Details for: DHX9

Gene ID: 1660

Symbol: DHX9

Ensembl ID: ENSG00000135829

Description: DExH-box helicase 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 322.4464
    Cell Significance Index: -50.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 209.2308
    Cell Significance Index: -53.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 144.6422
    Cell Significance Index: -59.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 129.7332
    Cell Significance Index: -61.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 125.3393
    Cell Significance Index: -50.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 114.1557
    Cell Significance Index: -58.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 53.8784
    Cell Significance Index: -51.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.1793
    Cell Significance Index: -58.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.9417
    Cell Significance Index: -56.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.2330
    Cell Significance Index: -60.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.9673
    Cell Significance Index: -42.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5548
    Cell Significance Index: -23.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5606
    Cell Significance Index: 143.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2648
    Cell Significance Index: 30.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9782
    Cell Significance Index: 52.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8752
    Cell Significance Index: 372.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5640
    Cell Significance Index: 313.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5520
    Cell Significance Index: 252.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1734
    Cell Significance Index: 31.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1204
    Cell Significance Index: 58.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0848
    Cell Significance Index: 133.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0387
    Cell Significance Index: 372.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9366
    Cell Significance Index: 168.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7611
    Cell Significance Index: 89.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7563
    Cell Significance Index: 48.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7256
    Cell Significance Index: 396.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6600
    Cell Significance Index: 31.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6382
    Cell Significance Index: 87.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6348
    Cell Significance Index: 280.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6312
    Cell Significance Index: 18.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6193
    Cell Significance Index: 428.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6101
    Cell Significance Index: 17.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5801
    Cell Significance Index: 36.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5528
    Cell Significance Index: 33.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4961
    Cell Significance Index: 17.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4732
    Cell Significance Index: 24.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4598
    Cell Significance Index: 20.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3983
    Cell Significance Index: 359.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3552
    Cell Significance Index: 15.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3183
    Cell Significance Index: 14.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3034
    Cell Significance Index: 38.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2110
    Cell Significance Index: 16.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2069
    Cell Significance Index: 5.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1979
    Cell Significance Index: 21.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1963
    Cell Significance Index: 13.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1772
    Cell Significance Index: 6.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1649
    Cell Significance Index: 11.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1300
    Cell Significance Index: 1.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1285
    Cell Significance Index: 24.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1110
    Cell Significance Index: 3.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1029
    Cell Significance Index: 65.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0798
    Cell Significance Index: 150.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0584
    Cell Significance Index: 1.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0537
    Cell Significance Index: 24.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0495
    Cell Significance Index: 6.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0345
    Cell Significance Index: 53.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0256
    Cell Significance Index: 47.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0226
    Cell Significance Index: 30.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0032
    Cell Significance Index: 2.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0254
    Cell Significance Index: -1.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0257
    Cell Significance Index: -2.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0272
    Cell Significance Index: -20.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0427
    Cell Significance Index: -31.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0728
    Cell Significance Index: -12.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0949
    Cell Significance Index: -53.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1000
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1084
    Cell Significance Index: -67.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1120
    Cell Significance Index: -3.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1444
    Cell Significance Index: -14.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1764
    Cell Significance Index: -50.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1895
    Cell Significance Index: -27.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2702
    Cell Significance Index: -4.6300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2848
    Cell Significance Index: -6.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2943
    Cell Significance Index: -9.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2970
    Cell Significance Index: -4.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3083
    Cell Significance Index: -64.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3194
    Cell Significance Index: -6.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3448
    Cell Significance Index: -40.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3478
    Cell Significance Index: -7.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3766
    Cell Significance Index: -43.1500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3972
    Cell Significance Index: -2.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4256
    Cell Significance Index: -22.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4401
    Cell Significance Index: -8.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4887
    Cell Significance Index: -50.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5676
    Cell Significance Index: -44.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6353
    Cell Significance Index: -13.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6594
    Cell Significance Index: -16.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6834
    Cell Significance Index: -41.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7037
    Cell Significance Index: -6.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7974
    Cell Significance Index: -20.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8181
    Cell Significance Index: -50.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8705
    Cell Significance Index: -23.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9693
    Cell Significance Index: -24.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9723
    Cell Significance Index: -21.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0082
    Cell Significance Index: -28.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0256
    Cell Significance Index: -27.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0702
    Cell Significance Index: -19.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.1203
    Cell Significance Index: -13.9000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.1287
    Cell Significance Index: -12.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1381
    Cell Significance Index: -37.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **RNA Helicase Activity**: DHX9 possesses high processivity and a high degree of specificity for single-stranded RNA, making it an essential component of RNA helicases. 2. **ATPase Activity**: DHX9 is an ATPase, which enables it to hydrolyze ATP and drive its helicase and exonuclease activities. 3. **Spliceosome Involvement**: DHX9 is involved in the assembly and function of the spliceosome, a complex responsible for RNA splicing. 4. **Immune Response**: DHX9 plays a critical role in the innate immune response, particularly in the activation of type I interferons and the production of inflammatory cytokines. 5. **DNA Replication and Repair**: DHX9 is involved in the regulation of DNA replication and repair, including the unwinding of DNA duplexes and the activation of DNA polymerases. **Pathways and Functions** 1. **RNA Splicing**: DHX9 participates in the assembly and function of the spliceosome, facilitating the removal of introns and the joining of exons. 2. **Immune Response**: DHX9 is crucial for the activation of type I interferons and the production of inflammatory cytokines, which are essential for the innate immune response. 3. **DNA Replication and Repair**: DHX9 regulates DNA replication and repair by unwinding DNA duplexes and activating DNA polymerases. 4. **Metabolism of RNA**: DHX9 is involved in the processing of RNA, including the removal of introns and the regulation of RNA stability. 5. **Cellular Response to Exogenous dsRNA**: DHX9 plays a key role in the cellular response to exogenous double-stranded RNA, which is a hallmark of viral infections. **Clinical Significance** 1. **Autoimmune Diseases**: DHX9 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where dysregulation of RNA metabolism and immune response contributes to disease progression. 2. **Cancer**: DHX9 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumorigenesis and cancer progression. 3. **Neurological Disorders**: DHX9 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis, where dysregulation of RNA metabolism and immune response contributes to disease progression. In conclusion, the DHX9 gene plays a critical role in various cellular processes, including RNA metabolism, DNA replication, and immune response. Its dysregulation has been implicated in the pathogenesis of autoimmune diseases, cancer, and neurological disorders, highlighting the importance of DHX9 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 1912381506

