Details for: DDIT3
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 31.42rCSI 42.96%PRS 36.27
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CSI 28.07rCSI 45.19%PRS 18.74
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CSI 27.51rCSI 26.45%PRS 47.52
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CSI 19.84rCSI 24.67%PRS 26.13
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CSI 17.94rCSI 40.95%PRS 20.98
-
CSI 16.14rCSI 20.54%PRS 28.17
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CSI 15.12rCSI 36.11%PRS 35.6
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CSI 13.59rCSI 26.44%PRS 25.13
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CSI 13.34rCSI 42.82%PRS 33.54
-
CSI 12.56rCSI 17.93%PRS 27.24
-
CSI 12.53rCSI 12.07%PRS 25.34
-
CSI 11.94rCSI 13.07%PRS 27.32
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CSI 10.53rCSI 20.87%PRS 57.12
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CSI 8.18rCSI 5.87%PRS 33.64
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CSI 8.14rCSI 18.25%PRS 15.33
-
CSI 7.95rCSI 12.7%PRS 26.78
-
CSI 7.95rCSI 8.14%PRS 43.13
-
CSI 7.38rCSI 8.3%PRS 38.55
-
CSI 7.06rCSI 22.89%PRS 28.93
-
CSI 6.85rCSI 29.61%PRS 42.49
-
CSI 6.7rCSI 8.04%PRS 23.84
-
CSI 6.58rCSI 5.45%PRS 23.24
-
CSI 6.49rCSI 37.77%PRS 35.46
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CSI 6.47rCSI 11.4%PRS 23.89
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CSI 5.17rCSI 5.54%PRS 22.53
-
CSI 4.97rCSI 6.79%PRS 27.56
-
CSI 4.48rCSI 9.92%PRS 22.61
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CSI 4.42rCSI 4.26%PRS 18.02
-
CSI 4.34rCSI 7.43%PRS 45.11
-
CSI 4.32rCSI 10.96%PRS 24.1
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CSI 4.28rCSI 8.24%PRS 52.97
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CSI 4.27rCSI 4.2%PRS 26.24
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CSI 4.24rCSI 12.29%PRS 19.05
-
CSI 4.21rCSI 23.54%PRS 41.5
-
CSI 4.09rCSI 3.78%PRS 43.01
-
CSI 4.04rCSI 3.73%PRS 25.57
-
CSI 4.01rCSI 3.96%PRS 69.12
-
CSI 3.99rCSI 24.9%PRS 19.3
-
CSI 3.96rCSI 4.64%PRS 34.33
-
CSI 3.95rCSI 2.62%PRS 29.16
-
CSI 3.81rCSI 18.78%PRS 32.85
-
CSI 3.7rCSI 7.01%PRS 60.06
-
CSI 3.69rCSI 5.48%PRS 28.45
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CSI 3.68rCSI 5.93%PRS 35.87
-
CSI 3.64rCSI 4.35%PRS 41.68
-
CSI 3.63rCSI 82.21%PRS 70.72
-
CSI 3.58rCSI 8.87%PRS 22.74
-
CSI 3.51rCSI 2.81%PRS 42.75
-
CSI 3.4rCSI 7.44%PRS 32.32
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CSI 3.32rCSI 18.1%PRS 51.7
-
CSI 3.25rCSI 9.41%PRS 27.35
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CSI 3.11rCSI 3.78%PRS 30.38
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CSI 3.1rCSI 7.22%PRS 52.63
-
CSI 3.09rCSI 3.24%PRS 25.97
-
CSI 3.01rCSI 2.53%PRS 38.57
-
CSI 3rCSI 15.04%PRS 32.37
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CSI 2.97rCSI 6.53%PRS 28.01
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CSI 2.9rCSI 5.02%PRS 18.72
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CSI 2.87rCSI 7.28%PRS 18.65
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CSI 2.84rCSI 6.27%PRS 17.5
-
CSI 2.74rCSI 5.13%PRS 17.77
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CSI 2.73rCSI 2.02%PRS 21
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CSI 2.68rCSI 4.72%PRS 31.4
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CSI 2.68rCSI 1.99%PRS 35.71
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CSI 2.67rCSI 4.68%PRS 18.84
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CSI 2.66rCSI 2.78%PRS 22.84
-
CSI 2.62rCSI 3.3%PRS 36.73
-
CSI 2.58rCSI 4.92%PRS 38.07
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CSI 2.53rCSI 2.18%PRS 35.98
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CSI 2.46rCSI 2.57%PRS 25.37
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CSI 2.44rCSI 3.37%PRS 32.84
-
CSI 2.42rCSI 2.15%PRS 24.7
-
CSI 2.41rCSI 1.84%PRS 32.48
-
CSI 2.41rCSI 2.24%PRS 24.45
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CSI 2.39rCSI 5.61%PRS 34.27
-
CSI 2.36rCSI 1.96%PRS 24.94
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CSI 2.35rCSI 3.71%PRS 24.58
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CSI 2.34rCSI 2.92%PRS 33.8
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CSI 2.28rCSI 2.93%PRS 23.44
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CSI 2.26rCSI 1.71%PRS 33.45
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CSI 2.18rCSI 6.14%PRS 30.74
-
CSI 2.15rCSI 7.26%PRS 37.43
