
  • Identical protein binding
    (GO:0042802)
  • Integrated stress response signaling
    (GO:0140467)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Intrinsic apoptotic signaling pathway in response to nitrosative stress
    (GO:1990442)
  • Leucine zipper domain binding
    (GO:0043522)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Negative regulation of determination of dorsal identity
    (GO:2000016)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of fat cell differentiation
    (GO:0045599)
  • Negative regulation of interleukin-4 production
    (GO:0032713)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of myoblast differentiation
    (GO:0045662)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Perk-mediated unfolded protein response
    (GO:0036499)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Proteasome-mediated ubiquitin-dependent protein catabolic process
    (GO:0043161)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Release of sequestered calcium ion into cytosol
    (GO:0051209)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to platelet-derived growth factor
    (GO:0036119)
  • Response to starvation
    (GO:0042594)
  • Response to unfolded protein
    (GO:0006986)
  • Response to wounding
    (GO:0009611)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sensory perception of sound
    (GO:0007605)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription corepressor activity
    (GO:0003714)
  • Transcription regulator activator activity
    (GO:0140537)
  • Transcription regulator inhibitor activity
    (GO:0140416)
  • Vascular associated smooth muscle cell migration
    (GO:1904738)
  • Vascular associated smooth muscle cell proliferation
    (GO:1990874)
  • Wnt signaling pathway
    (GO:0016055)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 239.8016
    Cell Significance Index: -37.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.0679
    Cell Significance Index: -35.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 91.5408
    Cell Significance Index: -37.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.6816
    Cell Significance Index: -33.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.3393
    Cell Significance Index: -37.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.2719
    Cell Significance Index: -37.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.7194
    Cell Significance Index: -38.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.9887
    Cell Significance Index: -34.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.4228
    Cell Significance Index: -37.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.0611
    Cell Significance Index: -32.3100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 11.1042
    Cell Significance Index: 117.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6007
    Cell Significance Index: -37.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9209
    Cell Significance Index: -27.4000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 8.0961
    Cell Significance Index: 31.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0300
    Cell Significance Index: -8.8200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.3589
    Cell Significance Index: 25.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.6209
    Cell Significance Index: 335.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.3111
    Cell Significance Index: 50.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7509
    Cell Significance Index: 91.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6985
    Cell Significance Index: 48.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3009
    Cell Significance Index: 81.9900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2322
    Cell Significance Index: 10.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1728
    Cell Significance Index: 53.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0935
    Cell Significance Index: 14.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9324
    Cell Significance Index: 26.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9041
    Cell Significance Index: 24.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7731
    Cell Significance Index: 84.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7525
    Cell Significance Index: 39.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7004
    Cell Significance Index: 32.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6615
    Cell Significance Index: 107.5900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.6366
    Cell Significance Index: 3.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6225
    Cell Significance Index: 85.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5571
    Cell Significance Index: 304.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5541
    Cell Significance Index: 54.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5536
    Cell Significance Index: 65.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5398
    Cell Significance Index: 4.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4701
    Cell Significance Index: 89.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4675
    Cell Significance Index: 206.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4425
    Cell Significance Index: 32.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3633
    Cell Significance Index: 7.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3138
    Cell Significance Index: 40.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2967
    Cell Significance Index: 7.2400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2908
    Cell Significance Index: 1.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2795
    Cell Significance Index: 50.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2779
    Cell Significance Index: 7.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2667
    Cell Significance Index: 240.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2358
    Cell Significance Index: 15.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2212
    Cell Significance Index: 27.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2193
    Cell Significance Index: 7.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2187
    Cell Significance Index: 5.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1973
    Cell Significance Index: 9.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1683
    Cell Significance Index: 28.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1640
    Cell Significance Index: 4.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1502
    Cell Significance Index: 30.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1486
    Cell Significance Index: 29.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1445
    Cell Significance Index: 3.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1177
    Cell Significance Index: 6.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1152
    Cell Significance Index: 71.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0783
    Cell Significance Index: 5.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0567
    Cell Significance Index: 20.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0441
    Cell Significance Index: 83.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0227
    Cell Significance Index: 17.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0156
    Cell Significance Index: 0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0089
    Cell Significance Index: 12.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0014
    Cell Significance Index: 1.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0086
    Cell Significance Index: -13.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0116
    Cell Significance Index: -21.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0177
    Cell Significance Index: -11.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0190
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0257
    Cell Significance Index: -2.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0303
    Cell Significance Index: -3.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0332
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0427
    Cell Significance Index: -24.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0470
    Cell Significance Index: -21.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0627
    Cell Significance Index: -2.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0648
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0742
    Cell Significance Index: -15.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0797
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0874
    Cell Significance Index: -10.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0951
    Cell Significance Index: -27.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0960
    Cell Significance Index: -6.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1413
    Cell Significance Index: -20.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1748
    Cell Significance Index: -3.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1821
    Cell Significance Index: -1.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1989
    Cell Significance Index: -2.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2253
    Cell Significance Index: -26.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2539
    Cell Significance Index: -2.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2857
    Cell Significance Index: -6.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3343
    Cell Significance Index: -34.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3891
    Cell Significance Index: -4.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3951
    Cell Significance Index: -31.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4155
    Cell Significance Index: -25.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4613
    Cell Significance Index: -28.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4619
    Cell Significance Index: -23.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4783
    Cell Significance Index: -32.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4787
    Cell Significance Index: -10.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5208
    Cell Significance Index: -21.3400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.5290
    Cell Significance Index: -4.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5859
    Cell Significance Index: -32.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DDIT3 is a transcription factor that regulates the expression of genes involved in the cellular response to stress. It is induced by ER stress, UPR, and DNA damage, and it acts as a transcriptional activator to promote the expression of genes involved in stress response. DDIT3 is characterized by its ability to bind to specific DNA sequences and regulate the transcription of target genes. It is also involved in the regulation of protein homeostasis, apoptosis, and cell cycle progression. **Pathways and Functions:** DDIT3 is involved in several signaling pathways, including: 1. **Endoplasmic Reticulum Stress Response (ER Stress Response):** DDIT3 is induced by ER stress and acts as a transcriptional activator to promote the expression of genes involved in the UPR. 2. **Unfolded Protein Response (UPR):** DDIT3 is involved in the regulation of protein homeostasis and apoptosis in response to ER stress. 3. **DNA Damage Response:** DDIT3 is induced by DNA damage and acts as a transcriptional activator to promote the expression of genes involved in DNA repair. 4. **Cellular Redox Homeostasis:** DDIT3 is involved in the regulation of cellular redox homeostasis and acts as a transcriptional activator to promote the expression of genes involved in antioxidant defense. 5. **Apoptosis:** DDIT3 is involved in the regulation of apoptosis and acts as a transcriptional activator to promote the expression of genes involved in apoptosis. **Clinical Significance:** DDIT3 dysregulation has been implicated in several diseases, including: 1. **Cancer:** DDIT3 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Neurodegenerative Disorders:** DDIT3 is involved in the regulation of apoptosis and cell cycle progression in neurons, and its dysregulation has been implicated in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 3. **Metabolic Disorders:** DDIT3 is involved in the regulation of glucose metabolism and insulin sensitivity, and its dysregulation has been implicated in metabolic disorders such as type 2 diabetes. 4. **Inflammatory Disorders:** DDIT3 is involved in the regulation of inflammation and immune responses, and its dysregulation has been implicated in inflammatory disorders such as rheumatoid arthritis and atherosclerosis. In conclusion, DDIT3 is a critical regulator of cellular stress response and plays a key role in the regulation of various cellular processes, including transcription, cell cycle, and apoptosis. Its dysregulation has been implicated in several diseases, including cancer, neurodegenerative disorders, and metabolic disorders. Further research is needed to fully understand the role of DDIT3 in human health and disease.

