Details for: DDX3X

Gene ID: 1654

Symbol: DDX3X

Ensembl ID: ENSG00000215301

Description: DEAD-box helicase 3 X-linked

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.98
    Marker Score: 3118
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.69
    Marker Score: 125401
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.37
    Marker Score: 3597.5
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.88
    Marker Score: 2180
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.79
    Marker Score: 7828
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.75
    Marker Score: 7592.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.71
    Marker Score: 5722.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.69
    Marker Score: 1160
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.6
    Marker Score: 26322
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.58
    Marker Score: 2546
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.49
    Marker Score: 2620
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.48
    Marker Score: 1947
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.45
    Marker Score: 137155
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.42
    Marker Score: 1649
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.4
    Marker Score: 2042
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.39
    Marker Score: 3523
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.39
    Marker Score: 4766
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.38
    Marker Score: 568
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.35
    Marker Score: 1055
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.32
    Marker Score: 1192.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.29
    Marker Score: 2145
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.28
    Marker Score: 706
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.25
    Marker Score: 11073
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.23
    Marker Score: 2546
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.22
    Marker Score: 955
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.19
    Marker Score: 1497.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.19
    Marker Score: 1335
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.18
    Marker Score: 718
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.18
    Marker Score: 1088
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.18
    Marker Score: 889
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 2.18
    Marker Score: 914
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.15
    Marker Score: 74594
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.15
    Marker Score: 1439
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.14
    Marker Score: 758
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.14
    Marker Score: 24118
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.14
    Marker Score: 1288
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.14
    Marker Score: 1549
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.13
    Marker Score: 13600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.13
    Marker Score: 1792
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.12
    Marker Score: 1899
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.11
    Marker Score: 522
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.1
    Marker Score: 2284
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.1
    Marker Score: 3049
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 2.09
    Marker Score: 852
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.08
    Marker Score: 4723
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.08
    Marker Score: 8022
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.08
    Marker Score: 2684
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.08
    Marker Score: 3518
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.07
    Marker Score: 721
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.06
    Marker Score: 3880
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.06
    Marker Score: 1625
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.06
    Marker Score: 2409
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.05
    Marker Score: 852
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.03
    Marker Score: 538
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.02
    Marker Score: 2023.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 2.02
    Marker Score: 439
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 2.02
    Marker Score: 573
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 2
    Marker Score: 692.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2
    Marker Score: 2609
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 2
    Marker Score: 498
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2
    Marker Score: 496
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2
    Marker Score: 1147
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.98
    Marker Score: 443
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.98
    Marker Score: 570
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.98
    Marker Score: 3510
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.96
    Marker Score: 2116
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.95
    Marker Score: 4453
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.95
    Marker Score: 481
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.95
    Marker Score: 7236
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.95
    Marker Score: 17132
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.95
    Marker Score: 4767.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.95
    Marker Score: 1294
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.94
    Marker Score: 658
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.94
    Marker Score: 553
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.94
    Marker Score: 4882
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.93
    Marker Score: 102094
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.93
    Marker Score: 22404
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.92
    Marker Score: 6602
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.92
    Marker Score: 441.5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.91
    Marker Score: 4616
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 1.91
    Marker Score: 574
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.91
    Marker Score: 718.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.9
    Marker Score: 1637
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.9
    Marker Score: 549
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.9
    Marker Score: 1081
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.89
    Marker Score: 434
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 1.89
    Marker Score: 534
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.89
    Marker Score: 3686
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.89
    Marker Score: 579
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.89
    Marker Score: 764
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.89
    Marker Score: 1821
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.88
    Marker Score: 380
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.88
    Marker Score: 1594
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.87
    Marker Score: 1091
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.87
    Marker Score: 493
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 1.87
    Marker Score: 729
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.87
    Marker Score: 725
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 1.86
    Marker Score: 550
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 1.86
    Marker Score: 861
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.86
    Marker Score: 1676

