Gene EEF2 - ENSG00000167658 | NCBI Gene ID: 1938

Details for: EEF2

Gene ID: 1938

Symbol: EEF2

Ensembl ID: ENSG00000167658

Description: eukaryotic translation elongation factor 2

Associated with

Bacterial infection pathways
(R-HSA-9824439)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-HSA-163841)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Neutrophil degranulation
(R-HSA-6798695)
Peptide chain elongation
(R-HSA-156902)
Post-translational protein modification
(R-HSA-597592)
Protein methylation
(R-HSA-8876725)
Synthesis of diphthamide-eef2
(R-HSA-5358493)
Translation
(R-HSA-72766)
Uptake and actions of bacterial toxins
(R-HSA-5339562)
Uptake and function of diphtheria toxin
(R-HSA-5336415)
Aggresome
(GO:0016235)
Cadherin binding
(GO:0045296)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Membrane
(GO:0016020)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of translation
(GO:0045727)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Ribonucleoprotein complex
(GO:1990904)
Ribosome
(GO:0005840)
Ribosome binding
(GO:0043022)
Rna binding
(GO:0003723)
Secretory granule lumen
(GO:0034774)
Synapse
(GO:0045202)
Translational elongation
(GO:0006414)
Translation elongation factor activity
(GO:0003746)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.28
Marker Score: 11075
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 5.21
Marker Score: 2938
Cell Name: endocardial cell (CL0002350)
Fold Change: 5.03
Marker Score: 2843
Cell Name: acinar cell (CL0000622)
Fold Change: 5
Marker Score: 3525
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 4.95
Marker Score: 3739
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 4.76
Marker Score: 19845
Cell Name: endocrine cell (CL0000163)
Fold Change: 4.62
Marker Score: 2390
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.56
Marker Score: 155145
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.48
Marker Score: 237124
Cell Name: naive B cell (CL0000788)
Fold Change: 4.48
Marker Score: 4001.5
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 4.47
Marker Score: 3398.5
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.38
Marker Score: 13827.5
Cell Name: secretory cell (CL0000151)
Fold Change: 4.36
Marker Score: 7953
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.33
Marker Score: 7435
Cell Name: mature T cell (CL0002419)
Fold Change: 4.25
Marker Score: 42064
Cell Name: naive T cell (CL0000898)
Fold Change: 4.24
Marker Score: 2729.5
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.17
Marker Score: 55028
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.12
Marker Score: 2508
Cell Name: taste receptor cell (CL0000209)
Fold Change: 4.05
Marker Score: 3502
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.04
Marker Score: 71776
Cell Name: theca cell (CL0000503)
Fold Change: 4.02
Marker Score: 2884
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.01
Marker Score: 9792
Cell Name: chromaffin cell (CL0000166)
Fold Change: 4
Marker Score: 5635
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.93
Marker Score: 938
Cell Name: blood cell (CL0000081)
Fold Change: 3.92
Marker Score: 45607
Cell Name: malignant cell (CL0001064)
Fold Change: 3.92
Marker Score: 52677
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.9
Marker Score: 16719
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.89
Marker Score: 8856
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.84
Marker Score: 4104
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 3.83
Marker Score: 11174
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.81
Marker Score: 3753
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.78
Marker Score: 28106
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.73
Marker Score: 4861
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.73
Marker Score: 208517
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 3.73
Marker Score: 3603
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.69
Marker Score: 2898.5
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.69
Marker Score: 6590
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.69
Marker Score: 3466
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.68
Marker Score: 2156
Cell Name: supporting cell (CL0000630)
Fold Change: 3.67
Marker Score: 6892
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.66
Marker Score: 3124
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.64
Marker Score: 23701
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.63
Marker Score: 8857
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.6
Marker Score: 10100
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.58
Marker Score: 9880
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.57
Marker Score: 4307
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.56
Marker Score: 3360.5
Cell Name: memory B cell (CL0000787)
Fold Change: 3.55
Marker Score: 2689
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.55
Marker Score: 3025
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.54
Marker Score: 23046
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.53
Marker Score: 4353
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.5
Marker Score: 3113
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.48
Marker Score: 5713
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.48
Marker Score: 2929
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.45
Marker Score: 791
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 3.45
Marker Score: 914
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.44
Marker Score: 16907.5
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.44
Marker Score: 4053.5
Cell Name: immature B cell (CL0000816)
Fold Change: 3.41
Marker Score: 2260
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.39
Marker Score: 2981
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.39
Marker Score: 892
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 3.38
Marker Score: 933
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.37
Marker Score: 11954.5
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.36
Marker Score: 1966
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.35
Marker Score: 5153
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.35
Marker Score: 2740
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.34
Marker Score: 2416
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 3.34
Marker Score: 1944
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.33
Marker Score: 8912
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.32
Marker Score: 4882
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 3.3
Marker Score: 12761
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.29
Marker Score: 2935
Cell Name: erythroblast (CL0000765)
Fold Change: 3.29
Marker Score: 2052.5
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.28
Marker Score: 12663
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 3.28
Marker Score: 3570
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.28
Marker Score: 5548
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.28
Marker Score: 2722
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.28
Marker Score: 113456.5
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.27
Marker Score: 2197
Cell Name: reticular cell (CL0000432)
Fold Change: 3.26
Marker Score: 1191
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 3.26
Marker Score: 4612.5
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.25
Marker Score: 2137
Cell Name: granulocyte (CL0000094)
Fold Change: 3.24
Marker Score: 1451
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.23
Marker Score: 7337
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.23
Marker Score: 5142
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.23
Marker Score: 1062
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.23
Marker Score: 916
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 3.22
Marker Score: 3893
Cell Name: hepatoblast (CL0005026)
Fold Change: 3.22
Marker Score: 10559
Cell Name: centroblast (CL0009112)
Fold Change: 3.2
Marker Score: 1579
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.2
Marker Score: 2825
Cell Name: stromal cell (CL0000499)
Fold Change: 3.2
Marker Score: 3753
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 3.2
Marker Score: 2010.5
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.2
Marker Score: 1027
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.19
Marker Score: 911
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.19
Marker Score: 24921
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.19
Marker Score: 845
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.19
Marker Score: 898
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.18
Marker Score: 1326
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.18
Marker Score: 1589

