Details for: STOM

Gene ID: 2040

Symbol: STOM

Ensembl ID: ENSG00000148175

Description: stomatin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.11
    Marker Score: 10449
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.53
    Marker Score: 3035
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.4
    Marker Score: 4928
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.39
    Marker Score: 4931
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.2
    Marker Score: 1811
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.81
    Marker Score: 1214
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.6
    Marker Score: 5184.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.49
    Marker Score: 4219
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.47
    Marker Score: 1034
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.45
    Marker Score: 1461
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.4
    Marker Score: 2046
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.31
    Marker Score: 8903.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.23
    Marker Score: 2396
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.21
    Marker Score: 2355
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.19
    Marker Score: 2186.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.18
    Marker Score: 2626
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.16
    Marker Score: 55352
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.16
    Marker Score: 9312
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.15
    Marker Score: 1929
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.11
    Marker Score: 1233
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.1
    Marker Score: 816
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.04
    Marker Score: 69482
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.02
    Marker Score: 3571
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.01
    Marker Score: 462
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.98
    Marker Score: 1864
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.96
    Marker Score: 5416.5
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.92
    Marker Score: 796
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.9
    Marker Score: 1718
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.89
    Marker Score: 1490
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.85
    Marker Score: 12056
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.85
    Marker Score: 393
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.85
    Marker Score: 448
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.83
    Marker Score: 4463
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.8
    Marker Score: 15662.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.8
    Marker Score: 2890
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.77
    Marker Score: 737
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.76
    Marker Score: 5565
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.74
    Marker Score: 404
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.73
    Marker Score: 3243
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.72
    Marker Score: 1730
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.72
    Marker Score: 1909.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.72
    Marker Score: 4498.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.72
    Marker Score: 27568
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.71
    Marker Score: 863
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.71
    Marker Score: 4785
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.69
    Marker Score: 406
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.68
    Marker Score: 1772.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.68
    Marker Score: 6597
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.65
    Marker Score: 1589
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.64
    Marker Score: 3596
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.63
    Marker Score: 1075
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.61
    Marker Score: 765
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.6
    Marker Score: 408
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.6
    Marker Score: 461
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.59
    Marker Score: 1867
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.59
    Marker Score: 391.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.57
    Marker Score: 343
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.56
    Marker Score: 4559.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.56
    Marker Score: 5545
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.55
    Marker Score: 1480
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.55
    Marker Score: 438
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.53
    Marker Score: 8019
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.52
    Marker Score: 1875
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.5
    Marker Score: 828
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.5
    Marker Score: 1316
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.49
    Marker Score: 2447.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.49
    Marker Score: 1266
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.49
    Marker Score: 7314
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.48
    Marker Score: 662
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.46
    Marker Score: 912
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.45
    Marker Score: 1674
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.45
    Marker Score: 1032
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.45
    Marker Score: 626
  • Cell Name: platelet (CL0000233)
    Fold Change: 1.45
    Marker Score: 656.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.45
    Marker Score: 2134
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.45
    Marker Score: 424
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.41
    Marker Score: 1650
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.41
    Marker Score: 351.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.4
    Marker Score: 440
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.4
    Marker Score: 1823.5
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.4
    Marker Score: 351.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.4
    Marker Score: 819
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.4
    Marker Score: 18419
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.39
    Marker Score: 13788
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.39
    Marker Score: 596.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.38
    Marker Score: 2522
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.38
    Marker Score: 29421
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.38
    Marker Score: 4739
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.38
    Marker Score: 858
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.37
    Marker Score: 2600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.37
    Marker Score: 781
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.35
    Marker Score: 309
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.34
    Marker Score: 302
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.34
    Marker Score: 415
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.33
    Marker Score: 1671
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.33
    Marker Score: 366
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.33
    Marker Score: 338
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.31
    Marker Score: 1168
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.31
    Marker Score: 896
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.31
    Marker Score: 14749.5

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Other Information

**Key characteristics:** * STOM is a protein of 511 amino acids. * It is expressed in a variety of cell types, including endothelial cells, macrophages, and neutrophils. * It is a key regulator of the Cdc42 gtpase cycle, which is involved in cell cycle regulation. * It is also involved in the activation of the Identical protein binding (IPB) pathway, which is involved in immune responses. **Pathways and functions:** * STOM is a key regulator of the Cdc42 gtpase cycle, which is involved in cell cycle regulation. * It is also involved in the activation of the Identical protein binding (IPB) pathway, which is involved in immune responses. * It is involved in the regulation of inflammation and tissue remodeling. * It is also involved in the regulation of angiogenesis. **Clinical significance:** * Mutations in the STOM gene have been linked to a number of human diseases, including cancer and cardiovascular disease. * STOM inhibitors are being investigated as a potential treatment for these diseases. **Additional information:** * The STOM gene is located on chromosome 17q21.1. * It is a member of the Rho GTPase family of proteins. * It is a highly conserved protein, with a similar protein found in mice and rats.

