Details for: RCAN1

Gene ID: 1827

Symbol: RCAN1

Ensembl ID: ENSG00000159200

Description: regulator of calcineurin 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.06
    Marker Score: 1,752
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.73
    Marker Score: 672
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.66
    Marker Score: 3,503
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6
    Marker Score: 1,250
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.56
    Marker Score: 1,062
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.55
    Marker Score: 3,143
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.55
    Marker Score: 15,954
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.53
    Marker Score: 3,847
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.51
    Marker Score: 2,548
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.48
    Marker Score: 3,488
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.47
    Marker Score: 54,263
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,125
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.38
    Marker Score: 5,632
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.33
    Marker Score: 1,926
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.28
    Marker Score: 10,992
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.28
    Marker Score: 801
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.27
    Marker Score: 3,133
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19,872
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.26
    Marker Score: 524
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.23
    Marker Score: 1,736
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.19
    Marker Score: 4,231
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.17
    Marker Score: 417
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.17
    Marker Score: 23,282
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.15
    Marker Score: 1,771
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.13
    Marker Score: 2,700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.13
    Marker Score: 25,194
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.12
    Marker Score: 352
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.11
    Marker Score: 1,150
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.1
    Marker Score: 354
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.08
    Marker Score: 566
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.07
    Marker Score: 10,845
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.07
    Marker Score: 4,432
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.07
    Marker Score: 4,120
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.04
    Marker Score: 4,500
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.03
    Marker Score: 232
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.03
    Marker Score: 38,995
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.02
    Marker Score: 62,534
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1
    Marker Score: 7,681
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,751
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,976
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.99
    Marker Score: 9,443
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Marker Score: 547
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.98
    Marker Score: 3,089
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.96
    Marker Score: 1,019
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.96
    Marker Score: 825
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.95
    Marker Score: 322
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.9
    Marker Score: 465
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.9
    Marker Score: 216
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.89
    Marker Score: 5,754
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.88
    Marker Score: 218
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.88
    Marker Score: 436
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.87
    Marker Score: 218
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,259
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,940
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.86
    Marker Score: 1,427
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.85
    Marker Score: 3,931
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.85
    Marker Score: 1,229
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.84
    Marker Score: 4,497
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.83
    Marker Score: 12,430
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.83
    Marker Score: 7,813
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.82
    Marker Score: 518
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.82
    Marker Score: 4,924
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.81
    Marker Score: 811
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 618
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.8
    Marker Score: 3,855
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.8
    Marker Score: 2,960
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.8
    Marker Score: 420
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.79
    Marker Score: 847
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.78
    Marker Score: 943
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.78
    Marker Score: 287
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.76
    Marker Score: 454
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.76
    Marker Score: 679
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.75
    Marker Score: 1,502
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.74
    Marker Score: 216
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.74
    Marker Score: 1,308
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,083
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.73
    Marker Score: 907
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.72
    Marker Score: 422
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.71
    Marker Score: 1,052
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.71
    Marker Score: 707
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.71
    Marker Score: 1,562
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.71
    Marker Score: 11,412
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 426
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7
    Marker Score: 23,970
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 641
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.7
    Marker Score: 332
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.7
    Marker Score: 319
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.69
    Marker Score: 403
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.69
    Marker Score: 691

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RCAN1 is a calcium-binding protein that inhibits the activity of calcineurin, a calcium-dependent phosphatase involved in the dephosphorylation and activation of transcription factors NFAT. This regulatory mechanism is essential for maintaining calcium homeostasis and preventing excessive calcineurin activity, which can lead to detrimental effects on cellular function and survival. RCAN1 is primarily expressed in cells of the immune system, including lymphoid progenitors, innate lymphoid cells, and dopaminergic neurons, as well as in various epithelial tissues. **Pathways and Functions:** RCAN1's primary function is to regulate the calcineurin-NFAT signaling cascade, which is involved in various physiological processes, including: 1. **Calcium-mediated signaling**: RCAN1 modulates calcium-dependent signaling pathways, influencing cellular responses to calcium fluctuations. 2. **Negative regulation of calcineurin-NFAT signaling cascade**: RCAN1 inhibits calcineurin activity, preventing excessive NFAT activation and subsequent transcriptional responses. 3. **Response to ischemia and oxidative stress**: RCAN1's regulatory activity helps mitigate cellular damage caused by ischemia and oxidative stress. 4. **Short-term memory**: RCAN1's involvement in calcium-mediated signaling suggests a potential role in short-term memory processes. **Clinical Significance:** RCAN1's dysregulation has been implicated in various diseases, including: 1. **Autoimmune disorders**: RCAN1's role in modulating the calcineurin-NFAT signaling cascade makes it a potential target for treating autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: RCAN1's involvement in calcium-mediated signaling and NFAT activation suggests a potential role in cancer progression and metastasis. 3. **Neurodegenerative diseases**: RCAN1's expression in dopaminergic neurons and its regulatory activity in calcium-mediated signaling imply a potential role in neurodegenerative diseases, such as Parkinson's disease. 4. **Cardiovascular disease**: RCAN1's involvement in calcium-mediated signaling and NFAT activation suggests a potential role in cardiovascular disease, including hypertension and atherosclerosis. In conclusion, RCAN1 is a crucial regulator of the calcineurin-NFAT signaling cascade, influencing various physiological and pathological processes. Further research on RCAN1's function and dysregulation will provide valuable insights into its role in immunological and physiological contexts, ultimately informing the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1901008028

