Details for: DOK1

Gene ID: 1796

Symbol: DOK1

Ensembl ID: ENSG00000115325

Description: docking protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.95
    Marker Score: 16463
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.17
    Marker Score: 1457
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71763
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47987
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.97
    Marker Score: 2427
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.96
    Marker Score: 2714
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.92
    Marker Score: 506
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5216
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2719
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.88
    Marker Score: 1533
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5262
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.82
    Marker Score: 20950
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1225
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.73
    Marker Score: 3008
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 547
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 636
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.69
    Marker Score: 4383
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2853
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.67
    Marker Score: 1304
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.66
    Marker Score: 37038
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.65
    Marker Score: 524
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.65
    Marker Score: 167
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.65
    Marker Score: 324
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.64
    Marker Score: 205
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1258
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.61
    Marker Score: 7041
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.58
    Marker Score: 202
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.57
    Marker Score: 580
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.57
    Marker Score: 280
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.57
    Marker Score: 683
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.56
    Marker Score: 293
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.55
    Marker Score: 176
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.52
    Marker Score: 1542
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.52
    Marker Score: 517
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.51
    Marker Score: 1328
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.5
    Marker Score: 364
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.49
    Marker Score: 2973
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.49
    Marker Score: 155
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.47
    Marker Score: 539
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.46
    Marker Score: 314
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.44
    Marker Score: 282
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.44
    Marker Score: 211
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.44
    Marker Score: 4461
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.44
    Marker Score: 2648
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.44
    Marker Score: 207
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.43
    Marker Score: 291
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.43
    Marker Score: 685
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.43
    Marker Score: 178
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.42
    Marker Score: 170
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.42
    Marker Score: 275
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 180
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.41
    Marker Score: 515.5
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.41
    Marker Score: 123
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.41
    Marker Score: 271
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.4
    Marker Score: 198
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.4
    Marker Score: 78
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.39
    Marker Score: 717
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.39
    Marker Score: 188
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.39
    Marker Score: 366
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.39
    Marker Score: 559
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 375
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.38
    Marker Score: 83
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.38
    Marker Score: 77
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 382
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.38
    Marker Score: 163.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.38
    Marker Score: 370
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.38
    Marker Score: 96
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.38
    Marker Score: 184
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.37
    Marker Score: 154
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.37
    Marker Score: 268
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.36
    Marker Score: 998
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.36
    Marker Score: 162
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 157
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.35
    Marker Score: 223
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.35
    Marker Score: 265
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.35
    Marker Score: 158
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.35
    Marker Score: 77
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.35
    Marker Score: 955.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 211
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.35
    Marker Score: 252
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 110
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.35
    Marker Score: 5426
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.35
    Marker Score: 262
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.34
    Marker Score: 119
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.34
    Marker Score: 85
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.34
    Marker Score: 822
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.34
    Marker Score: 106
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 140
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.34
    Marker Score: 79
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.33
    Marker Score: 99

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Other Information

**Key characteristics:** - DOK1 is a transmembrane protein with a molecular weight of approximately 150 kDa. - It belongs to the DOK family of docking proteins, which are characterized by their ability to interact with and regulate the activity of various signaling molecules. - DOK1 is a key regulator of the MAPK signaling pathway, a major signaling pathway involved in cell growth, differentiation, and survival. - It also plays a role in the regulation of the Ras signaling pathway and the ptk6 signaling pathway. **Pathways and functions:** - DOK1 is involved in the guidance of retinal neurons during development. - It is a key regulator of axon extension and guidance, ensuring that neurons form accurate and functional connections with their targets. - It also plays a role in the development and maintenance of the nervous system. - In the central nervous system (CNS), DOK1 is expressed in various neuronal and glial cell types, including retinal bipolar neurons, ganglion cells, and oligodendrocytes. - It is involved in the regulation of synaptic plasticity, learning, and memory. - In the periphery, DOK1 is expressed in immune cells, including macrophages and dendritic cells, where it regulates the activation of T cells. **Clinical significance:** - Mutations in the DOK1 gene have been linked to several human diseases, including retinal disorders, neurodegenerative diseases, and cancer. - In retinal disorders, DOK1 mutations can lead to the formation of abnormal, elongated nerve fibers, resulting in visual impairment. - In neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, DOK1 mutations have been associated with neuronal loss and dysfunction. - Targeting DOK1 has emerged as a potential therapeutic strategy for several human diseases, including cancer and neurodegenerative disorders. Overall, DOK1 is a critical regulator of cellular processes in the nervous system and is implicated in various human diseases. Understanding the role of DOK1 in these diseases could lead to the development of novel therapeutic interventions.

