Details for: FBL

Gene ID: 2091

Symbol: FBL

Ensembl ID: ENSG00000105202

Description: fibrillarin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.85
    Marker Score: 4016
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.89
    Marker Score: 7062
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.77
    Marker Score: 2963
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.44
    Marker Score: 9979
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.4
    Marker Score: 31611
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.34
    Marker Score: 1768
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.33
    Marker Score: 15133
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.32
    Marker Score: 1458.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.31
    Marker Score: 2472
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.27
    Marker Score: 1133
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.27
    Marker Score: 4734
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.24
    Marker Score: 1280
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.24
    Marker Score: 2105
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.18
    Marker Score: 1721
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.13
    Marker Score: 3805
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.11
    Marker Score: 5753
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.11
    Marker Score: 12514.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.1
    Marker Score: 2266
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.1
    Marker Score: 4988
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.1
    Marker Score: 3659
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.09
    Marker Score: 8066
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.06
    Marker Score: 109011
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.06
    Marker Score: 8865
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.04
    Marker Score: 4628
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.02
    Marker Score: 3427
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2
    Marker Score: 677
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.98
    Marker Score: 67400
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.95
    Marker Score: 1412
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.94
    Marker Score: 3445
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.94
    Marker Score: 1295
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.94
    Marker Score: 1952
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.92
    Marker Score: 2041
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.91
    Marker Score: 12228
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.91
    Marker Score: 2019
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.9
    Marker Score: 4473
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.9
    Marker Score: 3214.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.89
    Marker Score: 1336
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.87
    Marker Score: 3066
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.85
    Marker Score: 2625
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.85
    Marker Score: 20809
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.84
    Marker Score: 1245
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.83
    Marker Score: 5066
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.83
    Marker Score: 585
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.82
    Marker Score: 2133
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.81
    Marker Score: 7757
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.81
    Marker Score: 3609
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8
    Marker Score: 18159
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.79
    Marker Score: 1358
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.79
    Marker Score: 1408
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.79
    Marker Score: 2641
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.79
    Marker Score: 575
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.78
    Marker Score: 13919
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.78
    Marker Score: 669
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.77
    Marker Score: 1582
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.76
    Marker Score: 60968
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.75
    Marker Score: 921
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.74
    Marker Score: 2991
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.73
    Marker Score: 6791
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.72
    Marker Score: 2651
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.7
    Marker Score: 8366.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.7
    Marker Score: 5364
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.7
    Marker Score: 2443
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7
    Marker Score: 659
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.68
    Marker Score: 12477
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.67
    Marker Score: 3813
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.67
    Marker Score: 1250
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.66
    Marker Score: 14332
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.65
    Marker Score: 19188
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.65
    Marker Score: 3483
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.65
    Marker Score: 16328
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.65
    Marker Score: 807
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.65
    Marker Score: 2188
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.63
    Marker Score: 900
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.63
    Marker Score: 4437
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.63
    Marker Score: 571
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.62
    Marker Score: 388
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.62
    Marker Score: 3035
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.61
    Marker Score: 21665
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.61
    Marker Score: 1016
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.61
    Marker Score: 2581
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.6
    Marker Score: 2011
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6
    Marker Score: 16174
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.6
    Marker Score: 322
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.59
    Marker Score: 1160
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.59
    Marker Score: 784
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.58
    Marker Score: 1115
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.58
    Marker Score: 1139
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.58
    Marker Score: 949
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.57
    Marker Score: 380
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.57
    Marker Score: 477
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.57
    Marker Score: 487
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.57
    Marker Score: 1011
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.57
    Marker Score: 368
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.56
    Marker Score: 3886
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.56
    Marker Score: 4614
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.55
    Marker Score: 1452
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.54
    Marker Score: 1095
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.53
    Marker Score: 1976
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.53
    Marker Score: 1437
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.52
    Marker Score: 1500

