Details for: MEGF6

Gene ID: 1953

Symbol: MEGF6

Ensembl ID: ENSG00000162591

Description: multiple EGF like domains 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 52.0106
    Cell Significance Index: -8.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.7806
    Cell Significance Index: -7.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5534
    Cell Significance Index: -8.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.0654
    Cell Significance Index: -8.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.7451
    Cell Significance Index: 48.7700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.6549
    Cell Significance Index: 14.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9004
    Cell Significance Index: 12.2900
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.6411
    Cell Significance Index: 3.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6278
    Cell Significance Index: 13.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5744
    Cell Significance Index: 11.2100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.5495
    Cell Significance Index: 2.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3712
    Cell Significance Index: 70.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2917
    Cell Significance Index: 14.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2792
    Cell Significance Index: 27.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2697
    Cell Significance Index: 7.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2690
    Cell Significance Index: 3.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2627
    Cell Significance Index: 116.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2588
    Cell Significance Index: 5.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2273
    Cell Significance Index: 205.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2138
    Cell Significance Index: 6.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2071
    Cell Significance Index: 24.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1974
    Cell Significance Index: 5.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1732
    Cell Significance Index: 12.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1542
    Cell Significance Index: 4.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1476
    Cell Significance Index: 24.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1426
    Cell Significance Index: 8.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1390
    Cell Significance Index: 6.3000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1380
    Cell Significance Index: 2.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1360
    Cell Significance Index: 24.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1239
    Cell Significance Index: 13.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1086
    Cell Significance Index: 167.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1043
    Cell Significance Index: 2.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0960
    Cell Significance Index: 11.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0934
    Cell Significance Index: 18.7300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0810
    Cell Significance Index: 0.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0573
    Cell Significance Index: 11.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0495
    Cell Significance Index: 2.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0456
    Cell Significance Index: 24.8800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0242
    Cell Significance Index: 0.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0214
    Cell Significance Index: 2.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0204
    Cell Significance Index: 7.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0200
    Cell Significance Index: 0.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0165
    Cell Significance Index: 30.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0140
    Cell Significance Index: 0.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0129
    Cell Significance Index: 17.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0088
    Cell Significance Index: 0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0052
    Cell Significance Index: 3.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0032
    Cell Significance Index: 6.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0013
    Cell Significance Index: -0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0045
    Cell Significance Index: -0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0096
    Cell Significance Index: -7.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0100
    Cell Significance Index: -7.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0111
    Cell Significance Index: -1.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0127
    Cell Significance Index: -0.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0156
    Cell Significance Index: -9.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0157
    Cell Significance Index: -7.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0203
    Cell Significance Index: -0.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0210
    Cell Significance Index: -0.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0217
    Cell Significance Index: -6.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0217
    Cell Significance Index: -3.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0265
    Cell Significance Index: -1.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0293
    Cell Significance Index: -0.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0316
    Cell Significance Index: -2.4300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0347
    Cell Significance Index: -0.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0382
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0391
    Cell Significance Index: -8.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0447
    Cell Significance Index: -5.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0450
    Cell Significance Index: -6.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0460
    Cell Significance Index: -2.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0464
    Cell Significance Index: -5.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0472
    Cell Significance Index: -0.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0539
    Cell Significance Index: -4.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0659
    Cell Significance Index: -7.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0666
    Cell Significance Index: -1.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0732
    Cell Significance Index: -1.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0749
    Cell Significance Index: -7.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0753
    Cell Significance Index: -3.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0850
    Cell Significance Index: -5.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0918
    Cell Significance Index: -5.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0946
    Cell Significance Index: -7.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1108
    Cell Significance Index: -2.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1118
    Cell Significance Index: -7.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1261
    Cell Significance Index: -6.5700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1345
    Cell Significance Index: -0.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1524
    Cell Significance Index: -4.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1541
    Cell Significance Index: -8.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1568
    Cell Significance Index: -6.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1636
    Cell Significance Index: -5.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1636
    Cell Significance Index: -5.7300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1732
    Cell Significance Index: -1.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1741
    Cell Significance Index: -6.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1806
    Cell Significance Index: -7.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1827
    Cell Significance Index: -6.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2117
    Cell Significance Index: -7.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2155
    Cell Significance Index: -5.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2289
    Cell Significance Index: -5.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2312
    Cell Significance Index: -4.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2333
    Cell Significance Index: -6.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multiple EGF-like domains:** MEGF6 contains multiple epidermal growth factor-like domains, which are known to mediate protein-protein interactions, cell adhesion, and signaling events. 2. **Cellular localization:** MEGF6 is predominantly expressed in mural cells, lens epithelial cells, and other cell types involved in tissue development and maintenance. 3. **Signaling pathways:** MEGF6 is involved in various signaling pathways, including those regulating cell growth, differentiation, and survival. 4. **Immunological significance:** MEGF6 has been implicated in immune responses, particularly in the development and function of innate lymphoid cells. **Pathways and Functions:** MEGF6 is involved in several key biological processes, including: 1. **Cell growth and differentiation:** MEGF6 mediates cell growth, differentiation, and survival by interacting with other proteins and signaling molecules. 2. **Immune responses:** MEGF6 plays a role in the development and function of innate lymphoid cells, which are critical for initiating immune responses. 3. **Tissue development and homeostasis:** MEGF6 is expressed in various cell types involved in tissue development, including mural cells, lens epithelial cells, and cardiac muscle myoblasts. 4. **Ca2+ signaling:** MEGF6 interacts with calcium ions, which are essential for various cellular processes, including cell signaling and muscle contraction. **Clinical Significance:** Dysregulation of MEGF6 has been implicated in various diseases, including: 1. **Cancer:** Aberrant expression of MEGF6 has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Autoimmune diseases:** MEGF6 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it contributes to immune dysregulation. 3. **Cardiovascular disease:** MEGF6 expression is altered in cardiac muscle myoblasts in patients with cardiovascular disease, suggesting a potential role in cardiac development and function. 4. **Neurological disorders:** MEGF6 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it contributes to neuroinflammation and neuronal dysfunction. In conclusion, MEGF6 is a multifunctional gene that plays a critical role in regulating cellular processes, from cell growth and differentiation to immune responses. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying MEGF6 function and its role in human disease.

