Details for: STOM

Gene ID: 2040

Symbol: STOM

Ensembl ID: ENSG00000148175

Description: stomatin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 176.4288
    Cell Significance Index: -44.7500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.9506
    Cell Significance Index: -26.4400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.7839
    Cell Significance Index: -54.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 113.8934
    Cell Significance Index: -46.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 109.8232
    Cell Significance Index: -51.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 100.3236
    Cell Significance Index: -51.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.4633
    Cell Significance Index: -46.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.0261
    Cell Significance Index: -34.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.7127
    Cell Significance Index: -32.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.2818
    Cell Significance Index: -35.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.2183
    Cell Significance Index: -52.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.8831
    Cell Significance Index: -39.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.4013
    Cell Significance Index: 130.7900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 4.5983
    Cell Significance Index: 66.1400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.5979
    Cell Significance Index: 25.8400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.3709
    Cell Significance Index: 20.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.3399
    Cell Significance Index: 56.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7016
    Cell Significance Index: 201.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.1355
    Cell Significance Index: 24.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6100
    Cell Significance Index: 72.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5056
    Cell Significance Index: 43.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3884
    Cell Significance Index: 264.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2392
    Cell Significance Index: 170.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1161
    Cell Significance Index: 30.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9781
    Cell Significance Index: 45.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8146
    Cell Significance Index: 21.7500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.7472
    Cell Significance Index: 3.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7216
    Cell Significance Index: 93.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6663
    Cell Significance Index: 601.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6176
    Cell Significance Index: 47.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5671
    Cell Significance Index: 72.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5414
    Cell Significance Index: 239.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5076
    Cell Significance Index: 35.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4991
    Cell Significance Index: 61.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4595
    Cell Significance Index: 74.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4118
    Cell Significance Index: 81.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3216
    Cell Significance Index: 92.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3208
    Cell Significance Index: 8.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2147
    Cell Significance Index: 4.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2102
    Cell Significance Index: 1.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2039
    Cell Significance Index: 3.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1561
    Cell Significance Index: 15.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1122
    Cell Significance Index: 13.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0885
    Cell Significance Index: 40.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0773
    Cell Significance Index: 58.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0736
    Cell Significance Index: 40.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0659
    Cell Significance Index: 7.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0141
    Cell Significance Index: 5.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0076
    Cell Significance Index: -1.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0081
    Cell Significance Index: -15.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0096
    Cell Significance Index: -6.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0102
    Cell Significance Index: -0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0120
    Cell Significance Index: -22.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0134
    Cell Significance Index: -20.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0184
    Cell Significance Index: -0.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0209
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0223
    Cell Significance Index: -16.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0310
    Cell Significance Index: -19.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0333
    Cell Significance Index: -21.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0373
    Cell Significance Index: -50.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0449
    Cell Significance Index: -25.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0464
    Cell Significance Index: -34.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0636
    Cell Significance Index: -1.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1151
    Cell Significance Index: -13.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1200
    Cell Significance Index: -8.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1329
    Cell Significance Index: -3.8300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1357
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1392
    Cell Significance Index: -29.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1485
    Cell Significance Index: -25.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1527
    Cell Significance Index: -17.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1552
    Cell Significance Index: -31.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1741
    Cell Significance Index: -25.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2147
    Cell Significance Index: -12.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2277
    Cell Significance Index: -11.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2450
    Cell Significance Index: -4.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2483
    Cell Significance Index: -5.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2608
    Cell Significance Index: -4.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3248
    Cell Significance Index: -16.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3730
    Cell Significance Index: -43.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4124
    Cell Significance Index: -19.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4130
    Cell Significance Index: -25.3200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4155
    Cell Significance Index: -3.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4201
    Cell Significance Index: -21.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4563
    Cell Significance Index: -6.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4590
    Cell Significance Index: -12.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4616
    Cell Significance Index: -48.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5782
    Cell Significance Index: -37.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6134
    Cell Significance Index: -48.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6140
    Cell Significance Index: -16.4300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.6186
    Cell Significance Index: -7.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7310
    Cell Significance Index: -46.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7375
    Cell Significance Index: -45.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7604
    Cell Significance Index: -21.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7899
    Cell Significance Index: -53.1100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.7945
    Cell Significance Index: -10.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9229
    Cell Significance Index: -51.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9266
    Cell Significance Index: -48.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9936
    Cell Significance Index: -25.5400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -1.0136
    Cell Significance Index: -9.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0469
    Cell Significance Index: -19.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Stomatin is a protein complex composed of multiple subunits, with the most well-studied form consisting of four subunits (STOM1, STOM2, STOM3, and STOM4). Stomatin is primarily localized to the endoplasmic reticulum (ER) and the plasma membrane, where it regulates various cellular processes, including protein targeting, ion channel transport, and vesicle formation. Stomatin has been shown to interact with multiple proteins, including ion channels, transporters, and signaling molecules, to modulate cellular responses to stimuli. **Pathways and Functions:** Stomatin is involved in several key pathways, including: 1. **Neutrophil degranulation:** Stomatin regulates the release of granule proteins from neutrophils, which is essential for the clearance of pathogens. 2. **Immune system:** Stomatin interacts with immune receptors and signaling molecules to modulate immune responses, including the activation of immune cells and the production of cytokines. 3. **Cytoskeleton and cell signaling:** Stomatin regulates cytoskeletal dynamics and signaling pathways, including the Rho GTPase cycle, which is involved in cell migration, proliferation, and differentiation. 4. **Endoplasmic reticulum and membrane transport:** Stomatin regulates ER function and membrane transport, including the transport of small molecules and ions. **Clinical Significance:** Dysregulation of stomatin has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** Altered stomatin expression and function have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Infectious diseases:** Stomatin dysfunction has been implicated in the pathogenesis of infectious diseases, including tuberculosis and malaria. 3. **Cancer:** Stomatin has been shown to regulate tumor cell growth, invasion, and metastasis. 4. **Neurological disorders:** Stomatin has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, stomatin is a multifunctional protein complex that plays a critical role in regulating immune response, cell signaling, and membrane transport. Dysregulation of stomatin has been implicated in various immune-related disorders, highlighting the importance of stomatin in maintaining immune homeostasis and overall cellular function.

