Details for: EIF4EBP1

Gene ID: 1978

Symbol: EIF4EBP1

Ensembl ID: ENSG00000187840

Description: eukaryotic translation initiation factor 4E binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.8880
    Cell Significance Index: -22.0700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.1558
    Cell Significance Index: -33.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.2148
    Cell Significance Index: -33.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.9407
    Cell Significance Index: -17.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.6087
    Cell Significance Index: -32.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 49.1787
    Cell Significance Index: -33.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.4396
    Cell Significance Index: -28.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7471
    Cell Significance Index: -28.7900
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 9.6827
    Cell Significance Index: 7.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9700
    Cell Significance Index: -31.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.3860
    Cell Significance Index: 627.6800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 4.0917
    Cell Significance Index: 85.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4908
    Cell Significance Index: -7.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.3013
    Cell Significance Index: 153.9200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.0432
    Cell Significance Index: 26.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.6142
    Cell Significance Index: 28.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.0821
    Cell Significance Index: 26.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7514
    Cell Significance Index: 36.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.6799
    Cell Significance Index: 286.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6136
    Cell Significance Index: 42.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4953
    Cell Significance Index: 13.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4559
    Cell Significance Index: 188.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2856
    Cell Significance Index: 60.4200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.0864
    Cell Significance Index: 6.7500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0703
    Cell Significance Index: 8.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0138
    Cell Significance Index: 139.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9163
    Cell Significance Index: 59.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8589
    Cell Significance Index: 469.0900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.8413
    Cell Significance Index: 5.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8277
    Cell Significance Index: 15.3000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.8173
    Cell Significance Index: 5.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7859
    Cell Significance Index: 35.6200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.7813
    Cell Significance Index: 3.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7354
    Cell Significance Index: 54.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6781
    Cell Significance Index: 73.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6220
    Cell Significance Index: 9.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5643
    Cell Significance Index: 101.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5616
    Cell Significance Index: 71.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5168
    Cell Significance Index: 102.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4793
    Cell Significance Index: 91.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4349
    Cell Significance Index: 12.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3716
    Cell Significance Index: 60.4400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3566
    Cell Significance Index: 5.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3236
    Cell Significance Index: 39.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3217
    Cell Significance Index: 8.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2803
    Cell Significance Index: 123.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2575
    Cell Significance Index: 25.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2506
    Cell Significance Index: 189.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2315
    Cell Significance Index: 8.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1016
    Cell Significance Index: 1.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0989
    Cell Significance Index: 5.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0944
    Cell Significance Index: 2.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0772
    Cell Significance Index: 9.1000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0281
    Cell Significance Index: 0.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0053
    Cell Significance Index: 0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0039
    Cell Significance Index: 1.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0002
    Cell Significance Index: -0.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0006
    Cell Significance Index: -0.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0090
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0094
    Cell Significance Index: -17.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0220
    Cell Significance Index: -40.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0266
    Cell Significance Index: -40.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0278
    Cell Significance Index: -20.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0297
    Cell Significance Index: -40.3500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0304
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0307
    Cell Significance Index: -19.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0332
    Cell Significance Index: -22.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0382
    Cell Significance Index: -21.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0420
    Cell Significance Index: -26.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0496
    Cell Significance Index: -9.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0668
    Cell Significance Index: -30.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0688
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0714
    Cell Significance Index: -8.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0870
    Cell Significance Index: -25.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1017
    Cell Significance Index: -21.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1018
    Cell Significance Index: -2.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1024
    Cell Significance Index: -2.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1037
    Cell Significance Index: -3.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1370
    Cell Significance Index: -9.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1470
    Cell Significance Index: -4.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1769
    Cell Significance Index: -5.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1787
    Cell Significance Index: -25.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1794
    Cell Significance Index: -5.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1980
    Cell Significance Index: -12.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2152
    Cell Significance Index: -24.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2500
    Cell Significance Index: -6.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2649
    Cell Significance Index: -13.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2958
    Cell Significance Index: -30.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3482
    Cell Significance Index: -27.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3615
    Cell Significance Index: -27.7400
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: -0.3737
    Cell Significance Index: -2.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4222
    Cell Significance Index: -23.6900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4313
    Cell Significance Index: -6.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4606
    Cell Significance Index: -30.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4608
    Cell Significance Index: -28.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4766
    Cell Significance Index: -30.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4974
    Cell Significance Index: -13.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5415
    Cell Significance Index: -15.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6186
    Cell Significance Index: -8.4400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.6397
    Cell Significance Index: -3.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EIF4EBP1 is a phosphoprotein that exists in two isoforms, eIF4EBP1α and eIF4EBP1β, which are generated by alternative splicing. The protein is characterized by its ability to bind to eIF4E, inhibiting its guanine nucleotide exchange activity. This binding inhibits the recruitment of the 43S ribosomal subunit to the mRNA cap, thereby regulating the initiation of translation. EIF4EBP1 is also a substrate for protein kinase B (PKB/Akt) and protein kinase C (PKC), which phosphorylates and activates the protein. Phosphorylation of EIF4EBP1 promotes its release from eIF4E, allowing eIF4E to activate translation. **Pathways and Functions** EIF4EBP1 is involved in various cellular processes, including: 1. **Translation regulation**: EIF4EBP1 inhibits the activity of eIF4E, regulating the initiation of translation in response to various cellular signals. 2. **Cell growth and proliferation**: EIF4EBP1 is involved in the regulation of cell growth and proliferation by controlling protein synthesis in response to growth factors and energy availability. 3. **Stress response**: EIF4EBP1 is activated in response to cellular stress, including hypoxia, heat shock, and nutrient deprivation, promoting the inhibition of translation to protect cells from damage. 4. **Metabolism of proteins**: EIF4EBP1 regulates the metabolism of proteins by controlling the translation of specific mRNAs involved in protein degradation and synthesis. 5. **Signaling pathways**: EIF4EBP1 is involved in various signaling pathways, including the mTORC1 pathway, which regulates protein synthesis and cell growth. **Clinical Significance** Dysregulation of EIF4EBP1 has been implicated in various diseases, including: 1. **Cancer**: EIF4EBP1 is overexpressed in several types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth and proliferation. 2. **Neurodegenerative diseases**: EIF4EBP1 has been implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's disease, where it regulates protein synthesis and clearance. 3. **Metabolic disorders**: EIF4EBP1 is involved in the regulation of glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as diabetes and obesity. In conclusion, EIF4EBP1 is a critical regulator of protein synthesis in eukaryotic cells, playing a key role in controlling translation in response to various cellular signals. Its dysregulation has been implicated in various diseases, highlighting the importance of EIF4EBP1 in maintaining cellular homeostasis and promoting overall health.

