ELK1 | ENSG00000126767 | NCBI 2002

Details for: ELK1

Gene ID: 2002

Symbol: ELK1

Ensembl ID: ENSG00000126767

Description: ETS transcription factor ELK1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Erk/mapk targets
(R-HSA-198753)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Axon terminus
(GO:0043679)
Cell differentiation
(GO:0030154)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to testosterone stimulus
(GO:0071394)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Dendrite
(GO:0030425)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Gene expression
(GO:0010467)
Hippocampal neuron apoptotic process
(GO:0110088)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Mediator complex binding
(GO:0036033)
Mitochondrial membrane
(GO:0031966)
Neuronal cell body
(GO:0043025)
Nuclear receptor coactivator activity
(GO:0030374)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to ethanol
(GO:0045471)
Response to fibroblast growth factor
(GO:0071774)
Response to light stimulus
(GO:0009416)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator activator activity
(GO:0140537)
Transcription regulator inhibitor activity
(GO:0140416)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 102.7997
Cell Significance Index: -15.9900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 59.0593
Cell Significance Index: -14.9800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 33.3538
Cell Significance Index: -13.7400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.5974
Cell Significance Index: -16.7700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.4277
Cell Significance Index: -14.5400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 5.1180
Cell Significance Index: 65.5500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.3030
Cell Significance Index: -16.9800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.2260
Cell Significance Index: -12.9800
Cell Name: granulosa cell (CL0000501)
Fold Change: 3.3858
Cell Significance Index: 89.0300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.3478
Cell Significance Index: 232.2500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.0989
Cell Significance Index: 29.4500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0560
Cell Significance Index: 953.4900
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.9662
Cell Significance Index: 4.8200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8265
Cell Significance Index: 49.6200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.8188
Cell Significance Index: 95.4200
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.8149
Cell Significance Index: 11.4300
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7519
Cell Significance Index: 122.3000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6227
Cell Significance Index: 16.9500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6017
Cell Significance Index: 8.2100
Cell Name: decidual cell (CL2000002)
Fold Change: 0.5784
Cell Significance Index: 9.2800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5671
Cell Significance Index: 113.7500
Cell Name: theca cell (CL0000503)
Fold Change: 0.4570
Cell Significance Index: 2.6900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4212
Cell Significance Index: 29.1300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.3980
Cell Significance Index: 11.6900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3921
Cell Significance Index: 11.2400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3528
Cell Significance Index: 23.7200
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.3402
Cell Significance Index: 4.8800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3235
Cell Significance Index: 44.4200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.2808
Cell Significance Index: 80.7900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2573
Cell Significance Index: 113.7500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2262
Cell Significance Index: 11.7500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2024
Cell Significance Index: 110.5200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2006
Cell Significance Index: 71.9600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1981
Cell Significance Index: 35.7200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1842
Cell Significance Index: 22.6600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1748
Cell Significance Index: 5.0400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1368
Cell Significance Index: 8.6200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1321
Cell Significance Index: 6.1600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1319
Cell Significance Index: 9.3300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1082
Cell Significance Index: 21.4800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1023
Cell Significance Index: 12.0600
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0931
Cell Significance Index: 12.0300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0735
Cell Significance Index: 3.3300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0715
Cell Significance Index: 3.3600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0686
Cell Significance Index: 47.4200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0590
Cell Significance Index: 2.6100
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.0539
Cell Significance Index: 0.6100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0526
Cell Significance Index: 10.0100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0412
Cell Significance Index: 3.0700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0391
Cell Significance Index: 2.5200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0335
Cell Significance Index: 1.2700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.0309
Cell Significance Index: 0.9100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0210
Cell Significance Index: 0.5600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0194
Cell Significance Index: 2.4900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0169
Cell Significance Index: 0.5400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0039
Cell Significance Index: 7.3600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0007
Cell Significance Index: -0.0200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0064
Cell Significance Index: -8.7000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0069
Cell Significance Index: -12.8100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0072
Cell Significance Index: -11.1500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0093
Cell Significance Index: -0.1600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0094
Cell Significance Index: -0.3300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0111
Cell Significance Index: -0.2400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0120
Cell Significance Index: -9.0500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0124
Cell Significance Index: -9.1200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0138
Cell Significance Index: -8.7700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0187
Cell Significance Index: -13.8900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0249
Cell Significance Index: -0.5300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0269
Cell Significance Index: -12.2300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0273
Cell Significance Index: -15.3800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0276
Cell Significance Index: -2.8200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0286
Cell Significance Index: -17.8500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0437
Cell Significance Index: -1.5200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0474
Cell Significance Index: -8.1000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0488
Cell Significance Index: -7.1000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0548
Cell Significance Index: -1.3700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0750
Cell Significance Index: -1.5600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0776
Cell Significance Index: -4.7700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0784
Cell Significance Index: -6.0200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0831
Cell Significance Index: -9.5200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0888
Cell Significance Index: -18.7100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0916
Cell Significance Index: -4.8100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1397
Cell Significance Index: -7.8400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1533
Cell Significance Index: -15.9600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1640
Cell Significance Index: -12.9900
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.1698
Cell Significance Index: -1.8500
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.1703
Cell Significance Index: -1.6200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1787
Cell Significance Index: -2.0300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1961
Cell Significance Index: -12.0200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2139
Cell Significance Index: -6.1100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2283
Cell Significance Index: -5.0000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2622
Cell Significance Index: -13.6600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2709
Cell Significance Index: -5.6700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2952
Cell Significance Index: -4.9400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3065
Cell Significance Index: -7.8300
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3072
Cell Significance Index: -4.6300
Cell Name: peg cell (CL4033014)
Fold Change: -0.3090
Cell Significance Index: -7.1400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3099
Cell Significance Index: -15.6600
Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.3112
Cell Significance Index: -4.2000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3188
Cell Significance Index: -3.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Structural Homology**: ELK1 shares significant structural homology with other ETS family members, which suggests that it may function similarly in regulating gene expression. 2. **DNA Binding**: ELK1 binds to specific DNA sequences, including those containing the ETS motif, which is essential for its transcriptional activation functions. 3. **Phosphorylation**: ELK1 is phosphorylated by MAPK kinases, which activates its transcriptional activity and regulates its interaction with other proteins. 4. **Regulatory Interactions**: ELK1 interacts with various transcriptional regulators, including RNA polymerase II, to regulate gene expression. **Pathways and Functions** 1. **Cell Differentiation**: ELK1 regulates cell differentiation by controlling the expression of target genes involved in cell fate decisions. 2. **Immune Response**: ELK1 is involved in immune responses, including the regulation of cytokine signaling and the activation of immune cells. 3. **Growth and Development**: ELK1 regulates growth and development by controlling the expression of genes involved in cell proliferation and survival. 4. **Neurotransmission**: ELK1 is involved in neurotransmission, particularly in the regulation of GABAergic interneurons in the cerebral cortex. **Clinical Significance** 1. **Cancer**: ELK1 has been implicated in various cancers, including lung, breast, and colon cancer, where it may contribute to tumorigenesis and metastasis. 2. **Neurological Disorders**: ELK1 may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may influence neurotransmission and neuronal survival. 3. **Immune-Mediated Diseases**: ELK1 may contribute to immune-mediated diseases, such as rheumatoid arthritis and multiple sclerosis, where it may regulate immune cell function and cytokine signaling. 4. **Reproductive Disorders**: ELK1 has been implicated in reproductive disorders, including polycystic ovary syndrome (PCOS) and male infertility, where it may regulate gene expression in germ cells and reproductive tissues. In conclusion, ELK1 is a multifunctional transcription factor that plays a critical role in regulating various cellular processes, including cell differentiation, immune responses, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its molecular mechanisms and clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ETS domain-containing protein Elk-1
Q86SR6_HUMAN

