Details for: NR2F6

Gene ID: 2063

Symbol: NR2F6

Ensembl ID: ENSG00000160113

Description: nuclear receptor subfamily 2 group F member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 190.2341
    Cell Significance Index: -29.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.1466
    Cell Significance Index: -24.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.5872
    Cell Significance Index: -30.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.5828
    Cell Significance Index: -24.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.4210
    Cell Significance Index: -30.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1372
    Cell Significance Index: -29.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6634
    Cell Significance Index: -30.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.7098
    Cell Significance Index: 244.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.8929
    Cell Significance Index: 26.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9891
    Cell Significance Index: 358.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8954
    Cell Significance Index: 85.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8027
    Cell Significance Index: 984.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5319
    Cell Significance Index: 188.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3109
    Cell Significance Index: 61.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2486
    Cell Significance Index: 33.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1214
    Cell Significance Index: 70.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0926
    Cell Significance Index: 986.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0857
    Cell Significance Index: 215.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0437
    Cell Significance Index: 72.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9931
    Cell Significance Index: 22.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7855
    Cell Significance Index: 11.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7207
    Cell Significance Index: 20.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6005
    Cell Significance Index: 42.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5413
    Cell Significance Index: 74.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5356
    Cell Significance Index: 52.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4677
    Cell Significance Index: 206.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4394
    Cell Significance Index: 71.4600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3943
    Cell Significance Index: 2.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3604
    Cell Significance Index: 9.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3406
    Cell Significance Index: 16.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3377
    Cell Significance Index: 9.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2702
    Cell Significance Index: 2.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2511
    Cell Significance Index: 50.3700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2365
    Cell Significance Index: 2.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1838
    Cell Significance Index: 6.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1574
    Cell Significance Index: 4.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1465
    Cell Significance Index: 3.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1137
    Cell Significance Index: 14.5700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0892
    Cell Significance Index: 1.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0690
    Cell Significance Index: 11.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0637
    Cell Significance Index: 22.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0483
    Cell Significance Index: 9.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0313
    Cell Significance Index: 22.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0259
    Cell Significance Index: 1.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0249
    Cell Significance Index: 17.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0142
    Cell Significance Index: 0.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0008
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0020
    Cell Significance Index: -1.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0200
    Cell Significance Index: -36.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0223
    Cell Significance Index: -34.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0234
    Cell Significance Index: -31.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0312
    Cell Significance Index: -19.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0321
    Cell Significance Index: -23.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0496
    Cell Significance Index: -27.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0515
    Cell Significance Index: -23.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0558
    Cell Significance Index: -34.8400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0634
    Cell Significance Index: -0.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0731
    Cell Significance Index: -21.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0794
    Cell Significance Index: -2.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0921
    Cell Significance Index: -9.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0977
    Cell Significance Index: -2.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1099
    Cell Significance Index: -1.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1113
    Cell Significance Index: -8.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1120
    Cell Significance Index: -12.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1174
    Cell Significance Index: -13.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1426
    Cell Significance Index: -3.0900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1434
    Cell Significance Index: -0.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1447
    Cell Significance Index: -21.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1447
    Cell Significance Index: -8.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1592
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1652
    Cell Significance Index: -34.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1902
    Cell Significance Index: -15.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1928
    Cell Significance Index: -22.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2016
    Cell Significance Index: -13.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2148
    Cell Significance Index: -2.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2201
    Cell Significance Index: -1.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2232
    Cell Significance Index: -7.1500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.2497
    Cell Significance Index: -2.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2784
    Cell Significance Index: -7.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2858
    Cell Significance Index: -29.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3164
    Cell Significance Index: -19.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3187
    Cell Significance Index: -6.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3226
    Cell Significance Index: -21.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3754
    Cell Significance Index: -23.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3978
    Cell Significance Index: -20.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4329
    Cell Significance Index: -12.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4591
    Cell Significance Index: -11.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5066
    Cell Significance Index: -25.6000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5274
    Cell Significance Index: -8.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5352
    Cell Significance Index: -6.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5714
    Cell Significance Index: -5.9200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5729
    Cell Significance Index: -8.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5935
    Cell Significance Index: -26.2500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6197
    Cell Significance Index: -7.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6326
    Cell Significance Index: -18.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6368
    Cell Significance Index: -26.0900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.6377
    Cell Significance Index: -5.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6675
    Cell Significance Index: -19.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6729
    Cell Significance Index: -24.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NR2F6 shares structural and functional similarities with other nuclear receptors, including the presence of a DNA-binding domain, a ligand-binding domain, and a transcriptional activation domain. However, NR2F6 has distinct differences in its ligand-binding characteristics and its ability to regulate gene expression. NR2F6 is a ligand-activated transcription factor that binds to specific DNA sequences, known as response elements, to regulate the expression of target genes. The gene is also highly responsive to changes in cellular environment, such as temperature and light, which suggests its role in regulating cellular responses to environmental cues. **Pathways and Functions** NR2F6 is involved in various signaling pathways, including: 1. **Anatomical structure development**: NR2F6 regulates the development of various tissues, including the bladder, nasal mucosa, and pancreas, by controlling the expression of genes involved in cell differentiation and morphogenesis. 2. **Cell differentiation**: NR2F6 plays a crucial role in regulating the differentiation of cells, including the development of goblet cells in the nasal mucosa and the enterocytes in the intestine. 3. **Chromatin remodeling**: NR2F6 regulates chromatin structure and gene expression by interacting with chromatin-modifying enzymes and histone deacetylases. 4. **Sensory perception**: NR2F6 is involved in the detection of temperature stimuli, which is essential for regulating pain perception and the response to thermal stress. 5. **Circadian clock regulation**: NR2F6 is also involved in the regulation of the circadian clock by responding to light and darkness cues. **Clinical Significance** Dysregulation of NR2F6 has been implicated in various diseases, including: 1. **Bladder cancer**: NR2F6 is overexpressed in bladder cancer cells, suggesting its role in the development and progression of this disease. 2. **Pain disorders**: NR2F6 is involved in the regulation of pain perception, and its dysregulation may contribute to the development of chronic pain disorders. 3. **Circadian rhythm disorders**: NR2F6 is involved in the regulation of the circadian clock, and its dysregulation may contribute to the development of circadian rhythm disorders, such as delayed sleep phase syndrome. 4. **Pancreatic diseases**: NR2F6 is involved in the regulation of pancreatic cell differentiation and function, and its dysregulation may contribute to the development of pancreatic diseases, such as pancreatic cancer and diabetes. In conclusion, NR2F6 is a transcription factor that plays a crucial role in various biological processes, including cell differentiation, development, and the regulation of gene expression. Its dysregulation has been implicated in various diseases, including bladder cancer, pain disorders, circadian rhythm disorders, and pancreatic diseases. Further research is needed to fully understand the mechanisms of NR2F6 and its role in human disease.

