Details for: EIF5

Gene ID: 1983

Symbol: EIF5

Ensembl ID: ENSG00000100664

Description: eukaryotic translation initiation factor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 610.4977
    Cell Significance Index: -94.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 378.7996
    Cell Significance Index: -96.0800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 257.1443
    Cell Significance Index: -105.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 232.9067
    Cell Significance Index: -94.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 227.2079
    Cell Significance Index: -107.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 208.6957
    Cell Significance Index: -107.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 160.4567
    Cell Significance Index: -107.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 100.8439
    Cell Significance Index: -96.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 78.7701
    Cell Significance Index: -97.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.7751
    Cell Significance Index: -87.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.7341
    Cell Significance Index: -109.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.9561
    Cell Significance Index: -73.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.2290
    Cell Significance Index: -33.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.6768
    Cell Significance Index: 127.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.7983
    Cell Significance Index: 131.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.5371
    Cell Significance Index: 453.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2523
    Cell Significance Index: 152.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.7848
    Cell Significance Index: 73.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3147
    Cell Significance Index: 149.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2190
    Cell Significance Index: 63.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1483
    Cell Significance Index: 295.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1471
    Cell Significance Index: 97.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0508
    Cell Significance Index: 333.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9843
    Cell Significance Index: 1083.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9324
    Cell Significance Index: 237.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8504
    Cell Significance Index: 333.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7530
    Cell Significance Index: 92.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7431
    Cell Significance Index: 81.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7322
    Cell Significance Index: 129.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7098
    Cell Significance Index: 201.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5533
    Cell Significance Index: 80.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4456
    Cell Significance Index: 186.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4149
    Cell Significance Index: 37.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4009
    Cell Significance Index: 278.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3932
    Cell Significance Index: 151.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3679
    Cell Significance Index: 604.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3416
    Cell Significance Index: 38.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2275
    Cell Significance Index: 246.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1258
    Cell Significance Index: 12.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8527
    Cell Significance Index: 60.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7345
    Cell Significance Index: 12.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7331
    Cell Significance Index: 13.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6300
    Cell Significance Index: 9.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6203
    Cell Significance Index: 61.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5709
    Cell Significance Index: 11.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4759
    Cell Significance Index: 24.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4523
    Cell Significance Index: 162.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4125
    Cell Significance Index: 78.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2399
    Cell Significance Index: 40.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1625
    Cell Significance Index: 5.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1084
    Cell Significance Index: 79.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0662
    Cell Significance Index: 0.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0592
    Cell Significance Index: 44.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0221
    Cell Significance Index: 1.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0193
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0099
    Cell Significance Index: 18.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0217
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0310
    Cell Significance Index: -19.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0351
    Cell Significance Index: -22.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0389
    Cell Significance Index: -28.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0414
    Cell Significance Index: -76.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0442
    Cell Significance Index: -68.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0483
    Cell Significance Index: -4.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0493
    Cell Significance Index: -67.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0611
    Cell Significance Index: -1.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1402
    Cell Significance Index: -63.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1405
    Cell Significance Index: -79.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1479
    Cell Significance Index: -9.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1664
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2325
    Cell Significance Index: -48.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2726
    Cell Significance Index: -8.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3045
    Cell Significance Index: -8.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3056
    Cell Significance Index: -87.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3299
    Cell Significance Index: -20.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3684
    Cell Significance Index: -25.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3963
    Cell Significance Index: -57.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4210
    Cell Significance Index: -12.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4287
    Cell Significance Index: -32.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4404
    Cell Significance Index: -50.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5322
    Cell Significance Index: -62.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.5395
    Cell Significance Index: -3.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6524
    Cell Significance Index: -51.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6942
    Cell Significance Index: -46.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7018
    Cell Significance Index: -16.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9007
    Cell Significance Index: -23.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9631
    Cell Significance Index: -13.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9850
    Cell Significance Index: -21.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0198
    Cell Significance Index: -106.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0321
    Cell Significance Index: -21.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1679
    Cell Significance Index: -10.7600
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.4298
    Cell Significance Index: -8.4000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.4346
    Cell Significance Index: -21.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4707
    Cell Significance Index: -39.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5776
    Cell Significance Index: -69.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.6320
    Cell Significance Index: -39.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.6659
    Cell Significance Index: -10.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.7072
    Cell Significance Index: -33.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7430
    Cell Significance Index: -106.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.9434
    Cell Significance Index: -52.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.9603
    Cell Significance Index: -71.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF5 is a multifunctional protein that interacts with various proteins and RNAs to regulate translation initiation. It is composed of three domains: the N-terminal domain, the central domain, and the C-terminal domain. The N-terminal domain is responsible for binding to eIF2, the central domain interacts with eIF1 and eIF3, and the C-terminal domain is involved in the interaction with eIF4E and eIF4G. These interactions are essential for the recruitment of ribosomes to the mRNA and the initiation of translation. **Pathways and Functions:** EIF5 is involved in several key pathways, including: 1. **Cap-dependent translation initiation**: eIF5 binds to the 5' cap of mRNA, recruiting the ribosome and facilitating the initiation of translation. 2. **Cytoplasmic translation initiation**: eIF5 interacts with eIF3 and eIF1 to form the 40S ribosomal subunit, which is essential for the initiation of translation. 3. **GTP hydrolysis and joining of the 60S ribosomal subunit**: eIF5 interacts with eIF2 to facilitate the hydrolysis of GTP and the joining of the 60S ribosomal subunit to the 40S subunit. 4. **Regulation of translational initiation**: eIF5 regulates the recruitment of ribosomes to mRNA by interacting with eIF4E and eIF4G. **Clinical Significance:** EIF5 has been implicated in various diseases, including: 1. **Cancer**: eIF5 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential role in tumorigenesis. 2. **Neurodegenerative diseases**: eIF5 has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease, where it may play a role in the regulation of protein synthesis and aggregation. 3. **Immunological disorders**: eIF5 has been shown to be involved in the regulation of immune responses, and its dysregulation may contribute to immunological disorders such as autoimmune diseases. In conclusion, EIF5 is a critical protein involved in the regulation of eukaryotic translation initiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its role in human health and disease.

