Details for: ETV2

Gene ID: 2116

Symbol: ETV2

Ensembl ID: ENSG00000105672

Description: ETS variant transcription factor 2

Associated with

  • Blastocyst development
    (GO:0001824)
  • Blood vessel morphogenesis
    (GO:0048514)
  • Bmp signaling pathway
    (GO:0030509)
  • Cell differentiation
    (GO:0030154)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Erythrocyte differentiation
    (GO:0030218)
  • Mesoderm formation
    (GO:0001707)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleus
    (GO:0005634)
  • Placenta development
    (GO:0001890)
  • Positive regulation of endothelial cell differentiation
    (GO:0045603)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of mesoderm development
    (GO:2000382)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Wnt signaling pathway
    (GO:0016055)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.11
    Marker Score: 3033
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.05
    Marker Score: 2172
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5306
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 666
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.72
    Marker Score: 11249
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1438
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.68
    Marker Score: 516
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.67
    Marker Score: 270
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.66
    Marker Score: 208
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2707
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1173
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.61
    Marker Score: 1426
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.6
    Marker Score: 480
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.55
    Marker Score: 456
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 311
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.5
    Marker Score: 1408.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 148
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.46
    Marker Score: 293.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 268
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.44
    Marker Score: 644
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.43
    Marker Score: 330
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 197
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.41
    Marker Score: 171
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.36
    Marker Score: 764
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.36
    Marker Score: 3110
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.34
    Marker Score: 195
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.33
    Marker Score: 86
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 218
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.32
    Marker Score: 115
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.31
    Marker Score: 165
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.29
    Marker Score: 661
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.28
    Marker Score: 1365
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.27
    Marker Score: 415
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.27
    Marker Score: 488
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.27
    Marker Score: 2075
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.26
    Marker Score: 280
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.26
    Marker Score: 108
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.25
    Marker Score: 61
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.24
    Marker Score: 571
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 106
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.24
    Marker Score: 241
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.23
    Marker Score: 208
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.23
    Marker Score: 529
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.23
    Marker Score: 248
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.23
    Marker Score: 152
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.23
    Marker Score: 151
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.22
    Marker Score: 217
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.22
    Marker Score: 462
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.22
    Marker Score: 228
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.21
    Marker Score: 503
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.21
    Marker Score: 336
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.21
    Marker Score: 562
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.2
    Marker Score: 81
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.2
    Marker Score: 227
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.2
    Marker Score: 111
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.2
    Marker Score: 105
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.2
    Marker Score: 87
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.2
    Marker Score: 74
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2
    Marker Score: 334
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.19
    Marker Score: 1262
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.19
    Marker Score: 45
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.19
    Marker Score: 196
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.19
    Marker Score: 100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.19
    Marker Score: 1196
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.18
    Marker Score: 2422
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.18
    Marker Score: 52
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.18
    Marker Score: 193
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.18
    Marker Score: 55
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.18
    Marker Score: 568
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.18
    Marker Score: 118
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.18
    Marker Score: 38
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.18
    Marker Score: 86
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.18
    Marker Score: 39
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.18
    Marker Score: 472
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.18
    Marker Score: 168
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.17
    Marker Score: 80
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.17
    Marker Score: 35
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.17
    Marker Score: 118
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.17
    Marker Score: 39

