Details for: EDNRA

Gene ID: 1909

Symbol: EDNRA

Ensembl ID: ENSG00000151617

Description: endothelin receptor type A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.9472
    Cell Significance Index: -18.8600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 7.0335
    Cell Significance Index: 59.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4556
    Cell Significance Index: -11.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.1995
    Cell Significance Index: 66.9700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.1705
    Cell Significance Index: 19.6200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.6850
    Cell Significance Index: 7.7800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4422
    Cell Significance Index: 18.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.1928
    Cell Significance Index: 17.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0693
    Cell Significance Index: 82.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5751
    Cell Significance Index: 78.9800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.5135
    Cell Significance Index: 16.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3739
    Cell Significance Index: 10.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1239
    Cell Significance Index: 8.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0947
    Cell Significance Index: 42.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0876
    Cell Significance Index: 38.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0541
    Cell Significance Index: 0.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0427
    Cell Significance Index: 26.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0319
    Cell Significance Index: 11.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0019
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0066
    Cell Significance Index: -12.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0077
    Cell Significance Index: -11.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0113
    Cell Significance Index: -8.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0120
    Cell Significance Index: -16.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0145
    Cell Significance Index: -2.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0164
    Cell Significance Index: -9.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0184
    Cell Significance Index: -3.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0189
    Cell Significance Index: -13.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0228
    Cell Significance Index: -17.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0253
    Cell Significance Index: -18.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0254
    Cell Significance Index: -16.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0313
    Cell Significance Index: -6.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0339
    Cell Significance Index: -4.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0359
    Cell Significance Index: -19.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0360
    Cell Significance Index: -0.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0538
    Cell Significance Index: -15.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0661
    Cell Significance Index: -11.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0800
    Cell Significance Index: -11.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0801
    Cell Significance Index: -14.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1186
    Cell Significance Index: -14.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1373
    Cell Significance Index: -15.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1415
    Cell Significance Index: -18.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1559
    Cell Significance Index: -18.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1619
    Cell Significance Index: -16.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1626
    Cell Significance Index: -18.6300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1663
    Cell Significance Index: -2.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1825
    Cell Significance Index: -19.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2426
    Cell Significance Index: -14.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2548
    Cell Significance Index: -18.9900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2555
    Cell Significance Index: -2.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2623
    Cell Significance Index: -14.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2630
    Cell Significance Index: -5.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2722
    Cell Significance Index: -18.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2763
    Cell Significance Index: -7.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2784
    Cell Significance Index: -8.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2785
    Cell Significance Index: -14.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2878
    Cell Significance Index: -13.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2891
    Cell Significance Index: -15.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2911
    Cell Significance Index: -13.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2970
    Cell Significance Index: -18.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3252
    Cell Significance Index: -8.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3485
    Cell Significance Index: -11.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3522
    Cell Significance Index: -12.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3600
    Cell Significance Index: -8.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3758
    Cell Significance Index: -3.8900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3930
    Cell Significance Index: -3.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3948
    Cell Significance Index: -10.3800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.3981
    Cell Significance Index: -3.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4253
    Cell Significance Index: -18.8100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.4357
    Cell Significance Index: -4.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4370
    Cell Significance Index: -22.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4924
    Cell Significance Index: -18.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4958
    Cell Significance Index: -5.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4959
    Cell Significance Index: -10.6000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.5061
    Cell Significance Index: -3.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5078
    Cell Significance Index: -17.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5099
    Cell Significance Index: -13.8800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.5463
    Cell Significance Index: -3.4200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5465
    Cell Significance Index: -9.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5541
    Cell Significance Index: -20.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5723
    Cell Significance Index: -11.4900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5730
    Cell Significance Index: -9.0900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.5737
    Cell Significance Index: -8.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5802
    Cell Significance Index: -18.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6009
    Cell Significance Index: -16.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6133
    Cell Significance Index: -21.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6139
    Cell Significance Index: -15.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6179
    Cell Significance Index: -12.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6238
    Cell Significance Index: -14.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6259
    Cell Significance Index: -25.6400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6479
    Cell Significance Index: -8.3100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6587
    Cell Significance Index: -9.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6591
    Cell Significance Index: -18.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6642
    Cell Significance Index: -17.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6717
    Cell Significance Index: -11.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6734
    Cell Significance Index: -18.0500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6799
    Cell Significance Index: -14.1900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6881
    Cell Significance Index: -29.9200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7039
    Cell Significance Index: -17.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7352
    Cell Significance Index: -18.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **G-protein coupled receptor (GPCR)**: ETAR belongs to the class A/1 (rhodopsin-like receptors) and is characterized by its ability to bind to ET-1 and activate G-protein coupled signaling pathways. 2. **Vasoconstrictor response**: ETAR activation leads to the activation of phospholipase C (PLC) and the subsequent production of inositol trisphosphate (IP3) and diacylglycerol (DAG), resulting in vasoconstriction. 3. **Cardiac function regulation**: ETAR plays a crucial role in regulating cardiac function, including heart rate, cardiac chamber formation, and left ventricular cardiac muscle tissue morphogenesis. 4. **Smooth muscle contraction**: ETAR activation leads to the contraction of smooth muscle cells, which is essential for regulating blood pressure and vascular tone. **Pathways and Functions** The EDNRA gene's product, ETAR, is involved in various signaling pathways, including: 1. **Activation of adenylate cyclase activity**: ETAR activation leads to the activation of adenylate cyclase, resulting in an increase in cyclic AMP (cAMP) levels, which in turn regulates cardiac function and smooth muscle contraction. 2. **Activation of phospholipase C activity**: ETAR activation leads to the activation of PLC, resulting in the production of IP3 and DAG, which regulate calcium ion homeostasis and smooth muscle contraction. 3. **Regulation of blood pressure**: ETAR plays a crucial role in regulating blood pressure by modulating vascular tone and cardiac function. 4. **Cardiac neural crest cell migration**: ETAR is involved in the migration of cardiac neural crest cells, which is essential for the development of the heart. **Clinical Significance** Dysregulation of the EDNRA gene and its product, ETAR, has been implicated in various cardiovascular and neurological disorders, including: 1. **Hypertension**: ETAR overexpression has been linked to hypertension, as it leads to vasoconstriction and increased blood pressure. 2. **Cardiac arrhythmias**: ETAR dysregulation has been implicated in cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 3. **Neurological disorders**: ETAR has been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). In conclusion, the EDNRA gene plays a crucial role in regulating various physiological and pathological processes, including blood pressure, cardiac function, and smooth muscle contraction. Understanding the mechanisms of ETAR signaling is essential for the development of novel therapeutic strategies for cardiovascular and neurological disorders.

