Details for: DLG1

Gene ID: 1739

Symbol: DLG1

Ensembl ID: ENSG00000075711

Description: discs large MAGUK scaffold protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 512.7769
    Cell Significance Index: -79.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 316.5862
    Cell Significance Index: -80.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 188.3249
    Cell Significance Index: -77.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 181.6265
    Cell Significance Index: -85.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 168.7724
    Cell Significance Index: -68.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 156.1767
    Cell Significance Index: -80.3400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 127.8795
    Cell Significance Index: -85.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 71.9146
    Cell Significance Index: -68.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 66.8475
    Cell Significance Index: -82.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.0613
    Cell Significance Index: -80.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.7114
    Cell Significance Index: -75.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.0337
    Cell Significance Index: -83.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.4039
    Cell Significance Index: -38.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.3857
    Cell Significance Index: 246.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.3583
    Cell Significance Index: 121.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.7014
    Cell Significance Index: 734.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.6923
    Cell Significance Index: 94.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.5092
    Cell Significance Index: 155.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.3059
    Cell Significance Index: 253.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.2449
    Cell Significance Index: 122.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0191
    Cell Significance Index: 605.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.2198
    Cell Significance Index: 55.4900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.8971
    Cell Significance Index: 16.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8607
    Cell Significance Index: 302.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8068
    Cell Significance Index: 121.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.6091
    Cell Significance Index: 34.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5707
    Cell Significance Index: 1086.3400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.4178
    Cell Significance Index: 34.5900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.2788
    Cell Significance Index: 7.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2560
    Cell Significance Index: 226.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2321
    Cell Significance Index: 35.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0490
    Cell Significance Index: 128.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0276
    Cell Significance Index: 111.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8172
    Cell Significance Index: 15.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7934
    Cell Significance Index: 1493.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7880
    Cell Significance Index: 711.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7152
    Cell Significance Index: 256.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7012
    Cell Significance Index: 43.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.6709
    Cell Significance Index: 304.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6519
    Cell Significance Index: 356.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5666
    Cell Significance Index: 9.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5233
    Cell Significance Index: 332.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4207
    Cell Significance Index: 775.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4046
    Cell Significance Index: 622.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3476
    Cell Significance Index: 9.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3234
    Cell Significance Index: 22.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3087
    Cell Significance Index: 136.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2963
    Cell Significance Index: 402.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2324
    Cell Significance Index: 12.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2187
    Cell Significance Index: 30.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0401
    Cell Significance Index: 1.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0340
    Cell Significance Index: 3.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0238
    Cell Significance Index: 1.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0407
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0528
    Cell Significance Index: -39.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0662
    Cell Significance Index: -3.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0663
    Cell Significance Index: -48.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0751
    Cell Significance Index: -46.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0761
    Cell Significance Index: -14.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0859
    Cell Significance Index: -14.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1045
    Cell Significance Index: -79.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1146
    Cell Significance Index: -64.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1191
    Cell Significance Index: -1.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1341
    Cell Significance Index: -3.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1772
    Cell Significance Index: -11.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1786
    Cell Significance Index: -11.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1989
    Cell Significance Index: -5.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2000
    Cell Significance Index: -20.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2024
    Cell Significance Index: -23.8700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2136
    Cell Significance Index: -2.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2252
    Cell Significance Index: -32.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2444
    Cell Significance Index: -31.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2450
    Cell Significance Index: -51.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2532
    Cell Significance Index: -72.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3090
    Cell Significance Index: -39.9300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3326
    Cell Significance Index: -5.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3925
    Cell Significance Index: -40.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4386
    Cell Significance Index: -51.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5254
    Cell Significance Index: -8.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5493
    Cell Significance Index: -28.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5581
    Cell Significance Index: -8.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5621
    Cell Significance Index: -64.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5627
    Cell Significance Index: -13.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5864
    Cell Significance Index: -8.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6481
    Cell Significance Index: -48.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6489
    Cell Significance Index: -13.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6760
    Cell Significance Index: -77.1600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7058
    Cell Significance Index: -10.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7651
    Cell Significance Index: -54.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8884
    Cell Significance Index: -18.9200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.8888
    Cell Significance Index: -9.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9285
    Cell Significance Index: -73.5400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.9374
    Cell Significance Index: -12.5100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9456
    Cell Significance Index: -13.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1112
    Cell Significance Index: -58.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.1274
    Cell Significance Index: -39.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1718
    Cell Significance Index: -38.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.1748
    Cell Significance Index: -17.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1767
    Cell Significance Index: -72.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DLG1 is a large scaffold protein that belongs to the MAGUK (membrane-associated guanylate kinase) family. It is characterized by its unique structure, which consists of three main domains: the PDZ (PSD-95/Discs Large/Zonula Occludens-1) domain, the SH3 (Src homology 3) domain, and the guanylate kinase domain. The PDZ domain is responsible for binding to target proteins, while the SH3 domain interacts with other proteins to regulate protein-protein interactions. The guanylate kinase domain is involved in signaling pathways. DLG1 is highly expressed in neurons, where it plays a critical role in regulating synaptic transmission and plasticity. It is also expressed in other cell types, including immune cells, where it modulates immune responses. **Pathways and Functions** DLG1 is involved in various signaling pathways, including: 1. **Neurotransmitter receptor localization**: DLG1 regulates the localization of neurotransmitter receptors to the postsynaptic density, where it interacts with other proteins to modulate synaptic transmission. 2. **Synaptic plasticity**: DLG1 is involved in the regulation of synaptic plasticity, which is critical for learning and memory. 3. **Immune system function**: DLG1 modulates immune responses by regulating the activity of immune cells, such as T cells and dendritic cells. 4. **Cell-cell adhesion**: DLG1 is involved in regulating cell-cell adhesion, which is critical for maintaining tissue structure and function. 5. **Signaling pathways**: DLG1 interacts with various signaling molecules, including Ras and MAPK, to regulate cellular processes. **Clinical Significance** Dysregulation of DLG1 has been implicated in various neurological and immune disorders, including: 1. **Autism**: DLG1 mutations have been associated with autism spectrum disorder. 2. **Schizophrenia**: DLG1 dysregulation has been linked to schizophrenia. 3. **Autoimmune diseases**: DLG1 modulates immune responses, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Neurological disorders**: DLG1 is involved in regulating synaptic transmission and plasticity, and its dysregulation has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, DLG1 is a critical scaffold protein that plays a key role in regulating cellular processes, including cell-cell adhesion, synaptic plasticity, and immune system function. Its dysregulation has been implicated in various neurological and immune disorders, highlighting the importance of DLG1 in maintaining cellular homeostasis.

