Details for: E2F5

Gene ID: 1875

Symbol: E2F5

Ensembl ID: ENSG00000133740

Description: E2F transcription factor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.2836
    Cell Significance Index: -11.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.9594
    Cell Significance Index: -11.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.9442
    Cell Significance Index: -10.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.1339
    Cell Significance Index: -10.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.5381
    Cell Significance Index: -11.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6438
    Cell Significance Index: -12.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.8753
    Cell Significance Index: -5.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4175
    Cell Significance Index: 79.5400
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.2644
    Cell Significance Index: 2.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0397
    Cell Significance Index: 938.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9917
    Cell Significance Index: 116.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9396
    Cell Significance Index: 56.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8718
    Cell Significance Index: 173.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8597
    Cell Significance Index: 93.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6722
    Cell Significance Index: 109.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4764
    Cell Significance Index: 55.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4371
    Cell Significance Index: 7.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4325
    Cell Significance Index: 19.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4238
    Cell Significance Index: 32.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4229
    Cell Significance Index: 9.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4212
    Cell Significance Index: 15.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3491
    Cell Significance Index: 24.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3399
    Cell Significance Index: 68.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2969
    Cell Significance Index: 162.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2965
    Cell Significance Index: 205.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2474
    Cell Significance Index: 12.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2396
    Cell Significance Index: 14.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1916
    Cell Significance Index: 5.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1906
    Cell Significance Index: 27.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1634
    Cell Significance Index: 16.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1194
    Cell Significance Index: 21.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1081
    Cell Significance Index: 3.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1043
    Cell Significance Index: 2.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0917
    Cell Significance Index: 32.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0834
    Cell Significance Index: 5.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0809
    Cell Significance Index: 3.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0577
    Cell Significance Index: 7.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0549
    Cell Significance Index: 1.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0535
    Cell Significance Index: 0.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0500
    Cell Significance Index: 6.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0413
    Cell Significance Index: 18.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0332
    Cell Significance Index: 1.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0255
    Cell Significance Index: 4.8500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0231
    Cell Significance Index: 0.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0205
    Cell Significance Index: 0.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0194
    Cell Significance Index: 26.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0153
    Cell Significance Index: 23.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0138
    Cell Significance Index: 8.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0130
    Cell Significance Index: 24.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0127
    Cell Significance Index: 23.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0109
    Cell Significance Index: 0.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0017
    Cell Significance Index: 0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0080
    Cell Significance Index: -3.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0100
    Cell Significance Index: -7.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0102
    Cell Significance Index: -7.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0118
    Cell Significance Index: -8.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0124
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0126
    Cell Significance Index: -2.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0141
    Cell Significance Index: -0.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0157
    Cell Significance Index: -1.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0222
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0225
    Cell Significance Index: -14.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0304
    Cell Significance Index: -8.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0334
    Cell Significance Index: -0.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0440
    Cell Significance Index: -5.6800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0506
    Cell Significance Index: -0.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0507
    Cell Significance Index: -5.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0518
    Cell Significance Index: -2.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0525
    Cell Significance Index: -1.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0596
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0624
    Cell Significance Index: -13.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0632
    Cell Significance Index: -7.2400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0717
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0774
    Cell Significance Index: -2.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0790
    Cell Significance Index: -2.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0814
    Cell Significance Index: -1.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0993
    Cell Significance Index: -7.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1013
    Cell Significance Index: -10.5500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1026
    Cell Significance Index: -1.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1165
    Cell Significance Index: -1.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1335
    Cell Significance Index: -10.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1364
    Cell Significance Index: -8.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1384
    Cell Significance Index: -7.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1392
    Cell Significance Index: -3.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1409
    Cell Significance Index: -8.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1449
    Cell Significance Index: -3.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1555
    Cell Significance Index: -1.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1574
    Cell Significance Index: -5.4700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1664
    Cell Significance Index: -1.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1775
    Cell Significance Index: -2.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1790
    Cell Significance Index: -11.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1796
    Cell Significance Index: -1.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1940
    Cell Significance Index: -6.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2026
    Cell Significance Index: -6.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2044
    Cell Significance Index: -6.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2136
    Cell Significance Index: -11.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2151
    Cell Significance Index: -3.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2205
    Cell Significance Index: -7.7300
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.2437
    Cell Significance Index: -1.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulator:** E2F5 is a transcription factor that regulates the expression of target genes involved in cell cycle progression, differentiation, and survival. 2. **Cell Cycle Control:** E2F5 is involved in the regulation of cell cycle progression, particularly during the G1/S transition, where it promotes the expression of cyclin E and inhibits the expression of p21. 3. **DNA Damage Response:** E2F5 is also involved in the DNA damage response, where it regulates the expression of genes involved in DNA repair and apoptosis. 4. **Signaling Pathways:** E2F5 is regulated by various signaling pathways, including those mediated by TGF-β, Smad proteins, and the pRb/E2F pathway. 5. **Tissue Development:** E2F5 is significantly expressed in various cell types involved in tissue development, including germinal center B cells, GABAergic interneurons, and intestinal epithelial cells. **Pathways and Functions:** 1. **Cell Cycle Regulation:** E2F5 regulates the expression of cyclin E and inhibits the expression of p21, promoting the G1/S transition and cell cycle progression. 2. **DNA Damage Response:** E2F5 regulates the expression of genes involved in DNA repair and apoptosis, ensuring genome stability and preventing cancer. 3. **Signaling Pathways:** E2F5 is regulated by TGF-β, Smad proteins, and the pRb/E2F pathway, highlighting its involvement in various signaling cascades. 4. **Transcriptional Regulation:** E2F5 regulates the expression of target genes involved in cell differentiation, survival, and proliferation. **Clinical Significance:** 1. **Cancer:** E2F5 has been implicated in various cancers, including breast, lung, and colon cancer, where it is often overexpressed and contributes to tumorigenesis. 2. **Neurological Disorders:** E2F5 has been implicated in neurological disorders, including Alzheimer's disease, where it is involved in the regulation of amyloid precursor protein expression. 3. **Autoimmune Diseases:** E2F5 has been implicated in autoimmune diseases, including rheumatoid arthritis, where it is involved in the regulation of immune cell function and cytokine production. 4. **Regenerative Medicine:** E2F5 has been identified as a potential target for regenerative therapies, where it can be used to promote tissue repair and regeneration. In conclusion, E2F5 is a critical regulator of cell cycle progression, gene expression, and cellular differentiation. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and autoimmune diseases. Further studies are needed to fully understand the role of E2F5 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2076154531

