Details for: EPB41

Gene ID: 2035

Symbol: EPB41

Ensembl ID: ENSG00000159023

Description: erythrocyte membrane protein band 4.1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 229.0009
    Cell Significance Index: -35.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.1926
    Cell Significance Index: -41.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.5614
    Cell Significance Index: -39.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 88.0080
    Cell Significance Index: -45.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.8228
    Cell Significance Index: -39.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.6199
    Cell Significance Index: -36.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.2826
    Cell Significance Index: -40.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.9017
    Cell Significance Index: -45.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4368
    Cell Significance Index: -45.1300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 10.8409
    Cell Significance Index: 83.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.9653
    Cell Significance Index: -21.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 8.4752
    Cell Significance Index: 145.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.3160
    Cell Significance Index: 235.1400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 5.0316
    Cell Significance Index: 6.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.6341
    Cell Significance Index: 175.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.7742
    Cell Significance Index: 211.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.5556
    Cell Significance Index: 196.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.4572
    Cell Significance Index: 68.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.4186
    Cell Significance Index: 62.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0735
    Cell Significance Index: 411.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0376
    Cell Significance Index: 237.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.7250
    Cell Significance Index: 108.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6135
    Cell Significance Index: 35.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4138
    Cell Significance Index: 153.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3172
    Cell Significance Index: 12.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2925
    Cell Significance Index: 210.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2111
    Cell Significance Index: 242.9400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.1453
    Cell Significance Index: 11.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.0462
    Cell Significance Index: 1422.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0154
    Cell Significance Index: 702.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9521
    Cell Significance Index: 171.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7759
    Cell Significance Index: 22.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5824
    Cell Significance Index: 71.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5727
    Cell Significance Index: 1078.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5043
    Cell Significance Index: 95.9700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.4667
    Cell Significance Index: 6.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4467
    Cell Significance Index: 10.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4345
    Cell Significance Index: 22.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4226
    Cell Significance Index: 381.6100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.3308
    Cell Significance Index: 4.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3081
    Cell Significance Index: 21.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2898
    Cell Significance Index: 103.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.2724
    Cell Significance Index: 28.3600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2605
    Cell Significance Index: 2.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2213
    Cell Significance Index: 14.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2016
    Cell Significance Index: 2.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1909
    Cell Significance Index: 121.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1868
    Cell Significance Index: 84.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1603
    Cell Significance Index: 246.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1392
    Cell Significance Index: 6.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1390
    Cell Significance Index: 7.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1161
    Cell Significance Index: 214.2000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1035
    Cell Significance Index: 1.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0905
    Cell Significance Index: 10.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0782
    Cell Significance Index: 42.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0781
    Cell Significance Index: 34.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0636
    Cell Significance Index: 10.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0635
    Cell Significance Index: 2.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0612
    Cell Significance Index: 2.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0525
    Cell Significance Index: 0.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0202
    Cell Significance Index: 1.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0075
    Cell Significance Index: 0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0263
    Cell Significance Index: -19.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0287
