Details for: DNMT1

Gene ID: 1786

Symbol: DNMT1

Ensembl ID: ENSG00000130816

Description: DNA methyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.4812
    Cell Significance Index: -22.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 110.7263
    Cell Significance Index: -28.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.5620
    Cell Significance Index: -41.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.3400
    Cell Significance Index: -34.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.9571
    Cell Significance Index: -40.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.9419
    Cell Significance Index: -35.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.5469
    Cell Significance Index: -36.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8305
    Cell Significance Index: -37.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7401
    Cell Significance Index: -38.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.6371
    Cell Significance Index: -29.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5894
    Cell Significance Index: -16.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.6798
    Cell Significance Index: 151.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.7885
    Cell Significance Index: 328.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1770
    Cell Significance Index: 61.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1596
    Cell Significance Index: 126.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9826
    Cell Significance Index: 34.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9391
    Cell Significance Index: 60.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9290
    Cell Significance Index: 184.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9276
    Cell Significance Index: 52.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9129
    Cell Significance Index: 47.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8390
    Cell Significance Index: 458.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7043
    Cell Significance Index: 141.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5429
    Cell Significance Index: 88.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4643
    Cell Significance Index: 57.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4446
    Cell Significance Index: 159.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4042
    Cell Significance Index: 11.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3723
    Cell Significance Index: 67.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3590
    Cell Significance Index: 324.1200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3568
    Cell Significance Index: 2.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3403
    Cell Significance Index: 9.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3293
    Cell Significance Index: 45.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3270
    Cell Significance Index: 144.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2968
    Cell Significance Index: 205.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2711
    Cell Significance Index: 18.7500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2042
    Cell Significance Index: 2.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1920
    Cell Significance Index: 12.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1836
    Cell Significance Index: 8.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1565
    Cell Significance Index: 15.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1010
    Cell Significance Index: 7.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0846
    Cell Significance Index: 1.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0549
    Cell Significance Index: 7.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0524
    Cell Significance Index: 1.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0315
    Cell Significance Index: 58.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0276
    Cell Significance Index: 1.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0238
    Cell Significance Index: 1.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0199
    Cell Significance Index: 3.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0199
    Cell Significance Index: 30.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0053
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0035
    Cell Significance Index: 6.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0098
    Cell Significance Index: -0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0120
    Cell Significance Index: -16.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0242
    Cell Significance Index: -15.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0253
    Cell Significance Index: -18.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0291
    Cell Significance Index: -18.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0387
    Cell Significance Index: -28.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0460
    Cell Significance Index: -20.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0496
    Cell Significance Index: -27.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0523
    Cell Significance Index: -5.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0630
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0709
    Cell Significance Index: -8.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0841
    Cell Significance Index: -14.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0910
    Cell Significance Index: -13.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0979
    Cell Significance Index: -20.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1065
    Cell Significance Index: -7.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1120
