Details for: FARSA
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 20.64rCSI 16.69%PRS 74.31
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CSI 10.35rCSI 9.34%PRS 69.66
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CSI 7.2rCSI 6.24%PRS 76.96
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CSI 6.73rCSI 5.58%PRS 74.7
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CSI 6.65rCSI 10.58%PRS 64.73
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CSI 6.1rCSI 5.64%PRS 88.63
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CSI 5.92rCSI 7.92%PRS 89.25
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CSI 5.82rCSI 9.43%PRS 67.91
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CSI 4.69rCSI 26.91%PRS 79.57
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CSI 4.59rCSI 3.05%PRS 75.12
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CSI 4.54rCSI 16.42%PRS 89.09
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CSI 4.3rCSI 5.47%PRS 77.88
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CSI 4.07rCSI 4.15%PRS 83.31
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CSI 3.76rCSI 6.65%PRS 52.47
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CSI 3.73rCSI 7.44%PRS 86.42
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CSI 3.66rCSI 9.29%PRS 65.79
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CSI 3.51rCSI 3.95%PRS 86.86
-
CSI 3.5rCSI 2.67%PRS 85.07
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CSI 3.34rCSI 5.13%PRS 64.2
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CSI 3.12rCSI 3.07%PRS 74.91
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CSI 3.07rCSI 2.3%PRS 86.16
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CSI 3.03rCSI 6.79%PRS 53.98
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CSI 2.94rCSI 8.68%PRS 74.15
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CSI 2.9rCSI 15.65%PRS 81.04
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CSI 2.88rCSI 6.44%PRS 80.12
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CSI 2.82rCSI 6.23%PRS 71.04
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CSI 2.72rCSI 2.71%PRS 65.88
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CSI 2.7rCSI 5.43%PRS 61.47
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CSI 2.7rCSI 4.02%PRS 72.79
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CSI 2.65rCSI 1.97%PRS 84.51
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CSI 2.53rCSI 2.1%PRS 72.54
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CSI 2.53rCSI 1.95%PRS 74.3
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CSI 2.53rCSI 2%PRS 59.62
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CSI 2.52rCSI 3.64%PRS 79.95
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CSI 2.4rCSI 1.67%PRS 75.35
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CSI 2.38rCSI 1.66%PRS 86.73
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CSI 2.36rCSI 2.19%PRS 72.99
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CSI 2.34rCSI 4.2%PRS 65.36
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CSI 2.26rCSI 2.36%PRS 72.05
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CSI 2.26rCSI 1.78%PRS 78.73
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CSI 2.25rCSI 1.98%PRS 77.75
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CSI 2.21rCSI 5.01%PRS 74.21
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CSI 2.18rCSI 2.1%PRS 64.26
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CSI 2.18rCSI 3.1%PRS 73.76
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CSI 2.15rCSI 3.3%PRS 81.49
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CSI 2.15rCSI 2.93%PRS 77.67
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CSI 2.13rCSI 4.33%PRS 50.35
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CSI 2.12rCSI 2.62%PRS 69.42
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CSI 2.09rCSI 2.51%PRS 70.28
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CSI 2.03rCSI 2.6%PRS 68.76
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CSI 2.02rCSI 1.99%PRS 88.59
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CSI 1.97rCSI 3.02%PRS 76.47
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CSI 1.96rCSI 3.36%PRS 79.95
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CSI 1.96rCSI 1.72%PRS 60.51
-
CSI 1.92rCSI 2.01%PRS 69.31
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CSI 1.91rCSI 7.78%PRS 64.78
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CSI 1.88rCSI 1.97%PRS 69.95
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CSI 1.87rCSI 2.83%PRS 77.46
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CSI 1.84rCSI 2.16%PRS 74.33
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CSI 1.82rCSI 2.82%PRS 71.27
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CSI 1.8rCSI 2.39%PRS 78.49
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CSI 1.79rCSI 1.65%PRS 73.87
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CSI 1.76rCSI 2.19%PRS 51.41
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CSI 1.72rCSI 1.3%PRS 78.22
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CSI 1.7rCSI 1.96%PRS 64.47
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CSI 1.65rCSI 1.89%PRS 86.4
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CSI 1.65rCSI 1.46%PRS 70.15
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CSI 1.63rCSI 2.73%PRS 53.36
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CSI 1.62rCSI 2.24%PRS 70.83