    Cell Significance Index: -21.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0408
    Cell Significance Index: -30.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0539
    Cell Significance Index: -2.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0670
    Cell Significance Index: -37.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0806
    Cell Significance Index: -50.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0931
    Cell Significance Index: -6.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0934
    Cell Significance Index: -4.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0949
    Cell Significance Index: -12.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1106
    Cell Significance Index: -10.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1130
    Cell Significance Index: -7.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1295
    Cell Significance Index: -18.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1353
    Cell Significance Index: -38.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1383
    Cell Significance Index: -17.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1946
    Cell Significance Index: -26.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1992
    Cell Significance Index: -20.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2143
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2309
    Cell Significance Index: -48.6300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2345
    Cell Significance Index: -2.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2674
    Cell Significance Index: -7.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3123
    Cell Significance Index: -22.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3299
    Cell Significance Index: -37.7900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3415
    Cell Significance Index: -5.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3592
    Cell Significance Index: -7.6500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3790
    Cell Significance Index: -1.6500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.4173
    Cell Significance Index: -4.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4265
    Cell Significance Index: -5.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4314
    Cell Significance Index: -12.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4996
    Cell Significance Index: -39.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5051
    Cell Significance Index: -10.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5519
    Cell Significance Index: -19.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5554
    Cell Significance Index: -8.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5732
    Cell Significance Index: -18.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5823
    Cell Significance Index: -35.7000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.5847
    Cell Significance Index: -5.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6109
    Cell Significance Index: -15.2700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.6539
    Cell Significance Index: -5.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7321
    Cell Significance Index: -15.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The band 4.1 protein is a 28-kDa glycoprotein that is highly expressed in RBCs. It is a member of the band 4.1 family of proteins, which are characterized by their ability to bind to spectrin and other cytoskeletal proteins. EPB41 is also known for its ability to interact with a wide range of proteins, including actin, calmodulin, and neuronal proteins. The protein has several distinct domains, including a spectrin-binding domain, a calmodulin-binding domain, and a protein-protein interaction domain. **Pathways and Functions** EPB41 is involved in several key cellular pathways, including: 1. **Actin cytoskeleton organization**: EPB41 plays a crucial role in maintaining the structural integrity of the RBC cytoskeleton, which is composed of actin filaments, spectrin, and ankyrin. 2. **Cell cycle regulation**: EPB41 has been shown to regulate cell cycle progression by interacting with cyclin-dependent kinases and other cell cycle regulators. 3. **Protein-protein interactions**: EPB41 interacts with a wide range of proteins, including actin, calmodulin, and neuronal proteins, to regulate various cellular processes. 4. **Calcium ion transport**: EPB41 has been shown to regulate calcium ion transport across the RBC membrane, which is essential for maintaining cell shape and function. 5. **Intestinal absorption**: EPB41 has been implicated in regulating intestinal absorption, which is essential for maintaining proper nutrient homeostasis. **Clinical Significance** Dysregulation of EPB41 has been implicated in several diseases, including: 1. **Anemia**: Mutations in the EPB41 gene have been associated with anemia, which is characterized by a decrease in red blood cell count or hemoglobin levels. 2. **Thrombocytopenia**: EPB41 has been implicated in regulating platelet function, and mutations in the EPB41 gene have been associated with thrombocytopenia, a condition characterized by a low platelet count. 3. **Neurological disorders**: EPB41 has been implicated in regulating neuronal function, and mutations in the EPB41 gene have been associated with neurological disorders, including epilepsy and Alzheimer's disease. In conclusion, EPB41 is a multifunctional protein that plays a crucial role in maintaining the structural integrity and function of red blood cells. Its dysregulation has been implicated in several diseases, including anemia, thrombocytopenia, and neurological disorders. Further research is needed to fully understand the mechanisms by which EPB41 regulates various cellular processes and to develop effective therapeutic strategies for its dysregulation.

