Details for: GPR183

Gene ID: 1880

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: GPR183

Ensembl ID: ENSG00000169508

Description: G protein-coupled receptor 183

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • plasmacytoid dendritic cell, human CL0001058
    CSI 90.02
    rCSI 62.85%
    PRS 51.24
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 54.4
    rCSI 65.71%
    PRS 57.23
  • myeloid dendritic cell CL0000782
    CSI 48.99
    rCSI 70.98%
    PRS 65.54
  • conventional dendritic cell CL0000990
    CSI 35.63
    rCSI 29.74%
    PRS 67.5
  • dendritic cell CL0000451
    CSI 33.91
    rCSI 41.78%
    PRS 70.52
  • plasmacytoid dendritic cell CL0000784
    CSI 32.28
    rCSI 32.7%
    PRS 83.78
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 31.09
    rCSI 20.95%
    PRS 60.44
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 30.43
    rCSI 28.13%
    PRS 69.73
  • CD4-positive helper T cell CL0000492
    CSI 29.9
    rCSI 22.62%
    PRS 62.28
  • memory B cell CL0000787
    CSI 25.87
    rCSI 25.55%
    PRS 79.71
  • dendritic cell, human CL0001056
    CSI 25.05
    rCSI 38.47%
    PRS 56.66
  • Langerhans cell CL0000453
    CSI 23.36
    rCSI 35.68%
    PRS 66.23
  • elicited macrophage CL0000861
    CSI 23.35
    rCSI 21.44%
    PRS 57.13
  • macrophage CL0000235
    CSI 21.98
    rCSI 39.98%
    PRS 74.68
  • myeloid leukocyte CL0000766
    CSI 21.61
    rCSI 19.94%
    PRS 50.01
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 21.04
    rCSI 36%
    PRS 69.37
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 20.3
    rCSI 14.57%
    PRS 62.64
  • intermediate monocyte CL0002393
    CSI 19
    rCSI 28.66%
    PRS 51.66
  • T follicular helper cell CL0002038
    CSI 18.7
    rCSI 14%
    PRS 63.96
  • mature NK T cell CL0000814
    CSI 18.47
    rCSI 23.63%
    PRS 78.01
  • mature B cell CL0000785
    CSI 17.82
    rCSI 15.49%
    PRS 59.14
  • naive T cell CL0000898
    CSI 17.43
    rCSI 12.13%
    PRS 62.64
  • monocyte CL0000576
    CSI 15.04
    rCSI 27.18%
    PRS 69.19
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 15.01
    rCSI 8.86%
    PRS 65.28
  • T-helper 17 cell CL0000899
    CSI 14.99
    rCSI 11.91%
    PRS 71.53
  • colon macrophage CL0009038
    CSI 14.88
    rCSI 68.71%
    PRS 70.9
  • mononuclear phagocyte CL0000113
    CSI 14.67
    rCSI 32.3%
    PRS 53.26
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 13.84
    rCSI 18.13%
    PRS 62.58
  • mature T cell CL0002419
    CSI 13.72
    rCSI 10.67%
    PRS 67
  • myeloid dendritic cell, human CL0001057
    CSI 13.64
    rCSI 76.76%
    PRS 78.78
  • follicular B cell CL0000843
    CSI 13.63
    rCSI 49.56%
    PRS 79.96
  • naive thymus-derived CD4-positive, alpha-beta T cell CL0000895
    CSI 13.61
    rCSI 17.11%
    PRS 82.63
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 13.13
    rCSI 9.84%
    PRS 80.05
  • unswitched memory B cell CL0000970
    CSI 12.21
    rCSI 10.28%
    PRS 66.59
  • group 3 innate lymphoid cell CL0001071
    CSI 12.21
    rCSI 9.17%
    PRS 53.06
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 11.49
    rCSI 12.01%
    PRS 76.78
  • alpha-beta T cell CL0000789
    CSI 11.08
    rCSI 12.98%
    PRS 65.02
  • common dendritic progenitor CL0001029
    CSI 10.83
    rCSI 13.59%
    PRS 59.23
  • fraction A pre-pro B cell CL0002045
    CSI 10.77
    rCSI 12.32%
    PRS 71.48
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 10.67
    rCSI 8.55%
    PRS 70.64
  • double negative thymocyte CL0002489
    CSI 10.11
    rCSI 7.03%
    PRS 58.6
  • CD14-positive monocyte CL0001054
    CSI 9.59
    rCSI 11.95%
    PRS 60.31
  • transitional stage B cell CL0000818
    CSI 9.31
    rCSI 30.47%
    PRS 79.72
  • plasmablast CL0000980
    CSI 9.14
    rCSI 7.19%
    PRS 55.64
  • microglial cell CL0000129
    CSI 8.92
    rCSI 35.91%
    PRS 57.74
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 8.64
    rCSI 8.5%
    PRS 74.69
  • tissue-resident macrophage CL0000864
    CSI 8.47
    rCSI 39.62%
