Details for: ESR1

Gene ID: 2099

Symbol: ESR1

Ensembl ID: ENSG00000091831

Description: estrogen receptor 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.28
    Marker Score: 4,391
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.12
    Marker Score: 4,022
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.72
    Marker Score: 19,338
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.7
    Marker Score: 3,454
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.7
    Marker Score: 9,118
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.64
    Marker Score: 10,573
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.53
    Marker Score: 3,601
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.52
    Marker Score: 6,553
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,861
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.35
    Marker Score: 757
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.33
    Marker Score: 1,425
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.32
    Marker Score: 343
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.32
    Marker Score: 3,245
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.26
    Marker Score: 1,642
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.2
    Marker Score: 723
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18,751
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.19
    Marker Score: 373
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.19
    Marker Score: 383
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.18
    Marker Score: 41,038
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.15
    Marker Score: 641
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,792
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.03
    Marker Score: 376
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.02
    Marker Score: 6,143
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,035
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,301
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,282
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.86
    Marker Score: 1,529
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.85
    Marker Score: 1,596
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.84
    Marker Score: 2,989
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8
    Marker Score: 49,504
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.78
    Marker Score: 206
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.78
    Marker Score: 370
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.76
    Marker Score: 7,896
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.71
    Marker Score: 268
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.66
    Marker Score: 388
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.66
    Marker Score: 334
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.65
    Marker Score: 2,511
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.65
    Marker Score: 451
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.64
    Marker Score: 424
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.63
    Marker Score: 286
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.61
    Marker Score: 1,661
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.61
    Marker Score: 648
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.59
    Marker Score: 1,697
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.59
    Marker Score: 5,082
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.59
    Marker Score: 587
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.59
    Marker Score: 904
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.58
    Marker Score: 150
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.58
    Marker Score: 281
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 455
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.55
    Marker Score: 527
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.55
    Marker Score: 685
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.55
    Marker Score: 677
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.55
    Marker Score: 139
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.55
    Marker Score: 221
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.54
    Marker Score: 1,850
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.54
    Marker Score: 238
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.53
    Marker Score: 241
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.53
    Marker Score: 588
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.52
    Marker Score: 2,251
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.52
    Marker Score: 164
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.52
    Marker Score: 697
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.51
    Marker Score: 133
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.49
    Marker Score: 185
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.49
    Marker Score: 215
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.49
    Marker Score: 178
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.49
    Marker Score: 2,031
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.48
    Marker Score: 476
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.46
    Marker Score: 554
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.46
    Marker Score: 1,859
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.44
    Marker Score: 120
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.42
    Marker Score: 288
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.42
    Marker Score: 4,195
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.41
    Marker Score: 15,654
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.41
    Marker Score: 3,914
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 109
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.41
    Marker Score: 1,690
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.39
    Marker Score: 341
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.39
    Marker Score: 90
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.39
    Marker Score: 2,967
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.39
    Marker Score: 477
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.38
    Marker Score: 1,481
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.38
    Marker Score: 132
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.38
    Marker Score: 139
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.37
    Marker Score: 969
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 150
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.36
    Marker Score: 111
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.35
    Marker Score: 180
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.35
    Marker Score: 5,583

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Nuclear receptor**: ESR1 is a nuclear receptor that regulates gene expression by binding to estrogen response elements (EREs) in the promoter regions of target genes. 2. **Estrogen-dependent**: ESR1 is activated by estrogen, which binds to the ligand-binding domain of the receptor, inducing a conformational change that allows it to bind to EREs. 3. **Transcriptional regulation**: ESR1 regulates gene expression by recruiting coactivators and corepressors to the promoter regions of target genes. 4. **Cell-type specific**: ESR1 is expressed in various cell types, including kidney interstitial fibroblasts, cardiac endothelial cells, and ovarian stromal cells. **Pathways and Functions** 1. **Estrogen signaling pathway**: ESR1 is involved in the estrogen signaling pathway, which regulates various physiological processes, including cell proliferation, differentiation, and survival. 2. **Cell proliferation and survival**: ESR1 regulates cell proliferation and survival by modulating the expression of target genes involved in these processes. 3. **Gene expression regulation**: ESR1 regulates gene expression by binding to EREs in the promoter regions of target genes, thereby modulating their expression. 4. **Inflammation and immune responses**: ESR1 is involved in the regulation of inflammation and immune responses by modulating the expression of target genes involved in these processes. **Clinical Significance** 1. **Breast cancer**: ESR1 is overexpressed in approximately 70% of breast cancer cases, making it a potential target for therapy. 2. **Osteoporosis**: ESR1 is involved in the regulation of bone metabolism, and its dysregulation may contribute to osteoporosis. 3. **Cardiovascular disease**: ESR1 is involved in the regulation of cardiovascular disease, including hypertension and atherosclerosis. 4. **Immune responses**: ESR1 is involved in the regulation of immune responses, including inflammation and immune cell differentiation. In conclusion, ESR1 is a critical regulator of gene expression, cell proliferation, and survival. Its dysregulation is implicated in various diseases, including breast cancer, osteoporosis, cardiovascular disease, and immune responses. Further research is needed to fully elucidate the mechanisms by which ESR1 regulates gene expression and to develop targeted therapies for these diseases.

