Details for: ECT2

Gene ID: 1894

Symbol: ECT2

Ensembl ID: ENSG00000114346

Description: epithelial cell transforming 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.9340
    Cell Significance Index: -13.6800
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 53.3607
    Cell Significance Index: -8.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 33.1110
    Cell Significance Index: -13.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.3164
    Cell Significance Index: -11.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 21.0723
    Cell Significance Index: -14.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.9817
    Cell Significance Index: -13.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7769
    Cell Significance Index: 175.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2505
    Cell Significance Index: 136.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9985
    Cell Significance Index: 62.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9385
    Cell Significance Index: 152.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9168
    Cell Significance Index: 51.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6673
    Cell Significance Index: 132.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6421
    Cell Significance Index: 38.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4772
    Cell Significance Index: 24.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4463
    Cell Significance Index: 20.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3723
    Cell Significance Index: 9.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3688
    Cell Significance Index: 10.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3528
    Cell Significance Index: 192.6900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3523
    Cell Significance Index: 4.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3028
    Cell Significance Index: 6.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2822
    Cell Significance Index: 1.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2637
    Cell Significance Index: 52.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2494
    Cell Significance Index: 17.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2329
    Cell Significance Index: 27.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2183
    Cell Significance Index: 6.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2045
    Cell Significance Index: 6.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1942
    Cell Significance Index: 2.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1925
    Cell Significance Index: 4.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1900
    Cell Significance Index: 4.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1376
    Cell Significance Index: 16.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1334
    Cell Significance Index: 6.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1022
    Cell Significance Index: 3.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0904
    Cell Significance Index: 16.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0813
    Cell Significance Index: 35.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0717
    Cell Significance Index: 13.6400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0701
    Cell Significance Index: 1.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0406
    Cell Significance Index: 28.1000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0384
    Cell Significance Index: 0.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0210
    Cell Significance Index: 0.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0203
    Cell Significance Index: 1.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0198
    Cell Significance Index: 0.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0119
    Cell Significance Index: 18.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0111
    Cell Significance Index: 20.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0059
    Cell Significance Index: 7.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0053
    Cell Significance Index: 4.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0049
    Cell Significance Index: 9.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0052
    Cell Significance Index: -3.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0123
    Cell Significance Index: -6.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0132
    Cell Significance Index: -2.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0137
    Cell Significance Index: -4.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0215
    Cell Significance Index: -9.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0287
    Cell Significance Index: -3.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0360
    Cell Significance Index: -10.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0390
    Cell Significance Index: -4.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0399
    Cell Significance Index: -5.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0446
    Cell Significance Index: -4.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0453
    Cell Significance Index: -9.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0547
    Cell Significance Index: -6.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0575
    Cell Significance Index: -4.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0582
    Cell Significance Index: -7.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0618
    Cell Significance Index: -7.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0655
    Cell Significance Index: -8.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0684
    Cell Significance Index: -5.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0733
    Cell Significance Index: -3.4500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0785
    Cell Significance Index: -0.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0821
    Cell Significance Index: -3.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0831
    Cell Significance Index: -1.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0902
    Cell Significance Index: -1.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0951
    Cell Significance Index: -3.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1103
    Cell Significance Index: -7.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1113
    Cell Significance Index: -7.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1223
    Cell Significance Index: -12.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1407
    Cell Significance Index: -1.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1473
    Cell Significance Index: -9.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1622
    Cell Significance Index: -12.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1758
    Cell Significance Index: -11.3400
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1909
    Cell Significance Index: -2.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2110
    Cell Significance Index: -11.0800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2242
    Cell Significance Index: -1.6300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2266
    Cell Significance Index: -2.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2290
    Cell Significance Index: -14.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2754
    Cell Significance Index: -7.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2770
    Cell Significance Index: -6.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2771
    Cell Significance Index: -14.0000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2781
    Cell Significance Index: -1.6500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2909
    Cell Significance Index: -1.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2979
    Cell Significance Index: -8.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3101
    Cell Significance Index: -10.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3184
    Cell Significance Index: -4.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3201
    Cell Significance Index: -10.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3258
    Cell Significance Index: -8.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3269
    Cell Significance Index: -9.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3315
    Cell Significance Index: -12.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3328
    Cell Significance Index: -10.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3354
    Cell Significance Index: -8.8200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3409
    Cell Significance Index: -4.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GTPase Activity:** ECT2 is involved in the regulation of GTPase activity, which is essential for various cellular processes, including cell signaling, cytoskeletal dynamics, and protein degradation. 2. **Cell-Cell Junctions:** ECT2 is involved in the regulation of cell-cell junctions, including tight junctions, which are critical for maintaining tissue integrity and barrier function. 3. **Cytoskeletal Dynamics:** ECT2 regulates cytoskeletal dynamics, including the assembly and disassembly of actomyosin contractile rings, which is essential for cell migration, adhesion, and morphology. 4. **Signaling Pathways:** ECT2 is involved in the regulation of various signaling pathways, including the cdc42, Rac1, and Rho GTPase cycles, which are critical for cell signaling, migration, and proliferation. **Pathways and Functions:** 1. **Activation of GTPase Activity:** ECT2 regulates the activation of GTPase activity, which is essential for various cellular processes, including cell signaling, cytoskeletal dynamics, and protein degradation. 2. **Activation of Protein Kinase Activity:** ECT2 regulates the activation of protein kinase activity, which is critical for cell signaling, proliferation, and differentiation. 3. **Bicellular Tight Junction Assembly:** ECT2 is involved in the regulation of bicellular tight junction assembly, which is essential for maintaining tissue integrity and barrier function. 4. **Cell Death Signaling:** ECT2 regulates cell death signaling via NRAGE, NRIF, and NADE, which is critical for maintaining tissue homeostasis and preventing disease states. **Clinical Significance:** 1. **Tissue Homeostasis:** ECT2 plays a critical role in maintaining tissue homeostasis, and its dysregulation can lead to various disease states, including cancer, cardiovascular disease, and neurological disorders. 2. **Cancer:** ECT2 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and its dysregulation can lead to increased cell proliferation, migration, and invasion. 3. **Neurological Disorders:** ECT2 is involved in the regulation of neuronal development and function, and its dysregulation can lead to neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 4. **Immunological Disorders:** ECT2 regulates immune cell function, and its dysregulation can lead to immunological disorders, including autoimmune diseases and immunodeficiency diseases. In conclusion, the ECT2 gene is a multifaceted regulator of cellular processes, including cell-cell junctions, cytoskeletal dynamics, and signaling pathways. Its dysregulation can lead to various disease states, including cancer, cardiovascular disease, and neurological disorders. As an expert immunologist, it is essential to recognize the significance of ECT2 in maintaining tissue homeostasis and its implications in disease states.

