Details for: DUSP6

Gene ID: 1848

Symbol: DUSP6

Ensembl ID: ENSG00000139318

Description: dual specificity phosphatase 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 183.0979
    Cell Significance Index: -28.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.5248
    Cell Significance Index: -19.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.9551
    Cell Significance Index: -30.8400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 44.5887
    Cell Significance Index: -29.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.1071
    Cell Significance Index: -28.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4335
    Cell Significance Index: -27.9500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 9.6325
    Cell Significance Index: 25.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0548
    Cell Significance Index: -24.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2883
    Cell Significance Index: -28.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.3111
    Cell Significance Index: 79.6800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.0591
    Cell Significance Index: 21.9700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.9679
    Cell Significance Index: 12.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.7127
    Cell Significance Index: 30.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5314
    Cell Significance Index: 71.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4276
    Cell Significance Index: 779.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1771
    Cell Significance Index: 144.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1522
    Cell Significance Index: 13.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1056
    Cell Significance Index: 76.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9133
    Cell Significance Index: 21.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8352
    Cell Significance Index: 82.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7912
    Cell Significance Index: 714.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7621
    Cell Significance Index: 53.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6713
    Cell Significance Index: 17.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6089
    Cell Significance Index: 269.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6081
    Cell Significance Index: 120.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5797
    Cell Significance Index: 17.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5791
    Cell Significance Index: 30.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4862
    Cell Significance Index: 13.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4596
    Cell Significance Index: 74.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4390
    Cell Significance Index: 79.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4186
    Cell Significance Index: 45.5400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.4138
    Cell Significance Index: 2.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3408
    Cell Significance Index: 21.9900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3351
    Cell Significance Index: 3.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3221
    Cell Significance Index: 15.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3186
    Cell Significance Index: 4.9300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.3034
    Cell Significance Index: 1.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2060
    Cell Significance Index: 7.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1277
    Cell Significance Index: 25.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1239
    Cell Significance Index: 23.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0999
    Cell Significance Index: 75.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0715
    Cell Significance Index: 2.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0500
    Cell Significance Index: 1.4400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0198
    Cell Significance Index: 0.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0055
    Cell Significance Index: 0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0082
    Cell Significance Index: -0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0139
    Cell Significance Index: -26.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0179
    Cell Significance Index: -13.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0189
    Cell Significance Index: -34.8800
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0198
    Cell Significance Index: -0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0213
    Cell Significance Index: -32.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0247
    Cell Significance Index: -33.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0324
    Cell Significance Index: -4.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0358
    Cell Significance Index: -24.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0410
    Cell Significance Index: -26.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0417
    Cell Significance Index: -30.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0472
    Cell Significance Index: -16.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0485
    Cell Significance Index: -6.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0514
    Cell Significance Index: -32.0900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0537
    Cell Significance Index: -1.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0548
    Cell Significance Index: -1.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0548
    Cell Significance Index: -30.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0630
    Cell Significance Index: -28.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0636
    Cell Significance Index: -1.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0769
    Cell Significance Index: -22.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0869
    Cell Significance Index: -3.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0903
    Cell Significance Index: -12.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1164
    Cell Significance Index: -1.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1242
    Cell Significance Index: -18.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1466
    Cell Significance Index: -25.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1507
    Cell Significance Index: -17.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1575
    Cell Significance Index: -33.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1706
    Cell Significance Index: -4.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1715
    Cell Significance Index: -2.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1763
    Cell Significance Index: -4.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1897
    Cell Significance Index: -22.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1906
    Cell Significance Index: -2.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2125
    Cell Significance Index: -15.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2221
    Cell Significance Index: -25.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2767
    Cell Significance Index: -28.8100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3049
    Cell Significance Index: -4.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3161
    Cell Significance Index: -17.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3332
    Cell Significance Index: -25.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3431
    Cell Significance Index: -7.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3499
    Cell Significance Index: -27.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3630
    Cell Significance Index: -7.5300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.3934
    Cell Significance Index: -2.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3935
    Cell Significance Index: -26.4600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.4026
    Cell Significance Index: -2.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4100
    Cell Significance Index: -10.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4186
    Cell Significance Index: -3.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4487
    Cell Significance Index: -23.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4547
    Cell Significance Index: -27.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4633
    Cell Significance Index: -29.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4784
    Cell Significance Index: -21.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4917
    Cell Significance Index: -30.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5210
    Cell Significance Index: -14.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5446
    Cell Significance Index: -16.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5539
    Cell Significance Index: -17.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DUSP6 is a dual specificity phosphatase that specifically dephosphorylates and inactivates both the mitogen-activated protein kinase (MAPK) cascade and the extracellular signal-regulated kinase (ERK) 1 and 2 (ERK1/2) cascade. This dual specificity enables DUSP6 to regulate both the MAPK and ERK signaling pathways, which are essential for various cellular processes, including cell proliferation, differentiation, and survival. **Pathways and Functions:** DUSP6 is involved in several key signaling pathways, including: 1. **MAPK cascade:** DUSP6 dephosphorylates and inactivates the MAPK cascade, which is a critical regulator of cell proliferation, differentiation, and survival. 2. **ERK1/2 cascade:** DUSP6 also dephosphorylates and inactivates ERK1/2, which is involved in regulating cell proliferation, differentiation, and survival. 3. **Cytokine signaling:** DUSP6 is involved in regulating cytokine signaling, including the signaling pathways of interleukin-17 (IL-17) and Toll-like receptors (TLRs). 4. **Apoptosis:** DUSP6 can regulate apoptosis by dephosphorylating and inactivating pro-apoptotic proteins. **Clinical Significance:** DUSP6 has been implicated in various diseases, including: 1. **Inflammatory disorders:** DUSP6 has been shown to play a role in regulating inflammatory responses, and its dysregulation has been implicated in inflammatory disorders, such as rheumatoid arthritis and asthma. 2. **Cancer:** DUSP6 has been shown to regulate cell proliferation and survival, and its dysregulation has been implicated in various cancers, including breast cancer and lung cancer. 3. **Neurological disorders:** DUSP6 has been implicated in regulating neuroinflammation and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. **Significantly Expressed Cells:** DUSP6 is significantly expressed in various cell types, including: 1. **Monocytes:** DUSP6 is expressed in CD14-positive, CD16-negative classical monocytes, which are involved in regulating immune responses. 2. **Endothelial cells:** DUSP6 is expressed in alveolar capillary type 1 endothelial cells and endothelial cells of the uterus, which are involved in regulating vascular function and immune responses. 3. **Neural crest cells:** DUSP6 is expressed in migratory enteric neural crest cells, which are involved in regulating the development and function of the enteric nervous system. **Conclusion:** In conclusion, DUSP6 is a key regulator of immune signaling and cell differentiation, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms of DUSP6 and its role in regulating various cellular processes.