Genular Protein ID: 694989172

Symbol: ESR1_HUMAN

Name: Estrogen receptor

UniProtKB Accession Codes:

P03372 Q13511 Q14276 Q5T5H7 Q6MZQ9 Q9NU51 Q9UDZ7 Q9UIS7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 100 DrugCentral 1 ELM 1 EMBL 15 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 81 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PIRSF 2 PRINTS 3 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 14 RefSeq 17 SAM 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3754034

Title: Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.

PubMed ID: 3754034

DOI: 10.1038/320134a0

PubMed ID: 3753802

Title: Sequence and expression of human estrogen receptor complementary DNA.

PubMed ID: 3753802

DOI: 10.1126/science.3753802

PubMed ID: 8600466

Title: A novel 80 kDa human estrogen receptor containing a duplication of exons 6 and 7.

PubMed ID: 8600466

DOI: 10.1093/nar/24.5.962

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16165085

Title: Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66.

PubMed ID: 16165085

DOI: 10.1016/j.bbrc.2005.08.226

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7476978

Title: Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor.

PubMed ID: 7476978

DOI: 10.1210/mend.9.8.7476978

PubMed ID: 10619354

Title: Single nucleotide polymorphisms (SNPs) in the estrogen receptor gene and breast cancer susceptibility.

PubMed ID: 10619354

DOI: 10.1016/s0960-0760(99)00126-0

PubMed ID: 7916651

Title: Estrogen receptor variant messenger RNA lacking exon 4 in estrogen-responsive human breast cancer cell lines.

PubMed ID: 7916651

PubMed ID: 7539106

Title: Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.

PubMed ID: 7539106

DOI: 10.1210/mend.9.1.7539106

PubMed ID: 1577818

Title: Characterization of a temperature-sensitive mutation in the hormone binding domain of the human estrogen receptor. Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation.

PubMed ID: 1577818

DOI: 10.1016/s0021-9258(19)50174-0

PubMed ID: 1517211

Title: Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

PubMed ID: 1517211

DOI: 10.1016/s0021-9258(19)37087-5

PubMed ID: 7838153

Title: Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor.

PubMed ID: 7838153

DOI: 10.1210/mend.8.9.7838153

PubMed ID: 7651415

Title: Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta.

PubMed ID: 7651415

DOI: 10.1128/mcb.15.9.4971

PubMed ID: 8961262

Title: A transcriptionally active estrogen receptor mutant is a novel type of dominant negative inhibitor of estrogen action.

PubMed ID: 8961262

DOI: 10.1210/mend.10.12.8961262

PubMed ID: 10409727

Title: Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.

PubMed ID: 10409727

DOI: 10.1128/mcb.19.8.5363

PubMed ID: 24509260

Title:

PubMed ID: 24509260

DOI: 10.1128/mcb.01458-13

PubMed ID: 10970861

Title: Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1.

PubMed ID: 10970861

DOI: 10.1093/emboj/19.17.4688

PubMed ID: 11075817

Title: Function of N-terminal transactivation domain of the estrogen receptor requires a potential alpha-helical structure and is negatively regulated by the A domain.

PubMed ID: 11075817

DOI: 10.1210/mend.14.11.0546

PubMed ID: 12554772

Title: Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells.

PubMed ID: 12554772

DOI: 10.1210/me.2002-0351

PubMed ID: 12682286

Title: Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells.

PubMed ID: 12682286

DOI: 10.1073/pnas.0831079100

PubMed ID: 8999954

Title: A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine.

PubMed ID: 8999954

DOI: 10.1074/jbc.272.4.2421

PubMed ID: 9328340

Title: Functional synergy between the transcription factor Sp1 and the estrogen receptor.