Genular Protein ID: 863546009

Symbol: ECT2_HUMAN

Name: Protein ECT2

UniProtKB Accession Codes:

Q9H8V3 Q0MT80 Q2M269 Q6U836 Q9NSV8 Q9NVW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 4 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10579713

Title: Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.

PubMed ID: 10579713

DOI: 10.1083/jcb.147.5.921

PubMed ID: 14587037

Title: Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains.

PubMed ID: 14587037

DOI: 10.1002/jcb.10688

PubMed ID: 17115030

Title: The armadillo protein p0071 regulates Rho signalling during cytokinesis.

PubMed ID: 17115030

DOI: 10.1038/ncb1504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14645260

Title: Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.

PubMed ID: 14645260

DOI: 10.1074/jbc.m306725200

PubMed ID: 15254234

Title: Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity.

PubMed ID: 15254234

DOI: 10.1128/mcb.24.15.6665-6675.2004

PubMed ID: 15545273

Title: The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.

PubMed ID: 15545273

DOI: 10.1074/jbc.m409298200

PubMed ID: 15642749

Title: Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.

PubMed ID: 15642749

DOI: 10.1083/jcb.200408085

PubMed ID: 16103226

Title: An ECT2-centralspindlin complex regulates the localization and function of RhoA.

PubMed ID: 16103226

DOI: 10.1083/jcb.200501097

PubMed ID: 16129829

Title: MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.

PubMed ID: 16129829

DOI: 10.1073/pnas.0504145102

PubMed ID: 16495035

Title: Nucleotide exchange factor ECT2 regulates epithelial cell polarity.

