Gene NR2F6 - ENSG00000160113 | NCBI Gene ID: 2063

Details for: NR2F6

Gene ID: 2063

Symbol: NR2F6

Ensembl ID: ENSG00000160113

Description: nuclear receptor subfamily 2 group F member 6

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Nuclear receptor transcription pathway
(R-HSA-383280)
Rna polymerase ii transcription
(R-HSA-73857)
Anatomical structure development
(GO:0048856)
Cell differentiation
(GO:0030154)
Chromatin
(GO:0000785)
Detection of temperature stimulus involved in sensory perception of pain
(GO:0050965)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Entrainment of circadian clock by photoperiod
(GO:0043153)
Intracellular receptor signaling pathway
(GO:0030522)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron development
(GO:0048666)
Nuclear receptor activity
(GO:0004879)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 2.23
Marker Score: 77359
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.09
Marker Score: 3072
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.9
Marker Score: 1269
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.81
Marker Score: 11521
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.78
Marker Score: 6601.5
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.77
Marker Score: 510
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.62
Marker Score: 3417
Cell Name: enterocyte (CL0000584)
Fold Change: 1.55
Marker Score: 7442
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.55
Marker Score: 3532
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.42
Marker Score: 4473
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.4
Marker Score: 690
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.38
Marker Score: 643
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.33
Marker Score: 3263
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.32
Marker Score: 5170
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.26
Marker Score: 1311
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.2
Marker Score: 1154
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2
Marker Score: 1263
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.2
Marker Score: 3023
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.19
Marker Score: 1970
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.19
Marker Score: 2696
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.18
Marker Score: 1179.5
Cell Name: peptic cell (CL0000155)
Fold Change: 1.18
Marker Score: 492
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.16
Marker Score: 2061
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.12
Marker Score: 760
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.08
Marker Score: 2553
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.08
Marker Score: 933
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.06
Marker Score: 544
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.06
Marker Score: 3631
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.05
Marker Score: 9115
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251745
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1
Marker Score: 680
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71764.5
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1
Marker Score: 1889.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47987
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.99
Marker Score: 1116
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.99
Marker Score: 2650.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.97
Marker Score: 887.5
Cell Name: secretory cell (CL0000151)
Fold Change: 0.96
Marker Score: 1744
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 490
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.95
Marker Score: 1190.5
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2407
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.95
Marker Score: 4977
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.95
Marker Score: 282
Cell Name: stem cell (CL0000034)
Fold Change: 0.95
Marker Score: 2247
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 446
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.94
Marker Score: 334
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5296
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.92
Marker Score: 1499
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.92
Marker Score: 10372
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.92
Marker Score: 3255
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2721
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.91
Marker Score: 7820.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9
Marker Score: 14083
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.89
Marker Score: 222
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.89
Marker Score: 5825
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.88
Marker Score: 738
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.88
Marker Score: 1786
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.88
Marker Score: 2878
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.85
Marker Score: 906
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.84
Marker Score: 6270
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.84
Marker Score: 170
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.84
Marker Score: 312
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.83
Marker Score: 895
Cell Name: PP cell (CL0000696)
Fold Change: 0.82
Marker Score: 185
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.82
Marker Score: 307
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.82
Marker Score: 1154
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.81
Marker Score: 1288
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.8
Marker Score: 1520
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.79
Marker Score: 1269
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 603
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.79
Marker Score: 449
Cell Name: precursor cell (CL0011115)
Fold Change: 0.77
Marker Score: 188
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.77
Marker Score: 307
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.76
Marker Score: 504
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.76
Marker Score: 238
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.75
Marker Score: 708
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.75
Marker Score: 757
Cell Name: acinar cell (CL0000622)
Fold Change: 0.75
Marker Score: 526
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 383
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.74
Marker Score: 234
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 469
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.71
Marker Score: 5568
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.71
Marker Score: 1439
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7
Marker Score: 2948.5
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.7
Marker Score: 263
Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 634
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.68
Marker Score: 196
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.68
Marker Score: 303
Cell Name: paneth cell (CL0000510)
Fold Change: 0.67
Marker Score: 469
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.67
Marker Score: 1036
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.67
Marker Score: 742.5
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.67
Marker Score: 317
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.66
Marker Score: 6620.5
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.66
Marker Score: 792
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.65
Marker Score: 360.5
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.65
Marker Score: 338.5

