Details for: DHPS

Gene ID: 1725

Symbol: DHPS

Ensembl ID: ENSG00000095059

Description: deoxyhypusine synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 196.8559
    Cell Significance Index: -30.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 104.9505
    Cell Significance Index: -26.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.1031
    Cell Significance Index: -35.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.7909
    Cell Significance Index: -35.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.5452
    Cell Significance Index: -35.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.8842
    Cell Significance Index: -34.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.0800
    Cell Significance Index: -35.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4028
    Cell Significance Index: -22.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4009
    Cell Significance Index: -19.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.1855
    Cell Significance Index: 487.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8290
    Cell Significance Index: -8.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.4553
    Cell Significance Index: 154.7500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.4227
    Cell Significance Index: 20.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0295
    Cell Significance Index: 121.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7277
    Cell Significance Index: 90.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5233
    Cell Significance Index: 247.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1940
    Cell Significance Index: 12.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1393
    Cell Significance Index: 73.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9569
    Cell Significance Index: 522.6000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8770
    Cell Significance Index: 6.7600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.7467
    Cell Significance Index: 11.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7036
    Cell Significance Index: 90.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7011
    Cell Significance Index: 32.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6967
    Cell Significance Index: 95.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6760
    Cell Significance Index: 14.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6699
    Cell Significance Index: 46.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6369
    Cell Significance Index: 18.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6238
    Cell Significance Index: 46.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6115
    Cell Significance Index: 16.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5932
    Cell Significance Index: 72.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5881
    Cell Significance Index: 69.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5475
    Cell Significance Index: 242.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5363
    Cell Significance Index: 96.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5341
    Cell Significance Index: 18.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5123
    Cell Significance Index: 36.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4802
    Cell Significance Index: 13.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4721
    Cell Significance Index: 60.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4218
    Cell Significance Index: 80.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4115
    Cell Significance Index: 11.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3982
    Cell Significance Index: 39.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3587
    Cell Significance Index: 71.9600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3468
    Cell Significance Index: 3.9400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2831
    Cell Significance Index: 2.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2569
    Cell Significance Index: 11.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2298
    Cell Significance Index: 5.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2183
    Cell Significance Index: 37.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1523
    Cell Significance Index: 54.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1324
    Cell Significance Index: 26.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1193
    Cell Significance Index: 7.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1108
    Cell Significance Index: 5.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0678
    Cell Significance Index: 1.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0486
    Cell Significance Index: 1.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0415
    Cell Significance Index: 1.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0096
    Cell Significance Index: 7.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0064
    Cell Significance Index: -4.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0107
    Cell Significance Index: -6.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0143
    Cell Significance Index: -10.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0179
    Cell Significance Index: -0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0186
    Cell Significance Index: -34.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0212
    Cell Significance Index: -2.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0237
    Cell Significance Index: -43.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0276
    Cell Significance Index: -42.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0309
    Cell Significance Index: -1.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0333
    Cell Significance Index: -45.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0404
    Cell Significance Index: -22.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0490
    Cell Significance Index: -0.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0533
    Cell Significance Index: -33.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0770
    Cell Significance Index: -16.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0820
    Cell Significance Index: -37.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0914
    Cell Significance Index: -1.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0958
    Cell Significance Index: -27.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1273
    Cell Significance Index: -14.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1425
    Cell Significance Index: -3.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2063
    Cell Significance Index: -3.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2286
    Cell Significance Index: -6.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2384
    Cell Significance Index: -13.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2410
    Cell Significance Index: -35.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2813
    Cell Significance Index: -9.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2928
    Cell Significance Index: -33.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3049
    Cell Significance Index: -4.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3288
    Cell Significance Index: -25.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3412
    Cell Significance Index: -27.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3471
    Cell Significance Index: -36.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3598
    Cell Significance Index: -6.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3747
    Cell Significance Index: -7.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4048
    Cell Significance Index: -8.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4575
    Cell Significance Index: -12.2600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4672
    Cell Significance Index: -7.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4911
    Cell Significance Index: -30.1100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5058
    Cell Significance Index: -7.0900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5072
    Cell Significance Index: -3.3000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5187
    Cell Significance Index: -4.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5212
    Cell Significance Index: -6.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5223
    Cell Significance Index: -4.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5384
    Cell Significance Index: -36.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5413
    Cell Significance Index: -15.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6065
    Cell Significance Index: -15.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6563
    Cell Significance Index: -29.0300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6612
    Cell Significance Index: -4.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** DHPS catalyzes the conversion of hypusine to deoxyhypusine, a critical step in the hypusination process, which is essential for protein function and cellular regulation. 2. **Subcellular Localization:** DHPS is primarily found in the cytosol, where it exerts its enzymatic activity. 3. **Regulatory Mechanisms:** DHPS is regulated by various mechanisms, including identical protein binding, which ensures precise control over its activity and substrate specificity. 4. **Cellular Expression:** DHPS is expressed in a range of cell types, including peripheral nervous system neurons, neural cells, and immune cells, highlighting its importance in various cellular processes. **Pathways and Functions:** 1. **Hypusination Pathway:** DHPS is a critical component of the hypusination pathway, which involves the post-translational modification of lysine residues in proteins, resulting in the formation of hypusine and deoxyhypusine. 2. **Protein-Protein Interactions:** Deoxyhypusine, the product of DHPS activity, plays a crucial role in protein-protein interactions, influencing cellular signaling pathways and protein function. 3. **Cell Proliferation and Immune Regulation:** DHPS has been implicated in the regulation of cell proliferation and immune responses, particularly in T-cell proliferation, highlighting its importance in maintaining immune homeostasis. 4. **Glucose Homeostasis:** Recent studies have revealed that DHPS is involved in maintaining glucose homeostasis by regulating cellular metabolism and glucose uptake. **Clinical Significance:** The dysregulation of DHPS has been implicated in various diseases, including: 1. **Immune-Mediated Disorders:** Dysregulation of DHPS has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, highlighting its importance in immune regulation. 2. **Neurological Disorders:** DHPS has been implicated in neurological disorders, including Parkinson's disease and Alzheimer's disease, where hypusination dysregulation has been proposed as a contributing factor. 3. **Cancer:** DHPS has been found to be overexpressed in various cancers, suggesting its potential role in cancer development and progression. In conclusion, deoxyhypusine synthase (DHPS) is a critical enzyme involved in the synthesis of deoxyhypusine, a post-translational modification that plays a pivotal role in various cellular processes, including protein-protein interactions, cell proliferation, and immune regulation. Further research is needed to fully elucidate the mechanisms of DHPS and its role in disease, but its significance in maintaining cellular homeostasis and immune regulation is clear.