Genular Protein ID: 1835800574

Symbol: IF5_HUMAN

Name: Eukaryotic translation initiation factor 5

UniProtKB Accession Codes:

P55010 Q53XB3 Q9H5N2 Q9UG48

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8663286

Title: Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).

PubMed ID: 8663286

DOI: 10.1074/jbc.271.28.16934

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11166181

Title: Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein.

PubMed ID: 11166181

DOI: 10.1016/s0960-9822(00)00025-7

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21745818

Title: Mechanisms of translational regulation by a human eIF5-mimic protein.

PubMed ID: 21745818

DOI: 10.1093/nar/gkr339

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22813744

Title: The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2beta.

PubMed ID: 22813744

DOI: 10.1016/j.celrep.2012.04.007

PubMed ID: 24319994

Title: The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.

PubMed ID: 24319994

DOI: 10.1021/bi4009775

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24658146

Title: Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin.

PubMed ID: 24658146

DOI: 10.1371/journal.pone.0091465

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30211544

Title: Human eIF5 and eIF1A compete for binding to eIF5B.

PubMed ID: 30211544

DOI: 10.1021/acs.biochem.8b00839

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 431
  • Mass: 49223
  • Checksum: C6CCC3A255F9B9BC
  • Sequence:
    • MSVNVNRSVS DQFYRYKMPR LIAKVEGKGN GIKTVIVNMV DVAKALNRPP TYPTKYFGCE 
LGAQTQFDVK NDRYIVNGSH EANKLQDMLD GFIKKFVLCP ECENPETDLH VNPKKQTIGN 
SCKACGYRGM LDTHHKLCTF ILKNPPENSD SGTGKKEKEK KNRKGKDKEN GSVSSSETPP 
PPPPPNEINP PPHTMEEEED DDWGEDTTEE AQRRRMDEIS DHAKVLTLSD DLERTIEERV 
NILFDFVKKK KEEGVIDSSD KEIVAEAERL DVKAMGPLVL TEVLFNEKIR EQIKKYRRHF 
LRFCHNNKKA QRYLLHGLEC VVAMHQAQLI SKIPHILKEM YDADLLEEEV IISWSEKASK 
KYVSKELAKE IRVKAEPFIK WLKEAEEESS GGEEEDEDEN IEVVYSKAAS VPKVETVKSD 
NKDDDIDIDA I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.