Details for: MEGF6

Gene ID: 1953

Symbol: MEGF6

Ensembl ID: ENSG00000162591

Description: multiple EGF like domains 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169513
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.33
    Marker Score: 1604
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.17
    Marker Score: 2371
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.12
    Marker Score: 1273
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 16984
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.03
    Marker Score: 332
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71804
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1
    Marker Score: 2345
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5164
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 535
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.83
    Marker Score: 736
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.83
    Marker Score: 2252
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.82
    Marker Score: 258
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1249
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.75
    Marker Score: 240
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 665
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 546.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7
    Marker Score: 11305
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 280
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.67
    Marker Score: 376
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.65
    Marker Score: 2403
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.64
    Marker Score: 278
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 294
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 404
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.59
    Marker Score: 260
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.52
    Marker Score: 2148
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.49
    Marker Score: 291
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.48
    Marker Score: 1261
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.47
    Marker Score: 3090
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.46
    Marker Score: 555.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.46
    Marker Score: 257
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2750
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.45
    Marker Score: 562
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.45
    Marker Score: 210
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.45
    Marker Score: 111
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.43
    Marker Score: 252
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.43
    Marker Score: 160
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.43
    Marker Score: 238
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.42
    Marker Score: 502
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.42
    Marker Score: 167
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.41
    Marker Score: 238
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4
    Marker Score: 2620
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4
    Marker Score: 168
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 102
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.39
    Marker Score: 244
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.38
    Marker Score: 2016
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.38
    Marker Score: 871
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.37
    Marker Score: 715
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.36
    Marker Score: 83
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.35
    Marker Score: 566
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.35
    Marker Score: 367.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.35
    Marker Score: 466
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.35
    Marker Score: 325
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.34
    Marker Score: 2548
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.34
    Marker Score: 234
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.33
    Marker Score: 80
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.33
    Marker Score: 450
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.32
    Marker Score: 118
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.32
    Marker Score: 156
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.31
    Marker Score: 399
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.31
    Marker Score: 87
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.31
    Marker Score: 207
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.31
    Marker Score: 295
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.3
    Marker Score: 286
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.3
    Marker Score: 498
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.29
    Marker Score: 10006
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.29
    Marker Score: 86
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.29
    Marker Score: 315
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.28
    Marker Score: 126
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.28
    Marker Score: 300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.28
    Marker Score: 96
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.27
    Marker Score: 243
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.27
    Marker Score: 295
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.27
    Marker Score: 286
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.26
    Marker Score: 133
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.26
    Marker Score: 83
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.26
    Marker Score: 64
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.26
    Marker Score: 166
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.26
    Marker Score: 234
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.26
    Marker Score: 633
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.26
    Marker Score: 106
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.25
    Marker Score: 66
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.25
    Marker Score: 182
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.25
    Marker Score: 91
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.25
    Marker Score: 241

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Other Information

**Key characteristics:** * MEGF6 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the EGF family of proteins, which are known for their role in cell growth, differentiation, and migration. * MEGF6 is expressed in high levels in certain cell types, suggesting that it may play an important role in their function. **Pathways and functions:** * MEGF6 is a key regulator of cell migration and adhesion. * It is involved in the regulation of epithelial cell growth, differentiation, and remodeling. * It also plays a role in the regulation of angiogenesis and tissue development. **Clinical significance:** * Mutations in the MEGF6 gene have been linked to several human diseases, including cancer and developmental disorders. * One such disease is neuroblastoma, a cancer of the nervous system that is characterized by the presence of neuroblasts, cells that are derived from the neural tube. * MEGF6 is a promising target for the treatment of neuroblastoma. **Conclusion:** MEGF6 is a protein that is involved in a variety of cellular processes, including cell migration, adhesion, growth, differentiation, and angiogenesis. Its clinical significance makes it a potential target for the treatment of human diseases.