Genular Protein ID: 1830043159

Symbol: DHYS_HUMAN

Name: Deoxyhypusine synthase

UniProtKB Accession Codes:

P49366 A8K688 M0R1I5 Q13184 Q13276 Q9UDG0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 15 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 19 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7673224

Title: Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins.

PubMed ID: 7673224

DOI: 10.1074/jbc.270.38.22386

PubMed ID: 8549832

Title: Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus.

PubMed ID: 8549832

DOI: 10.1016/0014-5793(95)01456-x

PubMed ID: 8615810

Title: Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information.

PubMed ID: 8615810

DOI: 10.1042/bj3150429

PubMed ID: 9666110

Title: Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1.

PubMed ID: 9666110

DOI: 10.1016/s0378-1119(98)00254-6

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7750572

Title: Purification and characterization of human deoxyhypusine synthase from HeLa cells.

PubMed ID: 7750572

DOI: 10.1016/0014-5793(95)00394-o

PubMed ID: 9405486

Title: Enzyme-substrate intermediate at a specific lysine residue is required for deoxyhypusine synthesis. The role of Lys329 in human deoxyhypusine synthase.

PubMed ID: 9405486

DOI: 10.1074/jbc.272.51.32679

PubMed ID: 11311149

Title: Structure-function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD.

PubMed ID: 11311149

DOI: 10.1042/bj3550841

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 30661771

Title: Recessive rare variants in deoxyhypusine synthase, an enzyme involved in the synthesis of hypusine, are associated with a neurodevelopmental disorder.

PubMed ID: 30661771

DOI: 10.1016/j.ajhg.2018.12.017

PubMed ID: 9493264

Title: Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site.

PubMed ID: 9493264

DOI: 10.1016/s0969-2126(98)00004-5

PubMed ID: 15100216

Title: A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex.

PubMed ID: 15100216

DOI: 10.1074/jbc.m404095200

Sequence Information:

  • Length: 369
  • Mass: 40971
  • Checksum: 5314FED620AC9EE7
  • Sequence:
    • MEGSLEREAP AGALAAVLKH SSTLPPESTQ VRGYDFNRGV NYRALLEAFG TTGFQATNFG 
RAVQQVNAMI EKKLEPLSQD EDQHADLTQS RRPLTSCTIF LGYTSNLISS GIRETIRYLV 
QHNMVDVLVT TAGGVEEDLI KCLAPTYLGE FSLRGKELRE NGINRIGNLL VPNENYCKFE 
DWLMPILDQM VMEQNTEGVK WTPSKMIARL GKEINNPESV YYWAQKNHIP VFSPALTDGS 
LGDMIFFHSY KNPGLVLDIV EDLRLINTQA IFAKCTGMII LGGGVVKHHI ANANLMRNGA 
DYAVYINTAQ EFDGSDSGAR PDEAVSWGKI RVDAQPVKVY ADASLVFPLL VAETFAQKMD 
AFMHEKNED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.