Details for: EEF2

Gene ID: 1938

Symbol: EEF2

Ensembl ID: ENSG00000167658

Description: eukaryotic translation elongation factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1007.6812
    Cell Significance Index: -156.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 516.1183
    Cell Significance Index: -130.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 467.7537
    Cell Significance Index: -192.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 439.5246
    Cell Significance Index: -178.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 399.4407
    Cell Significance Index: -188.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 382.0677
    Cell Significance Index: -196.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 281.9132
    Cell Significance Index: -189.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 189.4960
    Cell Significance Index: -180.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 144.8389
    Cell Significance Index: -178.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 50.1326
    Cell Significance Index: -153.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 48.7830
    Cell Significance Index: -192.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 43.4868
    Cell Significance Index: -116.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 25.8477
    Cell Significance Index: -56.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.5697
    Cell Significance Index: 109.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.7973
    Cell Significance Index: 1007.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.6239
    Cell Significance Index: 355.4600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.5657
    Cell Significance Index: 133.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 6.8061
    Cell Significance Index: 319.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.7216
    Cell Significance Index: 923.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.6814
    Cell Significance Index: 232.1800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 6.5413
    Cell Significance Index: 38.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.5271
    Cell Significance Index: 171.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 6.3846
    Cell Significance Index: 133.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.0973
    Cell Significance Index: 454.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.8866
    Cell Significance Index: 694.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.8127
    Cell Significance Index: 46.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.5484
    Cell Significance Index: 682.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.4630
    Cell Significance Index: 59.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.3328
    Cell Significance Index: 910.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.2270
    Cell Significance Index: 337.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.1225
    Cell Significance Index: 268.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.0928
    Cell Significance Index: 145.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.8904
    Cell Significance Index: 2670.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.8759
    Cell Significance Index: 143.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.8259
    Cell Significance Index: 333.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.7907
    Cell Significance Index: 863.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.7838
    Cell Significance Index: 130.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.1963
    Cell Significance Index: 296.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.8838
    Cell Significance Index: 1717.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.1766
    Cell Significance Index: 73.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.9981
    Cell Significance Index: 34.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9068
    Cell Significance Index: 576.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5540
    Cell Significance Index: 73.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.4425
    Cell Significance Index: 313.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.1830
    Cell Significance Index: 113.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1511
    Cell Significance Index: 1942.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.0504
    Cell Significance Index: 54.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5880
    Cell Significance Index: 29.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5115
    Cell Significance Index: 68.5100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.1488
    Cell Significance Index: 2.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7716
    Cell Significance Index: 146.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7445
    Cell Significance Index: 80.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6870
    Cell Significance Index: 519.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5147
    Cell Significance Index: 83.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3578
    Cell Significance Index: 18.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3030
    Cell Significance Index: 2.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2987
    Cell Significance Index: 10.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2574
    Cell Significance Index: 29.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2199
    Cell Significance Index: 44.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2193
    Cell Significance Index: 3.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2164
    Cell Significance Index: 158.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0076
    Cell Significance Index: 2.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0229
    Cell Significance Index: -2.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0480
    Cell Significance Index: -90.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0657
    Cell Significance Index: -48.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1153
    Cell Significance Index: -212.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1360
    Cell Significance Index: -209.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1564
    Cell Significance Index: -97.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1593
    Cell Significance Index: -216.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2272
    Cell Significance Index: -144.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2351
    Cell Significance Index: -132.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2571
    Cell Significance Index: -25.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.2722
    Cell Significance Index: -188.2900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3359
    Cell Significance Index: -2.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3488
    Cell Significance Index: -158.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3569
    Cell Significance Index: -75.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5360
    Cell Significance Index: -14.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5782
    Cell Significance Index: -166.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7191
    Cell Significance Index: -18.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8230
    Cell Significance Index: -26.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8861
    Cell Significance Index: -70.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0360
    Cell Significance Index: -118.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0982
    Cell Significance Index: -67.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.1069
    Cell Significance Index: -160.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.1885
    Cell Significance Index: -138.5100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3383
    Cell Significance Index: -23.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4437
    Cell Significance Index: -24.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.5032
    Cell Significance Index: -90.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.5481
    Cell Significance Index: -33.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5798
    Cell Significance Index: -88.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5946
    Cell Significance Index: -39.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.6400
    Cell Significance Index: -103.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.7967
    Cell Significance Index: -187.0800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.1616
    Cell Significance Index: -13.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.1767
    Cell Significance Index: -58.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.1835
    Cell Significance Index: -167.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.1864
    Cell Significance Index: -29.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.3034
    Cell Significance Index: -154.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.5817
    Cell Significance Index: -158.2800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -3.0388
    Cell Significance Index: -22.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EEF2 is a GTP-binding protein that undergoes a conformational change in response to the binding of GTP. This change allows it to interact with the ribosome and the aminoacyl-tRNA, facilitating the translocation of the ribosome along the mRNA and the incorporation of amino acids into the growing protein chain. EEF2 is also involved in the regulation of protein synthesis, and its activity is influenced by various post-translational modifications, including phosphorylation and ubiquitination. The protein is composed of three domains: the GTP-binding domain, the ribosome-binding domain, and the aminoacyl-tRNA binding domain. **Pathways and Functions** EEF2 is involved in several cellular processes, including: 1. **Translation**: EEF2 plays a crucial role in the elongation phase of translation, facilitating the movement of the ribosome along the mRNA and the incorporation of amino acids into the growing protein chain. 2. **Protein Synthesis**: EEF2 is involved in the regulation of protein synthesis, and its activity is influenced by various post-translational modifications. 3. **Cellular Stress Response**: EEF2 has been shown to be involved in the cellular stress response, particularly in response to heat shock and oxidative stress. 4. **Immune Response**: EEF2 is expressed in immune cells, including T cells and B cells, and is involved in the regulation of protein synthesis in response to infection. 5. **Cancer**: EEF2 has been implicated in cancer, particularly in the regulation of protein synthesis and cell growth. **Clinical Significance** EEF2 has been implicated in various diseases, including: 1. **Cancer**: EEF2 has been shown to be overexpressed in several types of cancer, including breast cancer and lung cancer. 2. **Neurological Disorders**: EEF2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune System Disorders**: EEF2 has been shown to be involved in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 4. **Infectious Diseases**: EEF2 has been implicated in infectious diseases, such as diphtheria and bacterial infections. In conclusion, EEF2 is a crucial protein involved in the process of protein synthesis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of EEF2 in human health and disease.

