Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: taste receptor cell (CL0000209)
Fold Change: 3.04
Marker Score: 2,627 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.72
Marker Score: 1,585 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.63
Marker Score: 3,544 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.45
Marker Score: 2,963 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.14
Marker Score: 6,712 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.04
Marker Score: 30,518 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.01
Marker Score: 580 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.98
Marker Score: 35,156 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.95
Marker Score: 1,975 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.93
Marker Score: 1,154 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.9
Marker Score: 2,050 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.9
Marker Score: 6,738 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.89
Marker Score: 7,308 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.87
Marker Score: 1,442 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.82
Marker Score: 2,686 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.8
Marker Score: 755 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.77
Marker Score: 39,499 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.76
Marker Score: 28,297 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.76
Marker Score: 7,367 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.7
Marker Score: 13,060 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.68
Marker Score: 1,929 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.66
Marker Score: 2,001 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.65
Marker Score: 410 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.64
Marker Score: 10,477 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.64
Marker Score: 1,808 - Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.64
Marker Score: 451 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.63
Marker Score: 3,840 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.62
Marker Score: 99,933 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.62
Marker Score: 15,268 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.61
Marker Score: 16,607 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.6
Marker Score: 31,909 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.6
Marker Score: 1,089 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.6
Marker Score: 4,283 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.59
Marker Score: 33,924 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.59
Marker Score: 60,300 - Cell Name: neuron (CL0000540)
Fold Change: 1.59
Marker Score: 6,454 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.58
Marker Score: 510 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.57
Marker Score: 498 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.55
Marker Score: 3,714 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.55
Marker Score: 484 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.53
Marker Score: 14,578 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.52
Marker Score: 13,069 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.52
Marker Score: 55,962 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.51
Marker Score: 753 - Cell Name: mesangial cell (CL0000650)
Fold Change: 1.49
Marker Score: 1,794 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.47
Marker Score: 402 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.47
Marker Score: 3,224 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.46
Marker Score: 6,036 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.45
Marker Score: 2,792 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.44
Marker Score: 2,037 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.44
Marker Score: 12,629 - Cell Name: enterocyte (CL0000584)
Fold Change: 1.41
Marker Score: 6,765 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.4
Marker Score: 408 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.39
Marker Score: 504 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.38
Marker Score: 2,134 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.36
Marker Score: 672 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.36
Marker Score: 714 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.35
Marker Score: 1,346 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.35
Marker Score: 934 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.34
Marker Score: 385 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.34
Marker Score: 1,517 - Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.33
Marker Score: 350 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.33
Marker Score: 268 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.31
Marker Score: 4,660 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.31
Marker Score: 1,257 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.31
Marker Score: 873 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.29
Marker Score: 8,416 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.28
Marker Score: 20,074 - Cell Name: erythroblast (CL0000765)
Fold Change: 1.27
Marker Score: 794 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.27
Marker Score: 2,677 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.27
Marker Score: 761 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.26
Marker Score: 7,492 - Cell Name: acinar cell (CL0000622)
Fold Change: 1.25
Marker Score: 881 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.24
Marker Score: 12,571 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.24
Marker Score: 600 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.22
Marker Score: 3,084 - Cell Name: podocyte (CL0000653)
Fold Change: 1.21
Marker Score: 448 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.21
Marker Score: 1,152 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.2
Marker Score: 1,449 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.2
Marker Score: 1,102 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.19
Marker Score: 791 - Cell Name: proerythroblast (CL0000547)
Fold Change: 1.19
Marker Score: 807 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.19
Marker Score: 66,405 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.18
Marker Score: 613 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.18
Marker Score: 425 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.18
Marker Score: 1,272 - Cell Name: Unknown (CL0000548)
Fold Change: 1.17
Marker Score: 854 - Cell Name: plasmablast (CL0000980)
Fold Change: 1.17
Marker Score: 1,549 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.16
Marker Score: 1,230 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.16
Marker Score: 421 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.16
Marker Score: 433 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.15
Marker Score: 675 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.15
Marker Score: 275 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.15
Marker Score: 2,856 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.15
Marker Score: 256 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.14
Marker Score: 250 - Cell Name: melanocyte (CL0000148)
Fold Change: 1.12
Marker Score: 453 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.11
Marker Score: 11,202 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.1
Marker Score: 1,162 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.1
Marker Score: 1,594
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3868702210
Symbol: DYN2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7590285
Title: Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family.
PubMed ID: 7590285
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11583995
Title: Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton.
PubMed ID: 11583995
PubMed ID: 15048127
Title: Dynamin 2 binds gamma-tubulin and participates in centrosome cohesion.
PubMed ID: 15048127
DOI: 10.1038/ncb1112
PubMed ID: 16325581
Title: TTP specifically regulates the internalization of the transferrin receptor.
PubMed ID: 16325581
PubMed ID: 15703209
Title: SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.
PubMed ID: 15703209
PubMed ID: 17257598
Title: Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis.
PubMed ID: 17257598
PubMed ID: 17676042
Title: Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy.
PubMed ID: 17676042
DOI: 10.1038/ng2086
PubMed ID: 18353773
Title: A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
PubMed ID: 18353773
PubMed ID: 18480402
Title: The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.
PubMed ID: 18480402
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19605363
Title: Dynamin2 GTPase and cortactin remodel actin filaments.
PubMed ID: 19605363
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20496096
Title: Calcineurin activity is required for the completion of cytokinesis.
PubMed ID: 20496096
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22022388
Title: Identification of novel NPRAP/delta-catenin-interacting proteins and the direct association of NPRAP with dynamin 2.