PubMed ID: 9328340

DOI: 10.1210/mend.11.11.9916

PubMed ID: 9627117

Title: Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action.

PubMed ID: 9627117

DOI: 10.1038/sj.onc.1201783

PubMed ID: 10428798

Title: Potentiation of human estrogen receptor alpha transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex.

PubMed ID: 10428798

DOI: 10.1074/jbc.274.32.22296

PubMed ID: 10567404

Title: A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

PubMed ID: 10567404

DOI: 10.1074/jbc.274.48.34283

PubMed ID: 10359819

Title: An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens.

PubMed ID: 10359819

DOI: 10.1073/pnas.96.12.6947

PubMed ID: 11265755

Title: Synergy between estrogen receptor alpha activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2.

PubMed ID: 11265755

DOI: 10.1093/embo-reports/kvd028

PubMed ID: 10681512

Title: Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.

PubMed ID: 10681512

DOI: 10.1074/jbc.275.8.5379

PubMed ID: 10816575

Title: Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins.

PubMed ID: 10816575

DOI: 10.1074/jbc.m002188200

PubMed ID: 11581164

Title: Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.

PubMed ID: 11581164

DOI: 10.1101/gad.906301

PubMed ID: 11477071

Title: Characterization of the physical interaction between estrogen receptor alpha and JUN proteins.

PubMed ID: 11477071

DOI: 10.1074/jbc.m101806200

PubMed ID: 11358960

Title: Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription.

PubMed ID: 11358960

DOI: 10.1074/jbc.m100313200

PubMed ID: 11481323

Title: Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.

PubMed ID: 11481323

DOI: 10.1074/jbc.m103783200

PubMed ID: 11113208

Title: CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant.

PubMed ID: 11113208

DOI: 10.1128/mcb.21.1.343-353.2001

PubMed ID: 11682626

Title: Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains.

PubMed ID: 11682626

DOI: 10.1210/mend.15.11.0727

PubMed ID: 12039952

Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.

PubMed ID: 12039952

DOI: 10.1074/jbc.m201053200

PubMed ID: 12093804

Title: Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor.

PubMed ID: 12093804

DOI: 10.1074/jbc.m203531200

PubMed ID: 11971969

Title: ERAP140, a conserved tissue-specific nuclear receptor coactivator.

PubMed ID: 11971969

DOI: 10.1128/mcb.22.10.3358-3372.2002

PubMed ID: 11875103

Title: A negative coregulator for the human ER.

PubMed ID: 11875103

DOI: 10.1210/mend.16.3.0787

PubMed ID: 12415108

Title: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.

PubMed ID: 12415108

DOI: 10.1073/pnas.192569699

PubMed ID: 19666546

Title:

PubMed ID: 19666546

DOI: 10.1073/pnas.0908685106

PubMed ID: 12917342

Title: BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.

PubMed ID: 12917342

DOI: 10.1128/mcb.23.17.6210-6220.2003

PubMed ID: 15047147

Title: ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.

PubMed ID: 15047147

DOI: 10.1016/j.bbrc.2004.02.179

PubMed ID: 15078875

Title: The relative contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha transcriptional activity depends upon the differentiation stage of the cell.

PubMed ID: 15078875

DOI: 10.1074/jbc.m402148200

PubMed ID: 15199063

Title: An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.

PubMed ID: 15199063

DOI: 10.1074/jbc.m402753200

PubMed ID: 14963108

Title: Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc.

PubMed ID: 14963108

DOI: 10.1210/me.2003-0335

PubMed ID: 14764652

Title: Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription.

PubMed ID: 14764652

DOI: 10.1210/me.2003-0308

PubMed ID: 16043358

Title: Estrogen receptor inhibits interleukin-6 gene expression by disruption of nuclear factor kappaB transactivation.

PubMed ID: 16043358

DOI: 10.1016/j.cyto.2004.12.008

PubMed ID: 15891768

Title: Functional regulation of oestrogen receptor pathway by the dynein light chain 1.

PubMed ID: 15891768

DOI: 10.1038/sj.embor.7400417

PubMed ID: 15940264

Title: The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1.

PubMed ID: 15940264

DOI: 10.1038/sj.onc.1208728

PubMed ID: 16603732

Title: Identification of the MLL2 complex as a coactivator for estrogen receptor alpha.

PubMed ID: 16603732

DOI: 10.1074/jbc.m513245200

PubMed ID: 16684779

Title: Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells.

PubMed ID: 16684779

DOI: 10.1074/jbc.m600021200

PubMed ID: 16427018

Title: MUC1 oncoprotein stabilizes and activates estrogen receptor alpha.

PubMed ID: 16427018

DOI: 10.1016/j.molcel.2005.11.030

PubMed ID: 16772533

Title: WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors.

PubMed ID: 16772533

DOI: 10.1210/me.2005-0533

PubMed ID: 17085477

Title: ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases.

PubMed ID: 17085477

DOI: 10.1093/nar/gkl875

PubMed ID: 16617102

Title: MTA1, a transcriptional activator of breast cancer amplified sequence 3.

PubMed ID: 16617102

DOI: 10.1073/pnas.0601989103

PubMed ID: 17043237

Title: An inherent role of microtubule network in the action of nuclear receptor.

PubMed ID: 17043237

DOI: 10.1073/pnas.0607445103

PubMed ID: 17658481

Title: The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain.

PubMed ID: 17658481

DOI: 10.1016/j.bbrc.2007.06.179

PubMed ID: 17347654

Title: CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome.

PubMed ID: 17347654

DOI: 10.1038/sj.emboj.7601602

PubMed ID: 17914104

Title: Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity.

PubMed ID: 17914104

DOI: 10.1677/erc-06-0082

PubMed ID: 17006958

Title: MS-KIF18A, a kinesin, is associated with estrogen receptor.

PubMed ID: 17006958

DOI: 10.1002/jcb.21000

PubMed ID: 17587566

Title: PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.

PubMed ID: 17587566

DOI: 10.1016/j.jsbmb.2007.05.006

PubMed ID: 17505058

Title: Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).

PubMed ID: 17505058

DOI: 10.1210/me.2006-0514

PubMed ID: 17311814

Title: Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha.

PubMed ID: 17311814

DOI: 10.1093/nar/gkl1112

PubMed ID: 17998543

Title: ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification.

PubMed ID: 17998543

DOI: 10.1073/pnas.0705814104

PubMed ID: 18247370

Title: ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblasts.

PubMed ID: 18247370

DOI: 10.1002/jcp.21379

PubMed ID: 18657504

Title: Regulation of estrogen rapid signaling through arginine methylation by PRMT1.

PubMed ID: 18657504

DOI: 10.1016/j.molcel.2008.05.025

PubMed ID: 17932106

Title: CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.

PubMed ID: 17932106

DOI: 10.1210/me.2007-0324

PubMed ID: 17922032

Title: MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene.

PubMed ID: 17922032

DOI: 10.1038/sj.onc.1210839

PubMed ID: 18563714

Title: ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells.

PubMed ID: 18563714

DOI: 10.1002/pros.20774

PubMed ID: 19712589

Title: SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway.

PubMed ID: 19712589

DOI: 10.5483/bmbrep.2009.42.8.516

PubMed ID: 19117995

Title: Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.

PubMed ID: 19117995

DOI: 10.1158/0008-5472.can-08-1630

PubMed ID: 19423554

Title: Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia.

PubMed ID: 19423554

DOI: 10.1093/hmg/ddp215

PubMed ID: 19350539

Title: NF-kappaB and estrogen receptor alpha interactions: Differential function in estrogen receptor-negative and -positive hormone-independent breast cancer cells.

PubMed ID: 19350539

DOI: 10.1002/jcb.22141

PubMed ID: 19383985

Title: OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity.

PubMed ID: 19383985

DOI: 10.1074/jbc.m109.007484

PubMed ID: 19339517

Title: CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.

PubMed ID: 19339517

DOI: 10.1093/nar/gkp136

PubMed ID: 19718048

Title: The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer.

PubMed ID: 19718048

DOI: 10.1038/onc.2009.261

PubMed ID: 19636373

Title: The regulation of MS-KIF18A expression and cross talk with estrogen receptor.

PubMed ID: 19636373

DOI: 10.1371/journal.pone.0006407

PubMed ID: 20078863

Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.

PubMed ID: 20078863

DOI: 10.1186/1471-2199-11-3

PubMed ID: 20074560

Title: Repression of estrogen receptor beta function by putative tumor suppressor DBC1.

PubMed ID: 20074560

DOI: 10.1016/j.bbrc.2010.01.025

PubMed ID: 20705611

Title: Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{kappa}B cooperativity at adjacent response elements.

PubMed ID: 20705611

DOI: 10.1074/jbc.m110.155309

PubMed ID: 20720010

Title: ATBF1 inhibits estrogen receptor (ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cells.

PubMed ID: 20720010

DOI: 10.1074/jbc.m110.128330

PubMed ID: 19755138

Title: Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants.

PubMed ID: 19755138

DOI: 10.1016/j.mce.2009.09.007

PubMed ID: 21104395

Title: Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand.

PubMed ID: 21104395

DOI: 10.1007/s00109-010-0698-y

PubMed ID: 21937726

Title: Splice isoform estrogen receptors as integral transmembrane proteins.

PubMed ID: 21937726

DOI: 10.1091/mbc.e11-05-0416

PubMed ID: 21330404

Title: Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway.

PubMed ID: 21330404

DOI: 10.1210/me.2010-0425

PubMed ID: 21602804

Title: Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer.

PubMed ID: 21602804

DOI: 10.1038/nm.2351

PubMed ID: 22031296

Title: DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.

PubMed ID: 22031296

DOI: 10.1091/mbc.e11-07-0638

PubMed ID: 22083956

Title: CBP mediates NF-kappaB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter.

PubMed ID: 22083956

DOI: 10.1128/mcb.05869-11

PubMed ID: 23160374

Title: CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha.

PubMed ID: 23160374

DOI: 10.1038/onc.2012.518

PubMed ID: 23874500

Title: DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha.

PubMed ID: 23874500

DOI: 10.1371/journal.pone.0068075

PubMed ID: 25219498

Title: Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development.

PubMed ID: 25219498

DOI: 10.1016/j.molcel.2014.08.007

PubMed ID: 24498420

Title: JMJD6 regulates ERalpha methylation on arginine.

PubMed ID: 24498420

DOI: 10.1371/journal.pone.0087982

PubMed ID: 28068668

Title: The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha.

PubMed ID: 28068668

DOI: 10.1038/nature20829

PubMed ID: 2247153

Title: Solution structure of the DNA-binding domain of the oestrogen receptor.

PubMed ID: 2247153

DOI: 10.1038/348458a0

PubMed ID: 8221895

Title: The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements.

PubMed ID: 8221895

DOI: 10.1016/0092-8674(93)90390-c

PubMed ID: 9338790

Title: Molecular basis of agonism and antagonism in the oestrogen receptor.

PubMed ID: 9338790

DOI: 10.1038/39645

PubMed ID: 9600906

Title: Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains.

PubMed ID: 9600906

DOI: 10.1073/pnas.95.11.5998

Sequence Information:

  • Length: 595
  • Mass: 66216
  • Checksum: 5455C57AB0CCCAA7
  • Sequence:
    • MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY 
EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL NSVSPSPLML LHPPPQLSPF 
LQPHGQQVPY YLENEPSGYT VREAGPPAFY RPNSDNRRQG GRERLASTND KGSMAMESAK 
ETRYCAVCND YASGYHYGVW SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC 
RLRKCYEVGM MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR 
SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA DRELVHMINW 
AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG KLLFAPNLLL DRNQGKCVEG 
MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS IILLNSGVYT FLSSTLKSLE EKDHIHRVLD 
KITDTLIHLM AKAGLTLQQQ HQRLAQLLLI LSHIRHMSNK GMEHLYSMKC KNVVPLYDLL 
LEMLDAHRLH APTSRGGASV EETDQSHLAT AGSTSSHSLQ KYYITGEAEG FPATV

Genular Protein ID: 2365028280

Symbol: H0Y4W6_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0Y4W6

Database IDs:

ARBA 15 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PIRSF 1 PRINTS 2 PROSITE 5 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 310
  • Mass: 35298
  • Checksum: 051CA0996E56C356
  • Sequence:
    • MAMESAKETR YCAVCNDYAS GYHYGVWSCE GCKAFFKRSI QGHNDYMCPA TNQCTIDKNR 
RKSCQACRLR KCYEVGMMKG GIRKDRRGGR MLKHKRQRDD GEGRGEVGSA GDMRAANLWP 
SPLMIKRSKK NSLALSLTAD QMVSALLDAE PPILYSEYDP TRPFSEASMM GLLTNLADRE 
LVHMINWAKR VPGFVDLTLH DQVHLLECAW LEILMIGLVW RSMEHPGKLL FAPNLLLDRN 
QGKCVEGMVE IFDMLLATSS RFRMMNLQGE EFVCLKSIIL LNSGISHVEA KKRILNLHPK 
IFGNKWFPRV

