Details for: DDX10

Gene ID: 1662

Symbol: DDX10

Ensembl ID: ENSG00000178105

Description: DEAD-box helicase 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron (CL0000540)
    Fold Change: 1.84
    Marker Score: 7497.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.73
    Marker Score: 63899.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.72
    Marker Score: 105797.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.7
    Marker Score: 14563
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.69
    Marker Score: 16049
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.66
    Marker Score: 17181
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.65
    Marker Score: 32902
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.62
    Marker Score: 6276
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.62
    Marker Score: 15250
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.58
    Marker Score: 1361
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.57
    Marker Score: 59786
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.55
    Marker Score: 1711.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2371
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.52
    Marker Score: 6287
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.47
    Marker Score: 11291
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.46
    Marker Score: 21899
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.46
    Marker Score: 668
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167662
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.38
    Marker Score: 1220
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.37
    Marker Score: 1840
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.35
    Marker Score: 3861
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.32
    Marker Score: 1895
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.3
    Marker Score: 2491.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.29
    Marker Score: 1480.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.28
    Marker Score: 43352.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.28
    Marker Score: 1449
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.28
    Marker Score: 673
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19699
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.26
    Marker Score: 2109
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.23
    Marker Score: 2711
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.2
    Marker Score: 2837
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.2
    Marker Score: 714
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.19
    Marker Score: 342
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.18
    Marker Score: 4940.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.17
    Marker Score: 4170
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.17
    Marker Score: 899
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.16
    Marker Score: 5359
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.14
    Marker Score: 774
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.1
    Marker Score: 640
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1
    Marker Score: 19497
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.09
    Marker Score: 657
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.08
    Marker Score: 606.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2189.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.05
    Marker Score: 23498
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.05
    Marker Score: 307
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.04
    Marker Score: 376
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.03
    Marker Score: 1115
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.03
    Marker Score: 332
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.03
    Marker Score: 387
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.03
    Marker Score: 685
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.02
    Marker Score: 1281
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.02
    Marker Score: 6042
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.01
    Marker Score: 1217
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1
    Marker Score: 21295
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71679.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47905
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.99
    Marker Score: 317
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.98
    Marker Score: 6325
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30388
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.98
    Marker Score: 1038
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.97
    Marker Score: 408
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.97
    Marker Score: 3448.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.96
    Marker Score: 476
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.95
    Marker Score: 660
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.95
    Marker Score: 1378
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.94
    Marker Score: 528
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2394
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.92
    Marker Score: 977
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.92
    Marker Score: 288
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.91
    Marker Score: 957
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.91
    Marker Score: 1093
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9
    Marker Score: 3903
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2696
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.9
    Marker Score: 336
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.9
    Marker Score: 966.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9
    Marker Score: 5383
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.89
    Marker Score: 433
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1431
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.87
    Marker Score: 1822
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.87
    Marker Score: 509
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1220
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.85
    Marker Score: 815
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.85
    Marker Score: 13686
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.85
    Marker Score: 908
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.84
    Marker Score: 215
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.84
    Marker Score: 305
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.84
    Marker Score: 4509.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4772
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.83
    Marker Score: 1040
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.83
    Marker Score: 434
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.83
    Marker Score: 460.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.82
    Marker Score: 303
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.81
    Marker Score: 612
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.81
    Marker Score: 326
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.81
    Marker Score: 2032
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.81
    Marker Score: 1042

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * DDX10 is a highly conserved protein with a predicted molecular weight of 125 kDa. * It is found in both neurons and glial cells. * It is a member of the DEAD (DEAD-box helicase) family of RNA helicases. * DDX10 is a key regulator of gene expression, and its activity is essential for the development and function of the central nervous system. **Pathways and functions:** * DDX10 is involved in the regulation of anterior head development. It is expressed in the developing brain and is necessary for the survival and differentiation of neural stem cells. * It is also involved in the regulation of neuronal differentiation. It is expressed in the developing cerebral cortex and is necessary for the specification of neural cell fate. * DDX10 is also involved in synaptic plasticity. It is expressed in the hippocampus, a brain region that is important for learning and memory. DDX10 is necessary for the long-term potentiation of synaptic connections, which is a process that is thought to be involved in learning. **Clinical significance:** DDX10 is a promising target for the treatment of neurodegenerative diseases. Mutations in DDX10 have been linked to a number of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. By understanding the role of DDX10 in neurodevelopment and disease, it may be possible to develop new treatments for these disorders.

Genular Protein ID: 1303535604

Symbol: DDX10_HUMAN

Name: Probable ATP-dependent RNA helicase DDX10

UniProtKB Accession Codes:

Q13206 B2RCQ3 Q5BJD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 1 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8660968

Title: A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.

PubMed ID: 8660968

DOI: 10.1006/geno.1996.0184

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20941364

Title: Comparative structural analysis of human DEAD-box RNA helicases.

PubMed ID: 20941364

DOI: 10.1371/journal.pone.0012791

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 875
  • Mass: 100888
  • Checksum: B61BF325921C62FD
  • Sequence:
    • MGKTANSPGS GARPDPVRSF NRWKKKHSHR QNKKKQLRKQ LKKPEWQVER ESISRLMQNY 
EKINVNEITR FSDFPLSKKT LKGLQEAQYR LVTEIQKQTI GLALQGKDVL GAAKTGSGKT 
LAFLVPVLEA LYRLQWTSTD GLGVLIISPT RELAYQTFEV LRKVGKNHDF SAGLIIGGKD 
LKHEAERINN INILVCTPGR LLQHMDETVS FHATDLQMLV LDEADRILDM GFADTMNAVI 
ENLPKKRQTL LFSATQTKSV KDLARLSLKN PEYVWVHEKA KYSTPATLEQ NYIVCELQQK 
ISVLYSFLRS HLKKKSIVFF SSCKEVQYLY RVFCRLRPGV SILALHGRQQ QMRRMEVYNE 
FVRKRAAVLF ATDIAARGLD FPAVNWVLQF DCPEDANTYI HRAGRTARYK EDGEALLILL 
PSEKAMVQQL LQKKVPVKEI KINPEKLIDV QKKLESILAQ DQDLKERAQR CFVSYVRSVY 
LMKDKEVFDV SKLPIPEYAL SLGLAVAPRV RFLQKMQKQP TKELVRSQAD KVIEPRAPSL 
TNDEVEEFRA YFNEKMSILQ KGGKRLEGTE HRQDNDTGNE EQEEEEDDEE EMEEKLAKAK 
GSQAPSLPNT SEAQKIKEVP TQFLDRDEEE EDADFLKVKR HNVFGLDLKD EKTLQKKEPS 
KSSIKKKMTK VAEAKKVMKR NFKVNKKITF TDEGELVQQW PQMQKSAIKD AEEDDDTGGI 
NLHKAKERLQ EEDKFDKEEY RKKIKAKHRE KRLKEREARR EANKRQAKAK DEEEAFLDWS 
DDDDDDDDGF DPSTLPDPDK YRSSEDSDSE DMENKISDTK KKQGMKKRSN SEVEDVGPTS 
HNRKKARWDT LEPLDTGLSL AEDEELVLHL LRSQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.