Genular Protein ID: 2003569418

Symbol: 4EBP1_HUMAN

Name: Eukaryotic translation initiation factor 4E-binding protein 1

UniProtKB Accession Codes:

Q13541 B2R502 D3DSW8 Q6IBN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 9 EMDB 2 Ensembl 1 EvolutionaryTrace 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7935836

Title: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.

PubMed ID: 7935836

DOI: 10.1038/371762a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8521827

Title: Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

PubMed ID: 8521827

DOI: 10.1002/j.1460-2075.1995.tb00257.x

PubMed ID: 9465032

Title: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

PubMed ID: 9465032

DOI: 10.1073/pnas.95.4.1432

PubMed ID: 12150926

Title: Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

PubMed ID: 12150926

DOI: 10.1016/s0092-8674(02)00833-4

PubMed ID: 12747827

Title: TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.

PubMed ID: 12747827

DOI: 10.1016/s0960-9822(03)00329-4

PubMed ID: 12588975

Title: The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.

PubMed ID: 12588975

DOI: 10.1128/mcb.23.5.1546-1557.2003

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22684010

Title: 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.

PubMed ID: 22684010

DOI: 10.1016/j.febslet.2012.05.059

PubMed ID: 22578813

Title: Translational homeostasis via the mRNA cap-binding protein, eIF4E.

PubMed ID: 22578813

DOI: 10.1016/j.molcel.2012.04.004

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24403073

Title: Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.

PubMed ID: 24403073

DOI: 10.1074/jbc.m113.482067

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29750193

Title: Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.

PubMed ID: 29750193

DOI: 10.1126/sciadv.aao5838

PubMed ID: 9684899

Title: The interaction of eIF4E with 4E-BP1 is an induced fit to a completely disordered protein.

PubMed ID: 9684899

DOI: 10.1002/pro.5560070720

PubMed ID: 16271312

Title: Structural basis for mRNA cap-binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods.

PubMed ID: 16271312

DOI: 10.1016/j.bbapap.2005.07.023

PubMed ID: 17368478

Title: Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.

PubMed ID: 17368478

DOI: 10.1016/j.jmb.2007.02.019

PubMed ID: 17631896

Title: Crystallographic and mass spectrometric characterisation of eIF4E with N7-alkylated cap derivatives.

PubMed ID: 17631896

DOI: 10.1016/j.jmb.2007.06.033

PubMed ID: 25702871

Title: Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.

PubMed ID: 25702871

DOI: 10.1016/j.molcel.2015.01.017

PubMed ID: 29236692

Title: Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.

PubMed ID: 29236692

DOI: 10.1038/nature25023

Sequence Information:

  • Length: 118
  • Mass: 12580
  • Checksum: 1682A6BA74132966
  • Sequence:
    • MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT RIIYDRKFLM 
ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN SPEDKRAGGE ESQFEMDI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.