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**Key characteristics:** - NR2F6 is a nuclear receptor that is classified in the Nuclear receptor subfamily 2 group F (NR2F6). - It is a key regulator of cell differentiation and proliferation. - NR2F6 is expressed in a variety of cell types, including cells of the central nervous system, the immune system, and the reproductive system. - It is a key regulator of the development of the anatomical structure of the body. **Pathways and functions:** - NR2F6 is involved in the development of the anatomical structure of the body. - It is a key regulator of cell differentiation and proliferation. - NR2F6 is involved in the regulation of the development of the central nervous system, the immune system, and the reproductive system. - It is a key regulator of the expression of genes involved in cell differentiation and proliferation. **Clinical significance:** - NR2F6 is a potential therapeutic target for a variety of diseases. - It is a target for the treatment of cancer, neurodegenerative diseases, and autoimmune diseases. - NR2F6 inhibitors are being investigated as a treatment for cancer and other diseases. **Additional notes:** - NR2F6 is a well-known transcription factor that is involved in a variety of cellular processes, including cell growth, differentiation, and survival. - It is a key regulator of the development of the central nervous system, the immune system, and the reproductive system. - NR2F6 is a potential therapeutic target for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Nuclear receptor subfamily 2 group F member 6

Genular Protein ID: 472922295

Symbol: NR2F6_HUMAN

Name: Nuclear receptor subfamily 2 group F member 6

UniProtKB Accession Codes:

P10588 B2RC68 Q5XGA0 Q6P586 Q9BUE8

Database IDs:

Citations:

PubMed ID: 2905047

Title: Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.

PubMed ID: 2905047

DOI: 10.1093/nar/16.23.11057

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10644740

Title: Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.

PubMed ID: 10644740

DOI: 10.1074/jbc.275.4.2763

PubMed ID: 10713182

Title: The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function.

PubMed ID: 10713182

DOI: 10.1128/mcb.20.7.2604-2618.2000

PubMed ID: 11682620

Title: EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor.

PubMed ID: 11682620

DOI: 10.1210/mend.15.11.0720

PubMed ID: 18701084

Title: The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.

PubMed ID: 18701084

DOI: 10.1016/j.immuni.2008.06.008

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 404
Mass: 42979
Checksum: D1FFE523E782E969
Sequence:

MAMVTGGWGG PGGDTNGVDK AGGYPRAAED DSASPPGAAS DAEPGDEERP GLQVDCVVCG 
DKSSGKHYGV FTCEGCKSFF KRSIRRNLSY TCRSNRDCQI DQHHRNQCQY CRLKKCFRVG 
MRKEAVQRGR IPHSLPGAVA ASSGSPPGSA LAAVASGGDL FPGQPVSELI AQLLRAEPYP 
AAAGRFGAGG GAAGAVLGID NVCELAARLL FSTVEWARHA PFFPELPVAD QVALLRLSWS 
ELFVLNAAQA ALPLHTAPLL AAAGLHAAPM AAERAVAFMD QVRAFQEQVD KLGRLQVDSA 
EYGCLKAIAL FTPDACGLSD PAHVESLQEK AQVALTEYVR AQYPSQPQRF GRLLLRLPAL 
RAVPASLISQ LFFMRLVGKT PIETLIRDML LSGSTFNWPY GSGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: NR2F6

Associated with

Cells (max top 100)

Other Information

Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. PubMed ID: 2905047

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. PubMed ID: 10644740

The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. PubMed ID: 10713182

EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. PubMed ID: 11682620

The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity. PubMed ID: 18701084

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569