Genular Protein ID: 4276301094

Symbol: EPB41_HUMAN

Name: Protein 4.1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3467321

Title: Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton.

PubMed ID: 3467321

DOI: 10.1073/pnas.83.24.9512

PubMed ID: 3223413

Title: Expression of specific isoforms of protein 4.1 in erythroid and non-erythroid tissues.

PubMed ID: 3223413

DOI: 10.1007/978-1-4684-5571-7_12

PubMed ID: 3375238

Title: Selective expression of an erythroid-specific isoform of protein 4.1.

PubMed ID: 3375238

DOI: 10.1073/pnas.85.11.3713

PubMed ID: 2022644

Title: Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1.

PubMed ID: 2022644

DOI: 10.1016/s0021-9258(18)92973-x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3194408

Title: Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells.

PubMed ID: 3194408

DOI: 10.1073/pnas.85.23.9062

PubMed ID: 2171679

Title: Identification of two cAMP-dependent phosphorylation sites on erythrocyte protein 4.1.

PubMed ID: 2171679

DOI: 10.1016/0167-4889(90)90095-u

PubMed ID: 3531202

Title: Structure of the spectrin-actin binding site of erythrocyte protein 4.1.

PubMed ID: 3531202

DOI: 10.1016/s0021-9258(18)69313-5

PubMed ID: 2808371

Title: O-N-acetyl-D-glucosamine moiety on discrete peptide of multiple protein 4.1 isoforms regulated by alternative pathways.

PubMed ID: 2808371

DOI: 10.1016/s0021-9258(19)84689-6

PubMed ID: 1647028

Title: Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro.

PubMed ID: 1647028

DOI: 10.1073/pnas.88.12.5222

PubMed ID: 7937897

Title: Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

PubMed ID: 7937897

DOI: 10.1073/pnas.91.21.9818

PubMed ID: 10692436

Title: Ca(2+)-dependent and Ca(2+)-independent calmodulin binding sites in erythrocyte protein 4.1. Implications for regulation of protein 4.1 interactions with transmembrane proteins.

PubMed ID: 10692436

DOI: 10.1074/jbc.275.9.6360

PubMed ID: 11003675

Title: Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex.

PubMed ID: 11003675

DOI: 10.1128/mcb.20.20.7813-7825.2000

PubMed ID: 11432737

Title: Properties of the C-terminal domain of 4.1 proteins.

PubMed ID: 11432737

DOI: 10.1046/j.1432-1327.2001.02276.x

PubMed ID: 12427749

Title: An alternative domain containing a leucine-rich sequence regulates nuclear cytoplasmic localization of protein 4.1R.

PubMed ID: 12427749

DOI: 10.1074/jbc.m201521200

PubMed ID: 15525677

Title: Mitotic regulation of protein 4.1R involves phosphorylation by cdc2 kinase.

PubMed ID: 15525677

DOI: 10.1091/mbc.e04-05-0426

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23870127

Title: Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase.

PubMed ID: 23870127

DOI: 10.1016/j.cell.2013.06.010

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11017195

Title: Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization.

PubMed ID: 11017195

DOI: 10.1038/82819

Sequence Information:

  • Length: 864
  • Mass: 97017
  • Checksum: B466E7A9D7FBF12B
  • Sequence:
  • MTTEKSLVTE AENSQHQQKE EGEEAINSGQ QEPQQEESCQ TAAEGDNWCE QKLKASNGDT 
    PTHEDLTKNK ERTSESRGLS RLFSSFLKRP KSQVSEEEGK EVESDKEKGE GGQKEIEFGT 
    SLDEEIILKA PIAAPEPELK TDPSLDLHSL SSAETQPAQE ELREDPDFEI KEGEGLEECS 
    KIEVKEESPQ SKAETELKAS QKPIRKHRNM HCKVSLLDDT VYECVVEKHA KGQDLLKRVC 
    EHLNLLEEDY FGLAIWDNAT SKTWLDSAKE IKKQVRGVPW NFTFNVKFYP PDPAQLTEDI 
    TRYYLCLQLR QDIVAGRLPC SFATLALLGS YTIQSELGDY DPELHGVDYV SDFKLAPNQT 
    KELEEKVMEL HKSYRSMTPA QADLEFLENA KKLSMYGVDL HKAKDLEGVD IILGVCSSGL 
    LVYKDKLRIN RFPWPKVLKI SYKRSSFFIK IRPGEQEQYE STIGFKLPSY RAAKKLWKVC 
    VEHHTFFRLT STDTIPKSKF LALGSKFRYS GRTQAQTRQA SALIDRPAPH FERTASKRAS 
    RSLDGAAAVD SADRSPRPTS APAITQGQVA EGGVLDASAK KTVVPKAQKE TVKAEVKKED 
    EPPEQAEPEP TEAWKVEKTH IEVTVPTSNG DQTQKLAEKT EDLIRMRKKK RERLDGENIY 
    IRHSNLMLED LDKSQEEIKK HHASISELKK NFMESVPEPR PSEWDKRLST HSPFRTLNIN 
    GQIPTGEGPP LVKTQTVTIS DNANAVKSEI PTKDVPIVHT ETKTITYEAA QTDDNSGDLD 
    PGVLLTAQTI TSETPSSTTT TQITKTVKGG ISETRIEKRI VITGDADIDH DQVLVQAIKE 
    AKEQHPDMSV TKVVVHQETE IADE