Genular Protein ID: 2705587523

Symbol: DOK1_HUMAN

Name: Docking protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9008160

Title: p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells.

PubMed ID: 9008160

DOI: 10.1016/s0092-8674(00)81840-1

PubMed ID: 10940083

Title: Molecular cloning of a truncated p62Dok1 isoform, p22Dokdel.

PubMed ID: 10940083

DOI: 10.1046/j.1365-2370.2000.00203.x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11551902

Title: Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.

PubMed ID: 11551902

DOI: 10.1074/jbc.m102116200

PubMed ID: 12595900

Title: DOK4 and DOK5: new Dok-related genes expressed in human T cells.

PubMed ID: 12595900

DOI: 10.1038/sj.gene.6363891

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19481542

Title: Targeted mass spectrometric analysis of N-terminally truncated isoforms generated via alternative translation initiation.

PubMed ID: 19481542

DOI: 10.1016/j.febslet.2009.05.042

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23822091

Title: The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate Dok1.

PubMed ID: 23822091

DOI: 10.1111/febs.12420

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18156175

Title: An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.

PubMed ID: 18156175

DOI: 10.1074/jbc.m709435200

Sequence Information:

  • Length: 481
  • Mass: 52392
  • Checksum: E9D947831244BA6C
  • Sequence:
  • MDGAVMEGPL FLQSQRFGTK RWRKTWAVLY PASPHGVARL EFFDHKGSSS GGGRGSSRRL 
    DCKVIRLAEC VSVAPVTVET PPEPGATAFR LDTAQRSHLL AADAPSSAAW VQTLCRNAFP 
    KGSWTLAPTD NPPKLSALEM LENSLYSPTW EGSQFWVTVQ RTEAAERCGL HGSYVLRVEA 
    ERLTLLTVGA QSQILEPLLS WPYTLLRRYG RDKVMFSFEA GRRCPSGPGT FTFQTAQGND 
    IFQAVETAIH RQKAQGKAGQ GHDVLRADSH EGEVAEGKLP SPPGPQELLD SPPALYAEPL 
    DSLRIAPCPS QDSLYSDPLD STSAQAGEGV QRKKPLYWDL YEHAQQQLLK AKLTDPKEDP 
    IYDEPEGLAP VPPQGLYDLP REPKDAWWCQ ARVKEEGYEL PYNPATDDYA VPPPRSTKPL 
    LAPKPQGPAF PEPGTATGSG IKSHNSALYS QVQKSGASGS WDCGLSRVGT DKTGVKSEGS 
    T

Genular Protein ID: 247488736

Symbol: Q14CB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 267
  • Mass: 28683
  • Checksum: 02B8B44704097905
  • Sequence:
  • MFSFEAGRSC PSGPGTFTFQ TAQGNDIFQA VETAIHRQKA QGKAGQGHDV LRADSHEGEV 
    AEGKLPSPPG PQELLDSPPA LYAEPLDSLR IAPCPSQDSL YSDPLDSTSA QAGEGVQRKK 
    PLYWDLYEHA QQQLLKAKLT DPKEDPIYDE PEGLAPVPPQ GLYDLPREPK DAWWCQARVK 
    EEGYELPYNP ATDDYAVPPP RSTKPLLAPK PQGPAFPEPG TATGSGIKSH NSALYSQVQK 
    SGASGSWDCG LSRVGTDKTG VKSEGST

