Details for: EPHB2

Gene ID: 2048

Symbol: EPHB2

Ensembl ID: ENSG00000133216

Description: EPH receptor B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 163.7787
    Cell Significance Index: -25.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 100.4363
    Cell Significance Index: -25.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.2728
    Cell Significance Index: -24.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.2372
    Cell Significance Index: -24.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.6658
    Cell Significance Index: -25.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4698
    Cell Significance Index: -25.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.8747
    Cell Significance Index: 273.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.4044
    Cell Significance Index: 96.4400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.5417
    Cell Significance Index: 25.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.2201
    Cell Significance Index: 63.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.0238
    Cell Significance Index: 50.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9999
    Cell Significance Index: 120.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9740
    Cell Significance Index: 214.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5047
    Cell Significance Index: 68.2100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.4275
    Cell Significance Index: 17.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3798
    Cell Significance Index: 276.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9830
    Cell Significance Index: 195.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8730
    Cell Significance Index: 313.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6283
    Cell Significance Index: 38.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5892
    Cell Significance Index: 95.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5308
    Cell Significance Index: 12.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5303
    Cell Significance Index: 52.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4156
    Cell Significance Index: 287.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3284
    Cell Significance Index: 22.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3183
    Cell Significance Index: 11.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2620
    Cell Significance Index: 13.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2561
    Cell Significance Index: 48.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2414
    Cell Significance Index: 218.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2206
    Cell Significance Index: 25.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2025
    Cell Significance Index: 5.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1869
    Cell Significance Index: 4.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1092
    Cell Significance Index: 59.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1008
    Cell Significance Index: 18.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0863
    Cell Significance Index: 2.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0437
    Cell Significance Index: 0.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0236
    Cell Significance Index: 44.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0124
    Cell Significance Index: 0.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0014
    Cell Significance Index: -0.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0128
    Cell Significance Index: -23.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0130
    Cell Significance Index: -20.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0149
    Cell Significance Index: -20.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0269
    Cell Significance Index: -1.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0315
    Cell Significance Index: -23.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0328
    Cell Significance Index: -24.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0341
    Cell Significance Index: -21.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0343
    Cell Significance Index: -25.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0347
    Cell Significance Index: -4.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0386
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0461
    Cell Significance Index: -28.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0470
    Cell Significance Index: -26.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0529
    Cell Significance Index: -24.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0653
    Cell Significance Index: -8.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0764
    Cell Significance Index: -21.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0936
    Cell Significance Index: -1.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0986
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1190
    Cell Significance Index: -13.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1192
    Cell Significance Index: -20.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1252
    Cell Significance Index: -17.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1344
    Cell Significance Index: -28.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1524
    Cell Significance Index: -15.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2035
    Cell Significance Index: -26.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2246
    Cell Significance Index: -2.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2261
    Cell Significance Index: -7.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2384
    Cell Significance Index: -5.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2393
