Details for: ETV2

Gene ID: 2116

Symbol: ETV2

Ensembl ID: ENSG00000105672

Description: ETS variant transcription factor 2

Associated with

  • Blastocyst development
    (GO:0001824)
  • Blood vessel morphogenesis
    (GO:0048514)
  • Bmp signaling pathway
    (GO:0030509)
  • Cell differentiation
    (GO:0030154)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Erythrocyte differentiation
    (GO:0030218)
  • Mesoderm formation
    (GO:0001707)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleus
    (GO:0005634)
  • Placenta development
    (GO:0001890)
  • Positive regulation of endothelial cell differentiation
    (GO:0045603)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of mesoderm development
    (GO:2000382)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Wnt signaling pathway
    (GO:0016055)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 35.1666
    Cell Significance Index: -5.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.6840
    Cell Significance Index: -5.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.6183
    Cell Significance Index: -4.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 11.4165
    Cell Significance Index: -5.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.7893
    Cell Significance Index: -5.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.0307
    Cell Significance Index: -5.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.4977
    Cell Significance Index: -5.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1423
    Cell Significance Index: 59.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1369
    Cell Significance Index: 184.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9096
    Cell Significance Index: 89.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8222
    Cell Significance Index: 49.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7476
    Cell Significance Index: 675.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6946
    Cell Significance Index: 75.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5337
    Cell Significance Index: 24.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4120
    Cell Significance Index: 6.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3732
    Cell Significance Index: 25.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3731
    Cell Significance Index: 5.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3559
    Cell Significance Index: 10.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3093
    Cell Significance Index: 6.7000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2538
    Cell Significance Index: 1.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2462
    Cell Significance Index: 28.6900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2044
    Cell Significance Index: 3.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1926
    Cell Significance Index: 4.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1904
    Cell Significance Index: 2.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1577
    Cell Significance Index: 9.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1396
    Cell Significance Index: 3.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1356
    Cell Significance Index: 1.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1356
    Cell Significance Index: 6.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1155
    Cell Significance Index: 21.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0936
    Cell Significance Index: 1.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0719
    Cell Significance Index: 8.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0719
    Cell Significance Index: 31.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0681
    Cell Significance Index: 1.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0581
    Cell Significance Index: 0.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0546
    Cell Significance Index: 7.5000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0545
    Cell Significance Index: 0.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0481
    Cell Significance Index: 8.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0365
    Cell Significance Index: 1.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0363
    Cell Significance Index: 19.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0332
    Cell Significance Index: 4.2600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0242
    Cell Significance Index: 0.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0240
    Cell Significance Index: 0.6000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0213
    Cell Significance Index: 0.2200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0198
    Cell Significance Index: 0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0105
    Cell Significance Index: 0.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0082
    Cell Significance Index: 1.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0030
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0020
    Cell Significance Index: 0.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0015
    Cell Significance Index: 0.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0012
    Cell Significance Index: 0.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0006
    Cell Significance Index: 0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0004
    Cell Significance Index: -0.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0057
    Cell Significance Index: -7.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0072
    Cell Significance Index: -4.6000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0086
    Cell Significance Index: -0.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0089
    Cell Significance Index: -5.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0116
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0116
    Cell Significance Index: -7.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0120
    Cell Significance Index: -3.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0134
    Cell Significance Index: -6.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0134
    Cell Significance Index: -1.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0137
    Cell Significance Index: -1.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0190
    Cell Significance Index: -0.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0196
    Cell Significance Index: -0.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0233
    Cell Significance Index: -1.7400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0240
    Cell Significance Index: -0.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0272
    Cell Significance Index: -5.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0291
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0296
    Cell Significance Index: -6.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0302
    Cell Significance Index: -4.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0317
    Cell Significance Index: -0.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0324
    Cell Significance Index: -2.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0328
    Cell Significance Index: -0.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0343
    Cell Significance Index: -3.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0351
    Cell Significance Index: -0.2800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0395
    Cell Significance Index: -0.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0475
    Cell Significance Index: -1.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0568
    Cell Significance Index: -5.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0585
    Cell Significance Index: -4.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0609
    Cell Significance Index: -3.1700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0617
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0688
    Cell Significance Index: -2.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0716
    Cell Significance Index: -4.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0736
    Cell Significance Index: -4.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0761
    Cell Significance Index: -3.8500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0775
    Cell Significance Index: -1.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0827
    Cell Significance Index: -6.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0840
    Cell Significance Index: -2.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0867
    Cell Significance Index: -5.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0927
    Cell Significance Index: -2.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0956
    Cell Significance Index: -1.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0989
    Cell Significance Index: -5.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0996
    Cell Significance Index: -2.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1252
    Cell Significance Index: -3.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1340
    Cell Significance Index: -4.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ETV2 is a member of the ETS family of transcription factors, which are characterized by their DNA-binding domain and ability to regulate gene expression through specific DNA sequences. ETV2 is a transcription activator, meaning it promotes the expression of target genes by binding to specific DNA sequences and recruiting coactivators. Its ability to regulate gene expression is mediated through interactions with RNA polymerase II, a key enzyme involved in transcription. **Pathways and Functions:** ETV2 has been implicated in a wide range of cellular processes, including: 1. **Cell Differentiation:** ETV2 has been shown to regulate the differentiation of various cell types, including erythrocytes, endothelial cells, and mesodermal cells. 2. **Developmental Processes:** ETV2 is involved in the development of the placenta, blastocyst, and mesoderm formation. 3. **Signaling Pathways:** ETV2 has been shown to interact with various signaling pathways, including BMP, Wnt, and Notch, to regulate cellular responses. 4. **Gene Regulation:** ETV2 regulates the expression of target genes through specific DNA sequences, often involved in transcriptional activation. **Significantly Expressed Cells:** ETV2 has been found to be expressed in a range of cell types, including: 1. Respiratory basal cells 2. Kidney proximal convoluted tubule epithelial cells 3. Cerebral cortex GABAergic interneurons 4. Forebrain radial glial cells 5. Absorptive cells 6. Tuft cells of the colon 7. BEST4+ intestinal epithelial cells 8. Intestinal crypt stem cells 9. Transit amplifying cells **Clinical Significance:** ETV2 has been implicated in various diseases and disorders, including: 1. **Cancer:** ETV2 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma. 2. **Neurological Disorders:** ETV2 has been implicated in the regulation of gene expression in the nervous system, and its dysregulation has been linked to neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Immunological Disorders:** ETV2 has been found to play a role in the regulation of immune responses, and its dysregulation has been linked to autoimmune disorders such as rheumatoid arthritis. In conclusion, ETV2 is a multifaceted transcription factor involved in various cellular processes, including cell differentiation, development, and gene regulation. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of understanding its functions and mechanisms of action.

