Gene E2F5 - ENSG00000133740 | NCBI Gene ID: 1875

Details for: E2F5

Gene ID: 1875

Symbol: E2F5

Ensembl ID: ENSG00000133740

Description: E2F transcription factor 5

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
G0 and early g1
(R-HSA-1538133)
G1 phase
(R-HSA-69236)
G1/s-specific transcription
(R-HSA-69205)
G1/s transition
(R-HSA-69206)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-HSA-2173796)
S phase
(R-HSA-69242)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcription of e2f targets under negative control by dream complex
(R-HSA-1362277)
Transcription of e2f targets under negative control by p107 (rbl1) and p130 (rbl2) in complex with hdac1
(R-HSA-1362300)
Animal organ morphogenesis
(GO:0009887)
Cell projection organization
(GO:0030030)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Fibrillar center
(GO:0001650)
Intracellular membrane-bounded organelle
(GO:0043231)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.2
Marker Score: 3567
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.03
Marker Score: 1010
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71798
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48022.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494
Cell Name: centroblast (CL0009112)
Fold Change: 0.95
Marker Score: 469
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.93
Marker Score: 563
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2730
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.9
Marker Score: 5116
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 315
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.86
Marker Score: 303
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.85
Marker Score: 13301
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.77
Marker Score: 434
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 384
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.74
Marker Score: 445
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.73
Marker Score: 292.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.71
Marker Score: 543.5
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7
Marker Score: 2949
Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 632
Cell Name: germ cell (CL0000586)
Fold Change: 0.68
Marker Score: 1190
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.66
Marker Score: 423
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.66
Marker Score: 386
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.64
Marker Score: 437
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.61
Marker Score: 461
Cell Name: Unknown (CL0002371)
Fold Change: 0.6
Marker Score: 635
Cell Name: neural cell (CL0002319)
Fold Change: 0.6
Marker Score: 288
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.58
Marker Score: 1358
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.57
Marker Score: 523
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 433
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.54
Marker Score: 18605.5
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.53
Marker Score: 523
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.52
Marker Score: 908
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.51
Marker Score: 5287
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.5
Marker Score: 114
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.49
Marker Score: 4220
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.49
Marker Score: 416
Cell Name: neuron (CL0000540)
Fold Change: 0.49
Marker Score: 1986
Cell Name: B cell (CL0000236)
Fold Change: 0.49
Marker Score: 462
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.49
Marker Score: 245
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.47
Marker Score: 285
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.47
Marker Score: 195
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.46
Marker Score: 348
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.46
Marker Score: 28027
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.45
Marker Score: 4309
Cell Name: centrocyte (CL0009111)
Fold Change: 0.45
Marker Score: 106
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.44
Marker Score: 679
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.43
Marker Score: 1789.5
Cell Name: immature B cell (CL0000816)
Fold Change: 0.43
Marker Score: 284
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.43
Marker Score: 100
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.43
Marker Score: 9526
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.42
Marker Score: 363
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.42
Marker Score: 501.5
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.41
Marker Score: 202
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.41
Marker Score: 13689
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.4
Marker Score: 120
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.4
Marker Score: 167
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.4
Marker Score: 430
Cell Name: plasmablast (CL0000980)
Fold Change: 0.4
Marker Score: 527
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.39
Marker Score: 126
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.39
Marker Score: 561
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.38
Marker Score: 274.5
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.38
Marker Score: 164
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.37
Marker Score: 395
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.37
Marker Score: 757.5
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.37
Marker Score: 2238
Cell Name: interneuron (CL0000099)
Fold Change: 0.37
Marker Score: 170
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.37
Marker Score: 216
Cell Name: naive B cell (CL0000788)
Fold Change: 0.37
Marker Score: 328
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.36
Marker Score: 391
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.36
Marker Score: 358
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.36
Marker Score: 235
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.36
Marker Score: 3340
Cell Name: plasma cell (CL0000786)
Fold Change: 0.35
Marker Score: 394
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.35
Marker Score: 422
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.34
Marker Score: 120
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.34
Marker Score: 1213.5
Cell Name: memory B cell (CL0000787)
Fold Change: 0.34
Marker Score: 258
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.34
Marker Score: 352
Cell Name: male germ cell (CL0000015)
Fold Change: 0.33
Marker Score: 96
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.33
Marker Score: 256
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.33
Marker Score: 97
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.33
Marker Score: 438
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.33
Marker Score: 103
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.33
Marker Score: 886
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.32
Marker Score: 346
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.32
Marker Score: 102
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.32
Marker Score: 187
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.32
Marker Score: 119
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.32
Marker Score: 168
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.32
Marker Score: 663
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.31
Marker Score: 392
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.31
Marker Score: 294
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.31
Marker Score: 439.5
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.31
Marker Score: 82