Symbol: RCAN1_HUMAN

Name: Calcipressin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8595418

Title: A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart.

PubMed ID: 8595418

DOI: 10.1093/hmg/4.10.1935

PubMed ID: 9325060

Title: Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene.

PubMed ID: 9325060

DOI: 10.1006/geno.1997.4866

PubMed ID: 12809556

Title: Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

PubMed ID: 12809556

DOI: 10.1042/bj20030267

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10861295

Title: DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.

PubMed ID: 10861295

DOI: 10.1093/hmg/9.11.1681

PubMed ID: 15935327

Title: Raf-1 is a binding partner of DSCR1.

PubMed ID: 15935327

DOI: 10.1016/j.abb.2005.05.002

Sequence Information:

  • Length: 252
  • Mass: 28079
  • Checksum: 0B17133D03BD7AFA
  • Sequence:
  • MEDGVAGPQL GAAAEAAEAA EARARPGVTL RPFAPLSGAA EADEGGGDWS FIDCEMEEVD 
    LQDLPSATIA CHLDPRVFVD GLCRAKFESL FRTYDKDITF QYFKSFKRVR INFSNPFSAA 
    DARLQLHKTE FLGKEMKLYF AQTLHIGSSH LAPPNPDKQF LISPPASPPV GWKQVEDATP 
    VINYDLLYAI SKLGPGEKYE LHAATDTTPS VVVHVCESDQ EKEEEEEMER MRRPKPKIIQ 
    TRRPEYTPIH LS

Genular Protein ID: 2328595823

Symbol: Q6ZMM3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 242
  • Mass: 27851
  • Checksum: 4888F4EAB303BA81
  • Sequence:
  • MQGEQGRRLF RLLLNDLPGR DRLPCSYPQP HVEQASTSAS PRLLAVNIPE DTLLSYPESS 
    LPLQRHCAFH RFSKAKFESL FRTYDKDITF QYFKSFKRVR INFSNPFSAA DARLQLHKTE 
    FLGKEMKLYF AQTLHIGSSH LAPPNPDKQF LISPPASPPV GWKQVEDATP VINYDLLYAI 
    TKLGPGEKYE LHAATDTTPS VVVHVCESDQ EKEEEEEMER MRRPKPKIIQ TRRPEYTPIH 
    LS

Genular Protein ID: 670253693

Symbol: B7Z1F0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 205
  • Mass: 23125
  • Checksum: B457767BEEBF523E
  • Sequence:
  • MHFRNFNYSF SSLIACVANS DIFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN 
    PFSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV 
    EDATPVINYD LLYAISKLGP GEQGPRVGGR QGETQLLPCT GEQYHHYPRS SPEPMPACFV 
    SFSVFFCATV PCAGSMPASW HHLQC

Genular Protein ID: 1583620977

Symbol: V9GYW9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

Sequence Information:

  • Length: 205
  • Mass: 23224
  • Checksum: B457767BFFBF522F
  • Sequence:
  • MHFRNFNYSF SSLIACVANS DIFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN 
    PFSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV 
    EDATPVINYD LLYAISKLGP GEQGPRVGGR QGETQLLPCT REQYHHYPRS SPEPMPACFV 
    SFSVFFCATV PCAGSMPASW HHLQC

Genular Protein ID: 1065527046

Symbol: Q6FGP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 197
  • Mass: 22767
  • Checksum: 980A1FD7AA54A238
  • Sequence:
  • MHFRNFNYSF SSLIACVANS DIFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN 
    PFSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV 
    EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK 
    PKIIQTRRPE YTPIHLS

Genular Protein ID: 2510418821

Symbol: E9PDJ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

Sequence Information:

  • Length: 277
  • Mass: 31888
  • Checksum: E227930C927BEDE5
  • Sequence:
  • MNSTVRQLRV PSHVPLRDPS WESLRNVPKL KKSRGMQGEQ GRRLFRLLLN DLPGRDRLPC 
    SYPQPHVEQA STSASPRLLA VNIPEDTLLS YPESSLPLQR HCAFHRFSKA KFESLFRTYD 
    KDITFQYFKS FKRVRINFSN PFSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN 
    PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV 
    CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.