Details for: EEF1A2

Gene ID: 1917

Symbol: EEF1A2

Ensembl ID: ENSG00000101210

Description: eukaryotic translation elongation factor 1 alpha 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.8940
    Cell Significance Index: 45.4300
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 5.3877
    Cell Significance Index: 15.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.2313
    Cell Significance Index: 103.2400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 4.0328
    Cell Significance Index: 65.0700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.1167
    Cell Significance Index: 34.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7949
    Cell Significance Index: 93.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.6876
    Cell Significance Index: 48.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3412
    Cell Significance Index: 269.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2791
    Cell Significance Index: 149.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7421
    Cell Significance Index: 266.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6515
    Cell Significance Index: 43.8100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.6506
    Cell Significance Index: 5.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6309
    Cell Significance Index: 5.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5820
    Cell Significance Index: 44.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4896
    Cell Significance Index: 10.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3826
    Cell Significance Index: 23.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3145
    Cell Significance Index: 23.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2258
    Cell Significance Index: 3.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1551
    Cell Significance Index: 107.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1351
    Cell Significance Index: 3.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1314
    Cell Significance Index: 1.9400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1155
    Cell Significance Index: 2.8800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0663
    Cell Significance Index: 0.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0238
    Cell Significance Index: 1.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0195
    Cell Significance Index: 10.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0105
    Cell Significance Index: 0.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0093
    Cell Significance Index: 1.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0085
    Cell Significance Index: 1.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0144
    Cell Significance Index: -27.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0151
    Cell Significance Index: -27.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0181
    Cell Significance Index: -27.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0184
    Cell Significance Index: -13.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0202
    Cell Significance Index: -27.5000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0238
    Cell Significance Index: -0.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0245
    Cell Significance Index: -13.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0335
    Cell Significance Index: -24.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0378
    Cell Significance Index: -24.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0392
    Cell Significance Index: -17.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0447
    Cell Significance Index: -27.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0463
    Cell Significance Index: -1.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0498
    Cell Significance Index: -22.6000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0643
    Cell Significance Index: -0.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0774
    Cell Significance Index: -22.2700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1115
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1136
    Cell Significance Index: -23.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1149
    Cell Significance Index: -19.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1274
    Cell Significance Index: -25.2800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1289
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1342
    Cell Significance Index: -15.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1688
    Cell Significance Index: -21.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1699
    Cell Significance Index: -24.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1726
    Cell Significance Index: -9.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1960
    Cell Significance Index: -26.9100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1973
    Cell Significance Index: -2.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2190
    Cell Significance Index: -25.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2241
    Cell Significance Index: -22.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2624
    Cell Significance Index: -27.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2884
    Cell Significance Index: -6.1200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.2966
    Cell Significance Index: -2.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3036
    Cell Significance Index: -9.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3037
    Cell Significance Index: -19.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3042
    Cell Significance Index: -8.5000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3105
    Cell Significance Index: -6.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3218
    Cell Significance Index: -10.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3243
    Cell Significance Index: -6.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3432
    Cell Significance Index: -15.1800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3545
    Cell Significance Index: -4.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3632
    Cell Significance Index: -20.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3971
    Cell Significance Index: -25.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3990
    Cell Significance Index: -15.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4089
    Cell Significance Index: -25.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4168
    Cell Significance Index: -21.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4366
    Cell Significance Index: -19.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4522
    Cell Significance Index: -15.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4538
    Cell Significance Index: -21.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4703
    Cell Significance Index: -10.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5224
    Cell Significance Index: -13.0300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5368
    Cell Significance Index: -6.7800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5433
    Cell Significance Index: -5.1500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5553
    Cell Significance Index: -11.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5639
    Cell Significance Index: -8.0800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5820
    Cell Significance Index: -6.7900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.6221
    Cell Significance Index: -6.4800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6678
    Cell Significance Index: -14.2800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.6799
    Cell Significance Index: -10.1700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6966
    Cell Significance Index: -8.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7144
    Cell Significance Index: -24.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7268
    Cell Significance Index: -36.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7328
    Cell Significance Index: -26.9000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.7368
    Cell Significance Index: -9.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7732
    Cell Significance Index: -27.1700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7889
    Cell Significance Index: -15.5300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8320
    Cell Significance Index: -5.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.8363
    Cell Significance Index: -26.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8442
    Cell Significance Index: -24.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8461
    Cell Significance Index: -24.9200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8587
    Cell Significance Index: -37.3400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8654
    Cell Significance Index: -10.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8798
    Cell Significance Index: -25.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9202
    Cell Significance Index: -24.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EEF1A2 is a member of the elongation factor 1 alpha (EF1A) family, which is essential for the elongation phase of protein synthesis. The gene is characterized by its ability to bind to GTP, a crucial energy source for protein translation. EEF1A2 is also involved in regulating the activity of other proteins, including chaperone-mediated autophagy and lipid kinases, highlighting its pivotal role in modulating cellular metabolism. Notably, EEF1A2 is highly expressed in cells with high protein synthesis rates, such as neurons and skeletal muscle cells, underscoring its importance in maintaining cellular function and integrity. **Pathways and Functions:** EEF1A2 is integrated into several key cellular pathways, including: 1. **Eukaryotic Translation Elongation**: EEF1A2 facilitates the elongation phase of protein translation, ensuring the accurate assembly of amino acids into polypeptide chains. 2. **Apoptosis Regulation**: EEF1A2 modulates the apoptotic process by regulating the activity of pro-apoptotic and anti-apoptotic proteins. 3. **Lipid Kinase Activity**: EEF1A2 regulates the activity of lipid kinases, which are essential for lipid metabolism and cellular homeostasis. 4. **Chaperone-Mediated Autophagy**: EEF1A2 modulates the activity of chaperone-mediated autophagy, a process essential for maintaining cellular homeostasis. 5. **RNA Binding**: EEF1A2 interacts with RNA molecules, influencing the translation of specific mRNAs. **Clinical Significance:** Dysregulation of EEF1A2 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders**: EEF1A2 mutations have been linked to neurodegenerative disorders, such as Parkinson's disease and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: EEF1A2 is overexpressed in certain types of cancer, including colon cancer and glioblastoma. 3. **Metabolic Disorders**: EEF1A2 dysregulation has been implicated in metabolic disorders, such as obesity and type 2 diabetes. In conclusion, EEF1A2 is a critical gene that plays a multifaceted role in regulating protein synthesis, apoptosis, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the immunological significance of this gene.