Hover over a box to see details here...

**Key characteristics:** - EF2 is a large protein with a molecular weight of approximately 120 kDa. - It is a member of the EF-2 family of translation elongation factors. - EF2 is localized to the cytoplasm and nucleus. - It is a key regulator of protein synthesis and is involved in the initiation, elongation, and termination steps of translation. **Pathways and functions:** - EF2 is involved in various cellular processes, including bacterial infection pathways, disease, and metabolism of proteins. - It is important for the initiation of protein synthesis by promoting the binding of initiator tRNAs to the ribosome. - It is also involved in the elongation step of translation, where it facilitates the transfer of amino acids to the ribosome. - EF2 also plays a role in the regulation of protein turnover by targeting damaged or misfolded proteins for degradation. **Clinical significance:** - Mutations in EF2 genes have been linked to several human diseases, including cancer, autoimmune disorders, and metabolic diseases. - Dysregulation of EF2 has been implicated in the pathogenesis of many human diseases, including cancer, neurodegenerative diseases, and metabolic disorders. - Therefore, EF2 is a promising therapeutic target for the treatment of various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Elongation factor 2

Genular Protein ID: 50933990

Symbol: EF2_HUMAN

Name: Elongation factor 2

UniProtKB Accession Codes:

P13639 A0A384N6H1 B2RMP5 D6W618 Q58J86

Database IDs:

Citations:

PubMed ID: 2610926

Title: Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells.

PubMed ID: 2610926

DOI: 10.1515/bchm3.1989.370.2.1071

PubMed ID: 1596361

Title: Construction of a plasmid containing the complete coding region of human elongation factor 2.

PubMed ID: 1596361

DOI: 10.1515/bchm3.1992.373.1.201

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2840927

Title: Cloning and sequence analysis of a cDNA from human ovarian granulosa cells encoding the C-terminal part of human elongation factor 2.

PubMed ID: 2840927

DOI: 10.1515/bchm3.1988.369.1.247

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16901746

Title: Site-specific mutagenesis of the histidine precursor of diphthamide in the human elongation factor-2 gene confers resistance to diphtheria toxin.

PubMed ID: 16901746

DOI: 10.1016/j.mrgentox.2006.06.027

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19417104

Title: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

PubMed ID: 19417104

DOI: 10.1101/gad.1767209

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23184662

Title: Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.

PubMed ID: 23184662

DOI: 10.1128/mcb.01270-12

PubMed ID: 24648518

Title: C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2.