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CSI 2.14rCSI 2.69%PRS 31.72
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CSI 2.13rCSI 1.86%PRS 32.3
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CSI 2.12rCSI 2.89%PRS 36.23
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CSI 2.08rCSI 1.56%PRS 40.24
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CSI 2.08rCSI 1.62%PRS 23.7
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CSI 2.04rCSI 1.42%PRS 26.13
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CSI 2.03rCSI 2.7%PRS 26.84
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CSI 2.02rCSI 1.59%PRS 29.69
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CSI 2.01rCSI 4.82%PRS 41.73
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CSI 2rCSI 3.42%PRS 47.92
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CSI 2rCSI 3.06%PRS 27.92
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CSI 1.99rCSI 5.14%PRS 57.9
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CSI 1.98rCSI 1.94%PRS 37.61
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CSI 1.96rCSI 3.06%PRS 52.02
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CSI 1.94rCSI 3.67%PRS 49
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CSI 1.92rCSI 6.8%PRS 38.67
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CSI 1.91rCSI 7.28%PRS 23
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CSI 1.87rCSI 2.56%PRS 27.11
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CSI 0.2rCSI 1.0%PRS 35.7%
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CSI 0.2rCSI 0.6%PRS 21.1%
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CSI 0.2rCSI 1.6%PRS 23.5%
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CSI 0.3rCSI 5.5%PRS 58.2%
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CSI 0.3rCSI 4.3%PRS 58.4%
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CSI 0.3rCSI 0.4%PRS 25.9%
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CSI 0.3rCSI 0.9%PRS 15.5%
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CSI 0.3rCSI 7.4%PRS 61.1%
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CSI 0.3rCSI 1.8%PRS 67.3%
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CSI 0.4rCSI 4.7%PRS 61.9%
-
CSI 0.4rCSI 2.8%PRS 43.4%
-
CSI 0.4rCSI 1.9%PRS 38.1%
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CSI 0.4rCSI 2.5%PRS 57.3%
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CSI 0.4rCSI 2.4%PRS 50.7%
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CSI 0.4rCSI 1.5%PRS 13.9%
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CSI 0.4rCSI 2.0%PRS 50.0%
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CSI 0.4rCSI 1.9%PRS 40.8%
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CSI 0.5rCSI 0.9%PRS 40.2%
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CSI 0.5rCSI 4.7%PRS 56.4%
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CSI 0.5rCSI 3.1%PRS 53.7%
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CSI 0.5rCSI 0.9%PRS 14.7%
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CSI 0.6rCSI 6.2%PRS 53.3%
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CSI 0.6rCSI 1.4%PRS 14.4%
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CSI 0.6rCSI 0.7%PRS 15.3%
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CSI 0.6rCSI 2.4%PRS 53.5%
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CSI 0.6rCSI 3.2%PRS 41.1%
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CSI 0.6rCSI 1.4%PRS 25.0%
-
CSI 0.6rCSI 2.7%PRS 75.8%
-
CSI 0.6rCSI 6.2%PRS 78.0%
-
CSI 0.7rCSI 2.4%PRS 65.9%
-
CSI 0.7rCSI 1.9%PRS 37.4%
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CSI 0.7rCSI 1.2%PRS 14.5%
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CSI 0.7rCSI 1.2%PRS 16.0%
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CSI 0.7rCSI 1.4%PRS 45.6%
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CSI 0.8rCSI 2.1%PRS 39.8%
-
CSI 0.8rCSI 1.4%PRS 18.6%
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CSI 0.8rCSI 1.1%PRS 33.9%
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CSI 0.8rCSI 2.3%PRS 39.2%
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CSI 0.8rCSI 2.5%PRS 51.3%
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CSI 0.9rCSI 2.3%PRS 31.6%
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CSI 0.9rCSI 1.3%PRS 41.7%
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CSI 0.9rCSI 1.1%PRS 29.0%
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CSI 0.9rCSI 3.9%PRS 23.8%
