Details for: DNMT1

Gene ID: 1786

Symbol: DNMT1

Ensembl ID: ENSG00000130816

Description: DNA methyltransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.25
    Marker Score: 8848.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.21
    Marker Score: 6551
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.14
    Marker Score: 1761
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.87
    Marker Score: 1881
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.8
    Marker Score: 4908
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.7
    Marker Score: 1239.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.64
    Marker Score: 1539
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.59
    Marker Score: 2279
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.58
    Marker Score: 6479.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.57
    Marker Score: 6088
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.55
    Marker Score: 1053
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.54
    Marker Score: 1649
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.44
    Marker Score: 1077
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.43
    Marker Score: 5299.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.43
    Marker Score: 703.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.42
    Marker Score: 613
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.4
    Marker Score: 1689
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.38
    Marker Score: 16040
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.38
    Marker Score: 1082
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.36
    Marker Score: 1931
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.33
    Marker Score: 666
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.32
    Marker Score: 654
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.31
    Marker Score: 12996
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.3
    Marker Score: 1733
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.3
    Marker Score: 2202
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.29
    Marker Score: 68051
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.28
    Marker Score: 3602
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.28
    Marker Score: 44314
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.27
    Marker Score: 2276
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.26
    Marker Score: 11063
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.25
    Marker Score: 855
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.25
    Marker Score: 3077.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.25
    Marker Score: 16798.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.24
    Marker Score: 2425
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.24
    Marker Score: 16308
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.23
    Marker Score: 770
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.23
    Marker Score: 2569
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.2
    Marker Score: 419.5
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.2
    Marker Score: 418
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.19
    Marker Score: 12035.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.18
    Marker Score: 738
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.17
    Marker Score: 10045
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.17
    Marker Score: 572
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.14
    Marker Score: 832
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.13
    Marker Score: 4858
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.13
    Marker Score: 3558
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.12
    Marker Score: 282
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.12
    Marker Score: 16816
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.12
    Marker Score: 1059
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.12
    Marker Score: 1357
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.12
    Marker Score: 3861
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.12
    Marker Score: 849
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.12
    Marker Score: 1083
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.12
    Marker Score: 793
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.11
    Marker Score: 2870
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.11
    Marker Score: 1015
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.1
    Marker Score: 546
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.09
    Marker Score: 41577.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.09
    Marker Score: 6981
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.09
    Marker Score: 457
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.09
    Marker Score: 331
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.09
    Marker Score: 9452
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.09
    Marker Score: 797
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.08
    Marker Score: 528.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.08
    Marker Score: 4515
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.08
    Marker Score: 685
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.08
    Marker Score: 883
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.07
    Marker Score: 1157
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.07
    Marker Score: 255
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.07
    Marker Score: 342
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.06
    Marker Score: 214
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.06
    Marker Score: 712
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.06
    Marker Score: 65003
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.05
    Marker Score: 4292
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.05
    Marker Score: 38816
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.05
    Marker Score: 326
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.04
    Marker Score: 2456.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.04
    Marker Score: 1007
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.04
    Marker Score: 696
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.04
    Marker Score: 1127
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.03
    Marker Score: 591
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.03
    Marker Score: 355
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.03
    Marker Score: 576
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.02
    Marker Score: 1285
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.02
    Marker Score: 325
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.02
    Marker Score: 1170
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.02
    Marker Score: 2493
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.02
    Marker Score: 1134
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.02
    Marker Score: 9681
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.01
    Marker Score: 10463
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.01
    Marker Score: 7763
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.01
    Marker Score: 11383.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.01
    Marker Score: 689
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.01
    Marker Score: 1027
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.01
    Marker Score: 353
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.01
    Marker Score: 670
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.01
    Marker Score: 942
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1
    Marker Score: 220
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1
    Marker Score: 2732.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1
    Marker Score: 575