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Other Information

**Key characteristics:** - DDX3X is a protein of the DEAD-box helicase family of RNA helicases. - It is a highly conserved protein with a predicted molecular weight of approximately 120 kDa. - DDX3X is expressed in high levels in tissues where cell cycle regulation and apoptosis are important, such as embryonic development, cancer, and tissue homeostasis. **Pathways and functions:** - DDX3X is involved in a variety of cellular pathways, including cell cycle regulation, apoptosis, and differentiation. - In cell cycle regulation, DDX3X is required for the initiation of DNA replication and transcription, and its overexpression can lead to cell cycle abnormalities and cancer. - In apoptosis, DDX3X is essential for the recognition and degradation of damaged or dysfunctional DNA, and its overexpression can lead to cell survival and tumor growth. - In differentiation, DDX3X is required for the proper differentiation of cells into their mature phenotypes. **Clinical significance:** - Mutations in DDX3X have been linked to a number of human diseases, including cancer, developmental disorders, and neurodegenerative diseases. - Targeting DDX3X has been explored as a potential therapeutic strategy for these diseases. - In clinical trials, inhibitors of DDX3X have shown promise in treating cancer and other diseases that are characterized by cell cycle abnormalities and apoptosis.

Genular Protein ID: 461507136

Symbol: DDX3X_HUMAN

Name: ATP-dependent RNA helicase DDX3X

UniProtKB Accession Codes:

O00571 A8K538 B4E3E8 O15536

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 ELM 1 EMBL 13 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 86 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 14 PRIDE 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10329544

Title: Hepatitis C virus core protein interacts with a human DEAD box protein DDX3.

PubMed ID: 10329544

DOI: 10.1006/viro.1999.9659

PubMed ID: 9381176

Title: Functional coherence of the human Y chromosome.

PubMed ID: 9381176

DOI: 10.1126/science.278.5338.675

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10859333

Title: An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility complex class I proteins bind peptides with a blocked NH(2) terminus in vivo.

PubMed ID: 10859333

DOI: 10.1084/jem.191.12.2083

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15507209

Title: Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function.

PubMed ID: 15507209

DOI: 10.1016/j.cell.2004.09.029

PubMed ID: 15294876

Title: The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control.

PubMed ID: 15294876

DOI: 10.1093/hmg/ddh240

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16818630

Title: DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor.

PubMed ID: 16818630

DOI: 10.1158/0008-5472.can-05-2415

PubMed ID: 16301996

Title: DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control.

PubMed ID: 16301996

DOI: 10.1038/sj.onc.1209239

PubMed ID: 17357160

Title: Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity.

PubMed ID: 17357160

DOI: 10.1002/prot.21433

PubMed ID: 17095540

Title: Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.

PubMed ID: 17095540

DOI: 10.1261/rna.336807

PubMed ID: 18846110

Title: Identification of an antiapoptotic protein complex at death receptors.

PubMed ID: 18846110

DOI: 10.1038/cdd.2008.124

PubMed ID: 18583960

Title: The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.

PubMed ID: 18583960

DOI: 10.1038/emboj.2008.126

PubMed ID: 18636090

Title: Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.

PubMed ID: 18636090

DOI: 10.1038/emboj.2008.143

PubMed ID: 18632687

Title: TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.

PubMed ID: 18632687

DOI: 10.1093/hmg/ddn203

PubMed ID: 18596238

Title: The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.

PubMed ID: 18596238

DOI: 10.1091/mbc.e07-12-1264

PubMed ID: 18628297

Title: Human DDX3 functions in translation and interacts with the translation initiation factor eIF3.

PubMed ID: 18628297

DOI: 10.1093/nar/gkn454

PubMed ID: 17667941

Title: Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.

PubMed ID: 17667941

DOI: 10.1038/sj.onc.1210687

PubMed ID: 18264132

Title: Oncogenic role of DDX3 in breast cancer biogenesis.

PubMed ID: 18264132

DOI: 10.1038/onc.2008.33

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19029303

Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

PubMed ID: 19029303

DOI: 10.1261/rna.1175909

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20127681

Title: DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.

PubMed ID: 20127681

DOI: 10.1002/eji.200940203

PubMed ID: 20375222

Title: Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.

PubMed ID: 20375222

DOI: 10.1099/vir.0.020552-0

PubMed ID: 20837705

Title: DDX3 regulates cell growth through translational control of cyclin E1.

