Gene EPHA2 - ENSG00000142627 | NCBI Gene ID: 1969

Details for: EPHA2

Gene ID: 1969

Symbol: EPHA2

Ensembl ID: ENSG00000142627

Description: EPH receptor A2

Associated with

Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Epha-mediated growth cone collapse
(R-HSA-3928663)
Nervous system development
(R-HSA-9675108)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Rhou gtpase cycle
(R-HSA-9013420)
Rhov gtpase cycle
(R-HSA-9013424)
Rnd1 gtpase cycle
(R-HSA-9696273)
Rnd2 gtpase cycle
(R-HSA-9696270)
Rnd3 gtpase cycle
(R-HSA-9696264)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Activation of gtpase activity
(GO:0090630)
Atp binding
(GO:0005524)
Axial mesoderm formation
(GO:0048320)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:0002043)
Bone remodeling
(GO:0046849)
Branching involved in mammary gland duct morphogenesis
(GO:0060444)
Cadherin binding
(GO:0045296)
Camp metabolic process
(GO:0046058)
Cell adhesion
(GO:0007155)
Cell chemotaxis
(GO:0060326)
Cell migration
(GO:0016477)
Cell motility
(GO:0048870)
Cell surface
(GO:0009986)
Defense response to gram-positive bacterium
(GO:0050830)
Ephrin receptor activity
(GO:0005003)
Ephrin receptor signaling pathway
(GO:0048013)
Focal adhesion
(GO:0005925)
Growth factor binding
(GO:0019838)
Inflammatory response
(GO:0006954)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Keratinocyte differentiation
(GO:0030216)
Lamellipodium
(GO:0030027)
Lamellipodium membrane
(GO:0031258)
Leading edge membrane
(GO:0031256)
Lens fiber cell morphogenesis
(GO:0070309)
Mammary gland epithelial cell proliferation
(GO:0033598)
Molecular function activator activity
(GO:0140677)
Multicellular organism development
(GO:0007275)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of chemokine production
(GO:0032682)
Negative regulation of lymphangiogenesis
(GO:1901491)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Neural tube development
(GO:0021915)
Neuron differentiation
(GO:0030182)
Notochord cell development
(GO:0060035)
Notochord formation
(GO:0014028)
Osteoblast differentiation
(GO:0001649)
Osteoclast differentiation
(GO:0030316)
Pericyte cell differentiation
(GO:1904238)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of bicellular tight junction assembly
(GO:1903348)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Post-anal tail morphogenesis
(GO:0036342)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Receptor complex
(GO:0043235)
Regulation of angiogenesis
(GO:0045765)
Regulation of blood vessel endothelial cell migration
(GO:0043535)
Regulation of cell adhesion mediated by integrin
(GO:0033628)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of lamellipodium assembly
(GO:0010591)
Response to growth factor
(GO:0070848)
Ruffle membrane
(GO:0032587)
Skeletal system development
(GO:0001501)
Symbiont entry into host cell
(GO:0046718)
Tight junction
(GO:0070160)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Vasculogenesis
(GO:0001570)
Virus receptor activity
(GO:0001618)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.48
Marker Score: 1691
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.21
Marker Score: 3248
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.15
Marker Score: 5276
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.93
Marker Score: 1522
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.72
Marker Score: 10967
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.69
Marker Score: 3844
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.59
Marker Score: 1676
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.59
Marker Score: 931
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.51
Marker Score: 510
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168704
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.41
Marker Score: 1555.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.34
Marker Score: 3280
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.33
Marker Score: 385
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.33
Marker Score: 10396
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.29
Marker Score: 403
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.28
Marker Score: 2909
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.27
Marker Score: 850
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.24
Marker Score: 19377
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.21
Marker Score: 301
Cell Name: club cell (CL0000158)
Fold Change: 1.21
Marker Score: 1416
Cell Name: basal cell (CL0000646)
Fold Change: 1.14
Marker Score: 1470
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.12
Marker Score: 9629
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.07
Marker Score: 681
Cell Name: secretory cell (CL0000151)
Fold Change: 1.05
Marker Score: 1919
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251767
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.03
Marker Score: 2089
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71784
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48010
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.99
Marker Score: 281
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.99
Marker Score: 3663
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.99
Marker Score: 8592
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.98
Marker Score: 977
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.97
Marker Score: 455
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 502
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 456
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.96
Marker Score: 474
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.95
Marker Score: 452
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.94
Marker Score: 2955
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.93
Marker Score: 268
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2731
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.91
Marker Score: 31368
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.89
Marker Score: 6608
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5007
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.87
Marker Score: 906
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5275
Cell Name: enterocyte (CL0000584)
Fold Change: 0.83
Marker Score: 3967
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 626
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.81
Marker Score: 5264
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.79
Marker Score: 4134
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1270
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.78
Marker Score: 652
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.78
Marker Score: 1237
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.78
Marker Score: 466
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.77
Marker Score: 187
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 304
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.76
Marker Score: 917
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.76
Marker Score: 807
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 391
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.75
Marker Score: 1762
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 468
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.73
Marker Score: 176
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.72
Marker Score: 373
Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 651
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7
Marker Score: 2923.5
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.69
Marker Score: 1318
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.69
Marker Score: 197.5
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.67
Marker Score: 136
Cell Name: malignant cell (CL0001064)
Fold Change: 0.67
Marker Score: 9002
Cell Name: osteoblast (CL0000062)
Fold Change: 0.66
Marker Score: 354
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.66
Marker Score: 413
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.65
Marker Score: 913
Cell Name: stem cell (CL0000034)
Fold Change: 0.63
Marker Score: 1503
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.63
Marker Score: 1034
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.62
Marker Score: 487
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.61
Marker Score: 272
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.61
Marker Score: 406
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.61
Marker Score: 1214
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.6
Marker Score: 2961
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.6
Marker Score: 118
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.6
Marker Score: 520
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.6
Marker Score: 350
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.59
Marker Score: 546
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.59
Marker Score: 151
Cell Name: lactocyte (CL0002325)
Fold Change: 0.59
Marker Score: 9520
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.59
Marker Score: 634
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.58
Marker Score: 184
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.57
Marker Score: 138
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.57
Marker Score: 548
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.57
Marker Score: 1945
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.56
Marker Score: 1523
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.56
Marker Score: 497
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.56
Marker Score: 144
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.54
Marker Score: 126
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.52
Marker Score: 471