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Other Information

**Key characteristics:** * DNMT1 is a ubiquitin-dependent protein with a conserved catalytic domain. * It is involved in DNA methylation and plays a crucial role in gene regulation. * It is a key regulator of cell cycle progression, apoptosis, and tumor suppression. * Mutations in DNMT1 have been linked to various human cancers. **Pathways and functions:** * DNMT1 is involved in multiple pathways, including defective pyroptosis, disease, and signal transduction by growth factor receptors and second messengers. * It is a key regulator of cell cycle progression and apoptosis. * It suppresses the expression of tumor suppressor genes and promotes the proliferation of cancer cells. * It also plays a role in the regulation of gene expression through DNA methylation. **Clinical significance:** * Mutations in DNMT1 have been linked to various human cancers, including breast cancer, lung cancer, and leukemia. * Targeting DNMT1 has emerged as a promising therapeutic strategy for cancer treatment. * In clinical trials, inhibitors of DNMT1 have shown promising results in preclinical models of cancer. **Additional notes:** * DNMT1 is a highly conserved gene with important functions in mammals. * It is a target for cancer immunotherapy and is being investigated as a therapeutic agent. * Further research is needed to understand the role of DNMT1 in cancer development and to develop more effective therapeutic strategies.

Genular Protein ID: 3153774656

Symbol: DNMT1_HUMAN

Name: DNA (cytosine-5)-methyltransferase 1

UniProtKB Accession Codes:

P26358 A0AV63 B7ZLW6 Q9UHG5 Q9ULA2 Q9UMZ6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 2 ELM 1 EMBL 8 EMDB 4 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 34 PDBsum 21 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REBASE 2 RNAct 1 Reactome 5 RefSeq 4 Rhea 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1594447

Title: Isolation and characterization of the cDNA encoding human DNA methyltransferase.

PubMed ID: 1594447

DOI: 10.1093/nar/20.9.2287

PubMed ID: 8940105

Title: New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.

PubMed ID: 8940105

DOI: 10.1074/jbc.271.49.31092

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10449766

Title: Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues.

PubMed ID: 10449766

DOI: 10.1073/pnas.96.17.9751

PubMed ID: 10753866

Title: Characterization of the human DNA methyltransferase splice variant Dnmt1b.

PubMed ID: 10753866

DOI: 10.1074/jbc.275.15.10754

PubMed ID: 9302295

Title: Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1.

PubMed ID: 9302295

DOI: 10.1126/science.277.5334.1996

PubMed ID: 10947852

Title: MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase.

PubMed ID: 10947852

DOI: 10.1046/j.1365-2443.2000.00359.x

PubMed ID: 10888872

Title: DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.

PubMed ID: 10888872

DOI: 10.1038/77023

PubMed ID: 10888886

Title: DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.

PubMed ID: 10888886

DOI: 10.1038/77124

PubMed ID: 10325416

Title: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.

PubMed ID: 10325416

DOI: 10.1093/nar/27.11.2291

PubMed ID: 12145218

Title: Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.

PubMed ID: 12145218

DOI: 10.1093/emboj/cdf401

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16357870

Title: The Polycomb group protein EZH2 directly controls DNA methylation.

PubMed ID: 16357870

DOI: 10.1038/nature04431

PubMed ID: 17200670

Title: Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.

PubMed ID: 17200670

DOI: 10.1038/ng1950

PubMed ID: 18754681

Title: CXXC domain of human DNMT1 is essential for enzymatic activity.

PubMed ID: 18754681

DOI: 10.1021/bi8011725

PubMed ID: 18413740

Title: DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.

PubMed ID: 18413740

DOI: 10.1158/0008-5472.can-07-6654

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18438403

Title: Protein lysine methyltransferase G9a acts on non-histone targets.

PubMed ID: 18438403

DOI: 10.1038/nchembio.88

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19450230

Title: SUMOylation enhances DNA methyltransferase 1 activity.

PubMed ID: 19450230

DOI: 10.1042/bj20090142

PubMed ID: 19173286

Title: Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain.

PubMed ID: 19173286

DOI: 10.1002/jcb.22071

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21565170

Title: Phosphorylation of human DNMT1: implication of cyclin-dependent kinases.

PubMed ID: 21565170

DOI: 10.1016/j.bbrc.2011.04.115

PubMed ID: 21947282

Title: SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.

PubMed ID: 21947282

DOI: 10.1128/mcb.06147-11

PubMed ID: 21151116

Title: A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.

PubMed ID: 21151116

DOI: 10.1038/nsmb.1939

PubMed ID: 21745816

Title: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.

PubMed ID: 21745816

DOI: 10.1093/nar/gkr528

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24623306

Title: A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.

PubMed ID: 24623306

DOI: 10.7554/elife.02313

PubMed ID: 24492612

Title: Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.

PubMed ID: 24492612

DOI: 10.1074/jbc.m113.525279

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29691401

Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase.

