Details for: EIF5

Gene ID: 1983

Symbol: EIF5

Ensembl ID: ENSG00000100664

Description: eukaryotic translation initiation factor 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.66
    Marker Score: 2,865
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.45
    Marker Score: 2,943
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.34
    Marker Score: 3,570
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.09
    Marker Score: 105,153
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.94
    Marker Score: 3,556
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.85
    Marker Score: 2,160
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.73
    Marker Score: 2,694
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.69
    Marker Score: 7,543
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.67
    Marker Score: 1,195
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.65
    Marker Score: 1,105
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.63
    Marker Score: 2,063
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.62
    Marker Score: 4,300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6
    Marker Score: 6,361
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.59
    Marker Score: 3,729
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.56
    Marker Score: 2,155
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.55
    Marker Score: 610
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.49
    Marker Score: 1,503
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.44
    Marker Score: 84,685
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.42
    Marker Score: 5,080
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.4
    Marker Score: 23,769
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.39
    Marker Score: 133,472
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.38
    Marker Score: 2,584
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.37
    Marker Score: 1,186
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.37
    Marker Score: 24,056
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.37
    Marker Score: 18,517
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 2.36
    Marker Score: 963
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.35
    Marker Score: 4,693
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.34
    Marker Score: 123,977
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.33
    Marker Score: 20,041
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.32
    Marker Score: 1,457
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.32
    Marker Score: 17,256
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 2.31
    Marker Score: 537
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.31
    Marker Score: 26,797
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.3
    Marker Score: 4,681
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.3
    Marker Score: 814
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.29
    Marker Score: 1,558
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.28
    Marker Score: 30,078
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.28
    Marker Score: 2,133
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.27
    Marker Score: 561
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.27
    Marker Score: 1,548
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.27
    Marker Score: 8,738
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.27
    Marker Score: 8,390
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.26
    Marker Score: 1,712
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.26
    Marker Score: 1,026
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.25
    Marker Score: 2,124
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.25
    Marker Score: 697
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.25
    Marker Score: 1,281
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.24
    Marker Score: 2,161
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.23
    Marker Score: 4,198
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.23
    Marker Score: 2,001
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.23
    Marker Score: 3,885
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.22
    Marker Score: 1,889
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.22
    Marker Score: 587
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.21
    Marker Score: 19,227
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.21
    Marker Score: 1,270
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.21
    Marker Score: 1,580
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2
    Marker Score: 2,654
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.19
    Marker Score: 1,005
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.19
    Marker Score: 2,825
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.19
    Marker Score: 1,380
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.18
    Marker Score: 7,511
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.17
    Marker Score: 3,078
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.17
    Marker Score: 4,227
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.17
    Marker Score: 14,107
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.17
    Marker Score: 4,521
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.16
    Marker Score: 2,476
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.16
    Marker Score: 55,305
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.15
    Marker Score: 1,827
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 2.15
    Marker Score: 904
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.15
    Marker Score: 3,169
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.15
    Marker Score: 1,475
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 2.15
    Marker Score: 1,072
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.15
    Marker Score: 1,429
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.15
    Marker Score: 2,514
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.13
    Marker Score: 4,853
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.13
    Marker Score: 6,709
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2.12
    Marker Score: 1,214
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.11
    Marker Score: 594
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.11
    Marker Score: 1,400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.11
    Marker Score: 1,092
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.11
    Marker Score: 555
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.11
    Marker Score: 28,329
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.11
    Marker Score: 2,923
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.11
    Marker Score: 735
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.11
    Marker Score: 1,880
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.1
    Marker Score: 815
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.1
    Marker Score: 5,490
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.09
    Marker Score: 597
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.09
    Marker Score: 422
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 2.09
    Marker Score: 588
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.09
    Marker Score: 6,552
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 2.08
    Marker Score: 591
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.08
    Marker Score: 23,397
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.08
    Marker Score: 935
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.08
    Marker Score: 2,166
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.07
    Marker Score: 3,676
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.07
    Marker Score: 18,198
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.07
    Marker Score: 1,509
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.07
    Marker Score: 6,138
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.07
    Marker Score: 567