Genular Protein ID: 3713895659

Symbol: MEGF6_HUMAN

Name: Multiple epidermal growth factor-like domains protein 6

UniProtKB Accession Codes:

O75095 Q4AC86 Q5VV39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SAM 1 SMART 3 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9693030

Title: Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

PubMed ID: 9693030

DOI: 10.1006/geno.1998.5341

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 1541
  • Mass: 161185
  • Checksum: EF2A7CB65140A7BB
  • Sequence:
    • MSFLEEARAA GRAVVLALVL LLLPAVPVGA SVPPRPLLPL QPGMPHVCAE QELTLVGRRQ 
PCVQALSHTV PVWKAGCGWQ AWCVGHERRT VYYMGYRQVY TTEARTVLRC CRGWMQQPDE 
EGCLSAECSA SLCFHGGRCV PGSAQPCHCP PGFQGPRCQY DVDECRTHNG GCQHRCVNTP 
GSYLCECKPG FRLHTDSRTC LAINSCALGN GGCQHHCVQL TITRHRCQCR PGFQLQEDGR 
HCVRRSPCAN RNGSCMHRCQ VVRGLARCEC HVGYQLAADG KACEDVDECA AGLAQCAHGC 
LNTQGSFKCV CHAGYELGAD GRQCYRIEME IVNSCEANNG GCSHGCSHTS AGPLCTCPRG 
YELDTDQRTC IDVDDCADSP CCQQVCTNNP GGYECGCYAG YRLSADGCGC EDVDECASSR 
GGCEHHCTNL AGSFQCSCEA GYRLHEDRRG CSPLEEPMVD LDGELPFVRP LPHIAVLQDE 
LPQLFQDDDV GADEEEAELR GEHTLTEKFV CLDDSFGHDC SLTCDDCRNG GTCLLGLDGC 
DCPEGWTGLI CNETCPPDTF GKNCSFSCSC QNGGTCDSVT GACRCPPGVS GTNCEDGCPK 
GYYGKHCRKK CNCANRGRCH RLYGACLCDP GLYGRFCHLT CPPWAFGPGC SEECQCVQPH 
TQSCDKRDGS CSCKAGFRGE RCQAECELGY FGPGCWQACT CPVGVACDSV SGECGKRCPA 
GFQGEDCGQE CPVGTFGVNC SSSCSCGGAP CHGVTGQCRC PPGRTGEDCE ADCPEGRWGL 
GCQEICPACQ HAARCDPETG ACLCLPGFVG SRCQDVCPAG WYGPSCQTRC SCANDGHCHP 
ATGHCSCAPG WTGFSCQRAC DTGHWGPDCS HPCNCSAGHG SCDAISGLCL CEAGYVGPRC 
EQQCPQGHFG PGCEQRCQCQ HGAACDHVSG ACTCPAGWRG TFCEHACPAG FFGLDCRSAC 
NCTAGAACDA VNGSCLCPAG RRGPRCAETC PAHTYGHNCS QACACFNGAS CDPVHGQCHC 
APGWMGPSCL QACPAGLYGD NCRHSCLCQN GGTCDPVSGH CACPEGWAGL ACEKECLPRD 
VRAGCRHSGG CLNGGLCDPH TGRCLCPAGW TGDKCQSPCL RGWFGEACAQ RCSCPPGAAC 
HHVTGACRCP PGFTGSGCEQ ACPPGSFGED CAQMCQCPGE NPACHPATGT CSCAAGYHGP 
SCQQRCPPGR YGPGCEQLCG CLNGGSCDAA TGACRCPTGF LGTDCNLTCP QGRFGPNCTH 
VCGCGQGAAC DPVTGTCLCP PGRAGVRCER GCPQNRFGVG CEHTCSCRNG GLCHASNGSC 
SCGLGWTGRH CELACPPGRY GAACHLECSC HNNSTCEPAT GTCRCGPGFY GQACEHPCPP 
GFHGAGCQGL CWCQHGAPCD PISGRCLCPA GFHGHFCERG CEPGSFGEGC HQRCDCDGGA 
PCDPVTGLCL CPPGRSGATC NLDCRRGQFG PSCTLHCDCG GGADCDPVSG QCHCVDGYMG 
PTCREGGPLR LPENPSLAQG SAGTLPASSR PTSRSGGPAR H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.