Genular Protein ID: 472922295

Symbol: NR2F6_HUMAN

Name: Nuclear receptor subfamily 2 group F member 6

UniProtKB Accession Codes:

P10588 B2RC68 Q5XGA0 Q6P586 Q9BUE8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2905047

Title: Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.

PubMed ID: 2905047

DOI: 10.1093/nar/16.23.11057

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10644740

Title: Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.

PubMed ID: 10644740

DOI: 10.1074/jbc.275.4.2763

PubMed ID: 10713182

Title: The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function.

PubMed ID: 10713182

DOI: 10.1128/mcb.20.7.2604-2618.2000

PubMed ID: 11682620

Title: EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor.

PubMed ID: 11682620

DOI: 10.1210/mend.15.11.0720

PubMed ID: 18701084

Title: The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.

PubMed ID: 18701084

DOI: 10.1016/j.immuni.2008.06.008

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 404
  • Mass: 42979
  • Checksum: D1FFE523E782E969
  • Sequence:
    • MAMVTGGWGG PGGDTNGVDK AGGYPRAAED DSASPPGAAS DAEPGDEERP GLQVDCVVCG 
DKSSGKHYGV FTCEGCKSFF KRSIRRNLSY TCRSNRDCQI DQHHRNQCQY CRLKKCFRVG 
MRKEAVQRGR IPHSLPGAVA ASSGSPPGSA LAAVASGGDL FPGQPVSELI AQLLRAEPYP 
AAAGRFGAGG GAAGAVLGID NVCELAARLL FSTVEWARHA PFFPELPVAD QVALLRLSWS 
ELFVLNAAQA ALPLHTAPLL AAAGLHAAPM AAERAVAFMD QVRAFQEQVD KLGRLQVDSA 
EYGCLKAIAL FTPDACGLSD PAHVESLQEK AQVALTEYVR AQYPSQPQRF GRLLLRLPAL 
RAVPASLISQ LFFMRLVGKT PIETLIRDML LSGSTFNWPY GSGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.