PubMed ID: 29691401

DOI: 10.1038/s41467-018-04019-9

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

PubMed ID: 21389349

Title: The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.

PubMed ID: 21389349

DOI: 10.1074/jbc.m110.209882

PubMed ID: 21163962

Title: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.

PubMed ID: 21163962

DOI: 10.1126/science.1195380

PubMed ID: 21532572

Title: Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.

PubMed ID: 21532572

DOI: 10.1038/ng.830

PubMed ID: 22328086

Title: Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.

PubMed ID: 22328086

DOI: 10.1093/hmg/dds035

Sequence Information:

  • Length: 1616
  • Mass: 183165
  • Checksum: 1E833192D22AFA5B
  • Sequence:
    • MPARTAPARV PTLAVPAISL PDDVRRRLKD LERDSLTEKE CVKEKLNLLH EFLQTEIKNQ 
LCDLETKLRK EELSEEGYLA KVKSLLNKDL SLENGAHAYN REVNGRLENG NQARSEARRV 
GMADANSPPK PLSKPRTPRR SKSDGEAKPE PSPSPRITRK STRQTTITSH FAKGPAKRKP 
QEESERAKSD ESIKEEDKDQ DEKRRRVTSR ERVARPLPAE EPERAKSGTR TEKEEERDEK 
EEKRLRSQTK EPTPKQKLKE EPDREARAGV QADEDEDGDE KDEKKHRSQP KDLAAKRRPE 
EKEPEKVNPQ ISDEKDEDEK EEKRRKTTPK EPTEKKMARA KTVMNSKTHP PKCIQCGQYL 
DDPDLKYGQH PPDAVDEPQM LTNEKLSIFD ANESGFESYE ALPQHKLTCF SVYCKHGHLC 
PIDTGLIEKN IELFFSGSAK PIYDDDPSLE GGVNGKNLGP INEWWITGFD GGEKALIGFS 
TSFAEYILMD PSPEYAPIFG LMQEKIYISK IVVEFLQSNS DSTYEDLINK IETTVPPSGL 
NLNRFTEDSL LRHAQFVVEQ VESYDEAGDS DEQPIFLTPC MRDLIKLAGV TLGQRRAQAR 
RQTIRHSTRE KDRGPTKATT TKLVYQIFDT FFAEQIEKDD REDKENAFKR RRCGVCEVCQ 
QPECGKCKAC KDMVKFGGSG RSKQACQERR CPNMAMKEAD DDEEVDDNIP EMPSPKKMHQ 
GKKKKQNKNR ISWVGEAVKT DGKKSYYKKV CIDAETLEVG DCVSVIPDDS SKPLYLARVT 
ALWEDSSNGQ MFHAHWFCAG TDTVLGATSD PLELFLVDEC EDMQLSYIHS KVKVIYKAPS 
ENWAMEGGMD PESLLEGDDG KTYFYQLWYD QDYARFESPP KTQPTEDNKF KFCVSCARLA 
EMRQKEIPRV LEQLEDLDSR VLYYSATKNG ILYRVGDGVY LPPEAFTFNI KLSSPVKRPR 
KEPVDEDLYP EHYRKYSDYI KGSNLDAPEP YRIGRIKEIF CPKKSNGRPN ETDIKIRVNK 
FYRPENTHKS TPASYHADIN LLYWSDEEAV VDFKAVQGRC TVEYGEDLPE CVQVYSMGGP 
NRFYFLEAYN AKSKSFEDPP NHARSPGNKG KGKGKGKGKP KSQACEPSEP EIEIKLPKLR 
TLDVFSGCGG LSEGFHQAGI SDTLWAIEMW DPAAQAFRLN NPGSTVFTED CNILLKLVMA 
GETTNSRGQR LPQKGDVEML CGGPPCQGFS GMNRFNSRTY SKFKNSLVVS FLSYCDYYRP 
RFFLLENVRN FVSFKRSMVL KLTLRCLVRM GYQCTFGVLQ AGQYGVAQTR RRAIILAAAP 
GEKLPLFPEP LHVFAPRACQ LSVVVDDKKF VSNITRLSSG PFRTITVRDT MSDLPEVRNG 
ASALEISYNG EPQSWFQRQL RGAQYQPILR DHICKDMSAL VAARMRHIPL APGSDWRDLP 
NIEVRLSDGT MARKLRYTHH DRKNGRSSSG ALRGVCSCVE AGKACDPAAR QFNTLIPWCL 
PHTGNRHNHW AGLYGRLEWD GFFSTTVTNP EPMGKQGRVL HPEQHRVVSV RECARSQGFP 
DTYRLFGNIL DKHRQVGNAV PPPLAKAIGL EIKLCMLAKA RESASAKIKE EEAAKD