PubMed ID: 16495035

DOI: 10.1016/j.cellsig.2006.01.007

PubMed ID: 16394104

Title: Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle.

PubMed ID: 16394104

DOI: 10.1091/mbc.e05-03-0237

PubMed ID: 16236794

Title: Dissecting the role of Rho-mediated signaling in contractile ring formation.

PubMed ID: 16236794

DOI: 10.1091/mbc.e05-06-0569

PubMed ID: 16170345

Title: Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase.

PubMed ID: 16170345

DOI: 10.1038/sj.onc.1209078

PubMed ID: 16247472

Title: Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.

PubMed ID: 16247472

DOI: 10.1038/sj.onc.1209124

PubMed ID: 18511905

Title: Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis.

PubMed ID: 18511905

DOI: 10.1038/emboj.2008.112

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19129481

Title: Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle.

PubMed ID: 19129481

DOI: 10.1091/mbc.e08-01-0001

PubMed ID: 19617897

Title: Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.

PubMed ID: 19617897

DOI: 10.1038/onc.2009.217

PubMed ID: 19468300

Title: Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.

PubMed ID: 19468300

DOI: 10.1371/journal.pbio.1000110

PubMed ID: 19468302

Title: Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.

PubMed ID: 19468302

DOI: 10.1371/journal.pbio.1000111

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21189248

Title: Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.

PubMed ID: 21189248

DOI: 10.1074/jbc.m110.196113

PubMed ID: 21373644

Title: The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.

PubMed ID: 21373644

DOI: 10.1371/journal.pone.0017108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 25068414

Title: Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4.

PubMed ID: 25068414

DOI: 10.1016/j.febslet.2014.07.019

PubMed ID: 31888991

Title: Structure and regulation of human epithelial cell transforming 2 protein.

PubMed ID: 31888991

DOI: 10.1073/pnas.1913054117

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 914
  • Mass: 103505
  • Checksum: F40FC4F982FB8C78
  • Sequence:
    • MAENSVLTST TGRTSLADSS IFDSKVTEIS KENLLIGSTS YVEEEMPQIE TRVILVQEAG 
KQEELIKALK TIKIMEVPVI KIKESCPGKS DEKLIKSVIN MDIKVGFVKM ESVEEFEGLD 
SPEFENVFVV TDFQDSVFND LYKADCRVIG PPVVLNCSQK GEPLPFSCRP LYCTSMMNLV 
LCFTGFRKKE ELVRLVTLVH HMGGVIRKDF NSKVTHLVAN CTQGEKFRVA VSLGTPIMKP 
EWIYKAWERR NEQDFYAAVD DFRNEFKVPP FQDCILSFLG FSDEEKTNME EMTEMQGGKY 
LPLGDERCTH LVVEENIVKD LPFEPSKKLY VVKQEWFWGS IQMDARAGET MYLYEKANTP 
ELKKSVSMLS LNTPNSNRKR RRLKETLAQL SRETDVSPFP PRKRPSAEHS LSIGSLLDIS 
NTPESSINYG DTPKSCTKSS KSSTPVPSKQ SARWQVAKEL YQTESNYVNI LATIIQLFQV 
PLEEEGQRGG PILAPEEIKT IFGSIPDIFD VHTKIKDDLE DLIVNWDESK SIGDIFLKYS 
KDLVKTYPPF VNFFEMSKET IIKCEKQKPR FHAFLKINQA KPECGRQSLV ELLIRPVQRL 
PSVALLLNDL KKHTADENPD KSTLEKAIGS LKEVMTHINE DKRKTEAQKQ IFDVVYEVDG 
CPANLLSSHR SLVQRVETIS LGEHPCDRGE QVTLFLFNDC LEIARKRHKV IGTFRSPHGQ 
TRPPASLKHI HLMPLSQIKK VLDIRETEDC HNAFALLVRP PTEQANVLLS FQMTSDELPK 
ENWLKMLCRH VANTICKADA ENLIYTADPE SFEVNTKDMD STLSRASRAI KKTSKKVTRA 
FSFSKTPKRA LRRALMTSHG SVEGRSPSSN DKHVMSRLSS TSSLAGIPSP SLVSLPSFFE 
RRSHTLSRST THLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.