Details for: EIF4EBP1

Gene ID: 1978

Symbol: EIF4EBP1

Ensembl ID: ENSG00000187840

Description: eukaryotic translation initiation factor 4E binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.15
    Marker Score: 7168
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.1
    Marker Score: 3232.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.57
    Marker Score: 20066
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.53
    Marker Score: 1010
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.37
    Marker Score: 841
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.31
    Marker Score: 4092
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.24
    Marker Score: 19301
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.05
    Marker Score: 657
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.97
    Marker Score: 50527
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.95
    Marker Score: 2081
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.93
    Marker Score: 5258
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.92
    Marker Score: 1600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.9
    Marker Score: 1046
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.89
    Marker Score: 9295.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.88
    Marker Score: 24857
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.88
    Marker Score: 1273
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.87
    Marker Score: 1756
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.83
    Marker Score: 3865
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.82
    Marker Score: 1144
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.81
    Marker Score: 900
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.77
    Marker Score: 1885
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.76
    Marker Score: 98343
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.75
    Marker Score: 2819
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.75
    Marker Score: 11351
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.72
    Marker Score: 10470
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.71
    Marker Score: 3329
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.69
    Marker Score: 1821
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.65
    Marker Score: 1472.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.63
    Marker Score: 522
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.61
    Marker Score: 1844
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.61
    Marker Score: 3821
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.59
    Marker Score: 1786.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.59
    Marker Score: 765
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.58
    Marker Score: 3720
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.57
    Marker Score: 898
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.55
    Marker Score: 568
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.52
    Marker Score: 501
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.51
    Marker Score: 15209
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167077
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.44
    Marker Score: 603
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.43
    Marker Score: 585
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.43
    Marker Score: 1455
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.4
    Marker Score: 449
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.37
    Marker Score: 5601
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.36
    Marker Score: 644
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.35
    Marker Score: 3072
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.34
    Marker Score: 948
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.34
    Marker Score: 1281
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.33
    Marker Score: 15486
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.32
    Marker Score: 375
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.32
    Marker Score: 953
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.29
    Marker Score: 811.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.27
    Marker Score: 428
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.27
    Marker Score: 402
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.27
    Marker Score: 43836
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.26
    Marker Score: 586.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.26
    Marker Score: 3254
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.26
    Marker Score: 1328
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.25
    Marker Score: 2619
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.24
    Marker Score: 3082
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.22
    Marker Score: 605
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.21
    Marker Score: 5200
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.2
    Marker Score: 833
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2
    Marker Score: 13465
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.19
    Marker Score: 416
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.18
    Marker Score: 750.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.18
    Marker Score: 11986
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.18
    Marker Score: 2007
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 1.16
    Marker Score: 654
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.15
    Marker Score: 4273
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.15
    Marker Score: 1445
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.15
    Marker Score: 682
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.14
    Marker Score: 4404
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.13
    Marker Score: 849
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.13
    Marker Score: 391
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.11
    Marker Score: 1043
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.1
    Marker Score: 587
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.09
    Marker Score: 1446
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.08
    Marker Score: 817
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.08
    Marker Score: 1084
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.06
    Marker Score: 710
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.06
    Marker Score: 6270
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.05
    Marker Score: 425
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.05
    Marker Score: 235
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.04
    Marker Score: 1043.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.04
    Marker Score: 693
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.03
    Marker Score: 2856
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.02
    Marker Score: 1275
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.02
    Marker Score: 252
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.02
    Marker Score: 701
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.01
    Marker Score: 1561
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1
    Marker Score: 345
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71647
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47872
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.99
    Marker Score: 1798.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30383
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.98
    Marker Score: 1013
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.97
    Marker Score: 276
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.97
    Marker Score: 1428
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 15059

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Other Information

**Key characteristics:** - The EIF4EBP1 gene is located on chromosome 17p13.1. - It is a member of the EIF4EBP family of transcription factors. - It is highly expressed in various cell types, including acinar cells of the salivary gland, erythroid progenitor cells, stratified epithelial cells, serous secreting cells, mammary gland epithelial cells, luminal epithelial cells of the mammary gland, epithelial cells of the esophagus, embryonic stem cells, and alveolar macrophages. **Pathways and functions:** - EIF4EBP1 binds to the cap-binding complex and eifs, which are proteins that form the cap-dependent translation initiation complex. - Upon binding, it recruits 43s to the 5' cap of the mRNA, where it promotes the binding of eIF4G to the mRNA. - This binding initiates the cap-dependent translation initiation pathway, which is essential for the initiation of protein synthesis in eukaryotic cells. **Clinical significance:** - EIF4EBP1 mutations have been linked to various human diseases, including cancer and neurodegenerative disorders. - Inhibition of EIF4EBP1 has been shown to suppress cancer cell growth and metastasis. - Therefore, targeting EIF4EBP1 is a promising therapeutic strategy for cancer treatment.

Genular Protein ID: 2003569418

Symbol: 4EBP1_HUMAN

Name: Eukaryotic translation initiation factor 4E-binding protein 1

UniProtKB Accession Codes:

Q13541 B2R502 D3DSW8 Q6IBN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 10 EMDB 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 20 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7935836

Title: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.

PubMed ID: 7935836

DOI: 10.1038/371762a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8521827

Title: Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

PubMed ID: 8521827

DOI: 10.1002/j.1460-2075.1995.tb00257.x

PubMed ID: 9465032

Title: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

PubMed ID: 9465032

DOI: 10.1073/pnas.95.4.1432

PubMed ID: 12150926

Title: Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

PubMed ID: 12150926

DOI: 10.1016/s0092-8674(02)00833-4

PubMed ID: 12747827

Title: TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.

PubMed ID: 12747827

DOI: 10.1016/s0960-9822(03)00329-4

PubMed ID: 12588975

Title: The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.

PubMed ID: 12588975

DOI: 10.1128/mcb.23.5.1546-1557.2003

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22684010

Title: 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.

PubMed ID: 22684010

DOI: 10.1016/j.febslet.2012.05.059

PubMed ID: 22578813

Title: Translational homeostasis via the mRNA cap-binding protein, eIF4E.

PubMed ID: 22578813

DOI: 10.1016/j.molcel.2012.04.004

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24403073

Title: Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.

PubMed ID: 24403073

DOI: 10.1074/jbc.m113.482067

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29750193

Title: Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.

PubMed ID: 29750193

DOI: 10.1126/sciadv.aao5838

PubMed ID: 9684899

Title: The interaction of eIF4E with 4E-BP1 is an induced fit to a completely disordered protein.

PubMed ID: 9684899

DOI: 10.1002/pro.5560070720

PubMed ID: 16271312

Title: Structural basis for mRNA cap-binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods.

PubMed ID: 16271312

DOI: 10.1016/j.bbapap.2005.07.023

PubMed ID: 17368478

Title: Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.

PubMed ID: 17368478

DOI: 10.1016/j.jmb.2007.02.019

PubMed ID: 17631896

Title: Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives.

PubMed ID: 17631896

DOI: 10.1016/j.jmb.2007.06.033

PubMed ID: 25702871

Title: Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.

PubMed ID: 25702871

DOI: 10.1016/j.molcel.2015.01.017

PubMed ID: 29236692

Title: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.

PubMed ID: 29236692

DOI: 10.1038/nature25023

Sequence Information:

  • Length: 118
  • Mass: 12580
  • Checksum: 1682A6BA74132966
  • Sequence:
    • MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT RIIYDRKFLM 
ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN SPEDKRAGGE ESQFEMDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.