Symbol: E2F5_HUMAN

Name: Transcription factor E2F5

UniProtKB Accession Codes:

Q15329 E9PBN9 Q16601 Q92756

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 8 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8589754

Title: Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors.

PubMed ID: 8589754

PubMed ID: 7760804

Title: E2F-5, a new E2F family member that interacts with p130 in vivo.

PubMed ID: 7760804

DOI: 10.1128/mcb.15.6.3082

PubMed ID: 7892279

Title: E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

PubMed ID: 7892279

DOI: 10.1073/pnas.92.6.2403

PubMed ID: 9464260

Title: The molecular and functional characterization of E2F-5 transcription factor.

PubMed ID: 9464260

DOI: 10.1006/bbrc.1997.8010

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 16360038

Title: Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

PubMed ID: 16360038

DOI: 10.1016/j.cell.2005.09.044

PubMed ID: 17531812

Title: Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.

PubMed ID: 17531812

DOI: 10.1016/j.molcel.2007.04.015

Sequence Information:

  • Length: 346
  • Mass: 37610
  • Checksum: F1408A755E67D879
  • Sequence:
    • MAAAEPASSG QQAPAGQGQG QRPPPQPPQA QAPQPPPPPQ LGGAGGGSSR HEKSLGLLTT 
KFVSLLQEAK DGVLDLKAAA DTLAVRQKRR IYDITNVLEG IDLIEKKSKN SIQWKGVGAG 
CNTKEVIDRL RYLKAEIEDL ELKERELDQQ KLWLQQSIKN VMDDSINNRF SYVTHEDICN 
CFNGDTLLAI QAPSGTQLEV PIPEMGQNGQ KKYQINLKSH SGPIHVLLIN KESSSSKPVV 
FPVPPPDDLT QPSSQSLTPV TPQKSSMATQ NLPEQHVSER SQALQQTSAT DISSAGSISG 
DIIDELMSSD VFPLLRLSPT PADDYNFNLD DNEGVCDLFD VQILNY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.