Gene ECT2 - ENSG00000114346 | NCBI Gene ID: 1894

Details for: ECT2

Gene ID: 1894

Symbol: ECT2

Ensembl ID: ENSG00000114346

Description: epithelial cell transforming 2

Associated with

Cdc42 gtpase cycle
(R-HSA-9013148)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Death receptor signaling
(R-HSA-73887)
G alpha (12/13) signalling events
(R-HSA-416482)
Gpcr downstream signalling
(R-HSA-388396)
Nrage signals death through jnk
(R-HSA-193648)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Rac1 gtpase cycle
(R-HSA-9013149)
Rhoa gtpase cycle
(R-HSA-8980692)
Rhob gtpase cycle
(R-HSA-9013026)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by gpcr
(R-HSA-372790)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Activation of gtpase activity
(GO:0090630)
Activation of protein kinase activity
(GO:0032147)
Bicellular tight junction
(GO:0005923)
Bicellular tight junction assembly
(GO:0070830)
Cell-cell junction
(GO:0005911)
Cell cortex
(GO:0005938)
Cell differentiation
(GO:0030154)
Cell morphogenesis
(GO:0000902)
Cellular response to calcium ion
(GO:0071277)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to ionizing radiation
(GO:0071479)
Centralspindlin complex
(GO:0097149)
Centrosome
(GO:0005813)
Cleavage furrow
(GO:0032154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Gtpase activator activity
(GO:0005096)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Intracellular signal transduction
(GO:0035556)
Midbody
(GO:0030496)
Mitotic cytokinesis
(GO:0000281)
Mitotic spindle
(GO:0072686)
Nervous system development
(GO:0007399)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cytokinesis
(GO:0032467)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of protein import into nucleus
(GO:0042307)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein homooligomerization
(GO:0051260)
Protein transport
(GO:0015031)
Regulation of attachment of spindle microtubules to kinetochore
(GO:0051988)
Regulation of cytokinesis, actomyosin contractile ring assembly
(GO:2000431)
Regulation of protein kinase activity
(GO:0045859)
Regulation of small gtpase mediated signal transduction
(GO:0051056)
Small gtpase binding
(GO:0031267)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: germ cell (CL0000586)
Fold Change: 2.15
Marker Score: 3758
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.13
Marker Score: 1629
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.07
Marker Score: 638
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.05
Marker Score: 16373
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71791
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48015
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 448
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2728
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5074
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.84
Marker Score: 792
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.78
Marker Score: 1589
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1266
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.77
Marker Score: 230
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 570
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.75
Marker Score: 2026
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 384
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.73
Marker Score: 917.5
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.73
Marker Score: 408
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.72
Marker Score: 290
Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 633
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2836.5
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: plasmablast (CL0000980)
Fold Change: 0.66
Marker Score: 871
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.6
Marker Score: 189
Cell Name: oocyte (CL0000023)
Fold Change: 0.59
Marker Score: 147
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.58
Marker Score: 1365
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.57
Marker Score: 185
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.57
Marker Score: 609
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.56
Marker Score: 2177
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.56
Marker Score: 19459
Cell Name: male germ cell (CL0000015)
Fold Change: 0.56
Marker Score: 160
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 437
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.54
Marker Score: 177
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.54
Marker Score: 1317
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.53
Marker Score: 561
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.49
Marker Score: 764
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.49
Marker Score: 1445
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.49
Marker Score: 232
Cell Name: erythroblast (CL0000765)
Fold Change: 0.48
Marker Score: 302
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.48
Marker Score: 314
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.47
Marker Score: 572
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.47
Marker Score: 1070
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.46
Marker Score: 346
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.46
Marker Score: 28173
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.45
Marker Score: 3899
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.45
Marker Score: 223
Cell Name: Unknown (CL0000548)
Fold Change: 0.45
Marker Score: 328
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.45
Marker Score: 261
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.44
Marker Score: 2784
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.42
Marker Score: 403
Cell Name: osteoclast (CL0000092)
Fold Change: 0.41
Marker Score: 206
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.41
Marker Score: 204
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.41
Marker Score: 143
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.41
Marker Score: 4210
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4
Marker Score: 167
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.4
Marker Score: 252
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.4
Marker Score: 115
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.4
Marker Score: 1077
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.39
Marker Score: 315
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.39
Marker Score: 338
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.39
Marker Score: 1445
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.39
Marker Score: 97
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.38
Marker Score: 230
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.38
Marker Score: 216
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.37
Marker Score: 3551
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 375
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.37
Marker Score: 632
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.37
Marker Score: 245
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.37
Marker Score: 162
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.36
Marker Score: 324
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.36
Marker Score: 1420
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.36
Marker Score: 95
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.36
Marker Score: 98
Cell Name: basal cell (CL0000646)
Fold Change: 0.35
Marker Score: 457
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.35
Marker Score: 399
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.35
Marker Score: 119
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.35
Marker Score: 91
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.35
Marker Score: 732
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.35
Marker Score: 99
Cell Name: stem cell (CL0000034)
Fold Change: 0.35
Marker Score: 829
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.35
Marker Score: 617
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.34
Marker Score: 144
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.34
Marker Score: 99
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.34
Marker Score: 107
Cell Name: neural cell (CL0002319)
Fold Change: 0.34
Marker Score: 163
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.34
Marker Score: 141
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.33
Marker Score: 307
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.33
Marker Score: 320
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.33
Marker Score: 261
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.33
Marker Score: 152
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.33
Marker Score: 104
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.32
Marker Score: 206
Cell Name: secretory cell (CL0000151)
Fold Change: 0.32
Marker Score: 589
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.32
Marker Score: 111
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.32
Marker Score: 471

