Gene ELK1 - ENSG00000126767 | NCBI Gene ID: 2002

Details for: ELK1

Gene ID: 2002

Symbol: ELK1

Ensembl ID: ENSG00000126767

Description: ETS transcription factor ELK1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Erk/mapk targets
(R-HSA-198753)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Axon terminus
(GO:0043679)
Cell differentiation
(GO:0030154)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to testosterone stimulus
(GO:0071394)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Dendrite
(GO:0030425)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Gene expression
(GO:0010467)
Hippocampal neuron apoptotic process
(GO:0110088)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Mitochondrial membrane
(GO:0031966)
Neuronal cell body
(GO:0043025)
Nuclear receptor coactivator activity
(GO:0030374)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to fibroblast growth factor
(GO:0071774)
Response to light stimulus
(GO:0009416)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: germ cell (CL0000586)
Fold Change: 2.12
Marker Score: 3706
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.11
Marker Score: 13711
Cell Name: Unknown (CL0002371)
Fold Change: 2.07
Marker Score: 2204
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.72
Marker Score: 1853.5
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.59
Marker Score: 15953.5
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.03
Marker Score: 6134.5
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.02
Marker Score: 1473
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71752
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47976
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2403
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 484
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 438
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2714
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.88
Marker Score: 858
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4950
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5255
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308.5
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.84
Marker Score: 51635
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.84
Marker Score: 2276
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.83
Marker Score: 7862
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.8
Marker Score: 1240
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.79
Marker Score: 6799.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.79
Marker Score: 26805
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.78
Marker Score: 12163
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1257
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 568.5
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.74
Marker Score: 296
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.73
Marker Score: 6898
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.73
Marker Score: 776
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 375
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2907
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.68
Marker Score: 4345
Cell Name: brush cell (CL0002204)
Fold Change: 0.67
Marker Score: 612
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 170
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.64
Marker Score: 406.5
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.63
Marker Score: 789
Cell Name: theca cell (CL0000503)
Fold Change: 0.62
Marker Score: 446
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.62
Marker Score: 3050
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.61
Marker Score: 4641.5
Cell Name: oocyte (CL0000023)
Fold Change: 0.59
Marker Score: 146
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.58
Marker Score: 21995
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.58
Marker Score: 186
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.57
Marker Score: 1353
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.55
Marker Score: 173
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.55
Marker Score: 2019
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.54
Marker Score: 310
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 433
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.53
Marker Score: 557
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.52
Marker Score: 2027
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.51
Marker Score: 269
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.5
Marker Score: 7487
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5
Marker Score: 1051
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.49
Marker Score: 333
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.49
Marker Score: 311
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.49
Marker Score: 510.5
Cell Name: neural cell (CL0002319)
Fold Change: 0.49
Marker Score: 234
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.48
Marker Score: 109
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.48
Marker Score: 330
Cell Name: plasmablast (CL0000980)
Fold Change: 0.48
Marker Score: 639
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.48
Marker Score: 154
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.48
Marker Score: 135
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.47
Marker Score: 314
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.46
Marker Score: 762
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.46
Marker Score: 194
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.46
Marker Score: 201
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.46
Marker Score: 163
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.46
Marker Score: 420
Cell Name: Unknown (CL0000548)
Fold Change: 0.45
Marker Score: 330.5
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.45
Marker Score: 16527
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.44
Marker Score: 117
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.44
Marker Score: 293
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.43
Marker Score: 443
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.43
Marker Score: 4897
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.43
Marker Score: 894
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.43
Marker Score: 630
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.43
Marker Score: 463
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.42
Marker Score: 8393.5
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.42
Marker Score: 451.5
Cell Name: male germ cell (CL0000015)
Fold Change: 0.42
Marker Score: 121
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.42
Marker Score: 170
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.41
Marker Score: 399
Cell Name: fibroblast (CL0000057)
Fold Change: 0.41
Marker Score: 399
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.41
Marker Score: 414
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.41
Marker Score: 2447
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.41
Marker Score: 224
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.41
Marker Score: 14042.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.4
Marker Score: 620
Cell Name: stromal cell (CL0000499)
Fold Change: 0.4
Marker Score: 469
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.4
Marker Score: 190.5
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.4
Marker Score: 265
Cell Name: kidney cell (CL1000497)
Fold Change: 0.4
Marker Score: 266
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.4
Marker Score: 978.5
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.4
Marker Score: 138
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.4
Marker Score: 86
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.39
Marker Score: 90
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.39
Marker Score: 283
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.39
Marker Score: 180
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.39
Marker Score: 1613
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.39
Marker Score: 90