    PRS 66.78
  • immature B cell CL0000816
    CSI 8.42
    rCSI 6.26%
    PRS 62.49
  • lung interstitial macrophage CL4033043
    CSI 8.41
    rCSI 18.87%
    PRS 68.36
  • granulocyte CL0000094
    CSI 8.37
    rCSI 12.79%
    PRS 58.53
  • lung macrophage CL1001603
    CSI 8.26
    rCSI 18.46%
    PRS 55.99
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 7.99
    rCSI 10.89%
    PRS 76.21
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 7.64
    rCSI 21.91%
    PRS 67.66
  • regulatory T cell CL0000815
    CSI 7.38
    rCSI 8.56%
    PRS 67.52
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 7.16
    rCSI 8.55%
    PRS 69.54
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 6.44
    rCSI 10.04%
    PRS 75.94
  • early lymphoid progenitor CL0000936
    CSI 6.04
    rCSI 5.3%
    PRS 54.41
  • memory T cell CL0000813
    CSI 5.98
    rCSI 11.52%
    PRS 78.14
  • erythrocyte CL0000232
    CSI 5.88
    rCSI 13.33%
    PRS 54.36
  • inflammatory macrophage CL0000863
    CSI 5.64
    rCSI 9.64%
    PRS 75.18
  • Hofbauer cell CL3000001
    CSI 5.21
    rCSI 9.84%
    PRS 59.53
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 4.95
    rCSI 4.86%
    PRS 64.83
  • Kupffer cell CL0000091
    CSI 4.89
    rCSI 11.18%
    PRS 48.53
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 4.8
    rCSI 29.06%
    PRS 72.47
  • granulocyte monocyte progenitor cell CL0000557
    CSI 4.72
    rCSI 4.08%
    PRS 53.22
  • innate lymphoid cell CL0001065
    CSI 4.64
    rCSI 9.58%
    PRS 53.96
  • T-helper 1 cell CL0000545
    CSI 4.42
    rCSI 7.97%
    PRS 74.71
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 4.42
    rCSI 8.8%
    PRS 67.37
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 4.34
    rCSI 5.26%
    PRS 42.08
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 4.25
    rCSI 19.3%
    PRS 82.45
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 4.14
    rCSI 10.8%
    PRS 48.2
  • alternatively activated macrophage CL0000890
    CSI 4.05
    rCSI 5.09%
    PRS 62.58
  • alveolar macrophage CL0000583
    CSI 3.95
    rCSI 6.51%
    PRS 54.6
  • natural T-regulatory cell CL0000903
    CSI 3.79
    rCSI 7.17%
    PRS 81.7
  • class switched memory B cell CL0000972
    CSI 3.76
    rCSI 2.81%
    PRS 67.16
  • mature alpha-beta T cell CL0000791
    CSI 3.73
    rCSI 13.51%
    PRS 68.86
  • IgA plasma cell CL0000987
    CSI 3.34
    rCSI 3.42%
    PRS 66.71
  • megakaryocyte CL0000556
    CSI 3.29
    rCSI 14.29%
    PRS 64.63
  • IgM plasma cell CL0000986
    CSI 3.1
    rCSI 13.96%
    PRS 85.37
  • common myeloid progenitor CL0000049
    CSI 2.84
    rCSI 2.3%
    PRS 49.95
  • B-2 B cell CL0000822
    CSI 2.39
    rCSI 50.62%
    PRS 85.22
  • promyelocyte CL0000836
    CSI 2.11
    rCSI 3.05%
    PRS 59.08
  • vascular associated smooth muscle cell CL0000359
    CSI 2.09
    rCSI 6.77%
    PRS 51.49
  • IgG plasma cell CL0000985
    CSI 2.08
    rCSI 2.49%
    PRS 68.02
  • basophil CL0000767
    CSI 2.05
    rCSI 4.34%
    PRS 69.28
  • helper T cell CL0000912
    CSI 1.88
    rCSI 2.65%
    PRS 57.03
  • common lymphoid progenitor CL0000051
    CSI 1.56
    rCSI 2.08%
    PRS 71.94
  • renal intercalated cell CL0005010
    CSI 1.49
    rCSI 13.32%
    PRS 91.03
  • metallothionein-positive alveolar macrophage CL4033042
    CSI 1.29
    rCSI 14.08%
    PRS 76.95
  • promonocyte CL0000559
    CSI 1.27
    rCSI 2.18%
    PRS 58.78
  • enteric smooth muscle cell CL0002504
    CSI 1.01
    rCSI 1.44%
    PRS 51.75
  • double negative T regulatory cell CL0011024
    CSI 0.93
    rCSI 17.63%
    PRS 86.51
  • cytotoxic T cell CL0000910
    CSI 0.73
    rCSI 4.18%
    PRS 60.62
  • activated CD4-positive, alpha-beta T cell, human CL0001043
    CSI 0.54
    rCSI 1.29%
    PRS 86.61
  • group 2 innate lymphoid cell CL0001069
    CSI 0.42
    rCSI 2.29%
    PRS 82.59
  • eosinophil CL0000771
    CSI 0.32
    rCSI 2.1%
    PRS 79.59
  • pre-conventional dendritic cell CL0002010
    CSI 0.32
    rCSI 4.18%
    PRS 81.18