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Other Information

**Key characteristics:** - ETV2 is a transcription factor that is expressed in a wide variety of cell types, including embryonic and adult stem cells. - It is a key regulator of the development of the inner cell mass of the blastocyst. - ETV2 is a target for many human cancers. **Pathways and functions:** **1. Blastocyst development:** ETV2 is essential for the development of the inner cell mass of the blastocyst, the early lineage of all tissues and organs in the body. It is required for the formation of the embryonic and extraembryonic tissues, which give rise to all of the tissues and organs in the body. **2. Blood vessel morphogenesis:** ETV2 is also involved in the development of blood vessels. It is expressed in endothelial cells, which are responsible for the formation of blood vessels. ETV2 helps to regulate the migration and differentiation of endothelial cells into blood vessel endothelial cells. **3. Bmp signaling pathway:** ETV2 is a key regulator of the Bmp signaling pathway, which is a major signaling pathway involved in cell differentiation and proliferation. ETV2 is expressed in cells that are committed to becoming endothelial cells, and it is required for the activation of the Bmp signaling pathway. **4. Cell differentiation:** ETV2 is also involved in cell differentiation. It is expressed in cells that are committed to becoming neural cells, and it is required for the differentiation of neural stem cells into neurons. **5. Dna-binding transcription activator activity:** ETV2 is a key regulator of DNA-binding transcription activator (DNA-BA) activity. It is expressed in cells that are committed to becoming neural cells, and it is required for the activation of DNA-BA-dependent genes in these cells. **6. Rna polymerase ii-specific:** ETV2 is a rna polymerase ii-specific transcription factor. It is expressed in cells that are committed to becoming endothelial cells, and it is required for the transcription of genes that are involved in the development of the blood-brain barrier. **7. Erythrocyte differentiation:** ETV2 is also involved in erythrocyte differentiation. It is expressed in cells that are committed to becoming red blood cells, and it is required for the development of normal red blood cells. **8. Mesoderm formation:** ETV2 is involved in the formation of the mesoderm, which is a layer of cells that lies beneath the skin and organs. It is required for the development of the dermis, which is the skin and connective tissue layer of the body. **9. Notch signaling pathway:** ETV2 is also involved in the Notch signaling pathway, which is a major signaling pathway involved in cell survival, proliferation, and differentiation. ETV2 is expressed in cells that are committed to becoming neural cells, and it is required for the activation of Notch signaling pathway-dependent genes in these cells. **10. Nucleus:** ETV2 is also involved in the nucleus. It is expressed in cells that are committed to becoming neural cells, and it is required for the proper development of the nucleus in these cells. **Clinical significance:** EVT2 is a key tumor suppressor gene. Mutations in ETV2 have been linked to the development of a variety of human cancers, including lung cancer, breast cancer, and colon cancer. ETV2 is a promising target for cancer therapy, as it is frequently mutated in cancer cells.

Genular Protein ID: 470242510

Symbol: ETV2_HUMAN

Name: ETS translocation variant 2

UniProtKB Accession Codes:

O00321 A6NFN5 B3KUL0 B9EIN1 Q9UEA0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 342
  • Mass: 36633
  • Checksum: 9B0103D5D4B1AB8C
  • Sequence:
    • MDLWNWDEAS PQEVPPGNKL AGLEGAKLGF CFPDLALQGD TPTATAETCW KGTSSSLASF 
PQLDWGSALL HPEVPWGAEP DSQALPWSGD WTDMACTAWD SWSGASQTLG PAPLGPGPIP 
AAGSEGAAGQ NCVPVAGEAT SWSRAQAAGS NTSWDCSVGP DGDTYWGSGL GGEPRTDCTI 
SWGGPAGPDC TTSWNPGLHA GGTTSLKRYQ SSALTVCSEP SPQSDRASLA RCPKTNHRGP 
IQLWQFLLEL LHDGARSSCI RWTGNSREFQ LCDPKEVARL WGERKRKPGM NYEKLSRGLR 
YYYRRDIVRK SGGRKYTYRF GGRVPSLAYP DCAGGGRGAE TQ

Genular Protein ID: 3501831714

Symbol: K7ERX2_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7ERX2

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 249
  • Mass: 26651
  • Checksum: 369F0B53A2F60A17
  • Sequence:
    • MACTAWDSWS GASQTLGPAP LGPGPIPAAG SEGAAGQNCV PVAGEATSWS RAQAAGSNTS 
WDCSVGPDGD TYWGSGLGGE PRTDCTISWG GPAGPDCTTS WNPGLHAGGT TSLKRYQSSA 
LTVCSEPSPQ SDRASLARCP KTNHRGPIQL WQFLLELLHD GARSSCIRWT GNSREFQLCD 
PKEVARLWGE RKRKPGMNYE KLSRGLRYYY RRDIVRKSGG RKYTYRFGGR VPSLAYPDCA 
GGGRGAETQ

Genular Protein ID: 2361749273

Symbol: Q3KNT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q3KNT2

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 155
  • Mass: 17563
  • Checksum: D7B53A764E6C3143
  • Sequence:
    • MDLWNWDEAS PQEVPPGNKL AGLEGAKLGF CFPDLALQGD TPTATAETCW KGPIQLWQFL 
LELLHDGARS SCIRWTGNSR EFQLCDPKEV ARLWGERKRK PGMNYEKLSR GLRYYYRRDI 
VRKSGGRKYT YRFGGRVPSL AYPDCAGGGR GAETQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.