EPHA2 | ENSG00000142627 | NCBI 1969

Details for: EPHA2

Gene ID: 1969

Symbol: EPHA2

Ensembl ID: ENSG00000142627

Description: EPH receptor A2

Associated with

Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Epha-mediated growth cone collapse
(R-HSA-3928663)
Nervous system development
(R-HSA-9675108)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Rhou gtpase cycle
(R-HSA-9013420)
Rhov gtpase cycle
(R-HSA-9013424)
Rnd1 gtpase cycle
(R-HSA-9696273)
Rnd2 gtpase cycle
(R-HSA-9696270)
Rnd3 gtpase cycle
(R-HSA-9696264)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Activation of gtpase activity
(GO:0090630)
Atp binding
(GO:0005524)
Axial mesoderm formation
(GO:0048320)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:0002043)
Bone remodeling
(GO:0046849)
Branching involved in mammary gland duct morphogenesis
(GO:0060444)
Cadherin binding
(GO:0045296)
Camp metabolic process
(GO:0046058)
Cell adhesion
(GO:0007155)
Cell chemotaxis
(GO:0060326)
Cell migration
(GO:0016477)
Cell motility
(GO:0048870)
Cell surface
(GO:0009986)
Cell surface receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Defense response to gram-positive bacterium
(GO:0050830)
Ephrin receptor activity
(GO:0005003)
Ephrin receptor signaling pathway
(GO:0048013)
Focal adhesion
(GO:0005925)
Growth factor binding
(GO:0019838)
Inflammatory response
(GO:0006954)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Keratinocyte differentiation
(GO:0030216)
Lamellipodium
(GO:0030027)
Lamellipodium membrane
(GO:0031258)
Leading edge membrane
(GO:0031256)
Lens fiber cell morphogenesis
(GO:0070309)
Mammary gland epithelial cell proliferation
(GO:0033598)
Molecular function activator activity
(GO:0140677)
Multicellular organism development
(GO:0007275)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of chemokine production
(GO:0032682)
Negative regulation of lymphangiogenesis
(GO:1901491)
Neural tube development
(GO:0021915)
Neuron differentiation
(GO:0030182)
Notochord cell development
(GO:0060035)
Notochord formation
(GO:0014028)
Osteoblast differentiation
(GO:0001649)
Osteoclast differentiation
(GO:0030316)
Pericyte cell differentiation
(GO:1904238)
Plasma membrane
(GO:0005886)
Positive regulation of bicellular tight junction assembly
(GO:1903348)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Post-anal tail morphogenesis
(GO:0036342)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Protein phosphorylation
(GO:0006468)
Receptor complex
(GO:0043235)
Regulation of angiogenesis
(GO:0045765)
Regulation of blood vessel endothelial cell migration
(GO:0043535)
Regulation of cell adhesion mediated by integrin
(GO:0033628)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of lamellipodium assembly
(GO:0010591)
Response to growth factor
(GO:0070848)
Ruffle membrane
(GO:0032587)
Skeletal system development
(GO:0001501)
Symbiont entry into host cell
(GO:0046718)
Tight junction
(GO:0070160)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Vasculogenesis
(GO:0001570)
Virus receptor activity
(GO:0001618)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 37.0800
Cell Significance Index: -15.2800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 34.1902
Cell Significance Index: -13.8900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 32.5975
Cell Significance Index: -15.3900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 22.8755
Cell Significance Index: -15.3500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 14.4960
Cell Significance Index: -13.8400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 6.8420
Cell Significance Index: 355.4200
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 5.1076
Cell Significance Index: 15.1900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.3030
Cell Significance Index: -16.9800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 3.1574
Cell Significance Index: 47.3100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.9714
Cell Significance Index: 80.8800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.9585
Cell Significance Index: 85.2400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.8932
Cell Significance Index: 62.6800
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 2.8595
Cell Significance Index: 47.1200
Cell Name: epidermal cell (CL0000362)
Fold Change: 2.4396
Cell Significance Index: 5.5000
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.3653
Cell Significance Index: 33.6700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.0287
Cell Significance Index: -4.4400
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 1.7080
Cell Significance Index: 6.5400
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.5746
Cell Significance Index: 16.7300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3987
Cell Significance Index: 63.4000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.2409
Cell Significance Index: 236.1500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7120
Cell Significance Index: 87.5500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.6874
Cell Significance Index: 88.8100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6175
Cell Significance Index: 111.3200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5803
Cell Significance Index: 316.9200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.5554
Cell Significance Index: 19.5200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5263
Cell Significance Index: 475.2400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5055
Cell Significance Index: 4.6600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4856
Cell Significance Index: 29.1500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4852
Cell Significance Index: 62.2000
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.4629
Cell Significance Index: 4.7800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4467
Cell Significance Index: 44.1900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.3820
Cell Significance Index: 8.1400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3808
Cell Significance Index: 41.4200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.3669
Cell Significance Index: 6.1800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3534
Cell Significance Index: 19.8300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3134
Cell Significance Index: 50.9800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2853
Cell Significance Index: 13.4100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2635
Cell Significance Index: 116.4800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2520
Cell Significance Index: 11.7500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2193
Cell Significance Index: 15.1700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2140
Cell Significance Index: 5.9800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2116
Cell Significance Index: 42.0000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1980
Cell Significance Index: 14.7600
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.1446
Cell Significance Index: 0.9000
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.1022
Cell Significance Index: 1.1900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0756
Cell Significance Index: 1.8900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0728
Cell Significance Index: 99.0100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0616
