Details for: EVI2A

Gene ID: 2123

Symbol: EVI2A

Ensembl ID: ENSG00000126860

Description: ecotropic viral integration site 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 99.9066
    Cell Significance Index: -15.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.7377
    Cell Significance Index: -16.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.1531
    Cell Significance Index: -9.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.4100
    Cell Significance Index: -17.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.1437
    Cell Significance Index: -16.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.5552
    Cell Significance Index: -15.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2744
    Cell Significance Index: -16.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0268
    Cell Significance Index: -15.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.5304
    Cell Significance Index: 54.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8942
    Cell Significance Index: 35.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.5790
    Cell Significance Index: -4.2300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.3783
    Cell Significance Index: 13.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2468
    Cell Significance Index: 56.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0240
    Cell Significance Index: 194.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6248
    Cell Significance Index: 61.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5394
    Cell Significance Index: 487.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3616
    Cell Significance Index: 10.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3375
    Cell Significance Index: 21.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3352
    Cell Significance Index: 54.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2994
    Cell Significance Index: 32.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2969
    Cell Significance Index: 35.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2782
    Cell Significance Index: 5.9300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2265
    Cell Significance Index: 1.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1793
    Cell Significance Index: 4.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1584
    Cell Significance Index: 9.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1236
    Cell Significance Index: 8.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0517
    Cell Significance Index: 1.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0258
    Cell Significance Index: 7.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0108
    Cell Significance Index: 0.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0014
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0025
    Cell Significance Index: -4.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0051
    Cell Significance Index: -9.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0166
    Cell Significance Index: -3.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0178
    Cell Significance Index: -13.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0184
    Cell Significance Index: -6.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0239
    Cell Significance Index: -17.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0239
    Cell Significance Index: -17.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0258
    Cell Significance Index: -16.4100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0258
    Cell Significance Index: -0.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0281
    Cell Significance Index: -15.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0312
    Cell Significance Index: -17.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0325
    Cell Significance Index: -1.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0351
    Cell Significance Index: -15.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0363
    Cell Significance Index: -16.4600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0383
    Cell Significance Index: -0.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0385
    Cell Significance Index: -2.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0543
    Cell Significance Index: -9.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0574
    Cell Significance Index: -5.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0614
    Cell Significance Index: -12.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0805
    Cell Significance Index: -16.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0954
    Cell Significance Index: -1.9800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1027
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1044
    Cell Significance Index: -17.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1048
    Cell Significance Index: -15.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1079
    Cell Significance Index: -13.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1100
    Cell Significance Index: -15.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1169
    Cell Significance Index: -3.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1261
    Cell Significance Index: -1.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1282
    Cell Significance Index: -16.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1347
    Cell Significance Index: -3.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1356
    Cell Significance Index: -15.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1392
    Cell Significance Index: -17.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1409
    Cell Significance Index: -8.6600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1418
    Cell Significance Index: -1.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1489
    Cell Significance Index: -15.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1533
    Cell Significance Index: -17.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1833
    Cell Significance Index: -14.0700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1904
    Cell Significance Index: -2.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2070
    Cell Significance Index: -9.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2142
    Cell Significance Index: -12.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2208
    Cell Significance Index: -17.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2237
    Cell Significance Index: -16.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2259
    Cell Significance Index: -15.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2281
    Cell Significance Index: -9.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2345
    Cell Significance Index: -14.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2388
    Cell Significance Index: -16.0600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2528
    Cell Significance Index: -2.7100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2561
    Cell Significance Index: -4.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2999
    Cell Significance Index: -15.5800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3005
    Cell Significance Index: -2.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3049
    Cell Significance Index: -15.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3125
    Cell Significance Index: -16.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3219
    Cell Significance Index: -15.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3353
    Cell Significance Index: -14.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3943
    Cell Significance Index: -14.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3966
    Cell Significance Index: -10.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4011
    Cell Significance Index: -11.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4162
    Cell Significance Index: -14.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4330
    Cell Significance Index: -11.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4353
    Cell Significance Index: -8.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4440
    Cell Significance Index: -16.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4499
    Cell Significance Index: -14.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4710
    Cell Significance Index: -12.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4736
    Cell Significance Index: -15.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4919
    Cell Significance Index: -11.9200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.5238
    Cell Significance Index: -2.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5731
    Cell Significance Index: -15.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EVI2A is a non-coding gene that belongs to the ecotropic viral integration site family, which is a group of genes that are commonly found in retroviruses. Despite its non-coding nature, EVI2A has been shown to have functional roles in regulating gene expression and cellular signaling pathways. The gene is highly expressed in specific cell types, including: * Immune cells: T cells, monocytes, and natural killer cells * Retinal cells: Horizontal cells and eurydendroid cells * Thymic cells: DN3 thymocytes and DN1 thymic pro-T cells EVI2A has been shown to interact with various proteins, including transcription factors and signaling molecules, to regulate gene expression and cellular signaling. **Pathways and Functions** EVI2A has been implicated in several cellular pathways, including: 1. **Transmembrane signaling receptor activity**: EVI2A has been shown to interact with receptor tyrosine kinases, such as PDGFRβ, to regulate cell signaling and proliferation. 2. **Protein binding**: EVI2A has been shown to bind to various proteins, including transcription factors, such as NF-κB and AP-1, to regulate gene expression. 3. **Membrane trafficking**: EVI2A has been implicated in the regulation of membrane trafficking and endocytosis in immune cells. EVI2A has been shown to play a role in regulating various cellular processes, including: * Cell proliferation and differentiation * Gene expression and transcription * Immune cell function and regulation * Cancer development and progression **Clinical Significance** EVI2A has been implicated in various diseases, including: 1. **Cancer**: EVI2A has been shown to be overexpressed in several types of cancer, including leukemia, lymphoma, and breast cancer. 2. **Autoimmune disorders**: EVI2A has been implicated in the regulation of immune responses and has been shown to be overexpressed in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Infectious diseases**: EVI2A has been shown to play a role in the regulation of immune responses to viral infections, including HIV and herpes simplex virus. Overall, EVI2A is a complex gene that plays a critical role in regulating various cellular processes, particularly in immune cells. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 2509249758

Symbol: EVI2A_HUMAN

Name: Protein EVI2A

UniProtKB Accession Codes:

P22794 B2R5X2 B4DHX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2117566

Title: Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts.

PubMed ID: 2117566

DOI: 10.1016/0888-7543(90)90199-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 236
  • Mass: 26213
  • Checksum: 5C62B05746BD975D
  • Sequence:
    • MPTDMEHTGH YLHLAFLMTT VFSLSPGTKA NYTRLWANST SSWDSVIQNK TGRNQNENIN 
TNPITPEVDY KGNSTNMPET SHIVALTSKS EQELYIPSVV SNSPSTVQSI ENTSKSHGEI 
FKKDVCAENN NNMAMLICLI IIAVLFLICT FLFLSTVVLA NKVSSLRRSK QVGKRQPRSN 
GDFLASGLWP AESDTWKRTK QLTGPNLVMQ STGVLTATRE RKDEEGTEKL TNKQIG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.