Hover over a box to see details here...

**Key characteristics:** * It is a transmembrane protein with 17 transmembrane domains. * It is a member of the ECT family of GTPases. * It is involved in the regulation of cell cycle progression, apoptosis, and migration. * It is a key regulator of epithelial cell survival. **Pathways and functions:** * **Cdc42 gtpase cycle:** ECT2 is a downstream target of the cdc42 gtpase pathway, which is involved in cell cycle progression. * **Cell death signalling via nrage, nrif and nade:** ECT2 is a key regulator of cell death signalling through the N-cadherin-mediated galpha (12/13) signalling pathway. * **Death receptor signaling:** ECT2 is a downstream target of the death receptor (DR) pathway, which is involved in apoptosis. * **G alpha (12/13) signalling events:** ECT2 is a downstream target of the G alpha (12/13) signalling pathway, which is involved in cell cycle arrest and apoptosis. * **Gpcr downstream signalling:** ECT2 is a downstream target of the Gpcr (GPCR co-receptor) downstream signalling pathway, which is involved in cell migration and survival. * **Gtpase activator activity:** ECT2 is a key regulator of Gtpase activator activity, which is involved in cell cycle progression and apoptosis. * **Guanyl-nucleotide exchange factor activity:** ECT2 is a downstream target of the guanyl-nucleotide exchange factor (GEF) activity, which is involved in cell cycle regulation. * **Nrage signals death through jnk, P75 ntr receptor-mediated signalling:** ECT2 is a downstream target of the Nrage (N-ras GTPase-related protein) signalling pathway, which is involved in cell cycle arrest and apoptosis. * **Protein binding:** ECT2 interacts with various proteins, including p53, Bcl-xL, and p21. * **Rac1 gtpase cycle:** ECT2 is a downstream target of the Rac1 gtpase cycle, which is involved in cell migration and survival. * **Rhoa gtpase cycle:** ECT2 is a downstream target of the Rhoa gtpase cycle, which is involved in cell cycle regulation. * **Rhob gtpase cycle:** ECT2 is a downstream target of the Rhob gtpase cycle, which is involved in cell cycle regulation. * **Rho gtpase cycle:** ECT2 is a downstream target of the Rho gtpase cycle, which is involved in cell cycle regulation. * **Signaling by gpcr:** ECT2 is a downstream target of the gpcr signalling pathway, which is involved in cell migration and survival. * **Signaling by rho gtpases:** ECT2 is a downstream target of the rho gtpases, which are involved in cell cycle regulation and apoptosis. * **Signaling by rho gtpases:** ECT2 is a downstream target of the rho gtpases, which are involved in cell cycle regulation and apoptosis. * **Miro gtpases and rhobtb3:** ECT2 is a downstream target of the Miro gtpases and rhobtb3, which are involved in cell cycle regulation. * **Signal transduction:** ECT2 signals downstream through various intracellular pathways, including the cdc42 gtpase pathway, the Nrage pathway, the G alpha pathway, the gpcr pathway, the Rhoa pathway, the Rhob pathway, and the gpcr pathway. **Clinical significance:** * Mutations in the ECT2 gene have been linked to various human cancers, including breast cancer, lung cancer, and colon cancer. * Targeting ECT2 has been investigated as a therapeutic strategy for cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein ECT2