Genular Protein ID: 3713895659

Symbol: MEGF6_HUMAN

Name: Multiple epidermal growth factor-like domains protein 6

UniProtKB Accession Codes:

O75095 Q4AC86 Q5VV39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 1 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 3 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9693030

Title: Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

PubMed ID: 9693030

DOI: 10.1006/geno.1998.5341

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 1541
  • Mass: 161185
  • Checksum: EF2A7CB65140A7BB
  • Sequence:
    • MSFLEEARAA GRAVVLALVL LLLPAVPVGA SVPPRPLLPL QPGMPHVCAE QELTLVGRRQ 
PCVQALSHTV PVWKAGCGWQ AWCVGHERRT VYYMGYRQVY TTEARTVLRC CRGWMQQPDE 
EGCLSAECSA SLCFHGGRCV PGSAQPCHCP PGFQGPRCQY DVDECRTHNG GCQHRCVNTP 
GSYLCECKPG FRLHTDSRTC LAINSCALGN GGCQHHCVQL TITRHRCQCR PGFQLQEDGR 
HCVRRSPCAN RNGSCMHRCQ VVRGLARCEC HVGYQLAADG KACEDVDECA AGLAQCAHGC 
LNTQGSFKCV CHAGYELGAD GRQCYRIEME IVNSCEANNG GCSHGCSHTS AGPLCTCPRG 
YELDTDQRTC IDVDDCADSP CCQQVCTNNP GGYECGCYAG YRLSADGCGC EDVDECASSR 
GGCEHHCTNL AGSFQCSCEA GYRLHEDRRG CSPLEEPMVD LDGELPFVRP LPHIAVLQDE 
LPQLFQDDDV GADEEEAELR GEHTLTEKFV CLDDSFGHDC SLTCDDCRNG GTCLLGLDGC 
DCPEGWTGLI CNETCPPDTF GKNCSFSCSC QNGGTCDSVT GACRCPPGVS GTNCEDGCPK 
GYYGKHCRKK CNCANRGRCH RLYGACLCDP GLYGRFCHLT CPPWAFGPGC SEECQCVQPH 
TQSCDKRDGS CSCKAGFRGE RCQAECELGY FGPGCWQACT CPVGVACDSV SGECGKRCPA 
GFQGEDCGQE CPVGTFGVNC SSSCSCGGAP CHGVTGQCRC PPGRTGEDCE ADCPEGRWGL 
GCQEICPACQ HAARCDPETG ACLCLPGFVG SRCQDVCPAG WYGPSCQTRC SCANDGHCHP 
ATGHCSCAPG WTGFSCQRAC DTGHWGPDCS HPCNCSAGHG SCDAISGLCL CEAGYVGPRC 
EQQCPQGHFG PGCEQRCQCQ HGAACDHVSG ACTCPAGWRG TFCEHACPAG FFGLDCRSAC 
NCTAGAACDA VNGSCLCPAG RRGPRCAETC PAHTYGHNCS QACACFNGAS CDPVHGQCHC 
APGWMGPSCL QACPAGLYGD NCRHSCLCQN GGTCDPVSGH CACPEGWAGL ACEKECLPRD 
VRAGCRHSGG CLNGGLCDPH TGRCLCPAGW TGDKCQSPCL RGWFGEACAQ RCSCPPGAAC 
HHVTGACRCP PGFTGSGCEQ ACPPGSFGED CAQMCQCPGE NPACHPATGT CSCAAGYHGP 
SCQQRCPPGR YGPGCEQLCG CLNGGSCDAA TGACRCPTGF LGTDCNLTCP QGRFGPNCTH 
VCGCGQGAAC DPVTGTCLCP PGRAGVRCER GCPQNRFGVG CEHTCSCRNG GLCHASNGSC 
SCGLGWTGRH CELACPPGRY GAACHLECSC HNNSTCEPAT GTCRCGPGFY GQACEHPCPP 
GFHGAGCQGL CWCQHGAPCD PISGRCLCPA GFHGHFCERG CEPGSFGEGC HQRCDCDGGA 
PCDPVTGLCL CPPGRSGATC NLDCRRGQFG PSCTLHCDCG GGADCDPVSG QCHCVDGYMG 
PTCREGGPLR LPENPSLAQG SAGTLPASSR PTSRSGGPAR H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.