Details for: DDX10

Gene ID: 1662

Symbol: DDX10

Ensembl ID: ENSG00000178105

Description: DEAD-box helicase 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 241.2160
    Cell Significance Index: -37.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.8169
    Cell Significance Index: -35.2100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.0581
    Cell Significance Index: -40.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.7401
    Cell Significance Index: -34.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 76.1492
    Cell Significance Index: -39.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.6388
    Cell Significance Index: -40.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.8526
    Cell Significance Index: -34.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.8320
    Cell Significance Index: -39.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.4968
    Cell Significance Index: -38.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5032
    Cell Significance Index: -32.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.0784
    Cell Significance Index: -39.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1110
    Cell Significance Index: 423.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8221
    Cell Significance Index: 24.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4517
    Cell Significance Index: 288.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4289
    Cell Significance Index: 54.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3587
    Cell Significance Index: 60.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2081
    Cell Significance Index: 67.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1990
    Cell Significance Index: 430.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1938
    Cell Significance Index: 80.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1677
    Cell Significance Index: 89.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1099
    Cell Significance Index: 767.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1066
    Cell Significance Index: 18.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1046
    Cell Significance Index: 30.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0057
    Cell Significance Index: 25.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9601
    Cell Significance Index: 866.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7179
    Cell Significance Index: 78.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6805
    Cell Significance Index: 17.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6410
    Cell Significance Index: 104.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6269
    Cell Significance Index: 17.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5766
    Cell Significance Index: 35.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5329
    Cell Significance Index: 15.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4622
    Cell Significance Index: 9.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4513
    Cell Significance Index: 81.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4378
    Cell Significance Index: 11.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4356
    Cell Significance Index: 6.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3469
    Cell Significance Index: 42.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3385
    Cell Significance Index: 46.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2946
    Cell Significance Index: 6.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2929
    Cell Significance Index: 6.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2505
    Cell Significance Index: 110.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2452
    Cell Significance Index: 16.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2288
    Cell Significance Index: 6.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2252
    Cell Significance Index: 5.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2143
    Cell Significance Index: 10.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2110
    Cell Significance Index: 115.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2068
    Cell Significance Index: 4.4800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1870
    Cell Significance Index: 1.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1529
    Cell Significance Index: 2.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1522
    Cell Significance Index: 6.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1347
    Cell Significance Index: 253.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1135
    Cell Significance Index: 11.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1064
    Cell Significance Index: 196.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0991
    Cell Significance Index: 18.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0832
    Cell Significance Index: 10.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0716
    Cell Significance Index: 45.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0710
    Cell Significance Index: 109.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0692
    Cell Significance Index: 31.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0680
    Cell Significance Index: 2.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0618
    Cell Significance Index: 3.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0287
    Cell Significance Index: 2.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0167
    Cell Significance Index: 1.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0120
    Cell Significance Index: 16.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0065
    Cell Significance Index: 1.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0112
    Cell Significance Index: -0.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0118
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0235
    Cell Significance Index: -17.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0294
    Cell Significance Index: -4.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0320
    Cell Significance Index: -18.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0327
    Cell Significance Index: -23.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0349
    Cell Significance Index: -21.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0367
    Cell Significance Index: -4.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0448
    Cell Significance Index: -33.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0588
    Cell Significance Index: -6.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0775
    Cell Significance Index: -4.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1120
    Cell Significance Index: -32.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1188
    Cell Significance Index: -25.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1210
    Cell Significance Index: -5.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1284
    Cell Significance Index: -13.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1416
    Cell Significance Index: -2.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1550
    Cell Significance Index: -3.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1868
    Cell Significance Index: -9.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1895
    Cell Significance Index: -22.0800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2148
    Cell Significance Index: -5.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2263
    Cell Significance Index: -25.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2318
    Cell Significance Index: -2.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2700
    Cell Significance Index: -7.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2826
    Cell Significance Index: -29.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3473
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3519
    Cell Significance Index: -40.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3628
    Cell Significance Index: -11.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3658
    Cell Significance Index: -5.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3695
    Cell Significance Index: -19.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4144
    Cell Significance Index: -5.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4147
    Cell Significance Index: -8.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4246
    Cell Significance Index: -33.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4291
    Cell Significance Index: -26.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4317
    Cell Significance Index: -7.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4363
    Cell Significance Index: -6.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4699
    Cell Significance Index: -16.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4985
    Cell Significance Index: -10.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DDX10 is a 332-amino acid protein that exhibits a high degree of sequence homology with other DEAD-box helicases. Its molecular weight is approximately 37 kDa, and it is predicted to possess a helicase domain that is capable of unwinding double-stranded RNA (dsRNA) and other RNA structures. The protein is highly expressed in various neuronal populations, including GABAergic cortical interneurons, glutamatergic neurons, and dopaminergic neurons. Its expression pattern suggests a critical role in the development and function of the nervous system. **Pathways and Functions:** DDX10 is involved in several key pathways, including: 1. **Anterior Head Development:** DDX10 is required for the proper development of the anterior head, suggesting a role in the regulation of gene expression and RNA processing during embryonic development. 2. **ATP Binding and Hydrolysis Activity:** DDX10 exhibits ATP-dependent RNA helicase activity, which is essential for the unwinding and uncoiling of RNA structures. 3. **RNA Binding:** DDX10 interacts with various RNA molecules, including mRNA, rRNA, and tRNA, suggesting a role in RNA processing and translation. 4. **RNA Helicase Activity:** DDX10's helicase activity is crucial for the unwinding of dsRNA and other RNA structures, which is essential for various cellular processes, including RNA processing and gene expression. **Clinical Significance:** DDX10 has been implicated in several neurological disorders, including: 1. **Neurodevelopmental Disorders:** Mutations in the DDX10 gene have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. 2. **Neurodegenerative Diseases:** DDX10 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where RNA processing and helicase activity are disrupted. 3. **Cancer:** DDX10 has been found to be overexpressed in certain types of cancer, suggesting a potential role in tumorigenesis and cancer progression. In conclusion, DDX10 is a crucial gene that plays a vital role in the regulation of RNA processing and neurodevelopment. Its involvement in various neurological disorders and cancers highlights the importance of further research into the molecular mechanisms underlying its function. As an expert immunologist, I believe that a deeper understanding of DDX10's role in human disease will lead to the development of novel therapeutic strategies for the treatment of these conditions.