Genular Protein ID: 2032959935

Symbol: A0A2R8Y7Y3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 601
  • Mass: 67293
  • Checksum: 44095E39D69EC7DE
  • Sequence:
  • MHCKVSLLDD TVYECVVEKH AKGQDLLKRV CEHLNLLEED YFGLAIWDNA TSKTWLDSAK 
    EIKKQVRGVP WNFTFNVKFY PPDPAQLTED ITRYYLCLQL RQDIVAGRLP CSFATLALLG 
    SYTIQSELGD YDPELHGVDY VSDFKLAPNQ TKELEEKVME LHKSYRSMTP AQADLEFLEN 
    AKKLSMYGVD LHKAKDLEGV DIILGVCSSG LLVYKDKLRI NRFPWPKVLK ISYKRSSFFI 
    KIRPGEQEQY ESTIGFKLPS YRAAKKLWKV CVEHHTFFRL TSTDTIPKSK FLALGSKFRY 
    SGRTQAQTRQ ASALIDRPAP HFERTASKRA SRSLDGAAAV DSADRSPRPT SAPAITQGQV 
    AEGGVLDASA KKTVVPKAQK ETVKAEVKKE DEPPEQAEPE PTEAWKDLDK SQEEIKKHHA 
    SISELKKNFM ESVPEPRPSE WDKRLSTHSP FRTLNINGQI PTGEGPPLVK TQTVTISDNA 
    NAVKSEIPTK DVPIVHTETK TITYEAAQTD DNSGDLDPGV LLTAQTITSE TPSSTTTTQI 
    TKTVKGGISE TRIEKRIVIT GDADIDHDQV LVQAIKEAKE QHPDMSVTKV VVHQETEIAD 
    E

Genular Protein ID: 2225377896

Symbol: Q1WWM3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 742
  • Mass: 83213
  • Checksum: 213B601182F02966
  • Sequence:
  • PKSQVSEEEG KEVESDKEKG EGGQKEIEFG TSLDEEIILK APIAAPEPEL KTDPSLDLHS 
    LSSAETQPAQ EELREDPDFE IKEGEGLEEC SKIEVKEESP QSKAETELKA SQKPIRKHRN 
    MHCKVSLLDD TVYECVVEKH AKGQDLLKRV CEHLNLLEED YFGLAIWDNA TSKTWLDSAK 
    EIKKQVRGVP WNFTFNVKFY PPDPAQLTED ITRYYLCLQL RQDIVAGRLP CSFATLALLG 
    SYTIQSELGD YDPELHGVDY VSDFKLAPNQ TKELEEKVME LHKSYRSMTP AQADLEFLEN 
    AKKLSMYGVD LHKAKDLEGV DIILGVCSSG LLVYKDKLRI NRFPWPKVLK ISYKRSSFFI 
    KIRPGEQEQY ESTIGFKLPS YRAAKKLWKV CVEHHTFFRL TSTDTIPKSK FLALGSKFRY 
    SGRTQAQTRQ ASALIDRPAP HFERTASKRA SRSLDGAAAV DSADRSPRPT SAPAITQGQV 
    AEGGVLDASA KKTVVPKAQK ETVKAEVKKE DEPPEQAEPE PTEAWKKKRE RLDGENIYIR 
    HSNLMLEDLD KSQEEIKKHH ASISELKKNF MESVPEPRPS EWDKRLSTHS PFRTLNINGQ 
    IPTGEGPPLV KTQTVTISDN ANAVKSEIPT KDVPIVHTET KTITYEAAQT DDNSGDLDPG 
    VLLTAQTITS ETPSSTTTTQ ITKTVKGGIS ETRIEKRIVI TGDADIDHDQ VLVQAIKEAK 
    EQHPDMSVTK VVVHQETEIA DE