Symbol: DHX9_HUMAN

Name: DEAH box protein 9

UniProtKB Accession Codes:

Q08211 B2RNV4 Q05CI5 Q12803 Q32Q22 Q5VY62 Q6PD69 Q99556

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTAC 2 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 1 EvolutionaryTrace 1 GO 93 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8344961

Title: Human RNA helicase A is homologous to the maleless protein of Drosophila.

PubMed ID: 8344961

DOI: 10.1016/s0021-9258(19)85490-x

PubMed ID: 8690889

Title: Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles.

PubMed ID: 8690889

PubMed ID: 9111062

Title: Domain structure of human nuclear DNA helicase II (RNA helicase A).

PubMed ID: 9111062

DOI: 10.1074/jbc.272.17.11487

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11149922

Title: A functional interaction between the survival motor neuron complex and RNA polymerase II.

PubMed ID: 11149922

DOI: 10.1083/jcb.152.1.75

PubMed ID: 1537828

Title: A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3' to 5' direction.

PubMed ID: 1537828

DOI: 10.1016/s0021-9258(18)42849-9

PubMed ID: 9323138

Title: RNA helicase A mediates association of CBP with RNA polymerase II.

PubMed ID: 9323138

DOI: 10.1016/s0092-8674(00)80376-1

PubMed ID: 9162007

Title: A cellular cofactor for the constitutive transport element of type D retrovirus.

PubMed ID: 9162007

DOI: 10.1126/science.276.5317.1412

PubMed ID: 9662397

Title: BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.

PubMed ID: 9662397

DOI: 10.1038/930

PubMed ID: 10198287

Title: Pre-mRNA and mRNA binding of human nuclear DNA helicase II (RNA helicase A).