    Cell Significance Index: -32.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1214
    Cell Significance Index: -15.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1279
    Cell Significance Index: -14.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1423
    Cell Significance Index: -7.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1746
    Cell Significance Index: -13.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1982
    Cell Significance Index: -9.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2149
    Cell Significance Index: -5.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2283
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2327
    Cell Significance Index: -26.6600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2664
    Cell Significance Index: -5.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2765
    Cell Significance Index: -7.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3334
    Cell Significance Index: -22.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3471
    Cell Significance Index: -36.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3949
    Cell Significance Index: -11.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4074
    Cell Significance Index: -18.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4282
    Cell Significance Index: -5.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4306
    Cell Significance Index: -9.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4576
    Cell Significance Index: -36.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4789
    Cell Significance Index: -10.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4941
    Cell Significance Index: -14.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5089
    Cell Significance Index: -19.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5507
    Cell Significance Index: -14.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5795
    Cell Significance Index: -35.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6268
    Cell Significance Index: -17.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7053
    Cell Significance Index: -18.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7339
    Cell Significance Index: -17.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7471
    Cell Significance Index: -17.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7886
    Cell Significance Index: -25.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8334
    Cell Significance Index: -11.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8343
    Cell Significance Index: -26.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8371
    Cell Significance Index: -26.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8504
    Cell Significance Index: -42.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8815
    Cell Significance Index: -30.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8899
    Cell Significance Index: -10.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9123
    Cell Significance Index: -18.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNMT1 is a cytosine-5 DNA methyltransferase that exhibits self-primed synthesis, allowing it to maintain methylation patterns established during development. Unlike other DNA methyltransferases, DNMT1 does not require de novo DNA synthesis to methylate DNA. This unique property enables DNMT1 to efficiently maintain methylation patterns in somatic cells. DNMT1 is also characterized by its ability to recognize and methylate specific cytosine residues within CpG islands, which are regions of high GC content found in the promoter regions of genes. **Pathways and Functions:** DNMT1 plays a central role in the maintenance of epigenetic marks, including DNA methylation, histone modifications, and non-coding RNA expression. Its primary function involves the methylation of DNA, which is essential for: 1. **Gene silencing**: DNMT1-mediated methylation of gene promoters and enhancers leads to the silencing of gene expression, ensuring the proper regulation of gene expression during development and cell differentiation. 2. **Heterochromatin formation**: DNMT1 contributes to the formation of heterochromatin, a compact and transcriptionally inactive chromatin structure that regulates gene expression and maintains genome stability. 3. **Cell differentiation**: DNMT1 regulates cell differentiation by maintaining the methylation patterns of specific genes, ensuring the proper development and function of cells. 4. **Cancer development**: DNMT1 has been implicated in cancer development, where aberrant methylation patterns can lead to the silencing of tumor suppressor genes and the activation of oncogenes. **Clinical Significance:** DNMT1 has been implicated in various diseases, including: 1. **Cancer**: DNMT1 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumor progression and metastasis. 2. **Neurodegenerative diseases**: DNMT1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where aberrant methylation patterns contribute to neuronal dysfunction and death. 3. **Developmental disorders**: DNMT1 has been linked to developmental disorders, such as autism spectrum disorder and schizophrenia, where epigenetic dysregulation contributes to disease pathology. In conclusion, DNMT1 plays a critical role in maintaining epigenetic marks, regulating gene expression, and preventing disease. Further research into the mechanisms of DNMT1 and its role in disease will be essential for the development of novel therapeutic strategies for the treatment of various diseases. **References:** * Baylin, S. B., & Esteller, M. (2000). Epigenetics in cancer. Science, 287(5455), 553-559. * Esteller, M. (2008). Epigenetics in cancer. New England Journal of Medicine, 358(11), 1148-1159. * Klose, R. J., & Bird, A. (2006). Genomic DNA methylation. Genes & Development, 20(15), 1875-1893.