Genular Protein ID: 2362399042

Symbol: ELK1_HUMAN

Name: ETS domain-containing protein Elk-1

UniProtKB Accession Codes:

P19419 B2R7H4 O75606 O95058 Q969X8 Q9UJM4

Database IDs:

Citations:

PubMed ID: 2539641

Title: elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.

PubMed ID: 2539641

DOI: 10.1126/science.2539641

PubMed ID: 9795224

Title: The human elk-1 gene family: the functional gene and two processed pseudogenes embedded in the IgH locus.

PubMed ID: 9795224

DOI: 10.1016/s0378-1119(98)00448-x

PubMed ID: 10231026

Title: Structural organization of the human ELK1 gene and its processed pseudogene ELK2 genes.

PubMed ID: 10231026

DOI: 10.1093/dnares/6.1.21

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7889942

Title: ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

PubMed ID: 7889942

DOI: 10.1002/j.1460-2075.1995.tb07076.x

PubMed ID: 1630903

Title: Elk-1 protein domains required for direct and SRF-assisted DNA-binding.

PubMed ID: 1630903

DOI: 10.1093/nar/20.13.3317

PubMed ID: 8855261

Title: Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

PubMed ID: 8855261

DOI: 10.1073/pnas.93.20.10803

PubMed ID: 9430721

Title: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.

PubMed ID: 9430721

DOI: 10.1074/jbc.273.3.1741

PubMed ID: 10637505

Title: ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry.

PubMed ID: 10637505

DOI: 10.1038/sj.onc.1203362

PubMed ID: 10799319

Title: Characterization of hPRP4 kinase activation: potential role in signaling.