Genular Protein ID: 4181805302

Symbol: Q29RX4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 678
  • Mass: 75984
  • Checksum: 690855CAC0DD5F90
  • Sequence:
  • PKSQVSEEEG KEVESDKEKG EGGQKEIEFG TSLDEEIILK APIAAPEPEL KTDPSLDLHS 
    LSSAETQPAQ EELREDPDFE IKEGEGLEEC SKIEVKEESP QSKAETELKA SQKPIRKHRN 
    MHCKVSLLDD TVYECVVEKH AKGQDLLKRV CEHLNLLEED YFGLAIWDNA TSKTWLDSAK 
    EIKKQVRGVP WNFTFNVKFY PPDPAQLTED ITRYYLCLQL RQDIVAGRLP CSFATLALLG 
    SYTIQSELGD YDPELHGVDY VSDFKLAPNQ TKELEEKVME LHKSYRSMTP AQADLEFLEN 
    AKKLSMYGVD LHKAKDLEGV DIILGVCSSG LLVYKDKLRI NRFPWPKVLK ISYKRSSFFI 
    KIRPGEQEQY ESTIGFKLPS YRAAKKLWKV CVEHHTFFRL TSTDTIPKSK FLALGSKFRY 
    SGRTQAQTRQ ASALIDRPAP HFERTASKRA SRSLDGAAAV DSADRSPRPT SAPAITQGQV 
    AEGGVLDASA KKTVVPKAQK ETVKAEVKKE DEPPEQAEPE PTEAWKDLDK SQEEIKKHHA 
    SISELKKNFM ESVPEPRPSE WDKRLSTHSP FRTLNINGQI PTGEGTDDNS GDLDPGVLLT 
    AQTITSETPS STTTTQITKT VKGGISETRI EKRIVITGDA DIDHDQVLVQ AIKEAKEQHP 
    DMSVTKVVVH QETEIADE

Genular Protein ID: 2745306666

Symbol: Q59F12_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 827
  • Mass: 92203
  • Checksum: 2D2F25D6250C9E36
  • Sequence:
  • RARAARSQNA VGPVPAAPSP EKSLVTEAEN SQHQQKEEGE EAINSGQQEP QQEESCQTAA 
    EGDNWCEQKL KASNGDTPTH EDLTKNKERT SESRGLSRLF SSFLKRPKSQ VSEEEGKEVE 
    SDKEKGEGGQ KEIEFGTSLD EEIILKAPIA APEPELKTDP SLDLHSLSSA ETQPAQEELR 
    EDPDFEIKEG EGLEECSKIE VKEESPQSKA ETELKASQKP IRKHRNMHCK VSLLDDTVYE 
    CVVEKHAKGQ DLLKRVCEHL NLLEEDYFGL AIWDNATSKT WLDSAKEIKK QVRGVPWNFT 
    FNVKFYPPDP AQLTEDITRY YLCLQLRQDI VAGRLPCSFA TLALLGSYTI QSELGDYDPE 
    LHGVDYVSDF KLAPNQTKEL EEKVMELHKS CRSMTPAQAD LEFLENAKKL SMYGVDLHKA 
    KDLEGVDIIL GVCSSGLLVY KDKLRINRFP WPKVLKISYK RSSFFIKIRP GEQEQYESTI 
    GFKLPSYRAA KKLWKVCVEH HTFFRLTSTD TIPKSKFLAL GSKFRYSGRT QAQTRQASAL 
    IDRPAPHFER TASKRASRSL DGAAAVDSAD RSPRPTSAPA ITQGQVAEGG VLDASAKKTV 
    VPKAQKETVK AEVKKEDEPP EQAEPEPTEA WKDLDKSQEE IKKHHASISE LKKNFMESVP 
    EPRPSEWDKR LSTHSPFRTL NINGQIPTGE GPPLVKTQTV TISDNANAVK SEIPTKDVPI 
    VHTETKTITY EAAQTDDNSG DLDPGVLLTA QTITSETPSS TTTTQITKTV KGGISETRIE 
    KRIVITGDAD IDHDQVLVQA IKEAKEQHPD MSVTKVVVHQ ETEIADE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.