Genular Protein ID: 50933990

Symbol: EF2_HUMAN

Name: Elongation factor 2

UniProtKB Accession Codes:

P13639 A0A384N6H1 B2RMP5 D6W618 Q58J86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 5 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 9 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2610926

Title: Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells.

PubMed ID: 2610926

DOI: 10.1515/bchm3.1989.370.2.1071

PubMed ID: 1596361

Title: Construction of a plasmid containing the complete coding region of human elongation factor 2.

PubMed ID: 1596361

DOI: 10.1515/bchm3.1992.373.1.201

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2840927

Title: Cloning and sequence analysis of a cDNA from human ovarian granulosa cells encoding the C-terminal part of human elongation factor 2.

PubMed ID: 2840927

DOI: 10.1515/bchm3.1988.369.1.247

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16901746

Title: Site-specific mutagenesis of the histidine precursor of diphthamide in the human elongation factor-2 gene confers resistance to diphtheria toxin.

PubMed ID: 16901746

DOI: 10.1016/j.mrgentox.2006.06.027

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19417104

Title: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

PubMed ID: 19417104

DOI: 10.1101/gad.1767209

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23184662

Title: Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.

PubMed ID: 23184662

DOI: 10.1128/mcb.01270-12

PubMed ID: 24648518

Title: C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2.

PubMed ID: 24648518

DOI: 10.1074/jbc.m113.546481

PubMed ID: 25231979

Title: Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2).

PubMed ID: 25231979

DOI: 10.1074/jbc.m114.601658

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25064856

Title: Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.

PubMed ID: 25064856

DOI: 10.1093/nar/gku692

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26593721

Title: Functional dynamics within the human ribosome regulate the rate of active protein synthesis.

PubMed ID: 26593721

DOI: 10.1016/j.molcel.2015.09.013

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27115996

Title: Evidence for a negative cooperativity between eIF5A and eEF2 on binding to the ribosome.

PubMed ID: 27115996

DOI: 10.1371/journal.pone.0154205

PubMed ID: 30355441

Title: Structures of translationally inactive mammalian ribosomes.

PubMed ID: 30355441

DOI: 10.7554/elife.40486

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32687489

Title: Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.

PubMed ID: 32687489

DOI: 10.1371/journal.pbio.3000780

PubMed ID: 23001565

Title: A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult.

PubMed ID: 23001565

DOI: 10.1093/hmg/dds392

Sequence Information:

  • Length: 858
  • Mass: 95338
  • Checksum: 78BD1710236C0D9C
  • Sequence:
    • MVNFTVDQIR AIMDKKANIR NMSVIAHVDH GKSTLTDSLV CKAGIIASAR AGETRFTDTR 
KDEQERCITI KSTAISLFYE LSENDLNFIK QSKDGAGFLI NLIDSPGHVD FSSEVTAALR 
VTDGALVVVD CVSGVCVQTE TVLRQAIAER IKPVLMMNKM DRALLELQLE PEELYQTFQR 
IVENVNVIIS TYGEGESGPM GNIMIDPVLG TVGFGSGLHG WAFTLKQFAE MYVAKFAAKG 
EGQLGPAERA KKVEDMMKKL WGDRYFDPAN GKFSKSATSP EGKKLPRTFC QLILDPIFKV 
FDAIMNFKKE ETAKLIEKLD IKLDSEDKDK EGKPLLKAVM RRWLPAGDAL LQMITIHLPS 
PVTAQKYRCE LLYEGPPDDE AAMGIKSCDP KGPLMMYISK MVPTSDKGRF YAFGRVFSGL 
VSTGLKVRIM GPNYTPGKKE DLYLKPIQRT ILMMGRYVEP IEDVPCGNIV GLVGVDQFLV 
KTGTITTFEH AHNMRVMKFS VSPVVRVAVE AKNPADLPKL VEGLKRLAKS DPMVQCIIEE 
SGEHIIAGAG ELHLEICLKD LEEDHACIPI KKSDPVVSYR ETVSEESNVL CLSKSPNKHN 
RLYMKARPFP DGLAEDIDKG EVSARQELKQ RARYLAEKYE WDVAEARKIW CFGPDGTGPN 
ILTDITKGVQ YLNEIKDSVV AGFQWATKEG ALCEENMRGV RFDVHDVTLH ADAIHRGGGQ 
IIPTARRCLY ASVLTAQPRL MEPIYLVEIQ CPEQVVGGIY GVLNRKRGHV FEESQVAGTP 
MFVVKAYLPV NESFGFTADL RSNTGGQAFP QCVFDHWQIL PGDPFDNSSR PSQVVAETRK 
RKGLKEGIPA LDNFLDKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.