Genular Protein ID: 3153774656

Symbol: DNMT1_HUMAN

Name: DNA (cytosine-5)-methyltransferase 1

UniProtKB Accession Codes:

P26358 A0AV63 B7ZLW6 Q9UHG5 Q9ULA2 Q9UMZ6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 2 ELM 1 EMBL 8 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REBASE 2 RNAct 1 Reactome 7 RefSeq 4 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1594447

Title: Isolation and characterization of the cDNA encoding human DNA methyltransferase.

PubMed ID: 1594447

DOI: 10.1093/nar/20.9.2287

PubMed ID: 8940105

Title: New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.

PubMed ID: 8940105

DOI: 10.1074/jbc.271.49.31092

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10449766

Title: Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues.

PubMed ID: 10449766

DOI: 10.1073/pnas.96.17.9751

PubMed ID: 10753866

Title: Characterization of the human DNA methyltransferase splice variant Dnmt1b.

PubMed ID: 10753866

DOI: 10.1074/jbc.275.15.10754

PubMed ID: 9302295

Title: Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1.

PubMed ID: 9302295

DOI: 10.1126/science.277.5334.1996

PubMed ID: 10947852

Title: MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase.

PubMed ID: 10947852

DOI: 10.1046/j.1365-2443.2000.00359.x

PubMed ID: 10888872

Title: DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.

PubMed ID: 10888872

DOI: 10.1038/77023

PubMed ID: 10888886

Title: DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.

PubMed ID: 10888886

DOI: 10.1038/77124

PubMed ID: 10325416

Title: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.

PubMed ID: 10325416

DOI: 10.1093/nar/27.11.2291

PubMed ID: 12145218

Title: Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.

PubMed ID: 12145218

DOI: 10.1093/emboj/cdf401

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16357870

Title: The Polycomb group protein EZH2 directly controls DNA methylation.

PubMed ID: 16357870

DOI: 10.1038/nature04431

PubMed ID: 17200670

Title: Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.

PubMed ID: 17200670

DOI: 10.1038/ng1950

PubMed ID: 18754681

Title: CXXC domain of human DNMT1 is essential for enzymatic activity.

PubMed ID: 18754681

DOI: 10.1021/bi8011725

PubMed ID: 18413740

Title: DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.

PubMed ID: 18413740

DOI: 10.1158/0008-5472.can-07-6654

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18438403

Title: Protein lysine methyltransferase G9a acts on non-histone targets.

PubMed ID: 18438403

DOI: 10.1038/nchembio.88

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19450230

Title: SUMOylation enhances DNA methyltransferase 1 activity.

PubMed ID: 19450230

DOI: 10.1042/bj20090142

PubMed ID: 19173286

Title: Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain.

PubMed ID: 19173286

DOI: 10.1002/jcb.22071

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21565170

Title: Phosphorylation of human DNMT1: implication of cyclin-dependent kinases.

PubMed ID: 21565170

DOI: 10.1016/j.bbrc.2011.04.115

PubMed ID: 21947282

Title: SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.

PubMed ID: 21947282

DOI: 10.1128/mcb.06147-11

PubMed ID: 21151116

Title: A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.

PubMed ID: 21151116

DOI: 10.1038/nsmb.1939

PubMed ID: 21745816

Title: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.

PubMed ID: 21745816

DOI: 10.1093/nar/gkr528

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24623306

Title: A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.

PubMed ID: 24623306

DOI: 10.7554/elife.02313

PubMed ID: 24492612

Title: Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.

PubMed ID: 24492612

DOI: 10.1074/jbc.m113.525279

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29691401

Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase.

PubMed ID: 29691401

DOI: 10.1038/s41467-018-04019-9

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

PubMed ID: 21389349

Title: The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.

PubMed ID: 21389349

DOI: 10.1074/jbc.m110.209882

PubMed ID: 21163962

Title: Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.

PubMed ID: 21163962

DOI: 10.1126/science.1195380

PubMed ID: 21532572

Title: Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.

PubMed ID: 21532572

DOI: 10.1038/ng.830

PubMed ID: 22328086

Title: Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.

PubMed ID: 22328086

DOI: 10.1093/hmg/dds035

Sequence Information:

