Details for: RCAN1

Gene ID: 1827

Symbol: RCAN1

Ensembl ID: ENSG00000159200

Description: regulator of calcineurin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.06
    Marker Score: 1752
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.73
    Marker Score: 672
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.66
    Marker Score: 3503
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.6
    Marker Score: 1250
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.56
    Marker Score: 1062
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.55
    Marker Score: 3143
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.55
    Marker Score: 15954
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.53
    Marker Score: 3847
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.51
    Marker Score: 2548
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.48
    Marker Score: 3488
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.47
    Marker Score: 54263
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168125
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.38
    Marker Score: 5632
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.33
    Marker Score: 1926
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.28
    Marker Score: 10992
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.28
    Marker Score: 801
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.27
    Marker Score: 3133
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19872
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.26
    Marker Score: 524
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.23
    Marker Score: 1736
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.19
    Marker Score: 4231
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.17
    Marker Score: 417
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.17
    Marker Score: 23282
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.15
    Marker Score: 1771
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.13
    Marker Score: 2700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.13
    Marker Score: 25194
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.12
    Marker Score: 352
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.11
    Marker Score: 1150
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.1
    Marker Score: 354
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.08
    Marker Score: 566
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.07
    Marker Score: 10845
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.07
    Marker Score: 4432
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.07
    Marker Score: 4120
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.04
    Marker Score: 4500
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.03
    Marker Score: 232
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.03
    Marker Score: 38995
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.02
    Marker Score: 62534
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1
    Marker Score: 7681
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71751
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47976
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.99
    Marker Score: 9443
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Marker Score: 547
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.98
    Marker Score: 3089
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.96
    Marker Score: 1019
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.96
    Marker Score: 825
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.95
    Marker Score: 322
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.9
    Marker Score: 465
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.9
    Marker Score: 216
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.89
    Marker Score: 5754
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.88
    Marker Score: 218
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.88
    Marker Score: 436
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.87
    Marker Score: 218
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5259
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4940
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.86
    Marker Score: 1427
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.85
    Marker Score: 3931
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.85
    Marker Score: 1229
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.84
    Marker Score: 4497
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.83
    Marker Score: 12430
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.83
    Marker Score: 7813
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.82
    Marker Score: 518
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.82
    Marker Score: 4924
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.81
    Marker Score: 811
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 618
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.8
    Marker Score: 3855
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.8
    Marker Score: 2960
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.8
    Marker Score: 420
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.79
    Marker Score: 847
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.78
    Marker Score: 943
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.78
    Marker Score: 287
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.76
    Marker Score: 454
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.76
    Marker Score: 679
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.75
    Marker Score: 1502
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.74
    Marker Score: 216
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.74
    Marker Score: 1308
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3082.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.73
    Marker Score: 907
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.72
    Marker Score: 422
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.71
    Marker Score: 1052
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.71
    Marker Score: 707
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.71
    Marker Score: 1561.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.71
    Marker Score: 11412
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 426
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7
    Marker Score: 23970
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 641
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.7
    Marker Score: 332
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.7
    Marker Score: 319
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.69
    Marker Score: 403
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.69
    Marker Score: 691

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Other Information

**Key characteristics:** - RCAN1 is a transmembrane protein with a molecular weight of approximately 150 kDa. - It is a member of the immunoglobulin superfamily. - It has a conserved cysteine-rich domain and a transmembrane domain that is critical for its function. **Pathways and functions:** - RCAN1 negatively regulates the calcineurin-nfat signaling cascade. - It acts as a negative regulator by binding to the Calcineurin B-like protein 1 (CBL1) and preventing its interaction with the transcription factor NFAT. - This inhibits the activation of the calcineurin-nfat signaling cascade, which leads to the inhibition of various cellular processes. - RCAN1 also plays a role in regulating calcium-dependent protein serine/threonine phosphatase activity and calcium-mediated signaling. **Clinical significance:** - Mutations in RCAN1 have been linked to several human diseases, including prostate cancer, kidney disease, and metabolic syndrome. - RCAN1 inhibitors are being investigated as potential therapeutic agents for these diseases, as they could potentially block the calcineurin-nfat signaling cascade and relieve the pathological symptoms. **Additional notes:** - RCAN1 is a key regulator of the development and function of skeletal muscle fibers. - It is also involved in the regulation of inflammation and apoptosis. - It is a promising target for cancer therapy due to its role in tumor growth and metastasis.

