Details for: DHPS

Gene ID: 1725

Symbol: DHPS

Ensembl ID: ENSG00000095059

Description: deoxyhypusine synthase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.96
    Marker Score: 2202
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.73
    Marker Score: 836.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.71
    Marker Score: 2064
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.68
    Marker Score: 3407
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.66
    Marker Score: 1671.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.62
    Marker Score: 3389
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.6
    Marker Score: 1509
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.59
    Marker Score: 1905
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.58
    Marker Score: 4512
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.56
    Marker Score: 466
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.54
    Marker Score: 6285
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.52
    Marker Score: 957
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5
    Marker Score: 51951
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.49
    Marker Score: 502
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.47
    Marker Score: 4002
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.47
    Marker Score: 1381
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.46
    Marker Score: 869
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.46
    Marker Score: 1825
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.45
    Marker Score: 2457
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.44
    Marker Score: 2364
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.44
    Marker Score: 2033
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.42
    Marker Score: 3860.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.4
    Marker Score: 2012
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.4
    Marker Score: 1491
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.38
    Marker Score: 14007
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.38
    Marker Score: 652.5
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.36
    Marker Score: 1609
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.36
    Marker Score: 482
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.32
    Marker Score: 880
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.32
    Marker Score: 490.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.3
    Marker Score: 2268
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.26
    Marker Score: 3073
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.25
    Marker Score: 690
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.22
    Marker Score: 352
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.21
    Marker Score: 422
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.2
    Marker Score: 15850
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.19
    Marker Score: 4395.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.18
    Marker Score: 379
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.18
    Marker Score: 7544
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.18
    Marker Score: 627.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.17
    Marker Score: 2782
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.16
    Marker Score: 1921
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.16
    Marker Score: 1116
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.16
    Marker Score: 271
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.15
    Marker Score: 1221.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.14
    Marker Score: 1587
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.14
    Marker Score: 1809.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.13
    Marker Score: 2006.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.13
    Marker Score: 536
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.12
    Marker Score: 4329.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.12
    Marker Score: 816
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.11
    Marker Score: 543
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.11
    Marker Score: 1976
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.11
    Marker Score: 1039
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.1
    Marker Score: 58358
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.09
    Marker Score: 5356
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.08
    Marker Score: 10904
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.08
    Marker Score: 4238
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.08
    Marker Score: 9342.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.07
    Marker Score: 1008
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.06
    Marker Score: 445
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.06
    Marker Score: 835
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.06
    Marker Score: 527
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.05
    Marker Score: 762
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.05
    Marker Score: 4384
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.05
    Marker Score: 361.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.05
    Marker Score: 1968
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.05
    Marker Score: 250
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.05
    Marker Score: 2461
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.05
    Marker Score: 361
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.03
    Marker Score: 3063
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.03
    Marker Score: 654
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.03
    Marker Score: 2502
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.02
    Marker Score: 224
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.02
    Marker Score: 10066.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.02
    Marker Score: 595
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.02
    Marker Score: 4378.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.01
    Marker Score: 1054
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1
    Marker Score: 2503
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1
    Marker Score: 283
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71587.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.99
    Marker Score: 405
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47811
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.99
    Marker Score: 1594
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.98
    Marker Score: 13201
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.98
    Marker Score: 4714
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.98
    Marker Score: 33406.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30373
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.98
    Marker Score: 6356
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.98
    Marker Score: 245
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.98
    Marker Score: 444
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.97
    Marker Score: 206
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.97
    Marker Score: 195
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.96
    Marker Score: 1039.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.96
    Marker Score: 5715
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.96
    Marker Score: 255
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.96
    Marker Score: 727
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.96
    Marker Score: 857
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.96
    Marker Score: 252
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.96
    Marker Score: 649