Genular Protein ID: 1782228662

Symbol: DLG1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q12959 A5YKK7 B4DGU1 B4DGZ8 B7ZMM0 B9EIQ5 D3DXB8 D3DXB9 E7EWL7 E9PG21 Q12958

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 13 Ensembl 19 EvolutionaryTrace 1 ExpressionAtlas 1 GO 95 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 2 PIRSF 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 10 RefSeq 26 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7937897

Title: Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

PubMed ID: 7937897

DOI: 10.1073/pnas.91.21.9818

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7477295

Title: Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.

PubMed ID: 7477295

DOI: 10.1038/378085a0

PubMed ID: 8922391

Title: Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain.

PubMed ID: 8922391

DOI: 10.1083/jcb.135.4.1125

PubMed ID: 8638125

Title: Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

PubMed ID: 8638125

DOI: 10.1126/science.272.5264.1020

PubMed ID: 9192623

Title: Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein.

PubMed ID: 9192623

DOI: 10.1073/pnas.94.13.6670

PubMed ID: 10557085

Title: Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control.

PubMed ID: 10557085

DOI: 10.1038/sj.onc.1203008

PubMed ID: 10859302

Title: GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.

PubMed ID: 10859302

DOI: 10.1074/jbc.m000715200

PubMed ID: 10656683

Title: The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase.