    Cell Significance Index: -28.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2412
    Cell Significance Index: -5.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2449
    Cell Significance Index: -25.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2469
    Cell Significance Index: -6.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2556
    Cell Significance Index: -5.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2736
    Cell Significance Index: -21.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2746
    Cell Significance Index: -19.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2936
    Cell Significance Index: -18.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3051
    Cell Significance Index: -9.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3054
    Cell Significance Index: -16.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3115
    Cell Significance Index: -14.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3317
    Cell Significance Index: -26.2700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3553
    Cell Significance Index: -4.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3601
    Cell Significance Index: -26.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3687
    Cell Significance Index: -7.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3736
    Cell Significance Index: -7.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4125
    Cell Significance Index: -26.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4214
    Cell Significance Index: -11.0800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.4224
    Cell Significance Index: -4.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4319
    Cell Significance Index: -8.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4407
    Cell Significance Index: -28.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4469
    Cell Significance Index: -23.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4574
    Cell Significance Index: -7.6600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4650
    Cell Significance Index: -2.9200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4700
    Cell Significance Index: -5.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4761
    Cell Significance Index: -16.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4903
    Cell Significance Index: -12.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4995
    Cell Significance Index: -23.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5371
    Cell Significance Index: -18.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5568
    Cell Significance Index: -8.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5696
    Cell Significance Index: -12.1800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5886
    Cell Significance Index: -4.8000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6036
    Cell Significance Index: -7.7300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6274
    Cell Significance Index: -7.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6622
    Cell Significance Index: -24.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6804
    Cell Significance Index: -17.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Receptor Tyrosine Kinase**: EPHB2 is a receptor tyrosine kinase that phosphorylates tyrosine residues on downstream targets, initiating a signaling cascade. 2. **Ephrin Ligand Binding**: EPHB2 binds to ephrin ligands, which are secreted proteins that interact with the receptor to activate signaling. 3. **Cell Adhesion and Migration**: EPHB2 regulates cell adhesion and migration by modulating the activity of adhesion molecules and the cytoskeleton. 4. **Neuronal Development and Function**: EPHB2 plays a critical role in the development and function of the nervous system, including neuronal axon guidance, synapse formation, and synaptic plasticity. 5. **Tissue-Specific Expression**: EPHB2 is expressed in various tissues, including the brain, heart, and immune cells, suggesting its involvement in multiple physiological processes. **Pathways and Functions** 1. **Ephrin/Eph Signaling**: EPHB2 is part of the Ephrin/Eph signaling pathway, which regulates cell adhesion, migration, and differentiation. 2. **Axon Guidance**: EPHB2 guides axons during neuronal development, influencing the formation of neural circuits. 3. **Synapse Formation**: EPHB2 regulates the formation and maintenance of synapses, which are critical for neuronal communication. 4. **Immune Cell Function**: EPHB2 modulates the activity of immune cells, including T cells and macrophages, influencing immune responses. 5. **Cardiovascular Development**: EPHB2 is involved in the development of the cardiovascular system, including angiogenesis and vascular remodeling. **Clinical Significance** 1. **Neurological Disorders**: EPHB2 mutations or dysregulation have been implicated in various neurological disorders, including autism, schizophrenia, and Alzheimer's disease. 2. **Cancer**: EPHB2 is overexpressed in certain types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis. 3. **Inflammatory Diseases**: EPHB2 modulates the activity of immune cells, influencing inflammatory responses and potentially contributing to diseases such as rheumatoid arthritis and multiple sclerosis. 4. **Cardiovascular Disease**: EPHB2 is involved in cardiovascular development and function, making it a potential target for the treatment of cardiovascular diseases. 5. **Immunological Disorders**: EPHB2 plays a critical role in immune cell function, making it a potential target for the treatment of immunological disorders, including autoimmune diseases. In conclusion, EPHB2 is a complex gene that plays a crucial role in various cellular processes, including cell adhesion, migration, differentiation, and survival. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying EPHB2 function and its clinical significance.