Hover over a box to see details here...

**Key characteristics:** * EPHA2 is a transmembrane protein with a single extracellular domain and a single transmembrane domain. * It is a member of the Eph receptor family, which are characterized by their ability to bind to Eph growth factors and regulate their activity. * EPHA2 is expressed on a variety of cell types, including epithelial cells, endothelial cells, and immune cells. * It is a key regulator of epithelial cell migration, proliferation, and survival. **Pathways and functions:** * EPHA2 is a key regulator of axon guidance. It is expressed on neurons and is required for the correct guidance of neurons during development. * It is also involved in the regulation of epithelial cell migration and proliferation. * EPHA2 signaling is involved in a variety of developmental processes, including the formation of the neural tube, the growth of the cardiovascular system, and the development of the immune system. * It is also involved in the regulation of tumor growth and metastasis. **Clinical significance:** * Mutations in EPHA2 have been linked to a number of human cancers, including breast cancer, colon cancer, and lung cancer. * Targeting EPHA2 has been shown to be a promising approach for treating these cancers. * EPHA2 is a promising target for cancer immunotherapy. **Conclusion:** EPHA2 is a key regulator of cell migration, proliferation, and survival. It is involved in a variety of developmental processes and in the regulation of tumor growth and metastasis. Targeting EPHA2 has been shown to be a promising approach for treating cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ephrin type-A receptor 2

Genular Protein ID: 2527482516

Symbol: EPHA2_HUMAN

Name: Ephrin type-A receptor 2

UniProtKB Accession Codes:

P29317 B5A968 Q8N3Z2

Database IDs:

Citations:

PubMed ID: 2174105

Title: cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.

PubMed ID: 2174105

DOI: 10.1128/mcb.10.12.6316-6324.1990

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 10655584

Title: Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.

PubMed ID: 10655584

DOI: 10.1038/35000008

PubMed ID: 11280802

Title: EphA2 overexpression causes tumorigenesis of mammary epithelial cells.

PubMed ID: 11280802

PubMed ID: 12167657

Title: Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation.