Genular Protein ID: 23357273

Symbol: Q59FP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FP7

Database IDs:

ARBA 12 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 4 DNASU 1 EMBL 2 GO 5 Gene3D 4 GenomeRNAi 1 IntAct 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 9 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 5 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 1606
  • Mass: 182020
  • Checksum: 117205C54C17F54C
  • Sequence:
    • AVPAISLPDD VRRRLKDLER DSLTEKECVK EKLNLLHEFL QTEIKNQLCD LETKLRKEEL 
SEEGYLAKVK SLLNKDLSLE NGAHAYNREV NGRLENGNQA RSEARRVGMA DANSPPKPLS 
KPRTPRRSKS DGEAKPEPSP SPRITRKSTR QTTITSHFAK GPAKRKPQEE SERAKSDESI 
KEEDKDQDEK RRRVTSRERV ARPLPAEEPE RAKSGTRTEK EEERDEKEEK RLRSQTKEPT 
PKQKLKEEPD REARAGVQAD EDEDGDEKDE KKHRSQPKDL AAKRRPEEKE PEKVNPQISD 
EKDEDEKEEK RRKTTPKEPT EKKMARAKTV MNSKTHPPKC IQCGQYLDDP DLKYGQHPPD 
AVDEPQMLTN EKLSIFDANE SGFESYEALP QHKLTCFSVY CKHGHLCPID TGLIEKNIEL 
FFSGSAKPIY DDDPSLEGGV NGKNLGPINE WWITGFDGGE KALIGFSTSF AEYILMDPSP 
EYAPIFGLMQ EKIYISKIVV EFLQSNSDST YEDLINKIET TVPPSGLNLN RFTEDSLLRH 
AQFVVEQVES YDEAGDSDEQ PIFLTPCMRD LIKLAGVTLG QRRAQARRQT IRHSTREKDR 
GPTKATTTKL VYQIFDTFFA EQIEKDDRED KENAFKRRRC GVCEVCQQPE CGKCKACKDM 
VKFGGSGRSK QACQERRCPN MAMKEADDDE EVDDNIPEMP SPKKMHQGKK KKQNKNRISW 
VGEAVKTDGK KSYYKKVCID AETLEVGDCV SVIPDDSSKP LYLARVTALW EDSSNGQMFH 
AHWFCAGTDT VLGATSDPLE LFLVDECEDM QLSYIHSKVK VIYKAPSENW AMEGGMDPES 
LLEGDDGKTY FYQLWYDQDY ARFESPPKTQ PTEDNKFKFC VSCARLAEMR QKEIPRVLEQ 
LEDLDSRVLY YSATKNGILY RVGDGVYLPP EAFTFNIKLS SPVKRPRKEP VDEDLYPEHY 
RKYSDYIKGS NLDAPEPYRI GRIKEIFCPK KSNGRPNETD IKIRVNKFYR PENTHKSTPA 
SYHADINLLY WSDEEAVVDF KAVQGRCTVE YGEDLPECVQ VYSMGGPNRF YFLEAYNAKS 
KSFEDPPNHA RSPGNKGKGK GKGKGKPKSQ ACEPSEPEIE IKLPKLRTLD VFSGCGGLSE 
GFHQAGISDT LWAIEMWDPA AQAFRLNNPG STVFTEDCNI LLKLVMAGET TNSRGQRLPQ 
KGDVEMLCGG PPCQGFSGMN RFNSRTYSKF KNSLVVSFLS YCDYYRPRFF LLENVRNFVS 
FKRSMVLKLT LRCLVRMGYQ CTFGVLQAGQ YGVAQTRRRA IILAAAPGEK LPLFPEPLHV 
FAPRACQLSV VVDDKKFVSN ITRLSSGPFR TITVRDTMSD LPEVRNGASA LEISYNGEPQ 
SWFQRQLRGA QYQPILRDHI CKDMSALVAA RMRHIPLAPG SDWRDLPNIE VRLSDGTMAR 
KLRYTHHDRK NGRSSSGALR GVCSCVEGGS SGKACDPAAR QFNTLIPWCL PHTGNRHNHW 
AGLYGRLEWD GFFSTTVTNP EPMGKQGRVL HPEQHRVVSV RECARSQGFP DTYRLFGNIL 
DKHRQVGNAV PPPLAKAIGL EIKLCMLAKA RESASAKIKE EEAAKD

