Details for: GPR183

Gene ID: 1880

Symbol: GPR183

Ensembl ID: ENSG00000169508

Description: G protein-coupled receptor 183

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 123.2439
    Cell Significance Index: -19.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.9370
    Cell Significance Index: -18.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.8975
    Cell Significance Index: -21.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.1450
    Cell Significance Index: -21.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.4020
    Cell Significance Index: -18.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2460
    Cell Significance Index: -22.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0776
    Cell Significance Index: -24.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.6801
    Cell Significance Index: -14.6200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.9218
    Cell Significance Index: 91.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0582
    Cell Significance Index: -19.9600
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 5.0553
    Cell Significance Index: 21.0400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.1064
    Cell Significance Index: 43.6300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 3.2084
    Cell Significance Index: 55.1200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.7396
    Cell Significance Index: 18.1800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.1193
    Cell Significance Index: 21.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9753
    Cell Significance Index: 26.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3809
    Cell Significance Index: 7.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3623
    Cell Significance Index: 10.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1862
    Cell Significance Index: 12.0100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0569
    Cell Significance Index: 0.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0058
    Cell Significance Index: 0.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0055
    Cell Significance Index: 0.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0007
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0066
    Cell Significance Index: -12.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0113
    Cell Significance Index: -8.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0126
    Cell Significance Index: -7.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0186
    Cell Significance Index: -14.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0228
    Cell Significance Index: -12.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0236
    Cell Significance Index: -1.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0320
    Cell Significance Index: -23.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0336
    Cell Significance Index: -21.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0377
    Cell Significance Index: -20.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0402
    Cell Significance Index: -14.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0425
    Cell Significance Index: -19.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0452
    Cell Significance Index: -19.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0495
    Cell Significance Index: -8.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0525
    Cell Significance Index: -11.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0547
    Cell Significance Index: -0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0617
    Cell Significance Index: -17.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0651
    Cell Significance Index: -13.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0796
    Cell Significance Index: -3.2600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0812
    Cell Significance Index: -1.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0818
    Cell Significance Index: -14.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0916
    Cell Significance Index: -11.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1101
    Cell Significance Index: -12.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1286
    Cell Significance Index: -16.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1370
    Cell Significance Index: -18.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1413
    Cell Significance Index: -20.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1551
    Cell Significance Index: -17.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1589
    Cell Significance Index: -19.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1890
    Cell Significance Index: -19.6800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1955
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2164
    Cell Significance Index: -24.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2181
    Cell Significance Index: -10.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2410
    Cell Significance Index: -10.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2492
    Cell Significance Index: -19.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2938
    Cell Significance Index: -20.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2942
    Cell Significance Index: -21.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2991
    Cell Significance Index: -23.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3070
    Cell Significance Index: -20.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3145
    Cell Significance Index: -19.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3434
    Cell Significance Index: -17.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3515
    Cell Significance Index: -21.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3536
    Cell Significance Index: -19.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3567
    Cell Significance Index: -22.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3897
    Cell Significance Index: -20.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4476
    Cell Significance Index: -20.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4485
    Cell Significance Index: -23.5500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.4516
    Cell Significance Index: -3.2500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4618
    Cell Significance Index: -7.6100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.4790
    Cell Significance Index: -3.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4899
    Cell Significance Index: -21.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4975
    Cell Significance Index: -22.5500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.5473
    Cell Significance Index: -5.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5495
    Cell Significance Index: -20.1700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.5497
    Cell Significance Index: -5.7000
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.5638
    Cell Significance Index: -3.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5717
    Cell Significance Index: -21.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5719
    Cell Significance Index: -20.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5987
    Cell Significance Index: -17.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6052
    Cell Significance Index: -16.1600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6080
    Cell Significance Index: -8.0800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.6092
    Cell Significance Index: -6.2200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6327
    Cell Significance Index: -20.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6358
    Cell Significance Index: -22.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6460
    Cell Significance Index: -21.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6653
    Cell Significance Index: -21.1900
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.6700
    Cell Significance Index: -6.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6793
    Cell Significance Index: -23.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6887
    Cell Significance Index: -18.4600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7051
    Cell Significance Index: -13.7900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.7070
    Cell Significance Index: -5.9800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7100
    Cell Significance Index: -5.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7157
    Cell Significance Index: -18.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7257
    Cell Significance Index: -20.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7415
    Cell Significance Index: -21.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7819
    Cell Significance Index: -20.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR183 is a member of the class A/1 rhodopsin-like GPCR family, characterized by its seven transmembrane domains and ability to bind ligands. The receptor exhibits a wide range of signaling pathways, including Gαi signaling events, GPCR downstream signaling, and Erk1/2 cascade regulation. GPR183 is also involved in regulating the proliferation of B cells and the differentiation of T follicular helper cells. Notably, the receptor is highly expressed in cells of the immune system, including lung macrophages, myeloid leukocytes, and dendritic cells. **Pathways and Functions:** GPR183 is implicated in various immune-related processes, including: 1. **Adaptive Immune Response:** GPR183 plays a crucial role in B cell activation, proliferation, and differentiation. The receptor regulates the Erk1/2 cascade, which is essential for B cell development and function. 2. **Dendritic Cell Chemotaxis and Homeostasis:** GPR183 is involved in the regulation of dendritic cell migration, proliferation, and survival. The receptor interacts with Gαi signaling events to modulate dendritic cell function. 3. **Leukocyte Chemotaxis:** GPR183 is expressed in myeloid leukocytes and regulates their chemotaxis, which is essential for immune cell migration and response. 4. **T Cell Chemotaxis and Differentiation:** The receptor is involved in the regulation of T cell chemotaxis and differentiation, particularly in the context of T follicular helper cell development. **Clinical Significance:** The identification of GPR183 as a key player in immune responses has significant implications for the treatment of immune-related disorders. Some potential applications of GPR183 include: 1. **Immunotherapy:** Targeting GPR183 with specific ligands or inhibitors could enhance immune responses and improve treatment outcomes for patients with autoimmune diseases or cancer. 2. **Infectious Disease Treatment:** GPR183 modulates the activity of immune cells, which could be exploited to develop novel treatments for infectious diseases. 3. **Cancer Immunotherapy:** The receptor's role in T cell differentiation and chemotaxis could be leveraged to develop more effective cancer immunotherapies. In conclusion, GPR183 is a novel GPCR that plays a critical role in regulating immune responses. Further research is necessary to fully elucidate the mechanisms by which GPR183 modulates immune cell activity and to explore its potential therapeutic applications.