Genular Protein ID: 3265894552

Symbol: EDNRA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P25101 B2R723 B4E2V6 B7Z9G6 D3DP03 E7ER36 O43441 Q16432 Q16433 Q8TBH2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 14 DrugCentral 1 EMBL 22 Ensembl 7 GO 77 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1719979

Title: Cloning and characterization of cDNA encoding human A-type endothelin receptor.

PubMed ID: 1719979

DOI: 10.1016/s0006-291x(05)81332-4

PubMed ID: 1659806

Title: Cloning and chromosomal localization of a human endothelin ETA receptor.

PubMed ID: 1659806

DOI: 10.1016/s0006-291x(05)81399-3

PubMed ID: 1652463

Title: Cloning and expression of human endothelin-1 receptor cDNA.

PubMed ID: 1652463

DOI: 10.1016/0014-5793(91)80007-p

PubMed ID: 1291713

Title: Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells.

PubMed ID: 1291713

DOI: 10.1253/jcj.56.supplementv_1303

PubMed ID: 8440682

Title: Molecular characterization and regulation of the human endothelin receptors.

PubMed ID: 8440682

DOI: 10.1016/s0021-9258(18)53554-7

PubMed ID: 1326535

Title: Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor.

PubMed ID: 1326535

DOI: 10.1016/s0021-9258(19)37031-0

PubMed ID: 1415318

Title: Cloning and expression of a human endothelin receptor: subtype A.

PubMed ID: 1415318

DOI: 10.1097/00000441-199210000-00002

PubMed ID: 8611157

Title: Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts.

PubMed ID: 8611157

DOI: 10.1042/bj3130795

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8427579

Title: Molecular characterization of the 5'-flanking region of human genomic ETA gene.

PubMed ID: 8427579

DOI: 10.1006/bbrc.1993.1052

PubMed ID: 9284755

Title: Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.

PubMed ID: 9284755

DOI: 10.1210/jcem.82.9.4209

PubMed ID: 11262386

Title: Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling.

PubMed ID: 11262386

DOI: 10.1074/jbc.c000909200

PubMed ID: 25772936

Title: Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia.

PubMed ID: 25772936

DOI: 10.1016/j.ajhg.2015.01.015

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 427
  • Mass: 48722
  • Checksum: 207272D4A231404F
  • Sequence:
    • METLCLRASF WLALVGCVIS DNPERYSTNL SNHVDDFTTF RGTELSFLVT THQPTNLVLP 
SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA 
SLALGDLIYV VIDLPINVFK LLAGRWPFDH NDFGVFLCKL FPFLQKSSVG ITVLNLCALS 
VDRYRAVASW SRVQGIGIPL VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YRGEQHKTCM 
LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYNEMDKNR CELLSFLLLM DYIGINLATM 
NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM NGTSIQWKNH DQNNHNTDRS 
SHKDSMN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.