Genular Protein ID: 447885415

Symbol: Q2TA81_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 267
  • Mass: 28752
  • Checksum: 02B8B42C740979F0
  • Sequence:
  • MFSFEAGRRC PSGPGTFTFQ TAQGNDIFQA VETAIHRQKA QGKAGQGHDV LRADSHEGEV 
    AEGKLPSPPG PQELLDSPPA LYAEPLDSLR IAPCPSQDSL YSDPLDSTSA QAGEGVQRKK 
    PLYWDLYEHA QQQLLKAKLT DPKEDPIYDE PEGLAPVPPQ GLYDLPREPK DAWWCQARVK 
    EEGYELPYNP ATDDYAVPPP RSTKPLLAPK PQGPAFPEPG TATGSGIKSH NSALYSQVQK 
    SGASGSWDCG LSRVGTDKTG VKSEGST

Genular Protein ID: 101179555

Symbol: B4DJN1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 470
  • Mass: 51068
  • Checksum: F4DCD9AB4E6F0FA3
  • Sequence:
  • MPNLIRASSG WRKTWAVLYP ASPHGVARLE FFDHKGSSSG GGRGSSRRLD CKVIRLAECV 
    SVAPVTVETP PEPGATAFRL DTAQRSHLLA ADAPSSAAWV QTLCRNAFPK GSWTLAPTDN 
    PPKLSALEML ENSLYSPTWE GSQFWVTVQR TEAAERCGLH GSYVLRVEAE RLTLLTVGAQ 
    SQILEPLLSW PYTLLRRYGR DKVMFSFEAG RRCPSGPGTF TFQTAQGNDI FQAVETAIHR 
    QKAQGKAGQG HDVLRADSHE GEVAEGKLPS PPGPQELLDS PPALYAEPLD SLRIAPCPSQ 
    DSLYSDPLDS TSAQAGEGVQ RKKPLYWDLY EHAQQQLLKA KLTDPKEDPI YDEPEGLAPV 
    PPQGLYDLPR EPKDAWWCQA RVKEEGYELP YNPATDDYAV PPPRSTKPLL APKPQGPAFP 
    EPGTATGSGI KSHNSALYSQ VQKSGASGSW DCGLSRVGTD KTGVKSEGST

Genular Protein ID: 3407105697

Symbol: B3KP83_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 481
  • Mass: 52408
  • Checksum: 60A4C8D9A876C1DE
  • Sequence:
  • MDGAVMEGPL FLQSQRFGTK RWRKTWAVLY PASPHGVARL EFFDHKGSSS GGGRGSSRRL 
    DCKVIRLAEC VSVALVTVET PPEPGATAFR LDTAQRSHLL AADAPSSAAW VQTLCRNAFP 
    KGSWTLAPTD NPPKLSALEM LENSLYSPTW EGSQFWVTVQ RTEAAERCGL HGSYVLRVEA 
    ERLTLLTVGA QSQILEPLLS WPYTLLRRYG RDKVMFSFEA GRRCPSGPGT FTFQTAQGND 
    IFQAVETAIH RQKAQGKAGQ GHDVLRADSH EGEVAEGKLP SPPGPQELLD SPPALYAEPL 
    DSLRIAPCPS QDSLYSDPLD STSAQAGEGV QRKKPLYWDL YEHAQQQLLK AKLTDPKEDP 
    IYDEPEGLAP VPPQGLYDLP REPKDAWWCQ ARVKEEGYEL PYNPATDDYA VPPPRSTKPL 
    LAPKPQGPAF PEPGTATGSG IKSHNSALYS QVQKSGASGS WDCGLSRVGT DKTGVKSEGS 
    T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.