Genular Protein ID: 863546009

Symbol: ECT2_HUMAN

Name: Protein ECT2

UniProtKB Accession Codes:

Q9H8V3 Q0MT80 Q2M269 Q6U836 Q9NSV8 Q9NVW9

Database IDs:

Citations:

PubMed ID: 10579713

Title: Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.

PubMed ID: 10579713

DOI: 10.1083/jcb.147.5.921

PubMed ID: 14587037

Title: Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains.

PubMed ID: 14587037

DOI: 10.1002/jcb.10688

PubMed ID: 17115030

Title: The armadillo protein p0071 regulates Rho signalling during cytokinesis.

PubMed ID: 17115030

DOI: 10.1038/ncb1504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14645260

Title: Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.

PubMed ID: 14645260

DOI: 10.1074/jbc.m306725200

PubMed ID: 15254234

Title: Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity.

PubMed ID: 15254234

DOI: 10.1128/mcb.24.15.6665-6675.2004

PubMed ID: 15545273

Title: The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.

PubMed ID: 15545273

DOI: 10.1074/jbc.m409298200

PubMed ID: 15642749

Title: Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.

PubMed ID: 15642749

DOI: 10.1083/jcb.200408085

PubMed ID: 16103226

Title: An ECT2-centralspindlin complex regulates the localization and function of RhoA.

PubMed ID: 16103226

DOI: 10.1083/jcb.200501097

PubMed ID: 16129829

Title: MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.

PubMed ID: 16129829

DOI: 10.1073/pnas.0504145102

PubMed ID: 16495035

Title: Nucleotide exchange factor ECT2 regulates epithelial cell polarity.

PubMed ID: 16495035

DOI: 10.1016/j.cellsig.2006.01.007

PubMed ID: 16394104

Title: Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle.

PubMed ID: 16394104

DOI: 10.1091/mbc.e05-03-0237

PubMed ID: 16236794

Title: Dissecting the role of Rho-mediated signaling in contractile ring formation.

PubMed ID: 16236794

DOI: 10.1091/mbc.e05-06-0569

PubMed ID: 16170345

Title: Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase.

PubMed ID: 16170345

DOI: 10.1038/sj.onc.1209078

PubMed ID: 16247472

Title: Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.

PubMed ID: 16247472

DOI: 10.1038/sj.onc.1209124

PubMed ID: 18511905

Title: Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis.

PubMed ID: 18511905

DOI: 10.1038/emboj.2008.112

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19129481

Title: Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle.

PubMed ID: 19129481

DOI: 10.1091/mbc.e08-01-0001

PubMed ID: 19617897

Title: Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.

PubMed ID: 19617897

DOI: 10.1038/onc.2009.217

PubMed ID: 19468300

Title: Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.

PubMed ID: 19468300

DOI: 10.1371/journal.pbio.1000110

PubMed ID: 19468302

Title: Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.

PubMed ID: 19468302

DOI: 10.1371/journal.pbio.1000111

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21189248

Title: Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.

PubMed ID: 21189248

DOI: 10.1074/jbc.m110.196113

PubMed ID: 21373644

Title: The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.