Genular Protein ID: 1266484035

Symbol: STOM_HUMAN

Name: N/A

UniProtKB Accession Codes:

P27105 B1AM77 Q14087 Q15609 Q5VX96 Q96FK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1883838

Title: Cloning and nucleotide sequence of cDNA encoding human erythrocyte band 7 integral membrane protein.

PubMed ID: 1883838

DOI: 10.1016/0167-4781(91)90047-p

PubMed ID: 1547348

Title: Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes.

PubMed ID: 1547348

PubMed ID: 8825639

Title: The organization of the gene (EPB72) encoding the human erythrocyte band 7 integral membrane protein (protein 7.2b).

PubMed ID: 8825639

DOI: 10.1006/geno.1995.1273

PubMed ID: 7592848

Title: Structure, organization, and expression of the human band 7.2b gene, a candidate gene for hereditary hydrocytosis.

PubMed ID: 7592848

DOI: 10.1074/jbc.270.44.26358

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8373790

Title: Identification of the phosphorylation site on human erythrocyte band 7 integral membrane protein: implications for a monotopic protein structure.

PubMed ID: 8373790

DOI: 10.1016/0005-2736(93)90098-k

PubMed ID: 9243190

Title: Colocalization of stomatin (band 7.2b) and actin microfilaments in UAC epithelial cells.

PubMed ID: 9243190

PubMed ID: 9512664

Title: Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor.

PubMed ID: 9512664

DOI: 10.1016/s0167-4781(97)00178-4

PubMed ID: 9642292

Title: Oligomeric nature of the integral membrane protein stomatin.

PubMed ID: 9642292

DOI: 10.1074/jbc.273.27.17221

PubMed ID: 10338112

Title: Cysteine 29 is the major palmitoylation site on stomatin.

PubMed ID: 10338112

DOI: 10.1016/s0014-5793(99)00417-2

PubMed ID: 12130500

Title: Stomatin is a major lipid-raft component of platelet alpha granules.

PubMed ID: 12130500

DOI: 10.1182/blood.v100.3.897

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 16766530

Title: Characterization of the stomatin domain involved in homo-oligomerization and lipid raft association.

PubMed ID: 16766530

DOI: 10.1074/jbc.m513720200

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19696025

Title: Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes.

PubMed ID: 19696025

DOI: 10.1074/jbc.m109.014993

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23219802

Title: Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.

PubMed ID: 23219802

DOI: 10.1016/j.bbamem.2012.11.030

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28387307

Title: Stomatin modulates the activity of the Anion Exchanger 1 (AE1, SLC4A1).

PubMed ID: 28387307

DOI: 10.1038/srep46170

Sequence Information:

  • Length: 288
  • Mass: 31731
  • Checksum: 5FEDA92230D99A24
  • Sequence:
    • MAEKRHTRDS EAQRLPDSFK DSPSKGLGPC GWILVAFSFL FTVITFPISI WMCIKIIKEY 
ERAIIFRLGR ILQGGAKGPG LFFILPCTDS FIKVDMRTIS FDIPPQEILT KDSVTISVDG 
VVYYRVQNAT LAVANITNAD SATRLLAQTT LRNVLGTKNL SQILSDREEI AHNMQSTLDD 
ATDAWGIKVE RVEIKDVKLP VQLQRAMAAE AEASREARAK VIAAEGEMNA SRALKEASMV 
ITESPAALQL RYLQTLTTIA AEKNSTIVFP LPIDMLQGII GAKHSHLG

Genular Protein ID: 1792485307

Symbol: F8VSL7_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VSL7

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 168
  • Mass: 18699
  • Checksum: 9503EDEAFF533EE9
  • Sequence:
    • MAEKRHTRDS EAQRLPDSFK DSPSKGLGPC GWILVAFSFL FTVITFPISI WMCIKIIKEY 
ERAIIFRLGR ILQGGAKGPG LFFILPCTDS FIKVDMRTIS FDIPPQEILT KDSVTISVDG 
VVYYRVQNAT LAVANITNAD SATRLLAQTT LRNVLGTKNL SQISSLRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.