PubMed ID: 12167657

DOI: 10.1074/jbc.m207127200

PubMed ID: 16236711

Title: EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability.

PubMed ID: 16236711

DOI: 10.1074/jbc.m503786200

PubMed ID: 17332925

Title: Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK.

PubMed ID: 17332925

PubMed ID: 17135240

Title: Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation.

PubMed ID: 17135240

DOI: 10.1074/jbc.m608509200

PubMed ID: 18339848

Title: EphA2 is an essential mediator of UV radiation-induced apoptosis.

PubMed ID: 18339848

DOI: 10.1158/0008-5472.can-07-2372

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18794797

Title: Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor.

PubMed ID: 18794797

DOI: 10.1038/onc.2008.328

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19573808

Title: EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt.

PubMed ID: 19573808

DOI: 10.1016/j.ccr.2009.04.009

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19567782

Title: Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis.

PubMed ID: 19567782

DOI: 10.1158/1541-7786.mcr-08-0582

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20679435

Title: Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.

PubMed ID: 20679435

DOI: 10.1083/jcb.201005141

PubMed ID: 20861311

Title: Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1.

PubMed ID: 20861311

DOI: 10.1091/mbc.e10-03-0242

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20223987

Title: Restriction of receptor movement alters cellular response: physical force sensing by EphA2.

PubMed ID: 20223987

DOI: 10.1126/science.1181729

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21516087

Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

PubMed ID: 21516087

DOI: 10.1038/nm.2341

PubMed ID: 22332920

Title: Solution structure of the first Sam domain of Odin and binding studies with the EphA2 receptor.

PubMed ID: 22332920

DOI: 10.1021/bi300141h

PubMed ID: 22635007

Title: The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma-associated herpesvirus.

PubMed ID: 22635007

DOI: 10.1038/nm.2805

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23358419

Title: Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration.

PubMed ID: 23358419

DOI: 10.1128/mcb.01708-12

PubMed ID: 23936024

Title: Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors.

PubMed ID: 23936024

DOI: 10.1371/journal.pone.0069473

PubMed ID: 26158630

Title: Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.

PubMed ID: 26158630

DOI: 10.1038/ncomms8679

PubMed ID: 27385333

Title: Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation.

PubMed ID: 27385333

DOI: 10.1091/mbc.e16-01-0048

PubMed ID: 29292383

Title: Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry.

PubMed ID: 29292383

DOI: 10.1038/s41564-017-0080-8

PubMed ID: 29292384

Title: Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.

PubMed ID: 29292384

DOI: 10.1038/s41564-017-0081-7

PubMed ID: 34067457

Title: EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4.

PubMed ID: 34067457

DOI: 10.3390/cells10061290

PubMed ID: 37146061

Title: EphA2 is a functional entry receptor for HCMV infection of glioblastoma cells.

PubMed ID: 37146061

DOI: 10.1371/journal.ppat.1011304

PubMed ID: 12467573

Title: Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.

PubMed ID: 12467573

DOI: 10.1016/s0969-2126(02)00907-3

PubMed ID: 19525919

Title: Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.

PubMed ID: 19525919

DOI: 10.1038/embor.2009.91

PubMed ID: 20505120

Title: Architecture of Eph receptor clusters.

PubMed ID: 20505120

DOI: 10.1073/pnas.1004148107

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19005574

Title: The EPHA2 gene is associated with cataracts linked to chromosome 1p.

PubMed ID: 19005574

PubMed ID: 19306328

Title: Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract.

PubMed ID: 19306328

DOI: 10.1002/humu.20995

PubMed ID: 19649315

Title: EPHA2 is associated with age-related cortical cataract in mice and humans.

PubMed ID: 19649315

DOI: 10.1371/journal.pgen.1000584

PubMed ID: 22570727

Title: Human cataract mutations in EPHA2 SAM domain alter receptor stability and function.