Genular Protein ID: 3823853531

Symbol: GP183_HUMAN

Name: N/A

UniProtKB Accession Codes:

P32249 B2R8N5 Q53F99 Q5JUH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 4 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8383238

Title: Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.

PubMed ID: 8383238

DOI: 10.1128/jvi.67.4.2209-2220.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16540462

Title: Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity.

PubMed ID: 16540462

DOI: 10.1074/jbc.m602245200

PubMed ID: 18628402

Title: Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist.

PubMed ID: 18628402

DOI: 10.1124/mol.108.049676

PubMed ID: 21673108

Title: Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist.

PubMed ID: 21673108

DOI: 10.1074/jbc.m110.196345

PubMed ID: 21796212

Title: Oxysterols direct immune cell migration via EBI2.

PubMed ID: 21796212

DOI: 10.1038/nature10280

PubMed ID: 22913878

Title: EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5.

PubMed ID: 22913878

DOI: 10.1096/fj.12-208876

PubMed ID: 22875855

Title: Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).

PubMed ID: 22875855

DOI: 10.1074/jbc.m112.387894

PubMed ID: 22930711

Title: Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.

PubMed ID: 22930711

DOI: 10.1124/mol.112.080275

PubMed ID: 23772388

Title: Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation.

PubMed ID: 23772388

DOI: 10.1016/j.fob.2013.02.003

PubMed ID: 24678947

Title: Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.

PubMed ID: 24678947

DOI: 10.1021/jm4019355

PubMed ID: 25297897

Title: EBI2 regulates intracellular signaling and migration in human astrocyte.

PubMed ID: 25297897

DOI: 10.1002/glia.22757

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

  • Length: 361
  • Mass: 41224
  • Checksum: B5A2171F34C9C67B
  • Sequence:
    • MDIQMANNFT PPSATPQGND CDLYAHHSTA RIVMPLHYSL VFIIGLVGNL LALVVIVQNR 
KKINSTTLYS TNLVISDILF TTALPTRIAY YAMGFDWRIG DALCRITALV FYINTYAGVN 
FMTCLSIDRF IAVVHPLRYN KIKRIEHAKG VCIFVWILVF AQTLPLLINP MSKQEAERIT 
CMEYPNFEET KSLPWILLGA CFIGYVLPLI IILICYSQIC CKLFRTAKQN PLTEKSGVNK 
KALNTIILII VVFVLCFTPY HVAIIQHMIK KLRFSNFLEC SQRHSFQISL HFTVCLMNFN 
CCMDPFIYFF ACKGYKRKVM RMLKRQVSVS ISSAVKSAPE ENSREMTETQ MMIHSKSSNG 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.