PubMed ID: 24648518

DOI: 10.1074/jbc.m113.546481

PubMed ID: 25231979

Title: Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2).

PubMed ID: 25231979

DOI: 10.1074/jbc.m114.601658

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25064856

Title: Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.

PubMed ID: 25064856

DOI: 10.1093/nar/gku692

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26593721

Title: Functional dynamics within the human ribosome regulate the rate of active protein synthesis.

PubMed ID: 26593721

DOI: 10.1016/j.molcel.2015.09.013

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27115996

Title: Evidence for a negative cooperativity between eIF5A and eEF2 on binding to the ribosome.

PubMed ID: 27115996

DOI: 10.1371/journal.pone.0154205

PubMed ID: 30355441

Title: Structures of translationally inactive mammalian ribosomes.

PubMed ID: 30355441

DOI: 10.7554/elife.40486

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32687489

Title: Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.

PubMed ID: 32687489

DOI: 10.1371/journal.pbio.3000780

PubMed ID: 23001565

Title: A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult.

PubMed ID: 23001565

DOI: 10.1093/hmg/dds392

Sequence Information:

Length: 858
Mass: 95338
Checksum: 78BD1710236C0D9C
Sequence:

MVNFTVDQIR AIMDKKANIR NMSVIAHVDH GKSTLTDSLV CKAGIIASAR AGETRFTDTR 
KDEQERCITI KSTAISLFYE LSENDLNFIK QSKDGAGFLI NLIDSPGHVD FSSEVTAALR 
VTDGALVVVD CVSGVCVQTE TVLRQAIAER IKPVLMMNKM DRALLELQLE PEELYQTFQR 
IVENVNVIIS TYGEGESGPM GNIMIDPVLG TVGFGSGLHG WAFTLKQFAE MYVAKFAAKG 
EGQLGPAERA KKVEDMMKKL WGDRYFDPAN GKFSKSATSP EGKKLPRTFC QLILDPIFKV 
FDAIMNFKKE ETAKLIEKLD IKLDSEDKDK EGKPLLKAVM RRWLPAGDAL LQMITIHLPS 
PVTAQKYRCE LLYEGPPDDE AAMGIKSCDP KGPLMMYISK MVPTSDKGRF YAFGRVFSGL 
VSTGLKVRIM GPNYTPGKKE DLYLKPIQRT ILMMGRYVEP IEDVPCGNIV GLVGVDQFLV 
KTGTITTFEH AHNMRVMKFS VSPVVRVAVE AKNPADLPKL VEGLKRLAKS DPMVQCIIEE 
SGEHIIAGAG ELHLEICLKD LEEDHACIPI KKSDPVVSYR ETVSEESNVL CLSKSPNKHN 
RLYMKARPFP DGLAEDIDKG EVSARQELKQ RARYLAEKYE WDVAEARKIW CFGPDGTGPN 
ILTDITKGVQ YLNEIKDSVV AGFQWATKEG ALCEENMRGV RFDVHDVTLH ADAIHRGGGQ 
IIPTARRCLY ASVLTAQPRL MEPIYLVEIQ CPEQVVGGIY GVLNRKRGHV FEESQVAGTP 
MFVVKAYLPV NESFGFTADL RSNTGGQAFP QCVFDHWQIL PGDPFDNSSR PSQVVAETRK 
RKGLKEGIPA LDNFLDKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EEF2

Associated with

Cells (max top 100)

Other Information

Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells. PubMed ID: 2610926

Construction of a plasmid containing the complete coding region of human elongation factor 2. PubMed ID: 1596361

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and sequence analysis of a cDNA from human ovarian granulosa cells encoding the C-terminal part of human elongation factor 2. PubMed ID: 2840927

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. PubMed ID: 16139798

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Site-specific mutagenesis of the histidine precursor of diphthamide in the human elongation factor-2 gene confers resistance to diphtheria toxin. PubMed ID: 16901746

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. PubMed ID: 19417104

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. PubMed ID: 23184662

C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2. PubMed ID: 24648518

Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). PubMed ID: 25231979

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity. PubMed ID: 25064856

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

Functional dynamics within the human ribosome regulate the rate of active protein synthesis. PubMed ID: 26593721

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Evidence for a negative cooperativity between eIF5A and eEF2 on binding to the ribosome. PubMed ID: 27115996

Structures of translationally inactive mammalian ribosomes. PubMed ID: 30355441

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. PubMed ID: 32687489

A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult. PubMed ID: 23001565