Genular Protein ID: 1303535604

Symbol: DDX10_HUMAN

Name: Probable ATP-dependent RNA helicase DDX10

UniProtKB Accession Codes:

Q13206 B2RCQ3 Q5BJD8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8660968

Title: A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.

PubMed ID: 8660968

DOI: 10.1006/geno.1996.0184

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20941364

Title: Comparative structural analysis of human DEAD-box RNA helicases.

PubMed ID: 20941364

DOI: 10.1371/journal.pone.0012791

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 875
  • Mass: 100888
  • Checksum: B61BF325921C62FD
  • Sequence:
    • MGKTANSPGS GARPDPVRSF NRWKKKHSHR QNKKKQLRKQ LKKPEWQVER ESISRLMQNY 
EKINVNEITR FSDFPLSKKT LKGLQEAQYR LVTEIQKQTI GLALQGKDVL GAAKTGSGKT 
LAFLVPVLEA LYRLQWTSTD GLGVLIISPT RELAYQTFEV LRKVGKNHDF SAGLIIGGKD 
LKHEAERINN INILVCTPGR LLQHMDETVS FHATDLQMLV LDEADRILDM GFADTMNAVI 
ENLPKKRQTL LFSATQTKSV KDLARLSLKN PEYVWVHEKA KYSTPATLEQ NYIVCELQQK 
ISVLYSFLRS HLKKKSIVFF SSCKEVQYLY RVFCRLRPGV SILALHGRQQ QMRRMEVYNE 
FVRKRAAVLF ATDIAARGLD FPAVNWVLQF DCPEDANTYI HRAGRTARYK EDGEALLILL 
PSEKAMVQQL LQKKVPVKEI KINPEKLIDV QKKLESILAQ DQDLKERAQR CFVSYVRSVY 
LMKDKEVFDV SKLPIPEYAL SLGLAVAPRV RFLQKMQKQP TKELVRSQAD KVIEPRAPSL 
TNDEVEEFRA YFNEKMSILQ KGGKRLEGTE HRQDNDTGNE EQEEEEDDEE EMEEKLAKAK 
GSQAPSLPNT SEAQKIKEVP TQFLDRDEEE EDADFLKVKR HNVFGLDLKD EKTLQKKEPS 
KSSIKKKMTK VAEAKKVMKR NFKVNKKITF TDEGELVQQW PQMQKSAIKD AEEDDDTGGI 
NLHKAKERLQ EEDKFDKEEY RKKIKAKHRE KRLKEREARR EANKRQAKAK DEEEAFLDWS 
DDDDDDDDGF DPSTLPDPDK YRSSEDSDSE DMENKISDTK KKQGMKKRSN SEVEDVGPTS 
HNRKKARWDT LEPLDTGLSL AEDEELVLHL LRSQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.