Genular Protein ID: 615771353

Symbol: DUS6_HUMAN

Name: Dual specificity protein phosphatase 6

UniProtKB Accession Codes:

Q16828 O75109 Q53Y75 Q9BSH6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 5 ELM 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 2 Rhea 9 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8670865

Title: Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

PubMed ID: 8670865

DOI: 10.1002/j.1460-2075.1996.tb00731.x

PubMed ID: 9858808

Title: Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer.

PubMed ID: 9858808

DOI: 10.1159/000015091

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10048930

Title: Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.

PubMed ID: 10048930

DOI: 10.1038/5861

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

PubMed ID: 29043977

Title: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis.

PubMed ID: 29043977

DOI: 10.7554/elife.27356

PubMed ID: 32721402

Title: Enhanced MAPK1 function causes a neurodevelopmental disorder within the RASopathy clinical spectrum.

PubMed ID: 32721402

DOI: 10.1016/j.ajhg.2020.06.018

Sequence Information:

  • Length: 381
  • Mass: 42320
  • Checksum: 386612227F5D3B2A
  • Sequence:
    • MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI ESAINVAIPG 
IMLRRLQKGN LPVRALFTRG EDRDRFTRRC GTDTVVLYDE SSSDWNENTG GESVLGLLLK 
KLKDEGCRAF YLEGGFSKFQ AEFSLHCETN LDGSCSSSSP PLPVLGLGGL RISSDSSSDI 
ESDLDRDPNS ATDSDGSPLS NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT 
PNLPNLFENA GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS 
VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS SPCDNRVPAQ 
QLYFTTPSNQ NVYQVDSLQS T

Genular Protein ID: 2773716260

Symbol: Q53GP9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53GP9

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 235
  • Mass: 26482
  • Checksum: 24E7A48AA10D2D9D
  • Sequence:
    • MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI ESAINVAIPG 
IMLRRLQKGN LPVRALFTRG EDRDRFTRRC GTDTVVLYDE SSSDWNENTG GESLLGLLLK 
KLKDEGCRAF YLEDEARGKN CGVLVHCLAG ISRSVTVTVA YLMQKLNLSM NDAYDIVKMK 
KSNISPNFNF MGQLLDFERT LGLSSPCDNR VPAQQLYFTT PSNQNVYQVD SLQST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.