PubMed ID: 20837705

DOI: 10.1128/mcb.00560-10

PubMed ID: 21170385

Title: Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.

PubMed ID: 21170385

DOI: 10.1371/journal.pone.0014258

PubMed ID: 20657822

Title: Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion.

PubMed ID: 20657822

DOI: 10.1371/journal.ppat.1000986

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21589879

Title: A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication.

PubMed ID: 21589879

DOI: 10.1371/journal.pone.0019810

PubMed ID: 21730191

Title: DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation.

PubMed ID: 21730191

DOI: 10.1073/pnas.1106245108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21883093

Title: Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response.

PubMed ID: 21883093

DOI: 10.1042/bj20110739

PubMed ID: 22034099

Title: The DEAD-box RNA helicase DDX3 interacts with DDX5, co-localizes with it in the cytoplasm during the G2/M phase of the cycle, and affects its shuttling during mRNP export.

PubMed ID: 22034099

DOI: 10.1002/jcb.23428

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22323517

Title: The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes.

PubMed ID: 22323517

DOI: 10.1093/nar/gks070

PubMed ID: 22872150

Title: DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs.

PubMed ID: 22872150

DOI: 10.1038/emboj.2012.220

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23478265

Title: Human DEAD box helicase 3 couples IkappaB kinase epsilon to interferon regulatory factor 3 activation.

PubMed ID: 23478265

DOI: 10.1128/mcb.01603-12

PubMed ID: 23413191

Title: RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling.

PubMed ID: 23413191

DOI: 10.1126/science.1231499

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 26100019

Title: The DHX33 RNA Helicase Promotes mRNA Translation Initiation.

PubMed ID: 26100019

DOI: 10.1128/mcb.00315-15

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27546789

Title: RNA remodeling activity of DEAD box proteins tuned by protein concentration, RNA length, and ATP.

PubMed ID: 27546789

DOI: 10.1016/j.molcel.2016.07.010

PubMed ID: 27105836

Title: Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells.

PubMed ID: 27105836

DOI: 10.1016/j.antiviral.2016.04.008

PubMed ID: 27736973

Title: The DEAD-Box RNA Helicase DDX3 Interacts with NF-kappaB Subunit p65 and Suppresses p65-Mediated Transcription.

PubMed ID: 27736973

DOI: 10.1371/journal.pone.0164471

PubMed ID: 27980081

Title: DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.

PubMed ID: 27980081

DOI: 10.1042/bcj20160956

PubMed ID: 28733330

Title: The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.

PubMed ID: 28733330

DOI: 10.1042/bcj20170354

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28842590

Title: DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.

PubMed ID: 28842590

DOI: 10.1038/s41598-017-09779-w

PubMed ID: 29062139

Title: DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.

PubMed ID: 29062139

DOI: 10.1038/s41598-017-14262-7

PubMed ID: 28128295

Title: RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.

PubMed ID: 28128295

DOI: 10.1038/srep41452

PubMed ID: 30341167

Title: DDX3 directly facilitates IKKalpha activation and regulates downstream signalling pathways.

PubMed ID: 30341167

DOI: 10.1042/bcj20180163

PubMed ID: 30131165

Title: Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3.

PubMed ID: 30131165

DOI: 10.1016/j.ejcb.2018.08.001

PubMed ID: 29222110

Title: A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1epsilon.

PubMed ID: 29222110

DOI: 10.1242/jcs.207316

PubMed ID: 29899501

Title: The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity.

PubMed ID: 29899501

DOI: 10.1038/s41467-018-04776-7

PubMed ID: 30256975

Title: Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts.

PubMed ID: 30256975

DOI: 10.1093/nar/gky861

PubMed ID: 31575075

Title: Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity.

PubMed ID: 31575075

DOI: 10.3390/cells8101181

PubMed ID: 17401195

Title: Expression, purification, crystallization and preliminary X-ray diffraction analysis of the DDX3 RNA helicase domain.

PubMed ID: 17401195

DOI: 10.1107/s1744309107006434

PubMed ID: 17631897

Title: Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP.