PubMed ID: 10656683

DOI: 10.1038/sj.onc.1203309

PubMed ID: 10779557

Title: Characterization of PDZ-binding kinase, a mitotic kinase.

PubMed ID: 10779557

DOI: 10.1073/pnas.090102397

PubMed ID: 11602598

Title: Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells.

PubMed ID: 11602598

DOI: 10.1074/jbc.m107335200

PubMed ID: 12445884

Title: Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium.

PubMed ID: 12445884

DOI: 10.1016/s0008-6363(02)00602-8

PubMed ID: 11723125

Title: The distribution and function of alternatively spliced insertions in hDlg.

PubMed ID: 11723125

DOI: 10.1074/jbc.m108724200

PubMed ID: 12807908

Title: Protein 4.1-mediated membrane targeting of human discs large in epithelial cells.

PubMed ID: 12807908

DOI: 10.1074/jbc.m305209200

PubMed ID: 14699157

Title: Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells.

PubMed ID: 14699157

DOI: 10.1074/jbc.m309843200

PubMed ID: 15263016

Title: Discs large (Dlg1) complexes in lymphocyte activation.

PubMed ID: 15263016

DOI: 10.1083/jcb.200309044

PubMed ID: 15021905

Title: Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.

PubMed ID: 15021905

DOI: 10.1038/sj.onc.1207495

PubMed ID: 12766944

Title: Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer.

PubMed ID: 12766944

DOI: 10.1002/bies.10286

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16519681

Title: MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane.

PubMed ID: 16519681

DOI: 10.1111/j.1742-4658.2006.05140.x

PubMed ID: 16630835

Title: SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.

PubMed ID: 16630835

DOI: 10.1016/j.neuron.2006.04.005

PubMed ID: 17237226

Title: The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions.

PubMed ID: 17237226

DOI: 10.1074/jbc.m610002200

PubMed ID: 17332497

Title: The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation.

PubMed ID: 17332497

DOI: 10.1091/mbc.e06-11-0980

PubMed ID: 17980554

Title: DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

PubMed ID: 17980554

DOI: 10.1016/j.cellsig.2007.08.019

PubMed ID: 19118189

Title: Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.

PubMed ID: 19118189

DOI: 10.1523/jneurosci.3112-08.2008

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19213956

Title: Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes.

PubMed ID: 19213956

DOI: 10.1161/circresaha.108.191007

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20605917

Title: p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock.

PubMed ID: 20605917

DOI: 10.1242/jcs.066514

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21849460

Title: The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions.

PubMed ID: 21849460

DOI: 10.1128/jvi.05070-11

PubMed ID: 23676497

Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

PubMed ID: 23676497

DOI: 10.1172/jci65401

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24503895

Title: Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg.

PubMed ID: 24503895

DOI: 10.1371/journal.pone.0082894

PubMed ID: 25268382

Title: Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg.

PubMed ID: 25268382

DOI: 10.1371/journal.pone.0110062

PubMed ID: 25558062

Title: GPR124 functions as a WNT7-specific coactivator of canonical beta-catenin signaling.

PubMed ID: 25558062

DOI: 10.1016/j.celrep.2014.12.020

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8757139

Title: Crystal structure of a PDZ domain.

PubMed ID: 8757139

DOI: 10.1038/382649a0

PubMed ID: 20702775

Title: Structural basis for tandem L27 domain-mediated polymerization.

