Details for: DUSP6

Gene ID: 1848

Symbol: DUSP6

Ensembl ID: ENSG00000139318

Description: dual specificity phosphatase 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.66
    Marker Score: 148596
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.53
    Marker Score: 6421
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.16
    Marker Score: 3133
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.15
    Marker Score: 14007
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.11
    Marker Score: 2256.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.98
    Marker Score: 3866
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.92
    Marker Score: 1802
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.89
    Marker Score: 3774
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.81
    Marker Score: 9494
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.79
    Marker Score: 1684
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.75
    Marker Score: 60686
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.7
    Marker Score: 1943
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.62
    Marker Score: 771
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.55
    Marker Score: 3528
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.55
    Marker Score: 375
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.51
    Marker Score: 585
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.5
    Marker Score: 17396.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.49
    Marker Score: 2165
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.48
    Marker Score: 1596
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.46
    Marker Score: 3536
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167533
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.46
    Marker Score: 2344
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.4
    Marker Score: 877
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.34
    Marker Score: 1199
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.28
    Marker Score: 523
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.27
    Marker Score: 1151
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.26
    Marker Score: 5250
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.26
    Marker Score: 1787
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.26
    Marker Score: 1258
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.26
    Marker Score: 3946
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.26
    Marker Score: 606
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.24
    Marker Score: 298
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.23
    Marker Score: 1292
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.21
    Marker Score: 1789
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.21
    Marker Score: 3046
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.16
    Marker Score: 1905
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.16
    Marker Score: 997
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 18068
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.15
    Marker Score: 4507
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.13
    Marker Score: 506
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.12
    Marker Score: 1893
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.1
    Marker Score: 663
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.1
    Marker Score: 2732.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2224.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.09
    Marker Score: 653
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.06
    Marker Score: 306
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.05
    Marker Score: 3897
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.05
    Marker Score: 332
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.03
    Marker Score: 226
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.02
    Marker Score: 2411
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.01
    Marker Score: 235
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1
    Marker Score: 1010
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1
    Marker Score: 25658
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1
    Marker Score: 16055
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71684
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1
    Marker Score: 621
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47908
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.99
    Marker Score: 4041
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.98
    Marker Score: 209
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.98
    Marker Score: 559
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.97
    Marker Score: 406
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.97
    Marker Score: 336
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.97
    Marker Score: 1547
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.95
    Marker Score: 4683
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.95
    Marker Score: 6049
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2391
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.94
    Marker Score: 995
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.92
    Marker Score: 512
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5189
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.91
    Marker Score: 1009
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.91
    Marker Score: 5446
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.9
    Marker Score: 2043
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2689
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.9
    Marker Score: 289
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.9
    Marker Score: 419
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.89
    Marker Score: 430
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.88
    Marker Score: 896
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.87
    Marker Score: 2128
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.87
    Marker Score: 1130
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.86
    Marker Score: 1065
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 499
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.86
    Marker Score: 291
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.85
    Marker Score: 565
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.85
    Marker Score: 198.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.85
    Marker Score: 265
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 634
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 328
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.82
    Marker Score: 1709
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.82
    Marker Score: 515
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.81
    Marker Score: 429
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.8
    Marker Score: 440
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.8
    Marker Score: 411
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.79
    Marker Score: 925
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.79
    Marker Score: 240
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.79
    Marker Score: 539

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics**: * DUSP6 is a serine/threonine phosphatase that is highly conserved across species. * It has been shown to be a key regulator of inflammation and cell proliferation. * It is a key regulator of the MAPK signaling pathway, which is involved in inflammation and cell growth. * It is also involved in the regulation of the Toll-like receptor (TLR) signaling pathway, which is important for the recognition of pathogen-associated molecular patterns. **Pathways and functions**: * DUSP6 is involved in the regulation of inflammation through the MAPK signaling pathway. * It is a key regulator of the production of inflammatory cytokines and chemokines, such as IL-1β, IL-6, and TNF-α. * It also regulates the expression of inflammatory genes. * In addition to its role in inflammation, DUSP6 is also involved in cell proliferation and migration. * It is expressed in high levels in myeloid and endothelial cells, where it plays a role in the regulation of immune responses. **Clinical significance**: * Mutations in DUSP6 have been linked to a number of inflammatory diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. * DUSP6 inhibitors are being investigated as potential treatments for these diseases. **Additional points**: * DUSP6 is a multi-functional protein that can regulate inflammation and cell proliferation through different pathways. * It is a key regulator of the immune response, and its dysfunction can lead to the development of inflammatory diseases. * Understanding the role of DUSP6 in inflammation is important for the development of new therapeutic strategies for inflammatory diseases.

Genular Protein ID: 615771353

Symbol: DUS6_HUMAN

Name: Dual specificity protein phosphatase 6

UniProtKB Accession Codes:

Q16828 O75109 Q53Y75 Q9BSH6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 5 ELM 1 EMBL 9 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 2 Rhea 9 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8670865

Title: Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

PubMed ID: 8670865

DOI: 10.1002/j.1460-2075.1996.tb00731.x

PubMed ID: 9858808

Title: Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer.

PubMed ID: 9858808

DOI: 10.1159/000015091

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10048930

Title: Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.

PubMed ID: 10048930

DOI: 10.1038/5861

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

PubMed ID: 29043977

Title: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis.

PubMed ID: 29043977

DOI: 10.7554/elife.27356

PubMed ID: 32721402

Title: Enhanced MAPK1 function causes a neurodevelopmental disorder within the RASopathy clinical spectrum.

PubMed ID: 32721402

DOI: 10.1016/j.ajhg.2020.06.018

Sequence Information:

  • Length: 381
  • Mass: 42320
  • Checksum: 386612227F5D3B2A
  • Sequence:
    • MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI ESAINVAIPG 
IMLRRLQKGN LPVRALFTRG EDRDRFTRRC GTDTVVLYDE SSSDWNENTG GESVLGLLLK 
KLKDEGCRAF YLEGGFSKFQ AEFSLHCETN LDGSCSSSSP PLPVLGLGGL RISSDSSSDI 
ESDLDRDPNS ATDSDGSPLS NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT 
PNLPNLFENA GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS 
VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS SPCDNRVPAQ 
QLYFTTPSNQ NVYQVDSLQS T

Genular Protein ID: 2773716260

Symbol: Q53GP9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53GP9

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 235
  • Mass: 26482
  • Checksum: 24E7A48AA10D2D9D
  • Sequence:
    • MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI ESAINVAIPG 
IMLRRLQKGN LPVRALFTRG EDRDRFTRRC GTDTVVLYDE SSSDWNENTG GESLLGLLLK 
KLKDEGCRAF YLEDEARGKN CGVLVHCLAG ISRSVTVTVA YLMQKLNLSM NDAYDIVKMK 
KSNISPNFNF MGQLLDFERT LGLSSPCDNR VPAQQLYFTT PSNQNVYQVD SLQST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.