PubMed ID: 10198287

DOI: 10.1242/jcs.112.7.1055

PubMed ID: 10207077

Title: The carboxyl terminus of RNA helicase A contains a bidirectional nuclear transport domain.

PubMed ID: 10207077

DOI: 10.1128/mcb.19.5.3540

PubMed ID: 9892698

Title: A role for RNA helicase A in post-transcriptional regulation of HIV type 1.

PubMed ID: 9892698

DOI: 10.1073/pnas.96.2.709

PubMed ID: 10924507

Title: Specific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport element of type D retrovirus.

PubMed ID: 10924507

DOI: 10.1074/jbc.m003933200

PubMed ID: 11038348

Title: Sequence-specific DNA binding activity of RNA helicase A to the p16INK4a promoter.

PubMed ID: 11038348

DOI: 10.1074/jbc.m004481200

PubMed ID: 11096080

Title: A role of RNA helicase A in cis-acting transactivation response element-mediated transcriptional regulation of human immunodeficiency virus type 1.

PubMed ID: 11096080

DOI: 10.1074/jbc.m006892200

PubMed ID: 11402034

Title: Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses.

PubMed ID: 11402034

DOI: 10.1074/jbc.m102809200

PubMed ID: 11416126

Title: Dual roles of RNA helicase A in CREB-dependent transcription.

PubMed ID: 11416126

DOI: 10.1128/mcb.21.14.4460-4469.2001

PubMed ID: 11687588

Title: Nuclear DNA helicase II/RNA helicase A binds to filamentous actin.

PubMed ID: 11687588

DOI: 10.1074/jbc.m109393200

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 12946349

Title: Selective regulation of gene expression by nuclear factor 110, a member of the NF90 family of double-stranded RNA-binding proteins.

PubMed ID: 12946349

DOI: 10.1016/s0022-2836(03)00885-4

PubMed ID: 12665568

Title: Antithetic effects of MBD2a on gene regulation.

PubMed ID: 12665568

DOI: 10.1128/mcb.23.8.2645-2657.2003

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 12711669

Title: RNA helicase A interacts with dsDNA and topoisomerase IIalpha.

PubMed ID: 12711669

DOI: 10.1093/nar/gkg328

PubMed ID: 15355351

Title: RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator.

PubMed ID: 15355351

DOI: 10.1111/j.1432-1033.2004.04314.x

PubMed ID: 15084609

Title: Arginine methylation of RNA helicase a determines its subcellular localization.

PubMed ID: 15084609

DOI: 10.1074/jbc.c300512200

PubMed ID: 14704337

Title: DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner.

PubMed ID: 14704337

DOI: 10.1093/nar/gkg933

PubMed ID: 15613478

Title: Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II.

PubMed ID: 15613478

DOI: 10.1074/jbc.m411444200

PubMed ID: 15995249

Title: Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.

PubMed ID: 15995249

DOI: 10.1074/jbc.m503882200

PubMed ID: 16375861

Title: The nuclear import of RNA helicase A is mediated by importin-alpha3.

PubMed ID: 16375861

DOI: 10.1016/j.bbrc.2005.11.161

PubMed ID: 16680162

Title: RNA helicase A is necessary for translation of selected messenger RNAs.

PubMed ID: 16680162

DOI: 10.1038/nsmb1092

PubMed ID: 17303075

Title: The transcriptional factor Osterix directly interacts with RNA helicase A.

PubMed ID: 17303075

DOI: 10.1016/j.bbrc.2007.01.150

PubMed ID: 17498979

Title: Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome.

PubMed ID: 17498979

DOI: 10.1016/j.cellbi.2007.03.027

PubMed ID: 17251188

Title: ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A.

PubMed ID: 17251188

DOI: 10.1074/jbc.m610821200

PubMed ID: 17531811

Title: RNA helicase A interacts with RISC in human cells and functions in RISC loading.

PubMed ID: 17531811

DOI: 10.1016/j.molcel.2007.04.016

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19229320

Title: An antiviral response directed by PKR phosphorylation of the RNA helicase A.