Genular Protein ID: 353326526

Symbol: EPHB2_HUMAN

Name: Ephrin type-B receptor 2

UniProtKB Accession Codes:

P29323 O43477 Q5T0U6 Q5T0U7 Q5T0U8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 5 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 80 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 20 KEGG 1 MANE-Select 1 MIM 6 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 8 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8033077

Title: Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors.

PubMed ID: 8033077

PubMed ID: 8589679

Title: Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family.

PubMed ID: 8589679

DOI: 10.1093/hmg/4.11.2033

PubMed ID: 9696046

Title: A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals.

PubMed ID: 9696046

DOI: 10.1038/sj.onc.1201960

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 7898931

Title: cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.

PubMed ID: 7898931

PubMed ID: 7601466

Title: Identification of the human ERK gene as a putative receptor tyrosine kinase and its chromosomal localization to 1p36.1: a comparative mapping of human, mouse, and rat chromosomes.

PubMed ID: 7601466

DOI: 10.1016/0888-7543(95)80224-a

PubMed ID: 7688222

Title: Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer.

PubMed ID: 7688222

DOI: 10.1006/bbrc.1993.1878

PubMed ID: 1648701

Title: eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases.

PubMed ID: 1648701

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 28931592

Title: Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.

PubMed ID: 28931592

DOI: 10.1091/mbc.e17-07-0450

PubMed ID: 33280498

Title: RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.

PubMed ID: 33280498

DOI: 10.1080/15548627.2020.1851496

PubMed ID: 9933164

Title: Oligomeric structure of the human EphB2 receptor SAM domain.

PubMed ID: 9933164

DOI: 10.1126/science.283.5403.833

PubMed ID: 17897949

Title: Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.

PubMed ID: 17897949

DOI: 10.1074/jbc.m706340200

PubMed ID: 15300251

Title: Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer.

PubMed ID: 15300251

DOI: 10.1038/ng1408

PubMed ID: 16155194

Title: A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history.

PubMed ID: 16155194

DOI: 10.1136/jmg.2005.035790

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 30213874

Title: A mutation of the human EPHB2 gene leads to a major platelet functional defect.

PubMed ID: 30213874

DOI: 10.1182/blood-2018-04-845644

Sequence Information:

  • Length: 1055
  • Mass: 117493
  • Checksum: 4F8BFEDC45986483
  • Sequence:
    • MALRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ 
VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF 
DSATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RSGFYLAFQD 
YGGCMSLIAV RVFYRKCPRI IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY 
CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA 
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI 
ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF 
SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKELSE 
YNATAIKSPT NTVTVQGLKA GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIQEK 
LPLIIGSSAA GLVFLIAVVV IAIVCNRRGF ERADSEYTDK LQHYTSGHMT PGMKIYIDPF 
TYEDPNEAVR EFAKEIDISC VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT 
EKQRRDFLSE ASIMGQFDHP NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV 
IQLVGMLRGI AAGMKYLADM NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY 
TSALGGKIPI RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE 
QDYRLPPPMD CPSALHQLML DCWQKDRNHR PKFGQIVNTL DKMIRNPNSL KAMAPLSSGI 
NLPLLDRTIP DYTSFNTVDE WLEAIKMGQY KESFANAGFT SFDVVSQMMM EDILRVGVTL 
AGHQKKILNS IQVMRAQMNQ IQSVEGQPLA RRPRATGRTK RCQPRDVTKK TCNSNDGKKK 
GMGKKKTDPG RGREIQGIFF KEDSHKESND CSCGG

Genular Protein ID: 1505998436

Symbol: Q4LE53_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE53

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 5 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 6 InterPro 20 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 2 PROSITE 12 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 RefSeq 3 Rhea 3 SAM 2 SMART 5 SUPFAM 5

Sequence Information:

  • Length: 1004
  • Mass: 111512
  • Checksum: 0CBA9D22B278CA49
  • Sequence:
    • PGRPGPAAPR PEAPGSAAMA LRRLGAALLL LPLLAAVEET LMDSTTATAE LGWMVHPPSG 
WEEVSGYDEN MNTIRTYQVC NVFESSQNNW LRTKFIRRRG AHRIHVEMKF SVRDCSSIPS 
VPGSCKETFN LYYYEADFDS ATKTFPNWME NPWVKVDTIA ADESFSQVDL GGRVMKINTE 
VRSFGPVSRS GFYLAFQDYG GCMSLIAVRV FYRKCPRIIQ NGAIFQETLS GAESTSLVAA 
RGSCIANAEE VDVPIKLYCN GDGEWLVPIG RCMCKAGFEA VENGTVCRGC PSGTFKANQG 
DEACTHCPIN SRTTSEGATN CVCRNGYYRA DLDPLDMPCT TIPSAPQAVI SSVNETSLML 
EWTPPRDSGG REDLVYNIIC KSCGSGRGAC TRCGDNVQYA PRQLGLTEPR IYISDLLAHT 
QYTFEIQAVN GVTDQSPFSP QFASVNITTN QAAPSAVSIM HQVSRTVDSI TLSWSQPDQP 
NGVILDYELQ YYEKELSEYN ATAIKSPTNT VTVQGLKAGA IYVFQVRART VAGYGRYSGK 
MYFQTMTEAE YQTSIQEKLP LIIGSSAAGL VFLIAVVVIA IVCNRRGFER ADSEYTDKLQ 
HYTSGHMTPG MKIYIDPFTY EDPNEAVREF AKEIDISCVK IEQVIGAGEF GEVCSGHLKL 
PGKREIFVAI KTLKSGYTEK QRRDFLSEAS IMGQFDHPNV IHLEGVVTKS TPVMIITEFM 
ENGSLDSFLR QNDGQFTVIQ LVGMLRGIAA GMKYLADMNY VHRDLAARNI LVNSNLVCKV 
SDFGLSRFLE DDTSDPTYTS ALGGKIPIRW TAPEAIQYRK FTSASDVWSY GIVMWEVMSY 
GERPYWDMTN QDVINAIEQD YRLPPPMDCP SALHQLMLDC WQKDRNHRPK FGQIVNTLDK 
MIRNPNSLKA MAPLSSGINL PLLDRTIPDY TSFNTVDEWL EAIKMGQYKE SFANAGFTSF 
DVVSQMMMED ILRVGVTLAG HQKKILNSIQ VMRAQMNQIQ SVEV

Genular Protein ID: 2107416866

Symbol: B4DSE0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DSE0

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 5 CTD 1 ChEBI 7 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 6 InterPro 20 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 2 PROSITE 12 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 RefSeq 1 Rhea 3 SAM 1 SMART 5 SMR 1 SUPFAM 5

Sequence Information:

  • Length: 928
  • Mass: 103510
  • Checksum: A7A32A8A82504910
  • Sequence:
    • MALRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ 
VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF 
DSATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RSGFYLAFQD 
YGGCMSLIAV RVFYRKCPRI IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY 
CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA 
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI 
ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF 
SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKELSE 
YNATAIKSPT NTVTVQGLKA GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE VTPGMKIYID 
PFTYEDPNEA VREFAKEIDI SCVKIEQVIG AGEFGEVCSG HLKLPGKREI FVAIKTLKSG 
YTEKQRRDFL SEASIMGQFD HPNVIHLEGV VTKSTPVMII TEFMENGSLD SFLRQNDGQF 
TVIQLVGMLR GIAAGMKYLA DMNYVHRDLA ARNILVNSNL VCKVSDFGLS RFLEDDTSDP 
TYTSALGGKI PIRWTAPEAI QYRKFTSASD VWSYGIVMWE VMSYGERPYW DMTNQDVINA 
IEQDYRLPPP MDCPSALHQL MLDCWQKDRN HRPKFGQIVN TLDKMIRNPN SLKAMAPLSS 
GINLPLLDRT IPDYTSFNTV DEWLEAIKMG QYKESFANAG FTSFDVVSQM MMEDILRVGV 
TLTGHQKKIL NSIQVMRAQM NQIQSVEV

Genular Protein ID: 3612401510

Symbol: Q6NVW1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NVW1

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 4 Gene3D 4 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 10 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 4 SAM 1 SMART 3 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

Sequence Information:

  • Length: 482
  • Mass: 53252
  • Checksum: 29086541708507B5
  • Sequence:
    • MALRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ 
VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF 
DSATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RSGFYLAFQD 
YGGCMSLIAV RVFYRKCPRI IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY 
CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA 
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI 
ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF 
SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKMKTQ 
RS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.