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CSI 0.9rCSI 3.9%PRS 22.2%
-
CSI 0.9rCSI 2.3%PRS 59.2%
-
CSI 0.9rCSI 3.0%PRS 58.6%
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CSI 0.9rCSI 3.6%PRS 48.1%
-
CSI 0.9rCSI 1.3%PRS 37.8%
-
CSI 0.9rCSI 2.2%PRS 35.1%
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CSI 1.0rCSI 1.4%PRS 37.7%
-
CSI 1.0rCSI 2.1%PRS 36.3%
-
CSI 1.0rCSI 0.8%PRS 30.9%
-
CSI 1.0rCSI 0.8%PRS 24.7%
-
CSI 1.0rCSI 1.5%PRS 31.9%
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CSI 1.0rCSI 2.7%PRS 35.7%
-
CSI 1.0rCSI 1.6%PRS 25.1%
-
CSI 1.0rCSI 1.6%PRS 29.4%
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CSI 1.1rCSI 0.9%PRS 27.6%
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CSI 1.1rCSI 3.6%PRS 29.1%
-
CSI 1.1rCSI 1.8%PRS 28.8%
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CSI 1.1rCSI 2.0%PRS 20.3%
-
CSI 1.1rCSI 1.2%PRS 40.3%
-
CSI 1.1rCSI 4.2%PRS 15.2%
-
CSI 1.1rCSI 1.0%PRS 29.1%
-
CSI 1.1rCSI 2.1%PRS 31.1%
-
CSI 1.1rCSI 2.2%PRS 49.3%
-
CSI 1.2rCSI 1.1%PRS 22.3%
-
CSI 1.2rCSI 2.8%PRS 29.9%
-
CSI 1.2rCSI 1.4%PRS 41.6%
-
CSI 1.2rCSI 3.4%PRS 42.8%
-
CSI 1.2rCSI 3.4%PRS 36.7%
-
CSI 1.2rCSI 2.7%PRS 28.8%
-
CSI 1.2rCSI 1.9%PRS 31.7%
-
CSI 1.2rCSI 13.3%PRS 41.6%
-
CSI 1.2rCSI 4.4%PRS 41.2%
-
CSI 1.2rCSI 2.8%PRS 31.7%
-
CSI 1.2rCSI 5.0%PRS 40.3%
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CSI 1.2rCSI 1.4%PRS 18.1%
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CSI 1.3rCSI 2.7%PRS 68.7%
-
CSI 1.3rCSI 3.2%PRS 30.0%
-
CSI 1.3rCSI 1.9%PRS 22.9%
-
CSI 1.3rCSI 1.9%PRS 24.6%
-
CSI 1.3rCSI 3.4%PRS 45.7%
-
CSI 1.3rCSI 4.6%PRS 41.1%
-
CSI 1.3rCSI 4.1%PRS 16.8%
-
CSI 1.3rCSI 1.9%PRS 33.9%
-
CSI 1.3rCSI 2.1%PRS 20.8%
-
CSI 1.3rCSI 1.2%PRS 28.3%
-
CSI 1.3rCSI 2.0%PRS 39.0%
-
CSI 1.4rCSI 1.1%PRS 29.0%
-
CSI 1.4rCSI 1.9%PRS 24.8%
-
CSI 1.4rCSI 1.7%PRS 21.6%
-
CSI 1.4rCSI 2.3%PRS 18.9%
-
CSI 1.4rCSI 2.1%PRS 27.9%
-
CSI 1.4rCSI 1.1%PRS 26.2%
-
CSI 1.4rCSI 1.4%PRS 34.8%
-
CSI 1.4rCSI 1.1%PRS 42.8%
-
CSI 1.4rCSI 1.9%PRS 34.7%
-
CSI 1.5rCSI 2.5%PRS 33.0%
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CSI 1.5rCSI 1.8%PRS 29.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1650833018
Symbol: DDIT3_HUMAN
Name: DNA damage-inducible transcript 3 protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1339368
Title: Isolation, characterization and chromosomal localization of the human GADD153 gene.
PubMed ID: 1339368
PubMed ID: 8510758
Title: Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
PubMed ID: 8510758
DOI: 10.1038/363640a0
PubMed ID: 7503811
Title: Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
PubMed ID: 7503811
DOI: 10.1038/ng0693-175
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14685163
Title: Roles of CHOP/GADD153 in endoplasmic reticulum stress.
PubMed ID: 14685163
PubMed ID: 15322075
Title: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells.
PubMed ID: 15322075
PubMed ID: 15775988
Title: TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.
PubMed ID: 15775988
PubMed ID: 16434966
Title: The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals.
PubMed ID: 16434966
PubMed ID: 17872950
Title: Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.
PubMed ID: 17872950
PubMed ID: 17709599
Title: CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells.
PubMed ID: 17709599
PubMed ID: 18940792
Title: C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene.
PubMed ID: 18940792
PubMed ID: 19855386
Title: Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling.
PubMed ID: 19855386
DOI: 10.1038/ncb1996
PubMed ID: 19672300
Title: ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity.
PubMed ID: 19672300
PubMed ID: 20829347
Title: Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.
PubMed ID: 20829347
PubMed ID: 20876114
Title: Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression.
PubMed ID: 20876114
PubMed ID: 22210905
Title: CHOP is a multifunctional transcription factor in the ER stress response.
PubMed ID: 22210905
DOI: 10.1093/jb/mvr143
PubMed ID: 22761832
Title: CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress.
PubMed ID: 22761832
PubMed ID: 29083303
Title: Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins.
PubMed ID: 29083303
DOI: 10.7554/elife.27860
PubMed ID: 33384352
Title: QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
PubMed ID: 33384352
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 169
- Mass: 19175
- Checksum: 31905293FB1FBBE2
- Sequence:
MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA