Details for: FBL

Gene ID: 2091

Symbol: FBL

Ensembl ID: ENSG00000105202

Description: fibrillarin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 220.9647
    Cell Significance Index: -34.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 121.3989
    Cell Significance Index: -50.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 113.6965
    Cell Significance Index: -46.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 109.3148
    Cell Significance Index: -51.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 101.2276
    Cell Significance Index: -52.0700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 77.0466
    Cell Significance Index: -51.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.1381
    Cell Significance Index: -15.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.2227
    Cell Significance Index: -47.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.7734
    Cell Significance Index: -45.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7051
    Cell Significance Index: -50.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9221
    Cell Significance Index: -26.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.5915
    Cell Significance Index: -29.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.7708
    Cell Significance Index: -12.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.2781
    Cell Significance Index: 57.3800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.7781
    Cell Significance Index: 30.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3423
    Cell Significance Index: 69.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.3323
    Cell Significance Index: 430.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.2558
    Cell Significance Index: 57.5400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.9032
    Cell Significance Index: 37.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.7576
    Cell Significance Index: 72.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.5110
    Cell Significance Index: 177.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4622
    Cell Significance Index: 67.0200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.2136
    Cell Significance Index: 23.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1072
    Cell Significance Index: 28.7500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0757
    Cell Significance Index: 60.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9744
    Cell Significance Index: 271.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8943
    Cell Significance Index: 65.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8573
    Cell Significance Index: 228.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8236
    Cell Significance Index: 135.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8098
    Cell Significance Index: 800.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7578
    Cell Significance Index: 82.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7535
    Cell Significance Index: 1583.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.6848
    Cell Significance Index: 19.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4566
    Cell Significance Index: 262.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3518
    Cell Significance Index: 738.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2874
    Cell Significance Index: 83.0600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.2363
    Cell Significance Index: 9.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2261
    Cell Significance Index: 144.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2254
    Cell Significance Index: 35.3100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.1843
    Cell Significance Index: 7.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1519
    Cell Significance Index: 33.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0526
    Cell Significance Index: 54.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9246
    Cell Significance Index: 43.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8977
    Cell Significance Index: 153.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8359
    Cell Significance Index: 37.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7631
    Cell Significance Index: 17.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6501
    Cell Significance Index: 105.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6340
    Cell Significance Index: 68.9600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.6124
    Cell Significance Index: 8.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6046
    Cell Significance Index: 119.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5145
    Cell Significance Index: 65.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4718
    Cell Significance Index: 4.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4254
    Cell Significance Index: 80.9500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.3013
    Cell Significance Index: 1.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2921
    Cell Significance Index: 7.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2847
    Cell Significance Index: 28.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2498
    Cell Significance Index: 8.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2498
    Cell Significance Index: 6.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1679
    Cell Significance Index: 8.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0717
    Cell Significance Index: 1.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0669
    Cell Significance Index: 2.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0537
    Cell Significance Index: 40.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0338
    Cell Significance Index: 1.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0291
    Cell Significance Index: 5.8400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0184
    Cell Significance Index: 12.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0180
    Cell Significance Index: -33.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0240
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0252
    Cell Significance Index: -15.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0261
    Cell Significance Index: -19.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0266
    Cell Significance Index: -49.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0305
    Cell Significance Index: -47.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0355
    Cell Significance Index: -48.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0364
    Cell Significance Index: -13.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0468
    Cell Significance Index: -26.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0693
    Cell Significance Index: -44.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0909
    Cell Significance Index: -19.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0975
    Cell Significance Index: -44.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1088
    Cell Significance Index: -4.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1102
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1192
    Cell Significance Index: -13.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1359
    Cell Significance Index: -15.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1466
    Cell Significance Index: -42.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1482
    Cell Significance Index: -7.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2092
    Cell Significance Index: -5.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2424
    Cell Significance Index: -6.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2677
    Cell Significance Index: -16.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2869
    Cell Significance Index: -41.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3037
    Cell Significance Index: -6.5800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3223
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3830
    Cell Significance Index: -43.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4287
    Cell Significance Index: -7.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4734
    Cell Significance Index: -49.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4902
    Cell Significance Index: -27.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4932
    Cell Significance Index: -9.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5343
    Cell Significance Index: -42.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6256
    Cell Significance Index: -48.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6714
    Cell Significance Index: -10.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6718
    Cell Significance Index: -41.1900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.7274
    Cell Significance Index: -1.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Fibrillarin is a member of the fibrillarin family, which consists of three paralogous genes: FBL, FBLN1, and FBLN2. Fibrillarin is specifically associated with the nucleolus, where it plays a pivotal role in the biogenesis of ribosomal subunits. The gene is highly expressed in cells that require rapid proliferation and differentiation, such as erythroid progenitor cells, basal cells of prostate epithelium, and skeletal muscle satellite stem cells. **Pathways and Functions:** Fibrillarin is involved in several key pathways, including: 1. **RNA processing:** Fibrillarin is responsible for the 2'-O-methylation of snRNAs and rRNAs, which is essential for their proper processing and maturation. 2. **Ribosome biogenesis:** Fibrillarin contributes to the formation of ribosomal subunits by modifying rRNAs and facilitating their assembly. 3. **Cajal body formation:** Fibrillarin is a component of Cajal bodies, which are nuclear structures involved in the regulation of RNA processing and ribosome biogenesis. 4. **Chromatin remodeling:** Fibrillarin interacts with chromatin remodeling complexes to regulate gene expression and maintain genome stability. **Clinical Significance:** Fibrillarin has been implicated in various diseases and disorders, including: 1. **Cancer:** Altered expression of fibrillarin has been observed in various cancers, including leukemia, lymphoma, and solid tumors. 2. **Neurological disorders:** Fibrillarin has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Blood disorders:** Mutations in the FBL gene have been associated with hematological malignancies, such as acute myeloid leukemia. 4. **Reproductive disorders:** Fibrillarin has been implicated in reproductive diseases, including infertility and miscarriage. In conclusion, fibrillarin is a critical gene that plays a pivotal role in RNA processing, ribosome biogenesis, and chromatin remodeling. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the molecular mechanisms underlying fibrillarin's functions.