PubMed ID: 10799319

DOI: 10.1006/bbrc.2000.2651

PubMed ID: 12887893

Title: Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity.

PubMed ID: 12887893

DOI: 10.1016/s1097-2765(03)00265-x

PubMed ID: 15210726

Title: SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1.

PubMed ID: 15210726

DOI: 10.1083/jcb.200310136

PubMed ID: 14992729

Title: SUMO promotes HDAC-mediated transcriptional repression.

PubMed ID: 14992729

DOI: 10.1016/s1097-2765(04)00060-7

PubMed ID: 15920481

Title: PIASx acts as an Elk-1 coactivator by facilitating derepression.

PubMed ID: 15920481

DOI: 10.1038/sj.emboj.7600690

PubMed ID: 17296730

Title: Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1.

PubMed ID: 17296730

DOI: 10.1128/mcb.02276-06

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26612202

Title: Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.

PubMed ID: 26612202

DOI: 10.1093/hmg/ddv486

PubMed ID: 10742173

Title: Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA.

PubMed ID: 10742173

DOI: 10.1038/74055

PubMed ID: 28939839

Title: Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase.

PubMed ID: 28939839

DOI: 10.1038/s41467-017-00865-1

Sequence Information:

Length: 428
Mass: 44888
Checksum: 68F71F8ADB9D38CA
Sequence:

MDPSVTLWQF LLQLLREQGN GHIISWTSRD GGEFKLVDAE EVARLWGLRK NKTNMNYDKL 
SRALRYYYDK NIIRKVSGQK FVYKFVSYPE VAGCSTEDCP PQPEVSVTST MPNVAPAAIH 
AAPGDTVSGK PGTPKGAGMA GPGGLARSSR NEYMRSGLYS TFTIQSLQPQ PPPHPRPAVV 
LPSAAPAGAA APPSGSRSTS PSPLEACLEA EEAGLPLQVI LTPPEAPNLK SEELNVEPGL 
GRALPPEVKV EGPKEELEVA GERGFVPETT KAEPEVPPQE GVPARLPAVV MDTAGQAGGH 
AASSPEISQP QKGRKPRDLE LPLSPSLLGG PGPERTPGSG SGSGLQAPGP ALTPSLLPTH 
TLTPVLLTPS SLPPSIHFWS TLSPIAPRSP AKLSFQFPSS GSAQVHIPSI SVDGLSTPVV 
LSPGPQKP

Genular Protein ID: 1062449011

Symbol: Q86SR6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86SR6

Database IDs:

Sequence Information:

Length: 454
Mass: 47954
Checksum: 1A8081A3CD73327F
Sequence:

RSCQHCQRHR HATHRYPWDG VSTPPAMDPS VTLWQFLLQL LREQGNGHII SWTSRDGGEF 
KLVDAEEVAR LWGLRKNKTN MNYDKLSRAL RYYYDKNIIR KVSGQKFVYK FVSYPEVAGC 
STEDCPPQPE VSVTSTMPNV APAAIHAAPG DTVSGKPGTP KGAGMAGPGG LARSSRNEYM 
RSGLYSTFTI QSLQPQPPPH PRPAVVLPSA APAGAAAPPS GSRSTSPSPL EACLEAEEAG 
LPLQVILTPP EAPNLKSEEL NVEPGLGRAL PPEVKVEGPK EELEVAGERG FVPETTKAEP 
EVPPQEGVPA RLPAVVMDTA GQAGGHAASS PEISQPQKGR KPRDLELPLS PSLLGGPGPE 
RTPGSGSGSG LQAPGPALTP SLLPTHTLTP VLLTPSSLPP SIHFWSTLSP IAPRSPAKLS 
FQFPSSGSAQ VHIPSISVDG LSTPVVLSPG PQKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ELK1

Associated with

Cells (max top 100)

Other Information

elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. PubMed ID: 2539641

The human elk-1 gene family: the functional gene and two processed pseudogenes embedded in the IgH locus. PubMed ID: 9795224

Structural organization of the human ELK1 gene and its processed pseudogene ELK2 genes. PubMed ID: 10231026

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. PubMed ID: 7889942

Elk-1 protein domains required for direct and SRF-assisted DNA-binding. PubMed ID: 1630903

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. PubMed ID: 8855261

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. PubMed ID: 9430721

ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry. PubMed ID: 10637505

Characterization of hPRP4 kinase activation: potential role in signaling. PubMed ID: 10799319

Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. PubMed ID: 12887893

SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. PubMed ID: 15210726

SUMO promotes HDAC-mediated transcriptional repression. PubMed ID: 14992729

PIASx acts as an Elk-1 coactivator by facilitating derepression. PubMed ID: 15920481

Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1. PubMed ID: 17296730

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD. PubMed ID: 26612202

Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA. PubMed ID: 10742173

Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. PubMed ID: 28939839