Genular Protein ID: 470242510

Symbol: ETV2_HUMAN

Name: ETS translocation variant 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 342
  • Mass: 36633
  • Checksum: 9B0103D5D4B1AB8C
  • Sequence:
  • MDLWNWDEAS PQEVPPGNKL AGLEGAKLGF CFPDLALQGD TPTATAETCW KGTSSSLASF 
    PQLDWGSALL HPEVPWGAEP DSQALPWSGD WTDMACTAWD SWSGASQTLG PAPLGPGPIP 
    AAGSEGAAGQ NCVPVAGEAT SWSRAQAAGS NTSWDCSVGP DGDTYWGSGL GGEPRTDCTI 
    SWGGPAGPDC TTSWNPGLHA GGTTSLKRYQ SSALTVCSEP SPQSDRASLA RCPKTNHRGP 
    IQLWQFLLEL LHDGARSSCI RWTGNSREFQ LCDPKEVARL WGERKRKPGM NYEKLSRGLR 
    YYYRRDIVRK SGGRKYTYRF GGRVPSLAYP DCAGGGRGAE TQ

Genular Protein ID: 3501831714

Symbol: K7ERX2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 249
  • Mass: 26651
  • Checksum: 369F0B53A2F60A17
  • Sequence:
  • MACTAWDSWS GASQTLGPAP LGPGPIPAAG SEGAAGQNCV PVAGEATSWS RAQAAGSNTS 
    WDCSVGPDGD TYWGSGLGGE PRTDCTISWG GPAGPDCTTS WNPGLHAGGT TSLKRYQSSA 
    LTVCSEPSPQ SDRASLARCP KTNHRGPIQL WQFLLELLHD GARSSCIRWT GNSREFQLCD 
    PKEVARLWGE RKRKPGMNYE KLSRGLRYYY RRDIVRKSGG RKYTYRFGGR VPSLAYPDCA 
    GGGRGAETQ

Genular Protein ID: 2361749273

Symbol: Q3KNT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 155
  • Mass: 17563
  • Checksum: D7B53A764E6C3143
  • Sequence:
  • MDLWNWDEAS PQEVPPGNKL AGLEGAKLGF CFPDLALQGD TPTATAETCW KGPIQLWQFL 
    LELLHDGARS SCIRWTGNSR EFQLCDPKEV ARLWGERKRK PGMNYEKLSR GLRYYYRRDI 
    VRKSGGRKYT YRFGGRVPSL AYPDCAGGGR GAETQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.