Genular Protein ID: 1650833018

Symbol: DDIT3_HUMAN

Name: DNA damage-inducible transcript 3 protein

UniProtKB Accession Codes:

P35638 F8VS99

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 10 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 Ensembl 5 ExpressionAtlas 1 GO 75 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1339368

Title: Isolation, characterization and chromosomal localization of the human GADD153 gene.

PubMed ID: 1339368

DOI: 10.1016/0378-1119(92)90523-r

PubMed ID: 8510758

Title: Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.

PubMed ID: 8510758

DOI: 10.1038/363640a0

PubMed ID: 7503811

Title: Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.

PubMed ID: 7503811

DOI: 10.1038/ng0693-175

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14685163

Title: Roles of CHOP/GADD153 in endoplasmic reticulum stress.

PubMed ID: 14685163

DOI: 10.1038/sj.cdd.4401373

PubMed ID: 15322075

Title: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells.

PubMed ID: 15322075

DOI: 10.1074/jbc.m406933200

PubMed ID: 15775988

Title: TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.

PubMed ID: 15775988

DOI: 10.1038/sj.emboj.7600596

PubMed ID: 16434966

Title: The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals.

PubMed ID: 16434966

DOI: 10.1038/sj.onc.1209380

PubMed ID: 17872950

Title: Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.

PubMed ID: 17872950

DOI: 10.1074/jbc.m703735200

PubMed ID: 17709599

Title: CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells.

PubMed ID: 17709599

DOI: 10.1165/rcmb.2007-0197oc

PubMed ID: 18940792

Title: C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene.

PubMed ID: 18940792

DOI: 10.1074/jbc.m806874200

PubMed ID: 19855386

Title: Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling.

PubMed ID: 19855386

DOI: 10.1038/ncb1996

PubMed ID: 19672300

Title: ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity.

PubMed ID: 19672300

DOI: 10.1371/journal.pone.0006618

PubMed ID: 20829347

Title: Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.

PubMed ID: 20829347

DOI: 10.1074/jbc.m110.136259

PubMed ID: 20876114

Title: Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression.

PubMed ID: 20876114

DOI: 10.1073/pnas.1011736107

PubMed ID: 22210905

Title: CHOP is a multifunctional transcription factor in the ER stress response.

PubMed ID: 22210905

DOI: 10.1093/jb/mvr143

PubMed ID: 22761832

Title: CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress.

PubMed ID: 22761832

DOI: 10.1371/journal.pone.0039586

PubMed ID: 29083303

Title: Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins.

PubMed ID: 29083303

DOI: 10.7554/elife.27860

PubMed ID: 33384352

Title: QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.

PubMed ID: 33384352

DOI: 10.1126/science.abb6896

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 169
  • Mass: 19175
  • Checksum: 31905293FB1FBBE2
  • Sequence:
    • MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL 
AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM 
KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.