PubMed ID: 22022388
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29437695
Title: SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2.
PubMed ID: 29437695
PubMed ID: 33713620
Title: Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.
PubMed ID: 33713620
PubMed ID: 36445308
Title: GSK3alpha phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells.
PubMed ID: 36445308
PubMed ID: 15731758
Title: Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease.
PubMed ID: 15731758
DOI: 10.1038/ng1514
PubMed ID: 16227997
Title: Mutations in dynamin 2 cause dominant centronuclear myopathy.
PubMed ID: 16227997
DOI: 10.1038/ng1657
PubMed ID: 17932957
Title: Dynamin 2 mutations cause sporadic centronuclear myopathy with neonatal onset.
PubMed ID: 17932957
DOI: 10.1002/ana.21235
PubMed ID: 17636067
Title: Two novel mutations in dynamin-2 cause axonal Charcot-Marie-Tooth disease.
PubMed ID: 17636067
PubMed ID: 17825552
Title: Subtle central and peripheral nervous system abnormalities in a family with centronuclear myopathy and a novel dynamin 2 gene mutation.
PubMed ID: 17825552
PubMed ID: 18560793
Title: Magnetic resonance imaging findings of leg musculature in Charcot-Marie-Tooth disease type 2 due to dynamin 2 mutation.
PubMed ID: 18560793
PubMed ID: 19623537
Title: Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis.
PubMed ID: 19623537
DOI: 10.1002/humu.21086
PubMed ID: 19122038
Title: A new centronuclear myopathy phenotype due to a novel dynamin 2 mutation.
PubMed ID: 19122038
PubMed ID: 19932620
Title: Centronuclear myopathy with cataracts due to a novel dynamin 2 (DNM2) mutation.
PubMed ID: 19932620
PubMed ID: 19932619
Title: Adult course in dynamin 2 dominant centronuclear myopathy with neonatal onset.
PubMed ID: 19932619
PubMed ID: 20227276
Title: Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy.
PubMed ID: 20227276
PubMed ID: 22396310
Title: Mutation spectrum in the large GTPase dynamin 2, and genotype-phenotype correlation in autosomal dominant centronuclear myopathy.
PubMed ID: 22396310
DOI: 10.1002/humu.22067
PubMed ID: 23092955
Title: Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome.
PubMed ID: 23092955
PubMed ID: 24135484
Title: The myopathy-causing mutation DNM2-S619L leads to defective tubulation in vitro and in developing zebrafish.
PubMed ID: 24135484
DOI: 10.1242/dmm.012286
PubMed ID: 32315611
Title: A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.
PubMed ID: 32315611
PubMed ID: 34744632
Title: Gain-of-Function Properties of a Dynamin 2 Mutant Implicated in Charcot-Marie-Tooth Disease.
PubMed ID: 34744632
Sequence Information:
- Length: 870
- Mass: 98064
- Checksum: 2F4567B75980935D
- Sequence:
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG SGIVTRRPLI LQLIFSKTEH AEFLHCKSKK FTDFDEVRQE IEAETDRVTG TNKGISPVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRA ALAAERKFFL SHPAYRHMAD RMGTPHLQKT LNQQLTNHIR ESLPALRSKL QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT GLFTPDLAFE AIVKKQVVKL KEPCLKCVDL VIQELINTVR QCTSKLSSYP RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ QRSTQLNKKR AIPNQGEILV IRRGWLTINN ISLMKGGSKE YWFVLTAESL SWYKDEEEKE KKYMLPLDNL KIRDVEKGFM SNKHVFAIFN TEQRNVYKDL RQIELACDSQ EDVDSWKASF LRAGVYPEKD QAENEDGAQE NTFSMDPQLE RQVETIRNLV DSYVAIINKS IRDLMPKTIM HLMINNTKAF IHHELLAYLY SSADQSSLME ESADQAQRRD DMLRMYHALK EALNIIGDIS TSTVSTPVPP PVDDTWLQSA SSHSPTPQRR PVSSIHPPGR PPAVRGPTPG PPLIPVPVGA AASFSAPPIP SRPGPQSVFA NSDLFPAPPQ IPSRPVRIPP GIPPGVPSRR PPAAPSRPTI IRPAEPSLLD
Genular Protein ID: 958160286
Symbol: Q8N1K8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 464
- Mass: 52199
- Checksum: A56592DDAD9B7368
- Sequence:
MAFEAIVKKQ IVKLKEPSLK CVDLVVSELA TVIKKCAEKL SSYPRLREET ERIVTTYIRE REGRTKDQIL LLIDIEQSYI NTNHEDFIGF ANAQQRSTQL NKKRAIPNQG EILVIRRGWL TINNISLMKG GSKEYWFVLT AESLSWYKDE EEKEKKYMLP LDNLKIRDVE KGFMSNKHVF AIFNTEQRNV YKDLRQIELA CDSQEDVDSW KASFLRAGVY PEKDQAENED GAQENTFSMD PQLERQVETI RNLVDSYVAI INKSIRDLMP KTIMHLMINN TKAFIHHELL AYLYSSADQS SLMEESADQA QRRDDMLRMY HALKEALNII GDISTSTVST PVPPPVDDTW LQSASSHSPT PQRRPVSSIH PPGRPPAVRG PTPGPPLIPV PVGAAASFSA PPIPSRPGPQ SVFANSDLFP APPQIPSRPV RIPPGIPPGV PSRRPPAAPS RPTIIRPAEP SLLD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.