Genular Protein ID: 3640125432

Symbol: FBRL_HUMAN

Name: rRNA 2'-O-methyltransferase fibrillarin

UniProtKB Accession Codes:

P22087 B5BUE8 O75259 Q6IAT5 Q9UPI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 19 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 11 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1846968

Title: cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera.

PubMed ID: 1846968

DOI: 10.1073/pnas.88.3.931

PubMed ID: 2026646

Title: Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast.

PubMed ID: 2026646

DOI: 10.1083/jcb.113.4.715

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2414294

Title: Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine.

PubMed ID: 2414294

DOI: 10.1016/s0021-9258(17)38718-5

PubMed ID: 1714385

Title: An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs.

PubMed ID: 1714385

DOI: 10.1002/j.1460-2075.1991.tb07807.x

PubMed ID: 10837141

Title: The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase.

PubMed ID: 10837141

DOI: 10.1006/excr.2000.4886

PubMed ID: 14583623

Title: Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes.

PubMed ID: 14583623

DOI: 10.1074/jbc.m305604200

PubMed ID: 17498821

Title: Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing.

PubMed ID: 17498821

DOI: 10.1016/j.bbamcr.2007.04.002

PubMed ID: 17636026

Title: A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly.

PubMed ID: 17636026

DOI: 10.1128/mcb.01097-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19208757

Title: Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.

PubMed ID: 19208757

DOI: 10.1242/jcs.044461

PubMed ID: 20926688

Title: RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.

PubMed ID: 20926688

DOI: 10.1091/mbc.e10-04-0287

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21536856

Title: Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.

PubMed ID: 21536856

DOI: 10.1074/mcp.m110.006148

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22916032

Title: NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing.

PubMed ID: 22916032

DOI: 10.1371/journal.pgen.1002892

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24352239

Title: Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

PubMed ID: 24352239

DOI: 10.1038/nature12819

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30540930

Title: SIRT7-dependent deacetylation of fibrillarin controls histone H2A methylation and rRNA synthesis during the cell cycle.

PubMed ID: 30540930

DOI: 10.1016/j.celrep.2018.11.051

PubMed ID: 32017898

Title: The Alazami syndrome-associated protein LARP7 guides U6 small nuclear RNA modification and contributes to splicing robustness.

PubMed ID: 32017898

DOI: 10.1016/j.molcel.2020.01.001

PubMed ID: 34365507

Title: SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing.

PubMed ID: 34365507

DOI: 10.1093/nar/gkab647

PubMed ID: 36161484

Title: Human NOP2/NSUN1 regulates ribosome biogenesis through non-catalytic complex formation with box C/D snoRNPs.

PubMed ID: 36161484

DOI: 10.1093/nar/gkac817

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 321
  • Mass: 33784
  • Checksum: 2123F41E01EC557A
  • Sequence:
    • MKPGFSPRGG GFGGRGGFGD RGGRGGRGGF GGGRGRGGGF RGRGRGGGGG GGGGGGGGRG 
GGGFHSGGNR GRGRGGKRGN QSGKNVMVEP HRHEGVFICR GKEDALVTKN LVPGESVYGE 
KRVSISEGDD KIEYRAWNPF RSKLAAAILG GVDQIHIKPG AKVLYLGAAS GTTVSHVSDI 
VGPDGLVYAV EFSHRSGRDL INLAKKRTNI IPVIEDARHP HKYRMLIAMV DVIFADVAQP 
DQTRIVALNA HTFLRNGGHF VISIKANCID STASAEAVFA SEVKKMQQEN MKPQEQLTLE 
PYERDHAVVV GVYRPPPKVK N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.