Genular Protein ID: 1901008028

Symbol: RCAN1_HUMAN

Name: Calcipressin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8595418

Title: A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart.

PubMed ID: 8595418

DOI: 10.1093/hmg/4.10.1935

PubMed ID: 9325060

Title: Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene.

PubMed ID: 9325060

DOI: 10.1006/geno.1997.4866

PubMed ID: 12809556

Title: Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

PubMed ID: 12809556

DOI: 10.1042/bj20030267

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10861295

Title: DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.

PubMed ID: 10861295

DOI: 10.1093/hmg/9.11.1681

PubMed ID: 15935327

Title: Raf-1 is a binding partner of DSCR1.

PubMed ID: 15935327

DOI: 10.1016/j.abb.2005.05.002

Sequence Information:

  • Length: 252
  • Mass: 28079
  • Checksum: 0B17133D03BD7AFA
  • Sequence:
  • MEDGVAGPQL GAAAEAAEAA EARARPGVTL RPFAPLSGAA EADEGGGDWS FIDCEMEEVD 
    LQDLPSATIA CHLDPRVFVD GLCRAKFESL FRTYDKDITF QYFKSFKRVR INFSNPFSAA 
    DARLQLHKTE FLGKEMKLYF AQTLHIGSSH LAPPNPDKQF LISPPASPPV GWKQVEDATP 
    VINYDLLYAI SKLGPGEKYE LHAATDTTPS VVVHVCESDQ EKEEEEEMER MRRPKPKIIQ 
    TRRPEYTPIH LS

Genular Protein ID: 2328595823

Symbol: Q6ZMM3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 242
  • Mass: 27851
  • Checksum: 4888F4EAB303BA81
  • Sequence:
  • MQGEQGRRLF RLLLNDLPGR DRLPCSYPQP HVEQASTSAS PRLLAVNIPE DTLLSYPESS 
    LPLQRHCAFH RFSKAKFESL FRTYDKDITF QYFKSFKRVR INFSNPFSAA DARLQLHKTE 
    FLGKEMKLYF AQTLHIGSSH LAPPNPDKQF LISPPASPPV GWKQVEDATP VINYDLLYAI 
    TKLGPGEKYE LHAATDTTPS VVVHVCESDQ EKEEEEEMER MRRPKPKIIQ TRRPEYTPIH 
    LS

Genular Protein ID: 670253693

Symbol: B7Z1F0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 205
  • Mass: 23125
  • Checksum: B457767BEEBF523E
  • Sequence:
  • MHFRNFNYSF SSLIACVANS DIFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN 
    PFSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV 
    EDATPVINYD LLYAISKLGP GEQGPRVGGR QGETQLLPCT GEQYHHYPRS SPEPMPACFV 
    SFSVFFCATV PCAGSMPASW HHLQC

Genular Protein ID: 1583620977

Symbol: V9GYW9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

Sequence Information:

  • Length: 205
  • Mass: 23224
  • Checksum: B457767BFFBF522F
  • Sequence:
  • MHFRNFNYSF SSLIACVANS DIFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN 
    PFSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV 
    EDATPVINYD LLYAISKLGP GEQGPRVGGR QGETQLLPCT REQYHHYPRS SPEPMPACFV 
    SFSVFFCATV PCAGSMPASW HHLQC

Genular Protein ID: 1065527046

Symbol: Q6FGP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 197
  • Mass: 22767
  • Checksum: 980A1FD7AA54A238
  • Sequence:
  • MHFRNFNYSF SSLIACVANS DIFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN 
    PFSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV 
    EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK 
    PKIIQTRRPE YTPIHLS

Genular Protein ID: 2510418821

Symbol: E9PDJ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

Sequence Information:

  • Length: 277
  • Mass: 31888
  • Checksum: E227930C927BEDE5
  • Sequence:
  • MNSTVRQLRV PSHVPLRDPS WESLRNVPKL KKSRGMQGEQ GRRLFRLLLN DLPGRDRLPC 
    SYPQPHVEQA STSASPRLLA VNIPEDTLLS YPESSLPLQR HCAFHRFSKA KFESLFRTYD 
    KDITFQYFKS FKRVRINFSN PFSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN 
    PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV 
    CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.