PubMed ID: 20702775

DOI: 10.1096/fj.10-163857

Sequence Information:

  • Length: 904
  • Mass: 100455
  • Checksum: 6722993A84D0F761
  • Sequence:
    • MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI DIQEFYEVTL 
LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS LSPSVEKYRY QDEDTPPQEH 
ISPQITNEVI GPELVHVSEK NLSEIENVHG FVSHSHISPI KPTEAVLPSP PTVPVIPVLP 
VPAENTVILP TIPQANPPPV LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG 
GTDNPHIGDD SSIFITKIIT GGAAAQDGRL RVNDCILRVN EVDVRDVTHS KAVEALKEAG 
SIVRLYVKRR KPVSEKIMEI KLIKGPKGLG FSIAGGVGNQ HIPGDNSIYV TKIIEGGAAH 
KDGKLQIGDK LLAVNNVCLE EVTHEEAVTA LKNTSDFVYL KVAKPTSMYM NDGYAPPDIT 
NSSSQPVDNH VSPSSFLGQT PASPARYSPV SKAVLGDDEI TREPRKVVLH RGSTGLGFNI 
VGGEDGEGIF ISFILAGGPA DLSGELRKGD RIISVNSVDL RAASHEQAAA ALKNAGQAVT 
IVAQYRPEEY SRFEAKIHDL REQMMNSSIS SGSGSLRTSQ KRSLYVRALF DYDKTKDSGL 
PSQGLNFKFG DILHVINASD DEWWQARQVT PDGESDEVGV IPSKRRVEKK ERARLKTVKF 
NSKTRDKGEI PDDMGSKGLK HVTSNASDSE SSYRGQEEYV LSYEPVNQQE VNYTRPVIIL 
GPMKDRINDD LISEFPDKFG SCVPHTTRPK RDYEVDGRDY HFVTSREQME KDIQEHKFIE 
AGQYNNHLYG TSVQSVREVA EKGKHCILDV SGNAIKRLQI AQLYPISIFI KPKSMENIME 
MNKRLTEEQA RKTFERAMKL EQEFTEHFTA IVQGDTLEDI YNQVKQIIEE QSGSYIWVPA 
KEKL

Genular Protein ID: 2918359648

Symbol: A0A0C4DFT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DFT3

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 5 GO 7 Gene3D 5 GeneTree 1 HGNC 1 InterPro 15 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 9 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 3 SAM 1 SMART 5 SUPFAM 4 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 892
  • Mass: 99814
  • Checksum: 6F7C25A740EF5262
  • Sequence:
    • MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI DIQEFYEVTL 
LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS LSPSVEKYRY QDEDTPPQEH 
ISPQITNEVI GPELVHVSEK NLSEIENVHG FVSHSHISPI KANPPPVLVN TDSLETPTYV 
NGTDADYEYE EITLERGNSG LGFSIAGGTD NPHIGDDSSI FITKIITGGA AAQDGRLRVN 
DCILRVNEVD VRDVTHSKAV EALKEAGSIV RLYVKRRKPV SEKIMEIKLI KGPKGLGFSI 
AGGVGNQHIP GDNSIYVTKI IEGGAAHKDG KLQIGDKLLA VNNVCLEEVT HEEAVTALKN 
TSDFVYLKVA KPTSMYMNDG YAPPDITNSS SQPVDNHVSP SSFLGQTPAS PARYSPVSKA 
VLGDDEITRE PRKVVLHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDRII 
SVNSVDLRAA SHEQAAAALK NAGQAVTIVA QYRPEEYSRF EAKIHDLREQ MMNSSISSGS 
GSLRTSQKRS LYVRALFDYD KTKDSGLPSQ GLNFKFGDIL HVINASDDEW WQARQVTPDG 
ESDEVGVIPS KRRVEKKERA RLKTVKFNSK TRDKGSFNDK RKKNLFSRKF PFYKNKDQSE 
QETSDADQHV TSNASDSESS YRGQEEYVLS YEPVNQQEVN YTRPVIILGP MKDRINDDLI 
SEFPDKFGSC VPHTTRPKRD YEVDGRDYHF VTSREQMEKD IQEHKFIEAG QYNNHLYGTS 
VQSVREVAEK GKHCILDVSG NAIKRLQIAQ LYPISIFIKP KSMENIMEMN KRLTEEQARK 
TFERAMKLEQ EFTEHFTAIV QGDTLEDIYN QVKQIIEEQS GSYIWVPAKE KL