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [GPR183](/details-gene/1880), also known as Epstein-Barr virus-induced gene 2 (EBI2), is a G protein-coupled receptor that functions as a chemosensory receptor for oxysterols, particularly 7α,25-dihydroxycholesterol ([Link](https://doi.org/10.1038/nature10280)). It plays a crucial role in orchestrating the migration and positioning of immune cells. The expression profile of [GPR183](/details-gene/1880) shows it is a highly significant marker for several subsets of dendritic cells, B cells, and T cells. Its primary function involves transducing signals via G alpha (i) proteins to guide leukocyte chemotaxis, thereby critically influencing the architecture and dynamics of the adaptive immune response. ## Cellular Roles and Expression Landscape **Overall**, the expression pattern of [GPR183](/details-gene/1880) firmly establishes it as a key regulator within the immune system, with a particularly prominent role in antigen-presenting cells and lymphocytes. The gene exhibits its highest significance in [plasmacytoid dendritic cell, human](/details-cell/CL0001058) (CSI: 90.02), suggesting it is a defining marker and a critical functional component of this cell type, which is specialized in antiviral responses. High significance is also observed across other dendritic cell subsets, including [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399) (CSI: 54.40) and [myeloid dendritic cell](/details-cell/CL0000782) (CSI: 48.99), underscoring its general importance for dendritic cell biology, likely related to their migration and positioning in lymphoid tissues. Beyond dendritic cells, [GPR183](/details-gene/1880) is also a significant factor in lymphocyte populations. It is highly expressed in [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 31.09), [activated CD4-positive, alpha-beta T cell](/details-cell/CL0000896) (CSI: 30.43), and [memory B cell](/details-cell/CL0000787) (CSI: 25.87). This pattern is consistent with its known role in positioning these cells within secondary lymphoid organs, facilitating effective immune surveillance and response initiation. Furthermore, its expression in [macrophage](/details-cell/CL0000235) (CSI: 21.98) suggests a broader role in myeloid cell trafficking and function. ## Pathways and Molecular Function The molecular function of [GPR183](/details-gene/1880) is centered on its activity as a G protein-coupled receptor ([GO:0004930](https://www.ebi.ac.uk/QuickGO/term/GO:0004930)) located on the [plasma membrane](/details-cell/GO:0005886). It specifically binds oxysterols ([GO:0008142](https://www.ebi.ac.uk/QuickGO/term/GO:0008142)), which triggers downstream signaling cascades. Consistent with its GPCR nature, [GPR183](/details-gene/1880) is involved in [Gpcr ligand binding](/details-cell/R-HSA-500792) and subsequent [G alpha (i) signalling events](/details-cell/R-HSA-418594). This signaling cascade is integral to the biological process of [leukocyte chemotaxis](/details-cell/GO:0030595), which is the primary mechanism by which [GPR183](/details-gene/1880) exerts its influence on the immune system. This function is essential for a coordinated [adaptive immune response](/details-cell/GO:0002250). The functional annotations directly correlate with the cell types where [GPR183](/details-gene/1880) is most significant. Its involvement in [dendritic cell chemotaxis](/details-cell/GO:0002407), [T cell chemotaxis](/details-cell/GO:0010818), and [B cell activation involved in immune response](/details-cell/GO:0002312) provides a molecular explanation for its high CSI values in these respective cell lineages. Moreover, its role in T follicular helper cell differentiation ([GO:0061470](https://www.ebi.ac.uk/QuickGO/term/GO:0061470)) and its ability to heterodimerize with CXCR5 suggest a sophisticated role in organizing the germinal center reaction ([Link](https://doi.org/10.1096/fj.12-208876)). ## Research Directions The specific expression and function of [GPR183](/details-gene/1880) suggest it is a pivotal checkpoint in immune cell geography. Based on the available data, several testable hypotheses can be proposed: 1. Given its exceptionally high significance in [plasmacytoid dendritic cell, human](/details-cell/CL0001058), [GPR183](/details-gene/1880) may be the primary driver of pDC migration from the periphery to T-cell zones of lymph nodes in response to oxysterol gradients generated during viral infections. Its function could be essential for the initiation of Type I interferon-dependent antiviral immunity. 2. The high CSI of [GPR183](/details-gene/1880) in [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) suggests that it is not only important for primary immune responses but also for the maintenance and recall responses of memory T cells. It may mediate the preferential positioning of these cells in specific survival niches within lymphoid or non-lymphoid tissues. **Experimental Approach:** To test the first hypothesis regarding the role of [GPR183](/details-gene/1880) in pDC migration, a compelling experiment would involve a mouse model with a conditional knockout of *Gpr183* specifically in pDCs (e.g., using a Siglech-Cre driver line). These mice, along with wild-type controls, would be challenged with a respiratory virus like influenza. The number and location of pDCs in the draining mediastinal lymph nodes would be assessed at various time points post-infection using flow cytometry and immunofluorescence microscopy. A significant reduction in pDC accumulation in the lymph nodes of knockout mice would confirm that GPR183-mediated chemotaxis is critical for their mobilization during an antiviral response. **Therapeutic Potential:** As a cell surface GPCR with a restricted expression pattern on immune cells, [GPR183](/details-gene/1880) represents a promising therapeutic target. The ability to modulate immune cell trafficking is a key strategy in treating autoimmune and inflammatory diseases. The development of small molecule antagonists for [GPR183](/details-gene/1880) could prevent the pathological accumulation of dendritic cells, T cells, and B cells in tissues targeted by autoimmune attack, such as the central nervous system in multiple sclerosis or the joints in rheumatoid arthritis. Therefore, **inhibition** of [GPR183](/details-gene/1880) signaling is a plausible strategy for developing novel anti-inflammatory or immunosuppressive therapies.