PubMed ID: 19229320

DOI: 10.1371/journal.ppat.1000311

PubMed ID: 19029303

Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

PubMed ID: 19029303

DOI: 10.1261/rna.1175909

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20669935

Title: Human DHX9 helicase unwinds triple-helical DNA structures.

PubMed ID: 20669935

DOI: 10.1021/bi100795m

PubMed ID: 20696886

Title: Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells.

PubMed ID: 20696886

DOI: 10.1073/pnas.1006539107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21561811

Title: Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes.

PubMed ID: 21561811

DOI: 10.1016/j.dnarep.2011.04.013

PubMed ID: 21957149

Title: DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells.

PubMed ID: 21957149

DOI: 10.4049/jimmunol.1101307

PubMed ID: 21247876

Title: Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes.

PubMed ID: 21247876

DOI: 10.1093/nar/gkq1350

PubMed ID: 22190748

Title: A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs.

PubMed ID: 22190748

DOI: 10.1261/rna.030288.111

PubMed ID: 23640942

Title: Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains.

PubMed ID: 23640942

DOI: 10.1515/hsz-2013-0111

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23652018

Title: GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.

PubMed ID: 23652018

DOI: 10.1038/ncomms2823

PubMed ID: 24049074

Title: DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells.

PubMed ID: 24049074

DOI: 10.1093/nar/gkt804

PubMed ID: 23308148

Title: LMX1B is part of a transcriptional complex with PSPC1 and PSF.

PubMed ID: 23308148

DOI: 10.1371/journal.pone.0053122

PubMed ID: 25149208

Title: Role of the OB-fold of RNA helicase A in the synthesis of HIV-1 RNA.

PubMed ID: 25149208

DOI: 10.1016/j.bbagrm.2014.08.008

PubMed ID: 25062910

Title: Helicase associated 2 domain is essential for helicase activity of RNA helicase A.

PubMed ID: 25062910

DOI: 10.1016/j.bbapap.2014.07.001

PubMed ID: 24990949

Title: Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner.

PubMed ID: 24990949

DOI: 10.1074/jbc.m114.568535

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 27107641

Title: DHX9/RHA binding to the PBS-segment of the genomic RNA during HIV-1 assembly bolsters virion infectivity.

PubMed ID: 27107641

DOI: 10.1016/j.jmb.2016.04.011

PubMed ID: 28221134

Title: Human Nup98 regulates the localization and activity of DExH/D-box helicase DHX9.

PubMed ID: 28221134

DOI: 10.7554/elife.18825

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28355180

Title: DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome.

PubMed ID: 28355180

DOI: 10.1038/nature21715

PubMed ID: 28636595

Title: Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.

PubMed ID: 28636595

DOI: 10.1038/nature22967

PubMed ID: 30463980

Title: The Host DHX9 DExH-Box Helicase Is Recruited to Chikungunya Virus Replication Complexes for Optimal Genomic RNA Translation.

PubMed ID: 30463980

DOI: 10.1128/jvi.01764-18

PubMed ID: 30541834

Title: Cellular RNA Helicase DHX9 Interacts with the Essential Epstein-Barr Virus (EBV) Protein SM and Restricts EBV Lytic Replication.

PubMed ID: 30541834

DOI: 10.1128/jvi.01244-18

PubMed ID: 20510246

Title: Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein.

PubMed ID: 20510246

DOI: 10.1016/j.jmb.2010.05.046

PubMed ID: 23361462

Title: Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9).

PubMed ID: 23361462

DOI: 10.1093/nar/gkt042

Sequence Information:

  • Length: 1270
  • Mass: 140958
  • Checksum: A607DA8F4C4B217A
  • Sequence:
    • MGDVKNFLYA WCGKRKMTPS YEIRAVGNKN RQKFMCEVQV EGYNYTGMGN STNKKDAQSN 
AARDFVNYLV RINEIKSEEV PAFGVASPPP LTDTPDTTAN AEGDLPTTMG GPLPPHLALK 
AENNSEVGAS GYGVPGPTWD RGANLKDYYS RKEEQEVQAT LESEEVDLNA GLHGNWTLEN 
AKARLNQYFQ KEKIQGEYKY TQVGPDHNRS FIAEMTIYIK QLGRRIFARE HGSNKKLAAQ 
SCALSLVRQL YHLGVVEAYS GLTKKKEGET VEPYKVNLSQ DLEHQLQNII QELNLEILPP 
PEDPSVPVAL NIGKLAQFEP SQRQNQVGVV PWSPPQSNWN PWTSSNIDEG PLAFATPEQI 
SMDLKNELMY QLEQDHDLQA ILQERELLPV KKFESEILEA ISQNSVVIIR GATGCGKTTQ 
VPQFILDDFI QNDRAAECNI VVTQPRRISA VSVAERVAFE RGEEPGKSCG YSVRFESILP 
RPHASIMFCT VGVLLRKLEA GIRGISHVIV DEIHERDINT DFLLVVLRDV VQAYPEVRIV 
LMSATIDTSM FCEYFFNCPI IEVYGRTYPV QEYFLEDCIQ MTHFVPPPKD KKKKDKDDDG 
GEDDDANCNL ICGDEYGPET RLSMSQLNEK ETPFELIEAL LKYIETLNVP GAVLVFLPGW 
NLIYTMQKHL EMNPHFGSHR YQILPLHSQI PREEQRKVFD PVPVGVTKVI LSTNIAETSI 
TINDVVYVID SCKQKVKLFT AHNNMTNYAT VWASKTNLEQ RKGRAGRVRP GFCFHLCSRA 
RFERLETHMT PEMFRTPLHE IALSIKLLRL GGIGQFLAKA IEPPPLDAVI EAEHTLRELD 
ALDANDELTP LGRILAKLPI EPRFGKMMIM GCIFYVGDAI CTIAAATCFP EPFINEGKRL 
GYIHRNFAGN RFSDHVALLS VFQAWDDARM GGEEAEIRFC EHKRLNMATL RMTWEAKVQL 
KEILINSGFP EDCLLTQVFT NTGPDNNLDV VISLLAFGVY PNVCYHKEKR KILTTEGRNA 
LIHKSSVNCP FSSQDMKYPS PFFVFGEKIR TRAISAKGMT LVTPLQLLLF ASKKVQSDGQ 
IVLVDDWIKL QISHEAAACI TGLRAAMEAL VVEVTKQPAI ISQLDPVNER MLNMIRQISR 
PSAAGINLMI GSTRYGDGPR PPKMARYDNG SGYRRGGSSY SGGGYGGGYS SGGYGSGGYG 
GSANSFRAGY GAGVGGGYRG VSRGGFRGNS GGDYRGPSGG YRGSGGFQRG GGRGAYGTGY 
FGQGRGGGGY

Genular Protein ID: 3057354812

Symbol: B3KU66_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KU66

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 2 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 549
  • Mass: 59948
  • Checksum: FB91744CBC5DB8AF
  • Sequence:
    • MSLRINHFFL CRQKVKLFTA HNNMTNYATV WASKTNLEQR KGRAGRVRPG FCFHLCSRAR 
FERLETHMTP EMFRTPLHEI ALSIKLLRLG GIGQFLAKAI EPPPLDAVIE AEHTLRELDA 
LDANDELTPL GRILAKLPIE PRFGKMMIMG CIFYVGDAIC TIAAATCFPE PFINEGKRLG 
YIHRNFAGNR FSDHVALLSV FQAWDDARMG GEEAEIRFCE HKRLNMATLR MTWEAKVQLK 
EILINSGFPE DCLLTQVFTN TGPDNNLDVV TSLLAFGVYP NVCYHKEKRK ILTTEGRNAL 
IHKSSVNCPF SSQDMKYPSP FFVFGEKIRT RAISAKGMTL VTPLQLLLFA SKKVQSDGQI 
VLVDDWIKLQ ISHEAAACIT GLRAAMEALV VEVTKQPAII SQLDPVNERM LNMIRQISRP 
SAAGINLMIG STRYGDGPRP PKMARYDNGS GYRRGGSSYS GGGYGGGYSS GGYGSGGYGG 
SANSFRAGYG AGVGGGYRGV SRGGFRGNSG GDYRGPSGGY RGSGGFQRGG GRGAYGTGYF 
GQGRGGGGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.