PubMed ID: 17631897

DOI: 10.1016/j.jmb.2007.06.050

PubMed ID: 19913487

Title: Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7.

PubMed ID: 19913487

DOI: 10.1016/j.str.2009.09.005

PubMed ID: 31300642

Title: The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X.

PubMed ID: 31300642

DOI: 10.1038/s41467-019-11083-2

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 26235985

Title: Mutations in DDX3X are a common cause of unexplained intellectual disability with gender-specific effects on Wnt signaling.

PubMed ID: 26235985

DOI: 10.1016/j.ajhg.2015.07.004

Sequence Information:

  • Length: 662
  • Mass: 73243
  • Checksum: 7074D2B8A6EBBF09
  • Sequence:
    • MSHVAVENAL GLDQQFAGLD LNSSDNQSGG STASKGRYIP PHLRNREATK GFYDKDSSGW 
SSSKDKDAYS SFGSRSDSRG KSSFFSDRGS GSRGRFDDRG RSDYDGIGSR GDRSGFGKFE 
RGGNSRWCDK SDEDDWSKPL PPSERLEQEL FSGGNTGINF EKYDDIPVEA TGNNCPPHIE 
SFSDVEMGEI IMGNIELTRY TRPTPVQKHA IPIIKEKRDL MACAQTGSGK TAAFLLPILS 
QIYSDGPGEA LRAMKENGRY GRRKQYPISL VLAPTRELAV QIYEEARKFS YRSRVRPCVV 
YGGADIGQQI RDLERGCHLL VATPGRLVDM MERGKIGLDF CKYLVLDEAD RMLDMGFEPQ 
IRRIVEQDTM PPKGVRHTMM FSATFPKEIQ MLARDFLDEY IFLAVGRVGS TSENITQKVV 
WVEESDKRSF LLDLLNATGK DSLTLVFVET KKGADSLEDF LYHEGYACTS IHGDRSQRDR 
EEALHQFRSG KSPILVATAV AARGLDISNV KHVINFDLPS DIEEYVHRIG RTGRVGNLGL 
ATSFFNERNI NITKDLLDLL VEAKQEVPSW LENMAYEHHY KGSSRGRSKS SRFSGGFGAR 
DYRQSSGASS SSFSSSRASS SRSGGGGHGS SRGFGGGGYG GFYNSDGYGG NYNSQGVDWW 
GN

Genular Protein ID: 1715064653

Symbol: A0A2R8YFS5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8YFS5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 661
  • Mass: 73156
  • Checksum: 5B64EC6EAD7A3FA0
  • Sequence:
    • MSHVAVENAL GLDQQFAGLD LNSSDNQSGG STASKGRYIP PHLRNREATK GFYDKDSSGW 
SSSKDKDAYS SFGSRSDSRG KSSFFSDRGS GSRGRFDDRG RSDYDGIGSR GDRSGFGKFE 
RGGNSRWCDK SDEDDWSKPL PPSERLEQEL FSGGNTGINF EKYDDIPVEA TGNNCPPHIE 
SFSDVEMGEI IMGNIELTRY TRPTPVQKHA IPIIKEKRDL MACAQTGSGK TAAFLLPILS 
QIYSDGPGEA LRAMKENGRY GRRKQYPISL VLAPTRELAV QIYEEARKFS YRSRVRPCVV 
YGGADIGQQI RDLERGCHLL VATPGRLVDM MERGKIGLDF CKYLVLDEAD RMLDMGFEPQ 
IRRIVEQDTM PPKGVRHTMM FSATFPKEIQ MLARDFLDEY IFLAVGRVGS TSENITQKVV 
WVEESDKRSF LLDLLNATGK DSLTLVFVET KKGADSLEDF LYHEGYACTS IHGDRSQRDR 
EEALHQFRSG KSPILVATAV AARGLDISNV KHVINFDLPS DIEEYVHRIG RTGRVGNLGL 
ATSFFNERNI NITKDLLDLL VEAKQEVPSW LENMAYEHHY KGSSRGRSKS RFSGGFGARD 
YRQSSGASSS SFSSSRASSS RSGGGGHGSS RGFGGGGYGG FYNSDGYGGN YNSQGVDWWG 
N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.