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Other Information

**Key characteristics:** - DHPS is a transmembrane protein with a single transmembrane domain. - It is a member of the DHPS family of enzymes, which are involved in the synthesis of deoxyhypusine from other precursors. - DHPS is a highly regulated protein, with its expression being influenced by various factors, including growth factors, cytokines, and metabolic signals. **Pathways and functions:** - DHPS is involved in several important cellular pathways, including: - Glucose homeostasis: DHPS is crucial for the synthesis of glutamine from glutamine, which is a critical substrate for various cellular processes. - Spermidine catabolic process: DHPS is involved in the catabolism of spermidine, a precursor to the synthesis of collagen. - Translation: DHPS is involved in the translation of messenger RNA into proteins. **Clinical significance:** - DHPS mutations have been linked to several human diseases, including: - Neurodegenerative diseases: Mutations in DHPS have been linked to amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease characterized by muscle weakness and atrophy. - Cancer: DHPS mutations have also been linked to certain types of cancer, such as breast cancer and lung cancer. **Conclusion:** DHPS is a critical enzyme for maintaining cellular homeostasis and regulating various cellular processes. Its mutations have significant implications for human health, with potential implications for neurodegenerative diseases and cancer.

Genular Protein ID: 1830043159

Symbol: DHYS_HUMAN

Name: Deoxyhypusine synthase

UniProtKB Accession Codes:

P49366 A8K688 M0R1I5 Q13184 Q13276 Q9UDG0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 15 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 19 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7673224

Title: Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins.

PubMed ID: 7673224

DOI: 10.1074/jbc.270.38.22386

PubMed ID: 8549832

Title: Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus.

PubMed ID: 8549832

DOI: 10.1016/0014-5793(95)01456-x

PubMed ID: 8615810

Title: Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information.

PubMed ID: 8615810

DOI: 10.1042/bj3150429

PubMed ID: 9666110

Title: Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1.

PubMed ID: 9666110

DOI: 10.1016/s0378-1119(98)00254-6

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7750572

Title: Purification and characterization of human deoxyhypusine synthase from HeLa cells.

PubMed ID: 7750572

DOI: 10.1016/0014-5793(95)00394-o

PubMed ID: 9405486

Title: Enzyme-substrate intermediate at a specific lysine residue is required for deoxyhypusine synthesis. The role of Lys329 in human deoxyhypusine synthase.

PubMed ID: 9405486

DOI: 10.1074/jbc.272.51.32679

PubMed ID: 11311149

Title: Structure-function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD.

PubMed ID: 11311149

DOI: 10.1042/bj3550841

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 30661771

Title: Recessive rare variants in deoxyhypusine synthase, an enzyme involved in the synthesis of hypusine, are associated with a neurodevelopmental disorder.

PubMed ID: 30661771

DOI: 10.1016/j.ajhg.2018.12.017

PubMed ID: 9493264

Title: Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site.

PubMed ID: 9493264

DOI: 10.1016/s0969-2126(98)00004-5

PubMed ID: 15100216

Title: A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex.

PubMed ID: 15100216

DOI: 10.1074/jbc.m404095200

Sequence Information:

  • Length: 369
  • Mass: 40971
  • Checksum: 5314FED620AC9EE7
  • Sequence:
    • MEGSLEREAP AGALAAVLKH SSTLPPESTQ VRGYDFNRGV NYRALLEAFG TTGFQATNFG 
RAVQQVNAMI EKKLEPLSQD EDQHADLTQS RRPLTSCTIF LGYTSNLISS GIRETIRYLV 
QHNMVDVLVT TAGGVEEDLI KCLAPTYLGE FSLRGKELRE NGINRIGNLL VPNENYCKFE 
DWLMPILDQM VMEQNTEGVK WTPSKMIARL GKEINNPESV YYWAQKNHIP VFSPALTDGS 
LGDMIFFHSY KNPGLVLDIV EDLRLINTQA IFAKCTGMII LGGGVVKHHI ANANLMRNGA 
DYAVYINTAQ EFDGSDSGAR PDEAVSWGKI RVDAQPVKVY ADASLVFPLL VAETFAQKMD 
AFMHEKNED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.