Cell Significance Index: 7.0300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0577
Cell Significance Index: 4.0800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0489
Cell Significance Index: 30.5500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0482
Cell Significance Index: 2.5100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0445
Cell Significance Index: 68.5100
Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: 0.0306
Cell Significance Index: 0.2200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0229
Cell Significance Index: 0.2600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0196
Cell Significance Index: 36.0900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0108
Cell Significance Index: 0.0700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0068
Cell Significance Index: 4.3200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0057
Cell Significance Index: 4.3500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0011
Cell Significance Index: -0.0300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0067
Cell Significance Index: -12.6500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0084
Cell Significance Index: -6.1900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0118
Cell Significance Index: -8.1400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0131
Cell Significance Index: -2.2400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0162
Cell Significance Index: -11.8700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0180
Cell Significance Index: -0.2500
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0184
Cell Significance Index: -0.9300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0197
Cell Significance Index: -11.0900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0214
Cell Significance Index: -0.1800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0249
Cell Significance Index: -3.4200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0314
Cell Significance Index: -3.6000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0317
Cell Significance Index: -14.3900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0352
Cell Significance Index: -4.1000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0413
Cell Significance Index: -14.8200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0457
Cell Significance Index: -9.6200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0507
Cell Significance Index: -14.5800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0586
Cell Significance Index: -8.5100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0756
Cell Significance Index: -5.8000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0761
Cell Significance Index: -7.7700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0780
Cell Significance Index: -15.6600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0938
Cell Significance Index: -5.7500
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: -0.0941
Cell Significance Index: -1.0200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1119
Cell Significance Index: -4.5800
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1233
Cell Significance Index: -1.8200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1233
Cell Significance Index: -3.9500
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.1356
Cell Significance Index: -2.2800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1413
Cell Significance Index: -4.9100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1486
Cell Significance Index: -3.6000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1506
Cell Significance Index: -2.3300
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1514
Cell Significance Index: -2.1000
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: -0.1548
Cell Significance Index: -1.2800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1569
Cell Significance Index: -9.8900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1602
Cell Significance Index: -16.6800
Cell Name: photoreceptor cell (CL0000210)
Fold Change: -0.1666
Cell Significance Index: -2.3400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1890
Cell Significance Index: -14.9700
Cell Name: preosteoblast (CL0007010)
Fold Change: -0.1972
Cell Significance Index: -1.7900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2073
Cell Significance Index: -7.6100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2317
Cell Significance Index: -15.5800
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.2605
Cell Significance Index: -1.7700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2807
Cell Significance Index: -4.2300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2881
Cell Significance Index: -17.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** EPHA2 is a member of the Ephrin receptor family, which is characterized by its ability to bind to ephrin ligands and activate downstream signaling pathways. The EPHA2 protein is a type-A receptor, which is distinct from type-B receptors. EPHA2 is expressed in various cell types, including squamous epithelial cells, bladder urothelial cells, and stem cells of the epidermis. Its expression is also observed in the nervous system, where it is involved in axon guidance and neural development. **Pathways and Functions** EPHA2 is involved in multiple signaling pathways, including: 1. **Ephrin-Eph signaling pathway**: EPHA2 binds to ephrin ligands, which activates the receptor's tyrosine kinase activity and triggers downstream signaling pathways. 2. **Rho GTPase pathway**: EPHA2 interacts with Rho GTPases, such as Rac1 and RhoA, to regulate cell migration, adhesion, and morphology. 3. **Akt/mTOR pathway**: EPHA2 activates the Akt/mTOR pathway, which regulates cell growth, proliferation, and survival. 4. **MAPK/ERK pathway**: EPHA2 also activates the MAPK/ERK pathway, which is involved in cell differentiation, migration, and survival. **Clinical Significance** EPHA2 has been implicated in various diseases, including: 1. **Cancer**: EPHA2 is overexpressed in several types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with poor prognosis and metastasis. 2. **Immune system disorders**: EPHA2 is involved in the development and function of the immune system. Its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurological disorders**: EPHA2 is involved in the development and function of the nervous system. Its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Implications for Immunology** EPHA2 has significant implications for immunology, particularly in the context of cancer and autoimmune diseases. Its dysregulation can lead to the development of cancer and autoimmune diseases, highlighting the need for further research into the mechanisms of EPHA2 signaling and its role in immune system regulation. In conclusion, EPHA2 is a complex receptor tyrosine kinase that plays a crucial role in various biological processes, including cell adhesion, migration, and signaling pathways. Its dysregulation has been implicated in various diseases, including cancer, immune system disorders, and neurological disorders. Further research into the mechanisms of EPHA2 signaling and its role in immune system regulation is necessary to understand its implications for human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ephrin type-A receptor 2