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF5 is a multifunctional protein that interacts with various proteins and RNAs to regulate translation initiation. It is composed of three domains: the N-terminal domain, the central domain, and the C-terminal domain. The N-terminal domain is responsible for binding to eIF2, the central domain interacts with eIF1 and eIF3, and the C-terminal domain is involved in the interaction with eIF4E and eIF4G. These interactions are essential for the recruitment of ribosomes to the mRNA and the initiation of translation. **Pathways and Functions:** EIF5 is involved in several key pathways, including: 1. **Cap-dependent translation initiation**: eIF5 binds to the 5' cap of mRNA, recruiting the ribosome and facilitating the initiation of translation. 2. **Cytoplasmic translation initiation**: eIF5 interacts with eIF3 and eIF1 to form the 40S ribosomal subunit, which is essential for the initiation of translation. 3. **GTP hydrolysis and joining of the 60S ribosomal subunit**: eIF5 interacts with eIF2 to facilitate the hydrolysis of GTP and the joining of the 60S ribosomal subunit to the 40S subunit. 4. **Regulation of translational initiation**: eIF5 regulates the recruitment of ribosomes to mRNA by interacting with eIF4E and eIF4G. **Clinical Significance:** EIF5 has been implicated in various diseases, including: 1. **Cancer**: eIF5 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential role in tumorigenesis. 2. **Neurodegenerative diseases**: eIF5 has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease, where it may play a role in the regulation of protein synthesis and aggregation. 3. **Immunological disorders**: eIF5 has been shown to be involved in the regulation of immune responses, and its dysregulation may contribute to immunological disorders such as autoimmune diseases. In conclusion, EIF5 is a critical protein involved in the regulation of eukaryotic translation initiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its role in human health and disease.

Genular Protein ID: 1835800574

Symbol: IF5_HUMAN

Name: Eukaryotic translation initiation factor 5

UniProtKB Accession Codes:

P55010 Q53XB3 Q9H5N2 Q9UG48

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8663286

Title: Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).

PubMed ID: 8663286

DOI: 10.1074/jbc.271.28.16934

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11166181

Title: Eukaryotic translation initiation factor 5 (eIF5) acts as a classical GTPase-activator protein.

PubMed ID: 11166181

DOI: 10.1016/s0960-9822(00)00025-7

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21745818

Title: Mechanisms of translational regulation by a human eIF5-mimic protein.

PubMed ID: 21745818

DOI: 10.1093/nar/gkr339

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22813744

Title: The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2beta.

PubMed ID: 22813744

DOI: 10.1016/j.celrep.2012.04.007

PubMed ID: 24319994

Title: The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.

PubMed ID: 24319994

DOI: 10.1021/bi4009775

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24658146

Title: Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin.

PubMed ID: 24658146

DOI: 10.1371/journal.pone.0091465

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30211544

Title: Human eIF5 and eIF1A compete for binding to eIF5B.

PubMed ID: 30211544

DOI: 10.1021/acs.biochem.8b00839

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 431
  • Mass: 49223
  • Checksum: C6CCC3A255F9B9BC
  • Sequence:
    • MSVNVNRSVS DQFYRYKMPR LIAKVEGKGN GIKTVIVNMV DVAKALNRPP TYPTKYFGCE 
LGAQTQFDVK NDRYIVNGSH EANKLQDMLD GFIKKFVLCP ECENPETDLH VNPKKQTIGN 
SCKACGYRGM LDTHHKLCTF ILKNPPENSD SGTGKKEKEK KNRKGKDKEN GSVSSSETPP 
PPPPPNEINP PPHTMEEEED DDWGEDTTEE AQRRRMDEIS DHAKVLTLSD DLERTIEERV 
NILFDFVKKK KEEGVIDSSD KEIVAEAERL DVKAMGPLVL TEVLFNEKIR EQIKKYRRHF 
LRFCHNNKKA QRYLLHGLEC VVAMHQAQLI SKIPHILKEM YDADLLEEEV IISWSEKASK 
KYVSKELAKE IRVKAEPFIK WLKEAEEESS GGEEEDEDEN IEVVYSKAAS VPKVETVKSD 
NKDDDIDIDA I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.