Genular Protein ID: 1266484035

Symbol: STOM_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1883838

Title: Cloning and nucleotide sequence of cDNA encoding human erythrocyte band 7 integral membrane protein.

PubMed ID: 1883838

DOI: 10.1016/0167-4781(91)90047-p

PubMed ID: 1547348

Title: Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes.

PubMed ID: 1547348

PubMed ID: 8825639

Title: The organization of the gene (EPB72) encoding the human erythrocyte band 7 integral membrane protein (protein 7.2b).

PubMed ID: 8825639

DOI: 10.1006/geno.1995.1273

PubMed ID: 7592848

Title: Structure, organization, and expression of the human band 7.2b gene, a candidate gene for hereditary hydrocytosis.

PubMed ID: 7592848

DOI: 10.1074/jbc.270.44.26358

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8373790

Title: Identification of the phosphorylation site on human erythrocyte band 7 integral membrane protein: implications for a monotopic protein structure.

PubMed ID: 8373790

DOI: 10.1016/0005-2736(93)90098-k

PubMed ID: 9243190

Title: Colocalization of stomatin (band 7.2b) and actin microfilaments in UAC epithelial cells.

PubMed ID: 9243190

PubMed ID: 9512664

Title: Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor.

PubMed ID: 9512664

DOI: 10.1016/s0167-4781(97)00178-4

PubMed ID: 9642292

Title: Oligomeric nature of the integral membrane protein stomatin.

PubMed ID: 9642292

DOI: 10.1074/jbc.273.27.17221

PubMed ID: 10338112

Title: Cysteine 29 is the major palmitoylation site on stomatin.

PubMed ID: 10338112

DOI: 10.1016/s0014-5793(99)00417-2

PubMed ID: 12130500

Title: Stomatin is a major lipid-raft component of platelet alpha granules.

PubMed ID: 12130500

DOI: 10.1182/blood.v100.3.897

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 16766530

Title: Characterization of the stomatin domain involved in homo-oligomerization and lipid raft association.

PubMed ID: 16766530

DOI: 10.1074/jbc.m513720200

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19696025

Title: Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes.

PubMed ID: 19696025

DOI: 10.1074/jbc.m109.014993

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23219802

Title: Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.

PubMed ID: 23219802

DOI: 10.1016/j.bbamem.2012.11.030

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28387307

Title: Stomatin modulates the activity of the Anion Exchanger 1 (AE1, SLC4A1).

PubMed ID: 28387307

DOI: 10.1038/srep46170

Sequence Information:

  • Length: 288
  • Mass: 31731
  • Checksum: 5FEDA92230D99A24
  • Sequence:
  • MAEKRHTRDS EAQRLPDSFK DSPSKGLGPC GWILVAFSFL FTVITFPISI WMCIKIIKEY 
    ERAIIFRLGR ILQGGAKGPG LFFILPCTDS FIKVDMRTIS FDIPPQEILT KDSVTISVDG 
    VVYYRVQNAT LAVANITNAD SATRLLAQTT LRNVLGTKNL SQILSDREEI AHNMQSTLDD 
    ATDAWGIKVE RVEIKDVKLP VQLQRAMAAE AEASREARAK VIAAEGEMNA SRALKEASMV 
    ITESPAALQL RYLQTLTTIA AEKNSTIVFP LPIDMLQGII GAKHSHLG

Genular Protein ID: 1792485307

Symbol: F8VSL7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 168
  • Mass: 18699
  • Checksum: 9503EDEAFF533EE9
  • Sequence:
  • MAEKRHTRDS EAQRLPDSFK DSPSKGLGPC GWILVAFSFL FTVITFPISI WMCIKIIKEY 
    ERAIIFRLGR ILQGGAKGPG LFFILPCTDS FIKVDMRTIS FDIPPQEILT KDSVTISVDG 
    VVYYRVQNAT LAVANITNAD SATRLLAQTT LRNVLGTKNL SQISSLRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.