Hover over a box to see details here...

**Key characteristics:** - ELK1 is a transcription factor that belongs to the ETS family of transcription factors. - It is a key regulator of innate immunity and inflammation. - ELK1 is known to be a key regulator of the production of inflammatory cytokines and chemokines. - It is also involved in the regulation of cell cycle progression and apoptosis. **Pathways and functions:** - ELK1 is a key regulator of the innate immune response. - It is involved in the regulation of inflammation, cell cycle progression, and apoptosis. - It is also involved in the regulation of the immune response to viral infection. - ELK1 is a key regulator of the development and maintenance of immune tolerance. **Clinical significance:** - Mutations in ELK1 have been linked to a number of autoimmune diseases, including rheumatoid arthritis, lupus, and inflammatory bowel disease. - ELK1 inhibitors are being investigated as a treatment for these diseases. **Conclusion:** ELK1 is a key transcription factor that plays a crucial role in regulating immune responses and inflammation. Its overexpression is associated with a number of autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ETS domain-containing protein Elk-1
Q86SR6_HUMAN

Genular Protein ID: 2362399042

Symbol: ELK1_HUMAN

Name: ETS domain-containing protein Elk-1

UniProtKB Accession Codes:

P19419 B2R7H4 O75606 O95058 Q969X8 Q9UJM4

Database IDs:

Citations:

PubMed ID: 2539641

Title: elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.

PubMed ID: 2539641

DOI: 10.1126/science.2539641

PubMed ID: 9795224

Title: The human elk-1 gene family: the functional gene and two processed pseudogenes embedded in the IgH locus.

PubMed ID: 9795224

DOI: 10.1016/s0378-1119(98)00448-x

PubMed ID: 10231026

Title: Structural organization of the human ELK1 gene and its processed pseudogene ELK2 genes.

PubMed ID: 10231026

DOI: 10.1093/dnares/6.1.21

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7889942

Title: ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

PubMed ID: 7889942

DOI: 10.1002/j.1460-2075.1995.tb07076.x

PubMed ID: 1630903

Title: Elk-1 protein domains required for direct and SRF-assisted DNA-binding.

PubMed ID: 1630903

DOI: 10.1093/nar/20.13.3317

PubMed ID: 8855261

Title: Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

PubMed ID: 8855261

DOI: 10.1073/pnas.93.20.10803

PubMed ID: 9430721

Title: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.

PubMed ID: 9430721

DOI: 10.1074/jbc.273.3.1741

PubMed ID: 10637505

Title: ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry.

PubMed ID: 10637505

DOI: 10.1038/sj.onc.1203362

PubMed ID: 12887893

Title: Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity.

PubMed ID: 12887893

DOI: 10.1016/s1097-2765(03)00265-x

PubMed ID: 15210726

Title: SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1.

PubMed ID: 15210726

DOI: 10.1083/jcb.200310136

PubMed ID: 14992729

Title: SUMO promotes HDAC-mediated transcriptional repression.

PubMed ID: 14992729

DOI: 10.1016/s1097-2765(04)00060-7

PubMed ID: 15920481

Title: PIASx acts as an Elk-1 coactivator by facilitating derepression.