PubMed ID: 22570727

DOI: 10.1371/journal.pone.0036564

Sequence Information:

Length: 976
Mass: 108266
Checksum: 845D7E1BBCCAACCC
Sequence:

MELQAARACF ALLWGCALAA AAAAQGKEVV LLDFAAAGGE LGWLTHPYGK GWDLMQNIMN 
DMPIYMYSVC NVMSGDQDNW LRTNWVYRGE AERIFIELKF TVRDCNSFPG GASSCKETFN 
LYYAESDLDY GTNFQKRLFT KIDTIAPDEI TVSSDFEARH VKLNVEERSV GPLTRKGFYL 
AFQDIGACVA LLSVRVYYKK CPELLQGLAH FPETIAGSDA PSLATVAGTC VDHAVVPPGG 
EEPRMHCAVD GEWLVPIGQC LCQAGYEKVE DACQACSPGF FKFEASESPC LECPEHTLPS 
PEGATSCECE EGFFRAPQDP ASMPCTRPPS APHYLTAVGM GAKVELRWTP PQDSGGREDI 
VYSVTCEQCW PESGECGPCE ASVRYSEPPH GLTRTSVTVS DLEPHMNYTF TVEARNGVSG 
LVTSRSFRTA SVSINQTEPP KVRLEGRSTT SLSVSWSIPP PQQSRVWKYE VTYRKKGDSN 
SYNVRRTEGF SVTLDDLAPD TTYLVQVQAL TQEGQGAGSK VHEFQTLSPE GSGNLAVIGG 
VAVGVVLLLV LAGVGFFIHR RRKNQRARQS PEDVYFSKSE QLKPLKTYVD PHTYEDPNQA 
VLKFTTEIHP SCVTRQKVIG AGEFGEVYKG MLKTSSGKKE VPVAIKTLKA GYTEKQRVDF 
LGEAGIMGQF SHHNIIRLEG VISKYKPMMI ITEYMENGAL DKFLREKDGE FSVLQLVGML 
RGIAAGMKYL ANMNYVHRDL AARNILVNSN LVCKVSDFGL SRVLEDDPEA TYTTSGGKIP 
IRWTAPEAIS YRKFTSASDV WSFGIVMWEV MTYGERPYWE LSNHEVMKAI NDGFRLPTPM 
DCPSAIYQLM MQCWQQERAR RPKFADIVSI LDKLIRAPDS LKTLADFDPR VSIRLPSTSG 
SEGVPFRTVS EWLESIKMQQ YTEHFMAAGY TAIEKVVQMT NDDIKRIGVR LPGHQKRIAY 
SLLGLKDQVN TVGIPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EPHA2

Associated with

Cells (max top 100)

Other Information

cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. PubMed ID: 2174105

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. PubMed ID: 18593464

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Unified nomenclature for Eph family receptors and their ligands, the ephrins. PubMed ID: 9267020

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. PubMed ID: 10655584

EphA2 overexpression causes tumorigenesis of mammary epithelial cells. PubMed ID: 11280802

Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation. PubMed ID: 12167657

EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability. PubMed ID: 16236711

Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK. PubMed ID: 17332925

Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation. PubMed ID: 17135240

EphA2 is an essential mediator of UV radiation-induced apoptosis. PubMed ID: 18339848

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. PubMed ID: 18794797

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. PubMed ID: 19573808

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis. PubMed ID: 19567782

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. PubMed ID: 20679435

Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1. PubMed ID: 20861311

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Restriction of receptor movement alters cellular response: physical force sensing by EphA2. PubMed ID: 20223987

Initial characterization of the human central proteome. PubMed ID: 21269460

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. PubMed ID: 21516087

Solution structure of the first Sam domain of Odin and binding studies with the EphA2 receptor. PubMed ID: 22332920

The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma-associated herpesvirus. PubMed ID: 22635007

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration. PubMed ID: 23358419

Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors. PubMed ID: 23936024

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2. PubMed ID: 26158630

Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. PubMed ID: 27385333

Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry. PubMed ID: 29292383

Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus. PubMed ID: 29292384

EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4. PubMed ID: 34067457

EphA2 is a functional entry receptor for HCMV infection of glioblastoma cells. PubMed ID: 37146061

Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. PubMed ID: 12467573

Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. PubMed ID: 19525919

Architecture of Eph receptor clusters. PubMed ID: 20505120

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

The EPHA2 gene is associated with cataracts linked to chromosome 1p. PubMed ID: 19005574

Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract. PubMed ID: 19306328

EPHA2 is associated with age-related cortical cataract in mice and humans. PubMed ID: 19649315

Human cataract mutations in EPHA2 SAM domain alter receptor stability and function. PubMed ID: 22570727