PubMed ID: 21373644

DOI: 10.1371/journal.pone.0017108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 25068414

Title: Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4.

PubMed ID: 25068414

DOI: 10.1016/j.febslet.2014.07.019

PubMed ID: 31888991

Title: Structure and regulation of human epithelial cell transforming 2 protein.

PubMed ID: 31888991

DOI: 10.1073/pnas.1913054117

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 914
Mass: 103505
Checksum: F40FC4F982FB8C78
Sequence:

MAENSVLTST TGRTSLADSS IFDSKVTEIS KENLLIGSTS YVEEEMPQIE TRVILVQEAG 
KQEELIKALK TIKIMEVPVI KIKESCPGKS DEKLIKSVIN MDIKVGFVKM ESVEEFEGLD 
SPEFENVFVV TDFQDSVFND LYKADCRVIG PPVVLNCSQK GEPLPFSCRP LYCTSMMNLV 
LCFTGFRKKE ELVRLVTLVH HMGGVIRKDF NSKVTHLVAN CTQGEKFRVA VSLGTPIMKP 
EWIYKAWERR NEQDFYAAVD DFRNEFKVPP FQDCILSFLG FSDEEKTNME EMTEMQGGKY 
LPLGDERCTH LVVEENIVKD LPFEPSKKLY VVKQEWFWGS IQMDARAGET MYLYEKANTP 
ELKKSVSMLS LNTPNSNRKR RRLKETLAQL SRETDVSPFP PRKRPSAEHS LSIGSLLDIS 
NTPESSINYG DTPKSCTKSS KSSTPVPSKQ SARWQVAKEL YQTESNYVNI LATIIQLFQV 
PLEEEGQRGG PILAPEEIKT IFGSIPDIFD VHTKIKDDLE DLIVNWDESK SIGDIFLKYS 
KDLVKTYPPF VNFFEMSKET IIKCEKQKPR FHAFLKINQA KPECGRQSLV ELLIRPVQRL 
PSVALLLNDL KKHTADENPD KSTLEKAIGS LKEVMTHINE DKRKTEAQKQ IFDVVYEVDG 
CPANLLSSHR SLVQRVETIS LGEHPCDRGE QVTLFLFNDC LEIARKRHKV IGTFRSPHGQ 
TRPPASLKHI HLMPLSQIKK VLDIRETEDC HNAFALLVRP PTEQANVLLS FQMTSDELPK 
ENWLKMLCRH VANTICKADA ENLIYTADPE SFEVNTKDMD STLSRASRAI KKTSKKVTRA 
FSFSKTPKRA LRRALMTSHG SVEGRSPSSN DKHVMSRLSS TSSLAGIPSP SLVSLPSFFE 
RRSHTLSRST THLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ECT2

Associated with

Cells (max top 100)

Other Information

Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. PubMed ID: 10579713

Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains. PubMed ID: 14587037

The armadillo protein p0071 regulates Rho signalling during cytokinesis. PubMed ID: 17115030

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation. PubMed ID: 14645260

Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity. PubMed ID: 15254234

The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. PubMed ID: 15545273

Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. PubMed ID: 15642749

An ECT2-centralspindlin complex regulates the localization and function of RhoA. PubMed ID: 16103226

MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. PubMed ID: 16129829

Nucleotide exchange factor ECT2 regulates epithelial cell polarity. PubMed ID: 16495035

Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. PubMed ID: 16394104

Dissecting the role of Rho-mediated signaling in contractile ring formation. PubMed ID: 16236794

Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase. PubMed ID: 16170345

Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. PubMed ID: 16247472

Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. PubMed ID: 18511905

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. PubMed ID: 19129481

Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. PubMed ID: 19617897

Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PubMed ID: 19468300

Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PubMed ID: 19468302

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation. PubMed ID: 21189248

The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage. PubMed ID: 21373644

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4. PubMed ID: 25068414

Structure and regulation of human epithelial cell transforming 2 protein. PubMed ID: 31888991

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974