Details for: GPR183

Gene ID: 1880

Symbol: GPR183

Ensembl ID: ENSG00000169508

Description: G protein-coupled receptor 183

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.87
    Marker Score: 3285
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.74
    Marker Score: 1370
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.65
    Marker Score: 1083
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.29
    Marker Score: 1379
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.28
    Marker Score: 2753
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.28
    Marker Score: 5905
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.26
    Marker Score: 801
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.24
    Marker Score: 1442
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.22
    Marker Score: 21970
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2
    Marker Score: 3487
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.95
    Marker Score: 606
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.93
    Marker Score: 1131
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.86
    Marker Score: 1741
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.76
    Marker Score: 7564
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.67
    Marker Score: 88517
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.62
    Marker Score: 1747
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.6
    Marker Score: 821
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.56
    Marker Score: 360
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.53
    Marker Score: 4281
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.4
    Marker Score: 968
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.35
    Marker Score: 1330
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.35
    Marker Score: 1266
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.34
    Marker Score: 985
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.32
    Marker Score: 1107
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.31
    Marker Score: 2254
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.28
    Marker Score: 389
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.25
    Marker Score: 2806
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.25
    Marker Score: 1250
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.24
    Marker Score: 1378
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.23
    Marker Score: 964
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.22
    Marker Score: 1354
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.22
    Marker Score: 427
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.22
    Marker Score: 7422.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.22
    Marker Score: 607
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.17
    Marker Score: 505
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.16
    Marker Score: 1037
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.13
    Marker Score: 775
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.1
    Marker Score: 1125
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.09
    Marker Score: 788
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.07
    Marker Score: 643
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.06
    Marker Score: 279
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.05
    Marker Score: 2471
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.05
    Marker Score: 793
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.05
    Marker Score: 1011
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.04
    Marker Score: 992
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.03
    Marker Score: 340
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.03
    Marker Score: 807
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.03
    Marker Score: 741
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.03
    Marker Score: 2009.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.01
    Marker Score: 4211
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.01
    Marker Score: 741
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.01
    Marker Score: 1091
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71730
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1
    Marker Score: 11590
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47955
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.99
    Marker Score: 247
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.98
    Marker Score: 577
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.98
    Marker Score: 745
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.98
    Marker Score: 813
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.95
    Marker Score: 596
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.93
    Marker Score: 248
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5269
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14440
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2718
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.88
    Marker Score: 198
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5257
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.87
    Marker Score: 829.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.86
    Marker Score: 465
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.85
    Marker Score: 1780
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.84
    Marker Score: 419.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1594
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.83
    Marker Score: 907
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.83
    Marker Score: 266
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.82
    Marker Score: 1069
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.82
    Marker Score: 521
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.82
    Marker Score: 821
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.79
    Marker Score: 650
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 602
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.79
    Marker Score: 522
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.79
    Marker Score: 438
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.77
    Marker Score: 267
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.77
    Marker Score: 2133
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.76
    Marker Score: 4861
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1230
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 673
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.73
    Marker Score: 349
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1164
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.71
    Marker Score: 1292
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.71
    Marker Score: 255
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.71
    Marker Score: 629
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.68
    Marker Score: 582
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.68
    Marker Score: 214
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.68
    Marker Score: 1316
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.67
    Marker Score: 358
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.67
    Marker Score: 565
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.66
    Marker Score: 277.5

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Other Information

**Key characteristics:** - G protein-coupled receptor 183 - Ensembl ID: ENSG00000169508 - Pathway/Ontology: Adaptive immune response, B cell activation involved in immune response, Class a/1 (rhodopsin-like receptors), Dendritic cell chemotaxis, G alpha (i) signalling events, Gpcr downstream signalling, Gpcr ligand binding, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway **Pathways and functions:** GPR183 is involved in a variety of immune pathways, including the adaptive immune response, B cell activation, dendritic cell chemotaxis, and T cell chemotaxis. It is expressed on a variety of cell types, including macrophages, dendritic cells, and B cells, and is involved in the regulation of their immune responses. **Clinical significance:** GPR183 is a potential therapeutic target for a variety of diseases, including cancer and autoimmune disorders. It is currently being investigated as a target for the treatment of inflammatory diseases, such as rheumatoid arthritis and asthma.

Genular Protein ID: 3823853531

Symbol: GP183_HUMAN

Name: N/A

UniProtKB Accession Codes:

P32249 B2R8N5 Q53F99 Q5JUH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 4 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8383238

Title: Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.

PubMed ID: 8383238

DOI: 10.1128/jvi.67.4.2209-2220.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16540462

Title: Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity.

PubMed ID: 16540462

DOI: 10.1074/jbc.m602245200

PubMed ID: 18628402

Title: Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist.

PubMed ID: 18628402

DOI: 10.1124/mol.108.049676

PubMed ID: 21673108

Title: Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist.

PubMed ID: 21673108

DOI: 10.1074/jbc.m110.196345

PubMed ID: 21796212

Title: Oxysterols direct immune cell migration via EBI2.

PubMed ID: 21796212

DOI: 10.1038/nature10280

PubMed ID: 22913878

Title: EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5.

PubMed ID: 22913878

DOI: 10.1096/fj.12-208876

PubMed ID: 22875855

Title: Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).

PubMed ID: 22875855

DOI: 10.1074/jbc.m112.387894

PubMed ID: 22930711

Title: Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.

PubMed ID: 22930711

DOI: 10.1124/mol.112.080275

PubMed ID: 23772388

Title: Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation.

PubMed ID: 23772388

DOI: 10.1016/j.fob.2013.02.003

PubMed ID: 24678947

Title: Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.

PubMed ID: 24678947

DOI: 10.1021/jm4019355

PubMed ID: 25297897

Title: EBI2 regulates intracellular signaling and migration in human astrocyte.

PubMed ID: 25297897

DOI: 10.1002/glia.22757

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

Sequence Information:

  • Length: 361
  • Mass: 41224
  • Checksum: B5A2171F34C9C67B
  • Sequence:
    • MDIQMANNFT PPSATPQGND CDLYAHHSTA RIVMPLHYSL VFIIGLVGNL LALVVIVQNR 
KKINSTTLYS TNLVISDILF TTALPTRIAY YAMGFDWRIG DALCRITALV FYINTYAGVN 
FMTCLSIDRF IAVVHPLRYN KIKRIEHAKG VCIFVWILVF AQTLPLLINP MSKQEAERIT 
CMEYPNFEET KSLPWILLGA CFIGYVLPLI IILICYSQIC CKLFRTAKQN PLTEKSGVNK 
KALNTIILII VVFVLCFTPY HVAIIQHMIK KLRFSNFLEC SQRHSFQISL HFTVCLMNFN 
CCMDPFIYFF ACKGYKRKVM RMLKRQVSVS ISSAVKSAPE ENSREMTETQ MMIHSKSSNG 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.