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CSI 1.61rCSI 2.08%PRS 54.73
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CSI 1.57rCSI 1.88%PRS 53.21
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CSI 1.57rCSI 2.32%PRS 76.9
-
CSI 1.41rCSI 1.72%PRS 79.16
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CSI 1.36rCSI 2.17%PRS 63.93
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CSI 1.35rCSI 1.97%PRS 77.18
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CSI 1.34rCSI 2.05%PRS 85.63
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CSI 1.31rCSI 8.57%PRS 92.08
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CSI 1.28rCSI 1.24%PRS 71.79
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CSI 1.26rCSI 8.1%PRS 85.03
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CSI 1.25rCSI 1.7%PRS 76.13
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CSI 1.24rCSI 1.44%PRS 63.44
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CSI 1.22rCSI 1.53%PRS 82.06
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CSI 1.21rCSI 6.24%PRS 89.93
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CSI 1.17rCSI 3.34%PRS 80.51
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CSI 1.15rCSI 2.23%PRS 75.5
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CSI 1.1rCSI 5.87%PRS 93.41
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CSI 1.1rCSI 1.49%PRS 63.49
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CSI 1.07rCSI 1.57%PRS 67.16
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CSI 1.05rCSI 3.14%PRS 85
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CSI 1.02rCSI 1.55%PRS 68.75
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CSI 1.02rCSI 1.8%PRS 42.92
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CSI 1rCSI 1.62%PRS 61.66
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CSI 0.95rCSI 2.72%PRS 81.96
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CSI 0.91rCSI 2.84%PRS 55.18
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CSI 0.83rCSI 1.56%PRS 81.85
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CSI 0.79rCSI 1.88%PRS 79.53
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CSI 0.77rCSI 1.7%PRS 57.84
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CSI 0.76rCSI 2.65%PRS 82.37
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CSI 0.71rCSI 1.73%PRS 51.68
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CSI 0.55rCSI 2.19%PRS 81.87
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CSI 0.3rCSI 4.0%PRS 92.3%
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CSI 0.5rCSI 1.7%PRS 51.5%
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CSI 0.5rCSI 2.0%PRS 53.9%
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CSI 0.6rCSI 2.2%PRS 81.9%
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CSI 0.7rCSI 1.7%PRS 51.7%
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CSI 0.8rCSI 2.7%PRS 82.4%
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CSI 0.8rCSI 1.7%PRS 57.8%
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CSI 0.8rCSI 1.9%PRS 79.5%
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CSI 0.8rCSI 1.6%PRS 81.9%
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CSI 0.9rCSI 2.8%PRS 55.2%
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CSI 1.0rCSI 2.7%PRS 82.0%
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CSI 1.0rCSI 1.6%PRS 61.7%
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CSI 1.0rCSI 1.8%PRS 42.9%
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CSI 1.0rCSI 1.6%PRS 68.8%
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CSI 1.1rCSI 3.1%PRS 85.0%
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CSI 1.1rCSI 1.6%PRS 67.2%
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CSI 1.1rCSI 1.5%PRS 63.5%
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CSI 1.1rCSI 5.9%PRS 93.4%
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CSI 1.2rCSI 2.2%PRS 75.5%
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CSI 1.2rCSI 3.3%PRS 80.5%
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CSI 1.2rCSI 6.2%PRS 89.9%
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CSI 1.2rCSI 1.5%PRS 82.1%
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CSI 1.2rCSI 1.4%PRS 63.4%
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CSI 1.3rCSI 1.7%PRS 76.1%
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CSI 1.3rCSI 8.1%PRS 85.0%
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CSI 1.3rCSI 1.2%PRS 71.8%
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CSI 1.3rCSI 8.6%PRS 92.1%
-
CSI 1.3rCSI 2.1%PRS 85.6%
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CSI 1.4rCSI 2.0%PRS 77.2%
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CSI 1.4rCSI 2.2%PRS 63.9%
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CSI 1.4rCSI 1.7%PRS 79.2%
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CSI 1.6rCSI 2.3%PRS 76.9%
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CSI 1.6rCSI 1.9%PRS 53.2%
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CSI 1.6rCSI 2.1%PRS 54.7%
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CSI 1.6rCSI 2.2%PRS 70.8%
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CSI 1.6rCSI 2.7%PRS 53.4%
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CSI 1.7rCSI 1.5%PRS 70.2%
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CSI 1.7rCSI 1.9%PRS 86.4%
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CSI 1.7rCSI 2.0%PRS 64.5%
