Details for: DDX3X

Gene ID: 1654

Symbol: DDX3X

Ensembl ID: ENSG00000215301

Description: DEAD-box helicase 3 X-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 503.5191
    Cell Significance Index: -78.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 303.7730
    Cell Significance Index: -77.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 211.3254
    Cell Significance Index: -87.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 189.5105
    Cell Significance Index: -76.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 185.2061
    Cell Significance Index: -87.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 167.3648
    Cell Significance Index: -86.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 130.2043
    Cell Significance Index: -87.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 81.5717
    Cell Significance Index: -77.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 67.4639
    Cell Significance Index: -83.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.8299
    Cell Significance Index: -79.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.0017
    Cell Significance Index: -73.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.3287
    Cell Significance Index: -88.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.6516
    Cell Significance Index: -34.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.5785
    Cell Significance Index: 131.2500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.7942
    Cell Significance Index: 23.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.3420
    Cell Significance Index: 215.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7833
    Cell Significance Index: 342.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.6506
    Cell Significance Index: 477.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.5826
    Cell Significance Index: 68.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4307
    Cell Significance Index: 333.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3618
    Cell Significance Index: 64.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3479
    Cell Significance Index: 110.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2989
    Cell Significance Index: 294.7000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.1849
    Cell Significance Index: 38.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8721
    Cell Significance Index: 827.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7455
    Cell Significance Index: 19.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7432
    Cell Significance Index: 79.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.7373
    Cell Significance Index: 32.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7332
    Cell Significance Index: 90.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6370
    Cell Significance Index: 85.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6283
    Cell Significance Index: 75.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5788
    Cell Significance Index: 862.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4879
    Cell Significance Index: 110.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4329
    Cell Significance Index: 284.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2102
    Cell Significance Index: 85.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1930
    Cell Significance Index: 239.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9553
    Cell Significance Index: 22.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8007
    Cell Significance Index: 287.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6604
    Cell Significance Index: 107.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6459
    Cell Significance Index: 76.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6307
    Cell Significance Index: 81.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5765
    Cell Significance Index: 12.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5481
    Cell Significance Index: 59.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4952
    Cell Significance Index: 4.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3810
    Cell Significance Index: 343.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3607
    Cell Significance Index: 35.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3061
    Cell Significance Index: 8.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2243
    Cell Significance Index: 42.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2197
    Cell Significance Index: 7.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1954
    Cell Significance Index: 5.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0969
    Cell Significance Index: 61.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0634
    Cell Significance Index: 119.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0576
    Cell Significance Index: 3.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0329
    Cell Significance Index: 44.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0020
    Cell Significance Index: 3.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0029
    Cell Significance Index: -2.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0290
    Cell Significance Index: -21.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0349
    Cell Significance Index: -15.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1011
    Cell Significance Index: -10.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1056
    Cell Significance Index: -78.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1512
    Cell Significance Index: -85.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1531
    Cell Significance Index: -5.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1605
    Cell Significance Index: -100.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1750
    Cell Significance Index: -29.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1977
    Cell Significance Index: -15.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2034
    Cell Significance Index: -12.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2638
    Cell Significance Index: -75.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2707
    Cell Significance Index: -17.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2834
    Cell Significance Index: -7.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2969
    Cell Significance Index: -43.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3247
    Cell Significance Index: -9.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4236
    Cell Significance Index: -5.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4752
    Cell Significance Index: -100.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5618
    Cell Significance Index: -65.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5735
    Cell Significance Index: -15.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5779
    Cell Significance Index: -66.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6720
    Cell Significance Index: -4.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7607
    Cell Significance Index: -15.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7913
    Cell Significance Index: -53.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7939
    Cell Significance Index: -82.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8285
    Cell Significance Index: -43.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8359
    Cell Significance Index: -14.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8447
    Cell Significance Index: -66.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8586
    Cell Significance Index: -18.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8777
    Cell Significance Index: -21.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9210
    Cell Significance Index: -13.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9935
    Cell Significance Index: -19.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.1042
    Cell Significance Index: -32.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1166
    Cell Significance Index: -13.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1547
    Cell Significance Index: -24.1700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.2569
    Cell Significance Index: -32.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3673
    Cell Significance Index: -60.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4189
    Cell Significance Index: -86.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.4535
    Cell Significance Index: -73.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5655
    Cell Significance Index: -50.1400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.5764
    Cell Significance Index: -22.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.6497
    Cell Significance Index: -62.4700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.7947
    Cell Significance Index: -26.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.8834
    Cell Significance Index: -31.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DDX3X is a member of the DEAD-box helicase family, which is characterized by their ability to unwind RNA secondary structures and facilitate transcription and translation. The DDX3X protein is a hexameric enzyme that contains a conserved helicase domain and a C-terminal domain that interacts with RNA-binding proteins. The protein has been shown to have ATP-dependent RNA helicase activity, which is essential for its function in transcription and translation. **Pathways and Functions** DDX3X is involved in several cellular pathways, including: 1. **Transcription regulation**: DDX3X has been shown to interact with transcription factors and RNA-binding proteins to regulate gene expression. 2. **Translation regulation**: DDX3X has been implicated in the regulation of translation initiation and elongation. 3. **Apoptosis regulation**: DDX3X has been shown to inhibit apoptosis by regulating the activity of pro-apoptotic proteins. 4. **Immune response**: DDX3X has been implicated in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 5. **Cancer**: DDX3X has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. **Clinical Significance** DDX3X has been associated with several diseases, including: 1. **Autoimmune disorders**: DDX3X has been implicated in the regulation of immune responses and has been associated with autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer**: DDX3X has been shown to be overexpressed in several types of cancer and has been associated with poor prognosis. 3. **Neurological disorders**: DDX3X has been implicated in the regulation of neuronal function and has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Reproductive disorders**: DDX3X has been implicated in the regulation of reproductive function and has been associated with reproductive disorders, such as infertility and miscarriage. In conclusion, DDX3X is a multifunctional protein that plays a critical role in various cellular processes, including transcription, translation, and apoptosis. Its dysregulation has been associated with several diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 461507136

Symbol: DDX3X_HUMAN

Name: ATP-dependent RNA helicase DDX3X

UniProtKB Accession Codes:

O00571 A8K538 B4E3E8 O15536

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 DrugCentral 1 EC 1 ELM 1 EMBL 13 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 87 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PRIDE 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10329544

Title: Hepatitis C virus core protein interacts with a human DEAD box protein DDX3.

PubMed ID: 10329544

DOI: 10.1006/viro.1999.9659

PubMed ID: 9381176

Title: Functional coherence of the human Y chromosome.

PubMed ID: 9381176

DOI: 10.1126/science.278.5338.675

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10859333

Title: An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility complex class I proteins bind peptides with a blocked NH(2) terminus in vivo.

PubMed ID: 10859333

DOI: 10.1084/jem.191.12.2083

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15507209

Title: Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function.

PubMed ID: 15507209

DOI: 10.1016/j.cell.2004.09.029

PubMed ID: 15294876

Title: The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control.

PubMed ID: 15294876

DOI: 10.1093/hmg/ddh240

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16818630

Title: DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor.

PubMed ID: 16818630

DOI: 10.1158/0008-5472.can-05-2415

PubMed ID: 16301996

Title: DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control.

PubMed ID: 16301996

DOI: 10.1038/sj.onc.1209239

PubMed ID: 17357160

Title: Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity.

PubMed ID: 17357160

DOI: 10.1002/prot.21433

PubMed ID: 17095540

Title: Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.

PubMed ID: 17095540

DOI: 10.1261/rna.336807

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18583960

Title: The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.

PubMed ID: 18583960

DOI: 10.1038/emboj.2008.126

PubMed ID: 18636090

Title: Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.

PubMed ID: 18636090

DOI: 10.1038/emboj.2008.143

PubMed ID: 18632687

Title: TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.

PubMed ID: 18632687

DOI: 10.1093/hmg/ddn203

PubMed ID: 18596238

Title: The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.

PubMed ID: 18596238

DOI: 10.1091/mbc.e07-12-1264

PubMed ID: 18628297

Title: Human DDX3 functions in translation and interacts with the translation initiation factor eIF3.

PubMed ID: 18628297

DOI: 10.1093/nar/gkn454

PubMed ID: 17667941

Title: Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.

PubMed ID: 17667941

DOI: 10.1038/sj.onc.1210687

PubMed ID: 18264132

Title: Oncogenic role of DDX3 in breast cancer biogenesis.

PubMed ID: 18264132

DOI: 10.1038/onc.2008.33

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19029303

Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

PubMed ID: 19029303

DOI: 10.1261/rna.1175909

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20127681

Title: DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.

PubMed ID: 20127681

DOI: 10.1002/eji.200940203

PubMed ID: 20375222

Title: Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.

PubMed ID: 20375222

DOI: 10.1099/vir.0.020552-0

PubMed ID: 20837705

Title: DDX3 regulates cell growth through translational control of cyclin E1.

PubMed ID: 20837705

DOI: 10.1128/mcb.00560-10

PubMed ID: 21170385

Title: Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.

PubMed ID: 21170385

DOI: 10.1371/journal.pone.0014258

PubMed ID: 20657822

Title: Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion.

PubMed ID: 20657822

DOI: 10.1371/journal.ppat.1000986

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21589879

Title: A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication.

PubMed ID: 21589879

DOI: 10.1371/journal.pone.0019810

PubMed ID: 21730191

Title: DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation.

PubMed ID: 21730191

DOI: 10.1073/pnas.1106245108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21883093

Title: Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response.

PubMed ID: 21883093

DOI: 10.1042/bj20110739

PubMed ID: 22034099

Title: The DEAD-box RNA helicase DDX3 interacts with DDX5, co-localizes with it in the cytoplasm during the G2/M phase of the cycle, and affects its shuttling during mRNP export.

PubMed ID: 22034099

DOI: 10.1002/jcb.23428

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22323517

Title: The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes.

PubMed ID: 22323517

DOI: 10.1093/nar/gks070

PubMed ID: 22872150

Title: DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs.

PubMed ID: 22872150

DOI: 10.1038/emboj.2012.220

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23478265

Title: Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation.

PubMed ID: 23478265

DOI: 10.1128/mcb.01603-12

PubMed ID: 23413191

Title: RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling.

PubMed ID: 23413191

DOI: 10.1126/science.1231499

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26100019

Title: The DHX33 RNA Helicase Promotes mRNA Translation Initiation.

PubMed ID: 26100019

DOI: 10.1128/mcb.00315-15

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27546789

Title: RNA remodeling activity of DEAD box proteins tuned by protein concentration, RNA length, and ATP.

PubMed ID: 27546789

DOI: 10.1016/j.molcel.2016.07.010

PubMed ID: 27105836

Title: Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells.

PubMed ID: 27105836

DOI: 10.1016/j.antiviral.2016.04.008

PubMed ID: 27736973

Title: The DEAD-Box RNA Helicase DDX3 Interacts with NF-kappaB Subunit p65 and Suppresses p65-Mediated Transcription.

PubMed ID: 27736973

DOI: 10.1371/journal.pone.0164471

PubMed ID: 27980081

Title: DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.

PubMed ID: 27980081

DOI: 10.1042/bcj20160956

PubMed ID: 28733330

Title: The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.

PubMed ID: 28733330

DOI: 10.1042/bcj20170354

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28842590

Title: DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.

PubMed ID: 28842590

DOI: 10.1038/s41598-017-09779-w

PubMed ID: 29062139

Title: DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.

PubMed ID: 29062139

DOI: 10.1038/s41598-017-14262-7

PubMed ID: 28128295

Title: RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.

PubMed ID: 28128295

DOI: 10.1038/srep41452

PubMed ID: 30341167

Title: DDX3 directly facilitates IKKalpha activation and regulates downstream signalling pathways.

PubMed ID: 30341167

DOI: 10.1042/bcj20180163

PubMed ID: 30131165

Title: Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3.

PubMed ID: 30131165

DOI: 10.1016/j.ejcb.2018.08.001

PubMed ID: 29222110

Title: A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1epsilon.

PubMed ID: 29222110

DOI: 10.1242/jcs.207316

PubMed ID: 29899501

Title: The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity.

PubMed ID: 29899501

DOI: 10.1038/s41467-018-04776-7

PubMed ID: 30256975

Title: Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts.

PubMed ID: 30256975

DOI: 10.1093/nar/gky861

PubMed ID: 31575075

Title: Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity.

PubMed ID: 31575075

DOI: 10.3390/cells8101181

PubMed ID: 17401195

Title: Expression, purification, crystallization and preliminary X-ray diffraction analysis of the DDX3 RNA helicase domain.

PubMed ID: 17401195

DOI: 10.1107/s1744309107006434

PubMed ID: 17631897

Title: Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP.

PubMed ID: 17631897

DOI: 10.1016/j.jmb.2007.06.050

PubMed ID: 19913487

Title: Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7.

PubMed ID: 19913487

DOI: 10.1016/j.str.2009.09.005

PubMed ID: 31300642

Title: The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X.

PubMed ID: 31300642

DOI: 10.1038/s41467-019-11083-2

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 26235985

Title: Mutations in DDX3X are a common cause of unexplained intellectual disability with gender-specific effects on Wnt signaling.

PubMed ID: 26235985

DOI: 10.1016/j.ajhg.2015.07.004

Sequence Information:

  • Length: 662
  • Mass: 73243
  • Checksum: 7074D2B8A6EBBF09
  • Sequence:
    • MSHVAVENAL GLDQQFAGLD LNSSDNQSGG STASKGRYIP PHLRNREATK GFYDKDSSGW 
SSSKDKDAYS SFGSRSDSRG KSSFFSDRGS GSRGRFDDRG RSDYDGIGSR GDRSGFGKFE 
RGGNSRWCDK SDEDDWSKPL PPSERLEQEL FSGGNTGINF EKYDDIPVEA TGNNCPPHIE 
SFSDVEMGEI IMGNIELTRY TRPTPVQKHA IPIIKEKRDL MACAQTGSGK TAAFLLPILS 
QIYSDGPGEA LRAMKENGRY GRRKQYPISL VLAPTRELAV QIYEEARKFS YRSRVRPCVV 
YGGADIGQQI RDLERGCHLL VATPGRLVDM MERGKIGLDF CKYLVLDEAD RMLDMGFEPQ 
IRRIVEQDTM PPKGVRHTMM FSATFPKEIQ MLARDFLDEY IFLAVGRVGS TSENITQKVV 
WVEESDKRSF LLDLLNATGK DSLTLVFVET KKGADSLEDF LYHEGYACTS IHGDRSQRDR 
EEALHQFRSG KSPILVATAV AARGLDISNV KHVINFDLPS DIEEYVHRIG RTGRVGNLGL 
ATSFFNERNI NITKDLLDLL VEAKQEVPSW LENMAYEHHY KGSSRGRSKS SRFSGGFGAR 
DYRQSSGASS SSFSSSRASS SRSGGGGHGS SRGFGGGGYG GFYNSDGYGG NYNSQGVDWW 
GN

Genular Protein ID: 1715064653

Symbol: A0A2R8YFS5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8YFS5

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 661
  • Mass: 73156
  • Checksum: 5B64EC6EAD7A3FA0
  • Sequence:
    • MSHVAVENAL GLDQQFAGLD LNSSDNQSGG STASKGRYIP PHLRNREATK GFYDKDSSGW 
SSSKDKDAYS SFGSRSDSRG KSSFFSDRGS GSRGRFDDRG RSDYDGIGSR GDRSGFGKFE 
RGGNSRWCDK SDEDDWSKPL PPSERLEQEL FSGGNTGINF EKYDDIPVEA TGNNCPPHIE 
SFSDVEMGEI IMGNIELTRY TRPTPVQKHA IPIIKEKRDL MACAQTGSGK TAAFLLPILS 
QIYSDGPGEA LRAMKENGRY GRRKQYPISL VLAPTRELAV QIYEEARKFS YRSRVRPCVV 
YGGADIGQQI RDLERGCHLL VATPGRLVDM MERGKIGLDF CKYLVLDEAD RMLDMGFEPQ 
IRRIVEQDTM PPKGVRHTMM FSATFPKEIQ MLARDFLDEY IFLAVGRVGS TSENITQKVV 
WVEESDKRSF LLDLLNATGK DSLTLVFVET KKGADSLEDF LYHEGYACTS IHGDRSQRDR 
EEALHQFRSG KSPILVATAV AARGLDISNV KHVINFDLPS DIEEYVHRIG RTGRVGNLGL 
ATSFFNERNI NITKDLLDLL VEAKQEVPSW LENMAYEHHY KGSSRGRSKS RFSGGFGARD 
YRQSSGASSS SFSSSRASSS RSGGGGHGSS RGFGGGGYGG FYNSDGYGGN YNSQGVDWWG 
N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.