Genular Protein ID: 1826005495

Symbol: EF1A2_HUMAN

Name: Elongation factor 1-alpha 2

UniProtKB Accession Codes:

Q05639 B5BUF3 E1P5J1 P54266 Q0VGC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8354261

Title: Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha.

PubMed ID: 8354261

DOI: 10.1111/j.1432-1033.1993.tb18064.x

PubMed ID: 10950927

Title: The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity.

PubMed ID: 10950927

DOI: 10.1006/geno.2000.6271

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7945283

Title: Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway.

PubMed ID: 7945283

DOI: 10.1006/bbrc.1994.2336

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28108655

Title: The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A).

PubMed ID: 28108655

DOI: 10.1093/nar/gkx002

PubMed ID: 28520920

Title: Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.

PubMed ID: 28520920

DOI: 10.1093/nar/gkx432

PubMed ID: 30612740

Title: METTL13 methylation of eEF1A increases translational output to promote tumorigenesis.

PubMed ID: 30612740

DOI: 10.1016/j.cell.2018.11.038

PubMed ID: 30143613

Title: The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.

PubMed ID: 30143613

DOI: 10.1038/s41467-018-05646-y

PubMed ID: 18697946

Title: The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles.

PubMed ID: 18697946

DOI: 10.1073/pnas.0805810105

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 23647072

Title: Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.

PubMed ID: 23647072

DOI: 10.1111/epi.12201

PubMed ID: 24697219

Title: De novo EEF1A2 mutations in patients with characteristic facial features, intellectual disability, autistic behaviors and epilepsy.

PubMed ID: 24697219

DOI: 10.1111/cge.12394

PubMed ID: 26740508

Title: Identification of novel genetic causes of Rett syndrome-like phenotypes.

PubMed ID: 26740508

DOI: 10.1136/jmedgenet-2015-103568

Sequence Information:

  • Length: 463
  • Mass: 50470
  • Checksum: 31E4E341CEE797EC
  • Sequence:
    • MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL 
DKLKAERERG ITIDISLWKF ETTKYYITII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV 
GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP AYSEKRYDEI VKEVSAYIKK 
IGYNPATVPF VPISGWHGDN MLEPSPNMPW FKGWKVERKE GNASGVSLLE ALDTILPPTR 
PTDKPLRLPL QDVYKIGGIG TVPVGRVETG ILRPGMVVTF APVNITTEVK SVEMHHEALS 
EALPGDNVGF NVKNVSVKDI RRGNVCGDSK SDPPQEAAQF TSQVIILNHP GQISAGYSPV 
IDCHTAHIAC KFAELKEKID RRSGKKLEDN PKSLKSGDAA IVEMVPGKPM CVESFSQYPP 
LGRFAVRDMR QTVAVGVIKN VEKKSGGAGK VTKSAQKAQK AGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.