Genular Protein ID: 2125743781

Symbol: B4DF78_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DF78

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 4 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 2 SAM 1 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 587
  • Mass: 65397
  • Checksum: 8F61616474908BC7
  • Sequence:
    • MEIKLIKGPK GLGFSIAGGV GNQHIPGDNS IYVTKIIEGG AAHKDGKLQI GDKLLAVNNV 
CLEEVTHEEA VTALKNTSDF VYLKVAKPTS MYMNDGYAPP DITNSSSQPV DNHVSPSSFL 
GQTPASPARY SPVSKAVLGD DEITREPRKV VLHRGSMGLG FNIVGGEDGE GIFISFILAG 
GPADLSGELR KGDRIISVNS VDLRAASHEQ AAAALKNAGQ AVTIVAQYRP EEYSRFEAKI 
HDLREQMMNS SISSGSGSLR TSQKRSLYVR ALFDYDKTKD SGLPSQGLNF KFGDILHVIN 
ASDDEWWQAR QVTPDGESDE VGVIPSKRRV EKKERARLKT VKFNSKTRDK GEIPDDMGSK 
GLKHVTSNAS DSESSYRGQE EYVLSYEPVN QQEVNYTRPV IILGPMKDRI NDDLISEFPD 
KFGSCVPHTT RPKRDYEVDG RDYHFVTSRE QMEKDIQEHK FIEAGQYNNH LYGTSVQSVR 
EVAEKGKHCI LDVSGNAIKR LQIAQLYPIS IFIKPKSMEN IMEMNKRLTE EQARKTFERA 
MKLEQEFTEH FTAIVQGDTL EDIYNQVKQI IEEQSGSYIW VPAKEKL

Genular Protein ID: 2548852608

Symbol: A0A590UJ08_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A590UJ08

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 5 GeneTree 1 HGNC 1 InterPro 15 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 9 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 4 SAM 1 SMART 5 SMR 1 SUPFAM 4 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 875
  • Mass: 98032
  • Checksum: E5058DD304878DD3
  • Sequence:
    • MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI DIQEFYEVTL 
LDNPKCIDRS KPSEPIQPVN TWEISSLPSS TVTSETLPSS LSPSVEKYRY QDEDTPPQEH 
ISPQITNEVI GPELVHVSEK NLSEIENVHG FVSHSHISPI KVNGTDADYE YEEITLERGN 
SGLGFSIAGG TDNPHIGDDS SIFITKIITG GAAAQDGRLR VNDCILRVNE VDVRDVTHSK 
AVEALKEAGS IVRLYVKRRK PVSEKIMEIK LIKGPKGLGF SIAGGVGNQH IPGDNSIYVT 
KIIEGGAAHK DGKLQIGDKL LAVNNVCLEE VTHEEAVTAL KNTSDFVYLK VAKPTSMYMN 
DGYAPPDITN SSSQPVDNHV SPSSFLGQTP ASPARYSPVS KAVLGDDEIT REPRKVVLHR 
GSTGLGFNIV GGEDGEGIFI SFILAGGPAD LSGELRKGDR IISVNSVDLR AASHEQAAAA 
LKNAGQAVTI VAQYRPEEYS RFEAKIHDLR EQMMNSSISS GSGSLRTSQK RSLYVRALFD 
YDKTKDSGLP SQGLNFKFGD ILHVINASDD EWWQARQVTP DGESDEVGVI PSKRRVEKKE 
RARLKTVKFN SKTRDKGQSF NDKRKKNLFS RKFPFYKNKD QSEQETSDAD QHVTSNASDS 
ESSYRGQEEY VLSYEPVNQQ EVNYTRPVII LGPMKDRIND DLISEFPDKF GSCVPHTTRP 
KRDYEVDGRD YHFVTSREQM EKDIQEHKFI EAGQYNNHLY GTSVQSVREV AEKGKHCILD 
VSGNAIKRLQ IAQLYPISIF IKPKSMENIM EMNKRLTEEQ ARKTFERAMK LEQEFTEHFT 
AIVQGDTLED IYNQVKQIIE EQSGSYIWVP AKEKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.