Genular Protein ID: 2527482516

Symbol: EPHA2_HUMAN

Name: Ephrin type-A receptor 2

UniProtKB Accession Codes:

P29317 B5A968 Q8N3Z2

Database IDs:

Citations:

PubMed ID: 2174105

Title: cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.

PubMed ID: 2174105

DOI: 10.1128/mcb.10.12.6316-6324.1990

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 10655584

Title: Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.

PubMed ID: 10655584

DOI: 10.1038/35000008

PubMed ID: 11280802

Title: EphA2 overexpression causes tumorigenesis of mammary epithelial cells.

PubMed ID: 11280802

PubMed ID: 12167657

Title: Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation.

PubMed ID: 12167657

DOI: 10.1074/jbc.m207127200

PubMed ID: 16236711

Title: EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability.

PubMed ID: 16236711

DOI: 10.1074/jbc.m503786200

PubMed ID: 17332925

Title: Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK.

PubMed ID: 17332925

PubMed ID: 17135240

Title: Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation.

PubMed ID: 17135240

DOI: 10.1074/jbc.m608509200

PubMed ID: 18339848

Title: EphA2 is an essential mediator of UV radiation-induced apoptosis.

PubMed ID: 18339848

DOI: 10.1158/0008-5472.can-07-2372

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18794797

Title: Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor.

PubMed ID: 18794797

DOI: 10.1038/onc.2008.328

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19573808

Title: EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt.