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Other Information

**Key characteristics:** * The FBL gene is approximately 12.5 kb long. * It contains 10 exons and 9 introns. * It is located on chromosome 17q21.1. * It is a member of the FBL family of RNA-binding proteins. **Pathways and functions:** * The FBL protein is involved in at least 4 pathways: * Atpase binding * Box c/d rRNA 3'-end processing * Chromatin remodeling * Metabolism of RNA * It is involved in the regulation of gene expression through its binding to the Tfiid-class transcription factor complex. * It is also involved in the regulation of rRNA methylation and modification. **Clinical significance:** * Mutations in the FBL gene have been linked to several human diseases, including kidney cancer, breast cancer, and prostate cancer. * FBL is a potential therapeutic target for these diseases. **Additional information:** * The FBL protein is a highly conserved protein that is found in all vertebrates. * It is a well-characterized protein that has been extensively studied. * It is a promising target for cancer therapy.

Genular Protein ID: 3640125432

Symbol: FBRL_HUMAN

Name: rRNA 2'-O-methyltransferase fibrillarin

UniProtKB Accession Codes:

P22087 B5BUE8 O75259 Q6IAT5 Q9UPI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 19 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 3 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 11 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1846968

Title: cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera.

PubMed ID: 1846968

DOI: 10.1073/pnas.88.3.931

PubMed ID: 2026646

Title: Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast.

PubMed ID: 2026646

DOI: 10.1083/jcb.113.4.715

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2414294

Title: Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine.

PubMed ID: 2414294

DOI: 10.1016/s0021-9258(17)38718-5

PubMed ID: 1714385

Title: An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs.

PubMed ID: 1714385

DOI: 10.1002/j.1460-2075.1991.tb07807.x

PubMed ID: 10837141

Title: The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase.

PubMed ID: 10837141

DOI: 10.1006/excr.2000.4886

PubMed ID: 14583623

Title: Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes.

PubMed ID: 14583623

DOI: 10.1074/jbc.m305604200

PubMed ID: 17498821

Title: Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing.

PubMed ID: 17498821

DOI: 10.1016/j.bbamcr.2007.04.002

PubMed ID: 17636026

Title: A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly.

PubMed ID: 17636026

DOI: 10.1128/mcb.01097-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19208757

Title: Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.

PubMed ID: 19208757

DOI: 10.1242/jcs.044461

PubMed ID: 20926688

Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.

PubMed ID: 20926688

DOI: 10.1091/mbc.e10-04-0287

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21536856

Title: Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.

PubMed ID: 21536856

DOI: 10.1074/mcp.m110.006148

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22916032

Title: NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing.

PubMed ID: 22916032

DOI: 10.1371/journal.pgen.1002892

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24352239

Title: Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

PubMed ID: 24352239

DOI: 10.1038/nature12819

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30540930

Title: SIRT7-dependent deacetylation of fibrillarin controls histone H2A methylation and rRNA synthesis during the cell cycle.

PubMed ID: 30540930

DOI: 10.1016/j.celrep.2018.11.051

PubMed ID: 32017898

Title: The Alazami syndrome-associated protein LARP7 guides U6 small nuclear RNA modification and contributes to splicing robustness.

PubMed ID: 32017898

DOI: 10.1016/j.molcel.2020.01.001

PubMed ID: 34365507

Title: SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing.

PubMed ID: 34365507

DOI: 10.1093/nar/gkab647

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 321
  • Mass: 33784
  • Checksum: 2123F41E01EC557A
  • Sequence:
    • MKPGFSPRGG GFGGRGGFGD RGGRGGRGGF GGGRGRGGGF RGRGRGGGGG GGGGGGGGRG 
GGGFHSGGNR GRGRGGKRGN QSGKNVMVEP HRHEGVFICR GKEDALVTKN LVPGESVYGE 
KRVSISEGDD KIEYRAWNPF RSKLAAAILG GVDQIHIKPG AKVLYLGAAS GTTVSHVSDI 
VGPDGLVYAV EFSHRSGRDL INLAKKRTNI IPVIEDARHP HKYRMLIAMV DVIFADVAQP 
DQTRIVALNA HTFLRNGGHF VISIKANCID STASAEAVFA SEVKKMQQEN MKPQEQLTLE 
PYERDHAVVV GVYRPPPKVK N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.