Genular Protein ID: 4027110462

Symbol: I6L9H2_HUMAN

Name: N/A

UniProtKB Accession Codes:

I6L9H2

Database IDs:

ARBA 10 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 5 Gene3D 4 GenomeRNAi 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 RefSeq 4 Rhea 3 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1511
  • Mass: 171073
  • Checksum: F4C3F943A4C92DAD
  • Sequence:
    • MADANSPPKP LSKPRTPRRS KSDGEAKRSR DPPASASQVT GIRAEPSPSP RITRKSTRQT 
TITSHFAKGP AKRKPQEESE RAKSDESIKE EDKDQDEKRR RVTSRERVAR PLPAEEPERA 
KSGTRTEKEE ERDEKEEKRL RSQTKEPTPK QKLKEEPDRE ARAGVQADED EDGDEKDEKK 
HRSQPKDLAA KRRPEEKEPE KVNPQISDEK DEDEKEEKRR KTTPKEPTEK KMARAKTVMN 
SKTHPPKCIQ CGQYLDDPDL KYGQHPPDAV DEPQMLTNEK LSIFDANESG FESYEALPQH 
KLTCFSVYCK HGHLCPIDTG LIEKNIELFF SGSAKPIYDD DPSLEGGVNG KNLGPINEWW 
ITGFDGGEKA LIGFSTSFAE YILMDPSPEY APIFGLMQEK IYISKIVVEF LQSNSDSTYE 
DLINKIETTV PPSGLNLNRF TEDSLLRHAQ FVVEQVESYD EAGDSDEQPI FLTPCMRDLI 
KLAGVTLGQR RAQARRQTIR HSTREKDRGP TKATTTKLVY QIFDTFFAEQ IEKDDREDKE 
NAFKRRRCGV CEVCQQPECG KCKACKDMVK FGGSGRSKQA CQERRCPNMA MKEADDDEEV 
DDNIPEMPSP KKMHQGKKKK QNKNRISWVG EAVKTDGKKS YYKKVCIDAE TLEVGDCVSV 
IPDDSSKPLY LARVTALWED SSNGQMFHAH WFCAGTDTVL GATSDPLELF LVDECEDMQL 
SYIHSKVKVI YKAPSENWAM EGGMDPESLL EGDDGKTYFY QLWYDQDYAR FESPPKTQPT 
EDNKFKFCVS CARLAEMRQK EIPRVLEQLE DLDSRVLYYS ATKNGILYRV GDGVYLPPEA 
FTFNIKLSSP VKRPRKEPVD EDLYPEHYRK YSDYIKGSNL DAPEPYRIGR IKEIFCPKKS 
NGRPNETDIK IRVNKFYRPE NTHKSTPASY HADINLLYWS DEEAVVDFKA VQGRCTVEYG 
EDLPECVQVY SMGGPNRFYF LEAYNAKSKS FEDPPNHARS PGNKGKGKGK GKGKPKSQAC 
EPSEPEIEIK LPKLRTLDVF SGCGGLSEGF HQAGISDTLW AIEMWDPAAQ AFRLNNPGST 
VFTEDCNILL KLVMAGETTN SRGQRLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN 
SLVVSFLSYC DYYRPRFFLL ENVRNFVSFK RSMVLKLTLR CLVRMGYQCT FGVLQAGQYG 
VAQTRRRAII LAAAPGEKLP LFPEPLHVFA PRACQLSVVV DDKKFVSNIT RLSSGPFRTI 
TVRDTMSDLP EVRNGASALE ISYNGEPQSW FQRQLRGAQY QPILRDHICK DMSALVAARM 
RHIPLAPGSD WRDLPNIEVR LSDGTMARKL RYTHHDRKNG RSSSGALRGV CSCVEAGKAC 
DPAARQFNTL IPWCLPHTGN RHNHWAGLYG RLEWDGFFST TVTNPEPMGK QGRVLHPEQH 
RVVSVRECAR SQGFPDTYRL FGNILDKHRQ VGNAVPPPLA KAIGLEIKLC MLAKARESAS 
AKIKEEEAAK D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.