PubMed ID: 19573808

DOI: 10.1016/j.ccr.2009.04.009

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19567782

Title: Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis.

PubMed ID: 19567782

DOI: 10.1158/1541-7786.mcr-08-0582

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20679435

Title: Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.

PubMed ID: 20679435

DOI: 10.1083/jcb.201005141

PubMed ID: 20861311

Title: Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1.

PubMed ID: 20861311

DOI: 10.1091/mbc.e10-03-0242

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20223987

Title: Restriction of receptor movement alters cellular response: physical force sensing by EphA2.

PubMed ID: 20223987

DOI: 10.1126/science.1181729

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21516087

Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

PubMed ID: 21516087

DOI: 10.1038/nm.2341

PubMed ID: 22332920

Title: Solution structure of the first Sam domain of Odin and binding studies with the EphA2 receptor.

PubMed ID: 22332920

DOI: 10.1021/bi300141h

PubMed ID: 22635007

Title: The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma-associated herpesvirus.

PubMed ID: 22635007

DOI: 10.1038/nm.2805

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23358419

Title: Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration.

PubMed ID: 23358419

DOI: 10.1128/mcb.01708-12

PubMed ID: 23936024

Title: Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors.

PubMed ID: 23936024

DOI: 10.1371/journal.pone.0069473

PubMed ID: 26158630

Title: Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.

PubMed ID: 26158630

DOI: 10.1038/ncomms8679

PubMed ID: 27385333

Title: Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation.

PubMed ID: 27385333

DOI: 10.1091/mbc.e16-01-0048

PubMed ID: 29292383

Title: Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry.

PubMed ID: 29292383

DOI: 10.1038/s41564-017-0080-8

PubMed ID: 29292384

Title: Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.

PubMed ID: 29292384

DOI: 10.1038/s41564-017-0081-7

PubMed ID: 34067457

Title: EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4.

PubMed ID: 34067457

DOI: 10.3390/cells10061290

PubMed ID: 37146061

Title: EphA2 is a functional entry receptor for HCMV infection of glioblastoma cells.

PubMed ID: 37146061

DOI: 10.1371/journal.ppat.1011304

PubMed ID: 12467573

Title: Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.

PubMed ID: 12467573

DOI: 10.1016/s0969-2126(02)00907-3

PubMed ID: 19525919

Title: Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.

PubMed ID: 19525919

DOI: 10.1038/embor.2009.91

PubMed ID: 20505120

Title: Architecture of Eph receptor clusters.

PubMed ID: 20505120

DOI: 10.1073/pnas.1004148107

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19005574

Title: The EPHA2 gene is associated with cataracts linked to chromosome 1p.

PubMed ID: 19005574

PubMed ID: 19306328

Title: Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract.

PubMed ID: 19306328

DOI: 10.1002/humu.20995

PubMed ID: 19649315

Title: EPHA2 is associated with age-related cortical cataract in mice and humans.

PubMed ID: 19649315

DOI: 10.1371/journal.pgen.1000584

PubMed ID: 22570727

Title: Human cataract mutations in EPHA2 SAM domain alter receptor stability and function.

PubMed ID: 22570727

DOI: 10.1371/journal.pone.0036564

Sequence Information:

Length: 976
Mass: 108266
Checksum: 845D7E1BBCCAACCC
Sequence:

MELQAARACF ALLWGCALAA AAAAQGKEVV LLDFAAAGGE LGWLTHPYGK GWDLMQNIMN 
DMPIYMYSVC NVMSGDQDNW LRTNWVYRGE AERIFIELKF TVRDCNSFPG GASSCKETFN 
LYYAESDLDY GTNFQKRLFT KIDTIAPDEI TVSSDFEARH VKLNVEERSV GPLTRKGFYL 
AFQDIGACVA LLSVRVYYKK CPELLQGLAH FPETIAGSDA PSLATVAGTC VDHAVVPPGG 
EEPRMHCAVD GEWLVPIGQC LCQAGYEKVE DACQACSPGF FKFEASESPC LECPEHTLPS 
PEGATSCECE EGFFRAPQDP ASMPCTRPPS APHYLTAVGM GAKVELRWTP PQDSGGREDI 
VYSVTCEQCW PESGECGPCE ASVRYSEPPH GLTRTSVTVS DLEPHMNYTF TVEARNGVSG 
LVTSRSFRTA SVSINQTEPP KVRLEGRSTT SLSVSWSIPP PQQSRVWKYE VTYRKKGDSN 
SYNVRRTEGF SVTLDDLAPD TTYLVQVQAL TQEGQGAGSK VHEFQTLSPE GSGNLAVIGG 
VAVGVVLLLV LAGVGFFIHR RRKNQRARQS PEDVYFSKSE QLKPLKTYVD PHTYEDPNQA 
VLKFTTEIHP SCVTRQKVIG AGEFGEVYKG MLKTSSGKKE VPVAIKTLKA GYTEKQRVDF 
LGEAGIMGQF SHHNIIRLEG VISKYKPMMI ITEYMENGAL DKFLREKDGE FSVLQLVGML 
RGIAAGMKYL ANMNYVHRDL AARNILVNSN LVCKVSDFGL SRVLEDDPEA TYTTSGGKIP 
IRWTAPEAIS YRKFTSASDV WSFGIVMWEV MTYGERPYWE LSNHEVMKAI NDGFRLPTPM 
DCPSAIYQLM MQCWQQERAR RPKFADIVSI LDKLIRAPDS LKTLADFDPR VSIRLPSTSG 
SEGVPFRTVS EWLESIKMQQ YTEHFMAAGY TAIEKVVQMT NDDIKRIGVR LPGHQKRIAY 
SLLGLKDQVN TVGIPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EPHA2

Associated with

Cells (max top 100)

Other Information

cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. PubMed ID: 2174105

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. PubMed ID: 18593464

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Unified nomenclature for Eph family receptors and their ligands, the ephrins. PubMed ID: 9267020

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. PubMed ID: 10655584

EphA2 overexpression causes tumorigenesis of mammary epithelial cells. PubMed ID: 11280802

Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation. PubMed ID: 12167657

EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability. PubMed ID: 16236711

Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK. PubMed ID: 17332925

Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation. PubMed ID: 17135240

EphA2 is an essential mediator of UV radiation-induced apoptosis. PubMed ID: 18339848

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. PubMed ID: 18794797

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. PubMed ID: 19573808

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis. PubMed ID: 19567782

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. PubMed ID: 20679435

Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1. PubMed ID: 20861311

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Restriction of receptor movement alters cellular response: physical force sensing by EphA2. PubMed ID: 20223987

Initial characterization of the human central proteome. PubMed ID: 21269460

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. PubMed ID: 21516087

Solution structure of the first Sam domain of Odin and binding studies with the EphA2 receptor. PubMed ID: 22332920

The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma-associated herpesvirus. PubMed ID: 22635007

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration. PubMed ID: 23358419

Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors. PubMed ID: 23936024

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2. PubMed ID: 26158630

Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. PubMed ID: 27385333

Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry. PubMed ID: 29292383

Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus. PubMed ID: 29292384

EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4. PubMed ID: 34067457

EphA2 is a functional entry receptor for HCMV infection of glioblastoma cells. PubMed ID: 37146061

Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. PubMed ID: 12467573

Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. PubMed ID: 19525919

Architecture of Eph receptor clusters. PubMed ID: 20505120

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

The EPHA2 gene is associated with cataracts linked to chromosome 1p. PubMed ID: 19005574

Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataract. PubMed ID: 19306328

EPHA2 is associated with age-related cortical cataract in mice and humans. PubMed ID: 19649315

Human cataract mutations in EPHA2 SAM domain alter receptor stability and function. PubMed ID: 22570727