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**Key characteristics:** * E2F5 is a key transcription factor in the cell cycle. * It is involved in the regulation of cell cycle entry, cell cycle progression, and differentiation. * It is a target of the cyclin-dependent kinase 2 (cdk2) signaling pathway. * It is also a target of the tgf-beta receptor complex. * It is expressed in a variety of cell types, including germinal center B cells, memory B cells, and neuronal cell types. **Pathways and functions:** * E2F5 is involved in the regulation of cell cycle entry by binding to DNA sequences in the promoters of cell cycle genes. * It is also involved in the regulation of cell cycle progression by binding to DNA sequences in the promoters of cell cycle genes. * It is involved in the regulation of differentiation by binding to DNA sequences in the promoters of genes involved in differentiation. **Clinical significance:** * Mutations in E2F5 have been linked to a number of human cancers, including breast cancer, lung cancer, and leukemia. * Targeting E2F5 has been explored as a therapeutic strategy for cancer. **Additional information:** * E2F5 is a highly conserved protein that is found in all eukaryotes. * It is a member of the E2F family of transcription factors. * It is a key regulator of cell growth, proliferation, and differentiation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor E2F5

Genular Protein ID: 2076154531

Symbol: E2F5_HUMAN

Name: Transcription factor E2F5

UniProtKB Accession Codes:

Q15329 E9PBN9 Q16601 Q92756

Database IDs:

Citations:

PubMed ID: 8589754

Title: Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors.

PubMed ID: 8589754

PubMed ID: 7760804

Title: E2F-5, a new E2F family member that interacts with p130 in vivo.

PubMed ID: 7760804

DOI: 10.1128/mcb.15.6.3082

PubMed ID: 7892279

Title: E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

PubMed ID: 7892279

DOI: 10.1073/pnas.92.6.2403

PubMed ID: 9464260

Title: The molecular and functional characterization of E2F-5 transcription factor.

PubMed ID: 9464260

DOI: 10.1006/bbrc.1997.8010

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 16360038

Title: Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

PubMed ID: 16360038

DOI: 10.1016/j.cell.2005.09.044

PubMed ID: 17531812

Title: Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.

PubMed ID: 17531812

DOI: 10.1016/j.molcel.2007.04.015

Sequence Information:

Length: 346
Mass: 37610
Checksum: F1408A755E67D879
Sequence:

MAAAEPASSG QQAPAGQGQG QRPPPQPPQA QAPQPPPPPQ LGGAGGGSSR HEKSLGLLTT 
KFVSLLQEAK DGVLDLKAAA DTLAVRQKRR IYDITNVLEG IDLIEKKSKN SIQWKGVGAG 
CNTKEVIDRL RYLKAEIEDL ELKERELDQQ KLWLQQSIKN VMDDSINNRF SYVTHEDICN 
CFNGDTLLAI QAPSGTQLEV PIPEMGQNGQ KKYQINLKSH SGPIHVLLIN KESSSSKPVV 
FPVPPPDDLT QPSSQSLTPV TPQKSSMATQ NLPEQHVSER SQALQQTSAT DISSAGSISG 
DIIDELMSSD VFPLLRLSPT PADDYNFNLD DNEGVCDLFD VQILNY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: E2F5

Associated with

Cells (max top 100)

Other Information

Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. PubMed ID: 8589754

E2F-5, a new E2F family member that interacts with p130 in vivo. PubMed ID: 7760804

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. PubMed ID: 7892279

The molecular and functional characterization of E2F-5 transcription factor. PubMed ID: 9464260

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. PubMed ID: 16360038

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. PubMed ID: 17531812