Genular Protein ID: 559632766

Symbol: A8KAF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8KAF4

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 6 Gene3D 2 GenomeRNAi 1 InterPro 9 NCBI Taxonomy 1 PANTHER 2 PIRNR 1 PIRSF 2 PRINTS 3 PROSITE 5 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 594
  • Mass: 66169
  • Checksum: 48F6B6D48709786B
  • Sequence:
    • MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY 
EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL NSVSPSPLML LHPPPQLSPF 
LQPHGQQVPY YLENEPSGYT VREAGPPAFY RPNSDNRRQG GRERLASTND KGSMAMESAK 
ETRYCAVCND YASGYHYGVW SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC 
RLRKCYEVGM MKGIRKDRRG GRMLKHKRQR DDGEGRGEVG SAGDMRAANL WPSPLMIKRS 
KKNSLALSLT ADQMVSALLD AEPPILYPEY DPTRPFSEAS MMGLLTNLAD RELVHMINWA 
KRVPGFVDLT LHDQVHLLEC AWLEILMIGL VWRSMEHPGK LLFAPNLLLD RNQGKCVEGM 
VEIFDMLLAT SSRFRMMNLQ GEEFVCLKSI ILLNSGVYTF LSSTLKSLEE KDHIHRVLDK 
ITDTLIHLMA KAGLTLQQQH QRLAQLLLIL SHIRHMSNKG MEHLYSMKCK NVVPLYDLLL 
EMLDAHRLHA PTSRGGASVE ETDQSHLATA GSTSSHSLQK YYITGEAEGF PATV

Genular Protein ID: 4038487504

Symbol: A0A125SXW3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A125SXW3

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 6 Gene3D 2 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 PANTHER 2 PRINTS 3 PROSITE 5 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 26835991

Title: Human C-terminally truncated ER? variants resulting from the use of alternative exons in the ligand-binding domain.

PubMed ID: 26835991

DOI: 10.1016/j.mce.2016.01.026

Sequence Information:

  • Length: 483
  • Mass: 53748
  • Checksum: 2BD7CE2C94A8D1B9
  • Sequence:
    • MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY 
EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL NSVSPSPLML LHPPPQLSPF 
LQPHGQQVPY YLENEPSGYT VREAGPPAFY RPNSDNRRQG GRERLASTND KGSMAMESAK 
ETRYCAVCND YASGYHYGVW SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC 
RLRKCYEVGM MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR 
SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA DRELVHMINW 
AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG KLLFAPNLLL DRNQGKCVEG 
MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS IILLNSVLTT GRPGDTLPCL AQWVTRPWRL 
AHC

Genular Protein ID: 1749260428

Symbol: Q9UBT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UBT1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 GenomeRNAi 1 NCBI Taxonomy 1 PharmGKB 1 RefSeq 1

Citations:

PubMed ID: 3754034

Title: Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.

PubMed ID: 3754034

DOI: 10.1038/320134a0

PubMed ID: 3753802

Title: Sequence and expression of human estrogen receptor complementary DNA.

PubMed ID: 3753802

DOI: 10.1126/science.3753802

PubMed ID: 2015052

Title: Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene.

PubMed ID: 2015052

PubMed ID: 1567414

Title: Analysis of upstream sequences of the human estrogen receptor gene.

PubMed ID: 1567414

DOI: 10.1016/S0006-291X(05)80289-X

PubMed ID: 1476547

Title: Sequence analysis of the 5' flanking region of the human estrogen receptor gene.

PubMed ID: 1476547

PubMed ID: 8240974

Title: Sequencing of an RNA transcript of the human estrogen receptor gene: evidence for a new transcriptional event.

PubMed ID: 8240974

DOI: 10.1016/0960-0760(93)90179-Z

PubMed ID: 8647321

Title: Determination of transcription start sites in the human estrogen receptor gene and identification of a novel, tissue-specific, estrogen receptor-mRNA isoform.

PubMed ID: 8647321

DOI: 10.1016/0303-7207(95)03716-0

PubMed ID: 9393949

Title: Identification of two estrogen receptor transcripts with novel 5' exons isolated from a MCF7 cDNA library.

PubMed ID: 9393949

DOI: 10.1016/S0960-0760(97)00029-0

Sequence Information:

  • Length: 23
  • Mass: 2526
  • Checksum: 4A678094301081FD
  • Sequence:
    • MTMTLHTKAS GMALLHQIQG NEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.