  • Length: 1616
  • Mass: 183165
  • Checksum: 1E833192D22AFA5B
  • Sequence:
    • MPARTAPARV PTLAVPAISL PDDVRRRLKD LERDSLTEKE CVKEKLNLLH EFLQTEIKNQ 
LCDLETKLRK EELSEEGYLA KVKSLLNKDL SLENGAHAYN REVNGRLENG NQARSEARRV 
GMADANSPPK PLSKPRTPRR SKSDGEAKPE PSPSPRITRK STRQTTITSH FAKGPAKRKP 
QEESERAKSD ESIKEEDKDQ DEKRRRVTSR ERVARPLPAE EPERAKSGTR TEKEEERDEK 
EEKRLRSQTK EPTPKQKLKE EPDREARAGV QADEDEDGDE KDEKKHRSQP KDLAAKRRPE 
EKEPEKVNPQ ISDEKDEDEK EEKRRKTTPK EPTEKKMARA KTVMNSKTHP PKCIQCGQYL 
DDPDLKYGQH PPDAVDEPQM LTNEKLSIFD ANESGFESYE ALPQHKLTCF SVYCKHGHLC 
PIDTGLIEKN IELFFSGSAK PIYDDDPSLE GGVNGKNLGP INEWWITGFD GGEKALIGFS 
TSFAEYILMD PSPEYAPIFG LMQEKIYISK IVVEFLQSNS DSTYEDLINK IETTVPPSGL 
NLNRFTEDSL LRHAQFVVEQ VESYDEAGDS DEQPIFLTPC MRDLIKLAGV TLGQRRAQAR 
RQTIRHSTRE KDRGPTKATT TKLVYQIFDT FFAEQIEKDD REDKENAFKR RRCGVCEVCQ 
QPECGKCKAC KDMVKFGGSG RSKQACQERR CPNMAMKEAD DDEEVDDNIP EMPSPKKMHQ 
GKKKKQNKNR ISWVGEAVKT DGKKSYYKKV CIDAETLEVG DCVSVIPDDS SKPLYLARVT 
ALWEDSSNGQ MFHAHWFCAG TDTVLGATSD PLELFLVDEC EDMQLSYIHS KVKVIYKAPS 
ENWAMEGGMD PESLLEGDDG KTYFYQLWYD QDYARFESPP KTQPTEDNKF KFCVSCARLA 
EMRQKEIPRV LEQLEDLDSR VLYYSATKNG ILYRVGDGVY LPPEAFTFNI KLSSPVKRPR 
KEPVDEDLYP EHYRKYSDYI KGSNLDAPEP YRIGRIKEIF CPKKSNGRPN ETDIKIRVNK 
FYRPENTHKS TPASYHADIN LLYWSDEEAV VDFKAVQGRC TVEYGEDLPE CVQVYSMGGP 
NRFYFLEAYN AKSKSFEDPP NHARSPGNKG KGKGKGKGKP KSQACEPSEP EIEIKLPKLR 
TLDVFSGCGG LSEGFHQAGI SDTLWAIEMW DPAAQAFRLN NPGSTVFTED CNILLKLVMA 
GETTNSRGQR LPQKGDVEML CGGPPCQGFS GMNRFNSRTY SKFKNSLVVS FLSYCDYYRP 
RFFLLENVRN FVSFKRSMVL KLTLRCLVRM GYQCTFGVLQ AGQYGVAQTR RRAIILAAAP 
GEKLPLFPEP LHVFAPRACQ LSVVVDDKKF VSNITRLSSG PFRTITVRDT MSDLPEVRNG 
ASALEISYNG EPQSWFQRQL RGAQYQPILR DHICKDMSAL VAARMRHIPL APGSDWRDLP 
NIEVRLSDGT MARKLRYTHH DRKNGRSSSG ALRGVCSCVE AGKACDPAAR QFNTLIPWCL 
PHTGNRHNHW AGLYGRLEWD GFFSTTVTNP EPMGKQGRVL HPEQHRVVSV RECARSQGFP 
DTYRLFGNIL DKHRQVGNAV PPPLAKAIGL EIKLCMLAKA RESASAKIKE EEAAKD

Genular Protein ID: 4027110462

Symbol: I6L9H2_HUMAN

Name: N/A

UniProtKB Accession Codes:

I6L9H2

Database IDs:

ARBA 11 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 7 Gene3D 4 InterPro 10 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 RefSeq 4 Rhea 3 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1511
  • Mass: 171073
  • Checksum: F4C3F943A4C92DAD
  • Sequence:
    • MADANSPPKP LSKPRTPRRS KSDGEAKRSR DPPASASQVT GIRAEPSPSP RITRKSTRQT 
TITSHFAKGP AKRKPQEESE RAKSDESIKE EDKDQDEKRR RVTSRERVAR PLPAEEPERA 
KSGTRTEKEE ERDEKEEKRL RSQTKEPTPK QKLKEEPDRE ARAGVQADED EDGDEKDEKK 
HRSQPKDLAA KRRPEEKEPE KVNPQISDEK DEDEKEEKRR KTTPKEPTEK KMARAKTVMN 
SKTHPPKCIQ CGQYLDDPDL KYGQHPPDAV DEPQMLTNEK LSIFDANESG FESYEALPQH 
KLTCFSVYCK HGHLCPIDTG LIEKNIELFF SGSAKPIYDD DPSLEGGVNG KNLGPINEWW 
ITGFDGGEKA LIGFSTSFAE YILMDPSPEY APIFGLMQEK IYISKIVVEF LQSNSDSTYE 
DLINKIETTV PPSGLNLNRF TEDSLLRHAQ FVVEQVESYD EAGDSDEQPI FLTPCMRDLI 
KLAGVTLGQR RAQARRQTIR HSTREKDRGP TKATTTKLVY QIFDTFFAEQ IEKDDREDKE 
NAFKRRRCGV CEVCQQPECG KCKACKDMVK FGGSGRSKQA CQERRCPNMA MKEADDDEEV 
DDNIPEMPSP KKMHQGKKKK QNKNRISWVG EAVKTDGKKS YYKKVCIDAE TLEVGDCVSV 
IPDDSSKPLY LARVTALWED SSNGQMFHAH WFCAGTDTVL GATSDPLELF LVDECEDMQL 
SYIHSKVKVI YKAPSENWAM EGGMDPESLL EGDDGKTYFY QLWYDQDYAR FESPPKTQPT 
EDNKFKFCVS CARLAEMRQK EIPRVLEQLE DLDSRVLYYS ATKNGILYRV GDGVYLPPEA 
FTFNIKLSSP VKRPRKEPVD EDLYPEHYRK YSDYIKGSNL DAPEPYRIGR IKEIFCPKKS 
NGRPNETDIK IRVNKFYRPE NTHKSTPASY HADINLLYWS DEEAVVDFKA VQGRCTVEYG 
EDLPECVQVY SMGGPNRFYF LEAYNAKSKS FEDPPNHARS PGNKGKGKGK GKGKPKSQAC 
EPSEPEIEIK LPKLRTLDVF SGCGGLSEGF HQAGISDTLW AIEMWDPAAQ AFRLNNPGST 
VFTEDCNILL KLVMAGETTN SRGQRLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN 
SLVVSFLSYC DYYRPRFFLL ENVRNFVSFK RSMVLKLTLR CLVRMGYQCT FGVLQAGQYG 
VAQTRRRAII LAAAPGEKLP LFPEPLHVFA PRACQLSVVV DDKKFVSNIT RLSSGPFRTI 
TVRDTMSDLP EVRNGASALE ISYNGEPQSW FQRQLRGAQY QPILRDHICK DMSALVAARM 
RHIPLAPGSD WRDLPNIEVR LSDGTMARKL RYTHHDRKNG RSSSGALRGV CSCVEAGKAC 
DPAARQFNTL IPWCLPHTGN RHNHWAGLYG RLEWDGFFST TVTNPEPMGK QGRVLHPEQH 
RVVSVRECAR SQGFPDTYRL FGNILDKHRQ VGNAVPPPLA KAIGLEIKLC MLAKARESAS 
AKIKEEEAAK D

Genular Protein ID: 23357273

Symbol: Q59FP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FP7

Database IDs:

ARBA 13 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 4 IntAct 1 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 9 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 5 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 1606
  • Mass: 182020
  • Checksum: 117205C54C17F54C
  • Sequence:
    • AVPAISLPDD VRRRLKDLER DSLTEKECVK EKLNLLHEFL QTEIKNQLCD LETKLRKEEL 
SEEGYLAKVK SLLNKDLSLE NGAHAYNREV NGRLENGNQA RSEARRVGMA DANSPPKPLS 
KPRTPRRSKS DGEAKPEPSP SPRITRKSTR QTTITSHFAK GPAKRKPQEE SERAKSDESI 
KEEDKDQDEK RRRVTSRERV ARPLPAEEPE RAKSGTRTEK EEERDEKEEK RLRSQTKEPT 
PKQKLKEEPD REARAGVQAD EDEDGDEKDE KKHRSQPKDL AAKRRPEEKE PEKVNPQISD 
EKDEDEKEEK RRKTTPKEPT EKKMARAKTV MNSKTHPPKC IQCGQYLDDP DLKYGQHPPD 
AVDEPQMLTN EKLSIFDANE SGFESYEALP QHKLTCFSVY CKHGHLCPID TGLIEKNIEL 
FFSGSAKPIY DDDPSLEGGV NGKNLGPINE WWITGFDGGE KALIGFSTSF AEYILMDPSP 
EYAPIFGLMQ EKIYISKIVV EFLQSNSDST YEDLINKIET TVPPSGLNLN RFTEDSLLRH 
AQFVVEQVES YDEAGDSDEQ PIFLTPCMRD LIKLAGVTLG QRRAQARRQT IRHSTREKDR 
GPTKATTTKL VYQIFDTFFA EQIEKDDRED KENAFKRRRC GVCEVCQQPE CGKCKACKDM 
VKFGGSGRSK QACQERRCPN MAMKEADDDE EVDDNIPEMP SPKKMHQGKK KKQNKNRISW 
VGEAVKTDGK KSYYKKVCID AETLEVGDCV SVIPDDSSKP LYLARVTALW EDSSNGQMFH 
AHWFCAGTDT VLGATSDPLE LFLVDECEDM QLSYIHSKVK VIYKAPSENW AMEGGMDPES 
LLEGDDGKTY FYQLWYDQDY ARFESPPKTQ PTEDNKFKFC VSCARLAEMR QKEIPRVLEQ 
LEDLDSRVLY YSATKNGILY RVGDGVYLPP EAFTFNIKLS SPVKRPRKEP VDEDLYPEHY 
RKYSDYIKGS NLDAPEPYRI GRIKEIFCPK KSNGRPNETD IKIRVNKFYR PENTHKSTPA 
SYHADINLLY WSDEEAVVDF KAVQGRCTVE YGEDLPECVQ VYSMGGPNRF YFLEAYNAKS 
KSFEDPPNHA RSPGNKGKGK GKGKGKPKSQ ACEPSEPEIE IKLPKLRTLD VFSGCGGLSE 
GFHQAGISDT LWAIEMWDPA AQAFRLNNPG STVFTEDCNI LLKLVMAGET TNSRGQRLPQ 
KGDVEMLCGG PPCQGFSGMN RFNSRTYSKF KNSLVVSFLS YCDYYRPRFF LLENVRNFVS 
FKRSMVLKLT LRCLVRMGYQ CTFGVLQAGQ YGVAQTRRRA IILAAAPGEK LPLFPEPLHV 
FAPRACQLSV VVDDKKFVSN ITRLSSGPFR TITVRDTMSD LPEVRNGASA LEISYNGEPQ 
SWFQRQLRGA QYQPILRDHI CKDMSALVAA RMRHIPLAPG SDWRDLPNIE VRLSDGTMAR 
KLRYTHHDRK NGRSSSGALR GVCSCVEGGS SGKACDPAAR QFNTLIPWCL PHTGNRHNHW 
AGLYGRLEWD GFFSTTVTNP EPMGKQGRVL HPEQHRVVSV RECARSQGFP DTYRLFGNIL 
DKHRQVGNAV PPPLAKAIGL EIKLCMLAKA RESASAKIKE EEAAKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.