PubMed ID: 15920481

DOI: 10.1038/sj.emboj.7600690

PubMed ID: 17296730

Title: Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1.

PubMed ID: 17296730

DOI: 10.1128/mcb.02276-06

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26612202

Title: Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.

PubMed ID: 26612202

DOI: 10.1093/hmg/ddv486

PubMed ID: 10742173

Title: Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA.

PubMed ID: 10742173

DOI: 10.1038/74055

Sequence Information:

Length: 428
Mass: 44888
Checksum: 68F71F8ADB9D38CA
Sequence:

MDPSVTLWQF LLQLLREQGN GHIISWTSRD GGEFKLVDAE EVARLWGLRK NKTNMNYDKL 
SRALRYYYDK NIIRKVSGQK FVYKFVSYPE VAGCSTEDCP PQPEVSVTST MPNVAPAAIH 
AAPGDTVSGK PGTPKGAGMA GPGGLARSSR NEYMRSGLYS TFTIQSLQPQ PPPHPRPAVV 
LPSAAPAGAA APPSGSRSTS PSPLEACLEA EEAGLPLQVI LTPPEAPNLK SEELNVEPGL 
GRALPPEVKV EGPKEELEVA GERGFVPETT KAEPEVPPQE GVPARLPAVV MDTAGQAGGH 
AASSPEISQP QKGRKPRDLE LPLSPSLLGG PGPERTPGSG SGSGLQAPGP ALTPSLLPTH 
TLTPVLLTPS SLPPSIHFWS TLSPIAPRSP AKLSFQFPSS GSAQVHIPSI SVDGLSTPVV 
LSPGPQKP

Genular Protein ID: 1062449011

Symbol: Q86SR6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86SR6

Database IDs:

Sequence Information:

Length: 454
Mass: 47954
Checksum: 1A8081A3CD73327F
Sequence:

RSCQHCQRHR HATHRYPWDG VSTPPAMDPS VTLWQFLLQL LREQGNGHII SWTSRDGGEF 
KLVDAEEVAR LWGLRKNKTN MNYDKLSRAL RYYYDKNIIR KVSGQKFVYK FVSYPEVAGC 
STEDCPPQPE VSVTSTMPNV APAAIHAAPG DTVSGKPGTP KGAGMAGPGG LARSSRNEYM 
RSGLYSTFTI QSLQPQPPPH PRPAVVLPSA APAGAAAPPS GSRSTSPSPL EACLEAEEAG 
LPLQVILTPP EAPNLKSEEL NVEPGLGRAL PPEVKVEGPK EELEVAGERG FVPETTKAEP 
EVPPQEGVPA RLPAVVMDTA GQAGGHAASS PEISQPQKGR KPRDLELPLS PSLLGGPGPE 
RTPGSGSGSG LQAPGPALTP SLLPTHTLTP VLLTPSSLPP SIHFWSTLSP IAPRSPAKLS 
FQFPSSGSAQ VHIPSISVDG LSTPVVLSPG PQKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ELK1

Associated with

Cells (max top 100)

Other Information

elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. PubMed ID: 2539641

The human elk-1 gene family: the functional gene and two processed pseudogenes embedded in the IgH locus. PubMed ID: 9795224

Structural organization of the human ELK1 gene and its processed pseudogene ELK2 genes. PubMed ID: 10231026

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. PubMed ID: 7889942

Elk-1 protein domains required for direct and SRF-assisted DNA-binding. PubMed ID: 1630903

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. PubMed ID: 8855261

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. PubMed ID: 9430721

ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry. PubMed ID: 10637505

Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. PubMed ID: 12887893

SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. PubMed ID: 15210726

SUMO promotes HDAC-mediated transcriptional repression. PubMed ID: 14992729

PIASx acts as an Elk-1 coactivator by facilitating derepression. PubMed ID: 15920481

Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1. PubMed ID: 17296730

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD. PubMed ID: 26612202

Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA. PubMed ID: 10742173