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CSI 1.7rCSI 1.3%PRS 78.2%
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CSI 1.8rCSI 2.2%PRS 51.4%
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CSI 1.8rCSI 1.7%PRS 73.9%
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CSI 1.8rCSI 2.4%PRS 78.5%
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CSI 1.8rCSI 2.8%PRS 71.3%
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CSI 1.8rCSI 2.2%PRS 74.3%
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CSI 1.9rCSI 2.8%PRS 77.5%
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CSI 1.9rCSI 2.0%PRS 70.0%
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CSI 1.9rCSI 7.8%PRS 64.8%
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CSI 1.9rCSI 2.0%PRS 69.3%
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CSI 2.0rCSI 1.7%PRS 60.5%
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CSI 2.0rCSI 3.4%PRS 80.0%
-
CSI 2.0rCSI 3.0%PRS 76.5%
-
CSI 2.0rCSI 2.0%PRS 88.6%
-
CSI 2.0rCSI 2.6%PRS 68.8%
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CSI 2.1rCSI 2.5%PRS 70.3%
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CSI 2.1rCSI 2.6%PRS 69.4%
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CSI 2.1rCSI 4.3%PRS 50.4%
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CSI 2.2rCSI 2.9%PRS 77.7%
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CSI 2.2rCSI 3.3%PRS 81.5%
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CSI 2.2rCSI 3.1%PRS 73.8%
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CSI 2.2rCSI 2.1%PRS 64.3%
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CSI 2.2rCSI 5.0%PRS 74.2%
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CSI 2.3rCSI 2.0%PRS 77.8%
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CSI 2.3rCSI 1.8%PRS 78.7%
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CSI 2.3rCSI 2.4%PRS 72.1%
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CSI 2.3rCSI 4.2%PRS 65.4%
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CSI 2.4rCSI 2.2%PRS 73.0%
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CSI 2.4rCSI 1.7%PRS 86.7%
-
CSI 2.4rCSI 1.7%PRS 75.4%
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CSI 2.5rCSI 3.6%PRS 80.0%
-
CSI 2.5rCSI 2.0%PRS 59.6%
-
CSI 2.5rCSI 2.0%PRS 74.3%
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CSI 2.5rCSI 2.1%PRS 72.5%
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CSI 2.7rCSI 2.0%PRS 84.5%
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CSI 2.7rCSI 4.0%PRS 72.8%
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CSI 2.7rCSI 5.4%PRS 61.5%
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CSI 2.7rCSI 2.7%PRS 65.9%
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CSI 2.8rCSI 6.2%PRS 71.0%
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CSI 2.9rCSI 6.4%PRS 80.1%
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CSI 2.9rCSI 15.7%PRS 81.0%
-
CSI 2.9rCSI 8.7%PRS 74.2%
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CSI 3.0rCSI 6.8%PRS 54.0%
-
CSI 3.1rCSI 2.3%PRS 86.2%
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CSI 3.1rCSI 3.1%PRS 74.9%
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CSI 3.3rCSI 5.1%PRS 64.2%
-
CSI 3.5rCSI 2.7%PRS 85.1%
-
CSI 3.5rCSI 4.0%PRS 86.9%
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CSI 3.7rCSI 9.3%PRS 65.8%
-
CSI 3.7rCSI 7.4%PRS 86.4%
-
CSI 3.8rCSI 6.7%PRS 52.5%
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CSI 4.1rCSI 4.2%PRS 83.3%
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CSI 4.3rCSI 5.5%PRS 77.9%
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CSI 4.5rCSI 16.4%PRS 89.1%
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CSI 4.6rCSI 3.1%PRS 75.1%
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CSI 4.7rCSI 26.9%PRS 79.6%
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CSI 5.8rCSI 9.4%PRS 67.9%
-
CSI 5.9rCSI 7.9%PRS 89.3%
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CSI 6.1rCSI 5.6%PRS 88.6%
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CSI 6.7rCSI 10.6%PRS 64.7%
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CSI 6.7rCSI 5.6%PRS 74.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3613397020
Symbol: SYFA_HUMAN
Name: Phenylalanine--tRNA ligase alpha subunit
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9177188
Title: Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent.
PubMed ID: 9177188
PubMed ID: 10049785
Title: Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells.
PubMed ID: 10049785
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 31355908
Title: FARSA mutations mimic phenylalanyl-tRNA synthetase deficiency caused by FARSB defects.
PubMed ID: 31355908
DOI: 10.1111/cge.13614
PubMed ID: 20223217
Title: Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns.
PubMed ID: 20223217
Sequence Information:
- Length: 508
- Mass: 57564
- Checksum: 99BC12E1F3C5FCFD
- Sequence:
MADGQVAELL LRRLEASDGG LDSAELAAEL GMEHQAVVGA VKSLQALGEV IEAELRSTKH WELTAEGEEI AREGSHEARV FRSIPPEGLA QSELMRLPSG KVGFSKAMSN KWIRVDKSAA DGPRVFRVVD SMEDEVQRRL QLVRGGQAEK LGEKERSELR KRKLLAEVTL KTYWVSKGSA FSTSISKQET ELSPEMISSG SWRDRPFKPY NFLAHGVLPD SGHLHPLLKV RSQFRQIFLE MGFTEMPTDN FIESSFWNFD ALFQPQQHPA RDQHDTFFLR DPAEALQLPM DYVQRVKRTH SQGGYGSQGY KYNWKLDEAR KNLLRTHTTS ASARALYRLA QKKPFTPVKY FSIDRVFRNE TLDATHLAEF HQIEGVVADH GLTLGHLMGV LREFFTKLGI TQLRFKPAYN PYTEPSMEVF SYHQGLKKWV EVGNSGVFRP EMLLPMGLPE NVSVIAWGLS LERPTMIKYG INNIRELVGH KVNLQMVYDS PLCRLDAEPR PPPTQEAA