Details for: EEF1A2

Gene ID: 1917

Symbol: EEF1A2

Ensembl ID: ENSG00000101210

Description: eukaryotic translation elongation factor 1 alpha 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 4.55
    Marker Score: 3461
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.59
    Marker Score: 5048
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.33
    Marker Score: 1724
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.52
    Marker Score: 831
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.28
    Marker Score: 2562
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.14
    Marker Score: 8697
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.79
    Marker Score: 590
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.7
    Marker Score: 17527
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.53
    Marker Score: 513
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.48
    Marker Score: 619
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169008
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.45
    Marker Score: 19247
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.34
    Marker Score: 11477
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.33
    Marker Score: 81863
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.29
    Marker Score: 1990
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18766
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.2
    Marker Score: 45469
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.18
    Marker Score: 4547
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.17
    Marker Score: 5420
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.17
    Marker Score: 319
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.17
    Marker Score: 1718
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4814
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.15
    Marker Score: 10891
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.14
    Marker Score: 724.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.11
    Marker Score: 41076
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.09
    Marker Score: 10219
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.07
    Marker Score: 240
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.06
    Marker Score: 4399
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.06
    Marker Score: 628
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.05
    Marker Score: 713
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.05
    Marker Score: 20869
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.02
    Marker Score: 533
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.02
    Marker Score: 15190
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1
    Marker Score: 7697
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1
    Marker Score: 472
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.94
    Marker Score: 433
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.93
    Marker Score: 20676
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.88
    Marker Score: 29555
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.85
    Marker Score: 1928
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.79
    Marker Score: 401.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.71
    Marker Score: 253
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7
    Marker Score: 1334
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.67
    Marker Score: 196
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.67
    Marker Score: 2572
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.66
    Marker Score: 201
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.63
    Marker Score: 1125
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.63
    Marker Score: 189.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.63
    Marker Score: 3764
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 395.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.59
    Marker Score: 2105
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.59
    Marker Score: 389
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.59
    Marker Score: 220
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.58
    Marker Score: 289
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.53
    Marker Score: 3973
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.53
    Marker Score: 9352
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.52
    Marker Score: 1205
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.5
    Marker Score: 520
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.5
    Marker Score: 834
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.48
    Marker Score: 3081
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 199
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.47
    Marker Score: 148
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.46
    Marker Score: 147
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.45
    Marker Score: 1890
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.45
    Marker Score: 948
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.44
    Marker Score: 2365
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.44
    Marker Score: 2913
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.44
    Marker Score: 181
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.43
    Marker Score: 174
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.43
    Marker Score: 680
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.42
    Marker Score: 520
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.42
    Marker Score: 844
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.4
    Marker Score: 380
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.39
    Marker Score: 940
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.38
    Marker Score: 126
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.37
    Marker Score: 829
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.36
    Marker Score: 3667
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.35
    Marker Score: 167
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.35
    Marker Score: 1819

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Other Information

**Key characteristics:** * EF1A2 is a cytoplasmic protein with a molecular weight of approximately 120 kDa. * It is a key component of the eukaryotic translation elongation factor 1 (EEF1A1/EF1A3) complex. * EF1A2 is responsible for the initiation of translation elongation by promoting the release of eEF2 from its interaction with GTP. * It also regulates the activity of other translation factors, such as EF1A1 and EF1A3. **Pathways and functions:** * EF1A2 is involved in various cellular processes, including protein synthesis, cell cycle regulation, and apoptosis. * It is essential for the initiation of translation elongation in eukaryotic cells. * It interacts with the 4E-BP1 protein, which is a negative regulator of translation. * By binding to 4E-BP1, EF1A2 prevents its interaction with eEF2, which is required for the initiation of translation elongation. * This allows eEF2 to bind to the ribosome and initiate translation. **Clinical significance:** * Mutations in the EEF1A2 gene have been linked to several human diseases, including cancer, neurodegenerative disorders, and metabolic diseases. * Overexpression of EF1A2 has been observed in cancer cells, where it promotes tumor growth and metastasis. * Inhibition of EF1A2 has shown antitumor effects in preclinical models. **Additional information:** * EF1A2 is a highly conserved protein in mammals. * It is a well-characterized target for cancer therapy. * The expression of EF1A2 is regulated by various factors, including growth factors, cytokines, and hormones.

Genular Protein ID: 1826005495

Symbol: EF1A2_HUMAN

Name: Elongation factor 1-alpha 2

UniProtKB Accession Codes:

Q05639 B5BUF3 E1P5J1 P54266 Q0VGC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8354261

Title: Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha.

PubMed ID: 8354261

DOI: 10.1111/j.1432-1033.1993.tb18064.x

PubMed ID: 10950927

Title: The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity.

PubMed ID: 10950927

DOI: 10.1006/geno.2000.6271

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7945283

Title: Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway.

PubMed ID: 7945283

DOI: 10.1006/bbrc.1994.2336

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28108655

Title: The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A).

PubMed ID: 28108655

DOI: 10.1093/nar/gkx002

PubMed ID: 28520920

Title: Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.

PubMed ID: 28520920

DOI: 10.1093/nar/gkx432

PubMed ID: 30612740

Title: METTL13 methylation of eEF1A increases translational output to promote tumorigenesis.

PubMed ID: 30612740

DOI: 10.1016/j.cell.2018.11.038

PubMed ID: 30143613

Title: The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.

PubMed ID: 30143613

DOI: 10.1038/s41467-018-05646-y

PubMed ID: 18697946

Title: The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles.

PubMed ID: 18697946

DOI: 10.1073/pnas.0805810105

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 23647072

Title: Exome sequencing reveals new causal mutations in children with epileptic encephalopathies.

PubMed ID: 23647072

DOI: 10.1111/epi.12201

PubMed ID: 24697219

Title: De novo EEF1A2 mutations in patients with characteristic facial features, intellectual disability, autistic behaviors and epilepsy.

PubMed ID: 24697219

DOI: 10.1111/cge.12394

PubMed ID: 26740508

Title: Identification of novel genetic causes of Rett syndrome-like phenotypes.

PubMed ID: 26740508

DOI: 10.1136/jmedgenet-2015-103568

Sequence Information:

  • Length: 463
  • Mass: 50470
  • Checksum: 31E4E341CEE797EC
  • Sequence:
    • MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL 
DKLKAERERG ITIDISLWKF ETTKYYITII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV 
GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP AYSEKRYDEI VKEVSAYIKK 
IGYNPATVPF VPISGWHGDN MLEPSPNMPW FKGWKVERKE GNASGVSLLE ALDTILPPTR 
PTDKPLRLPL QDVYKIGGIG TVPVGRVETG ILRPGMVVTF APVNITTEVK SVEMHHEALS 
EALPGDNVGF NVKNVSVKDI RRGNVCGDSK SDPPQEAAQF TSQVIILNHP GQISAGYSPV 
IDCHTAHIAC KFAELKEKID RRSGKKLEDN PKSLKSGDAA IVEMVPGKPM CVESFSQYPP 
LGRFAVRDMR QTVAVGVIKN VEKKSGGAGK VTKSAQKAQK AGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.