Genular Protein ID: 3823853531

Symbol: GP183_HUMAN

Name: N/A

UniProtKB Accession Codes:

P32249 B2R8N5 Q53F99 Q5JUH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 4 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8383238

Title: Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.

PubMed ID: 8383238

DOI: 10.1128/jvi.67.4.2209-2220.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16540462

Title: Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity.

PubMed ID: 16540462

DOI: 10.1074/jbc.m602245200

PubMed ID: 18628402

Title: Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist.

PubMed ID: 18628402

DOI: 10.1124/mol.108.049676

PubMed ID: 21673108

Title: Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist.

PubMed ID: 21673108

DOI: 10.1074/jbc.m110.196345

PubMed ID: 21796212

Title: Oxysterols direct immune cell migration via EBI2.

PubMed ID: 21796212

DOI: 10.1038/nature10280

PubMed ID: 22913878

Title: EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5.

PubMed ID: 22913878

DOI: 10.1096/fj.12-208876

PubMed ID: 22875855

Title: Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).

PubMed ID: 22875855

DOI: 10.1074/jbc.m112.387894

PubMed ID: 22930711

Title: Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.

PubMed ID: 22930711

DOI: 10.1124/mol.112.080275

PubMed ID: 23772388

Title: Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation.

PubMed ID: 23772388

DOI: 10.1016/j.fob.2013.02.003

PubMed ID: 24678947

Title: Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.

PubMed ID: 24678947

DOI: 10.1021/jm4019355

PubMed ID: 25297897

Title: EBI2 regulates intracellular signaling and migration in human astrocyte.

PubMed ID: 25297897

DOI: 10.1002/glia.22757

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

  • Length: 361
  • Mass: 41224
  • Checksum: B5A2171F34C9C67B
  • Sequence:
    • MDIQMANNFT PPSATPQGND CDLYAHHSTA RIVMPLHYSL VFIIGLVGNL LALVVIVQNR 
KKINSTTLYS TNLVISDILF TTALPTRIAY YAMGFDWRIG DALCRITALV FYINTYAGVN 
FMTCLSIDRF IAVVHPLRYN KIKRIEHAKG VCIFVWILVF AQTLPLLINP MSKQEAERIT 
CMEYPNFEET KSLPWILLGA CFIGYVLPLI IILICYSQIC CKLFRTAKQN PLTEKSGVNK 
KALNTIILII VVFVLCFTPY HVAIIQHMIK KLRFSNFLEC SQRHSFQISL HFTVCLMNFN 
CCMDPFIYFF ACKGYKRKVM RMLKRQVSVS ISSAVKSAPE ENSREMTETQ MMIHSKSSNG 
K