Details for: FARSA

Gene ID: 2193

Symbol: FARSA

Ensembl ID: ENSG00000179115

Description: phenylalanyl-tRNA synthetase subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.67
    Marker Score: 6819
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.56
    Marker Score: 6149
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.56
    Marker Score: 1626
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.52
    Marker Score: 1030
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.37
    Marker Score: 1970
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.36
    Marker Score: 1699.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.34
    Marker Score: 386
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.31
    Marker Score: 986
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.27
    Marker Score: 2643
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.26
    Marker Score: 405
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.26
    Marker Score: 1264
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.23
    Marker Score: 2509
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.22
    Marker Score: 608
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.22
    Marker Score: 1291
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.21
    Marker Score: 1615
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.21
    Marker Score: 3299
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.2
    Marker Score: 579
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.19
    Marker Score: 1260
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.14
    Marker Score: 761
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.13
    Marker Score: 622
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.13
    Marker Score: 1213
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.12
    Marker Score: 1581
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.11
    Marker Score: 1883
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.1
    Marker Score: 2614
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.09
    Marker Score: 1227
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.07
    Marker Score: 527
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.06
    Marker Score: 10661
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.05
    Marker Score: 2857
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.04
    Marker Score: 350
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.04
    Marker Score: 363
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.02
    Marker Score: 8782
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1
    Marker Score: 4328
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1
    Marker Score: 11648
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1
    Marker Score: 247
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71669
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47893
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Marker Score: 546
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.99
    Marker Score: 714
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30385
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.97
    Marker Score: 809
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.97
    Marker Score: 3579
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.96
    Marker Score: 6136
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.95
    Marker Score: 9791
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.94
    Marker Score: 593
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14707
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2388
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.94
    Marker Score: 1378
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.93
    Marker Score: 993
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.93
    Marker Score: 872
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.93
    Marker Score: 217
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.92
    Marker Score: 670
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.92
    Marker Score: 5952
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.91
    Marker Score: 1498
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.91
    Marker Score: 608
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5180
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.9
    Marker Score: 570.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2685
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.89
    Marker Score: 1076
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.89
    Marker Score: 837
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.88
    Marker Score: 1566
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.87
    Marker Score: 815
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.86
    Marker Score: 1957
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.86
    Marker Score: 6375
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.86
    Marker Score: 419
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.85
    Marker Score: 507
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.84
    Marker Score: 441
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.83
    Marker Score: 4938
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.83
    Marker Score: 1952.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.82
    Marker Score: 292
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.82
    Marker Score: 387
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.81
    Marker Score: 2239
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.8
    Marker Score: 4876
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 319.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.8
    Marker Score: 1387
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.79
    Marker Score: 423
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.79
    Marker Score: 3883
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.79
    Marker Score: 188
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.79
    Marker Score: 450
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.79
    Marker Score: 703
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.77
    Marker Score: 205
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.77
    Marker Score: 480.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.77
    Marker Score: 510
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.76
    Marker Score: 1180
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.76
    Marker Score: 26380
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.76
    Marker Score: 519
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.75
    Marker Score: 2370
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.75
    Marker Score: 7622
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.75
    Marker Score: 213
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.75
    Marker Score: 1187
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.75
    Marker Score: 364
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.75
    Marker Score: 1236
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.74
    Marker Score: 303
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.74
    Marker Score: 778

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Other Information

## Summary FARSA is a protein that is involved in the biosynthesis of phenylalanine, an essential amino acid for human health. It is encoded by the ENSG00000179115 gene. ## Key characteristics * FARSA is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including pro-T cells, placental villous trophoblast, erythroid progenitor cells, and primitive germ cells. * FARSA is a key regulator of phenylalanine synthesis and is involved in maintaining normal blood phenylalanine levels. ## Pathways and functions FARSA is involved in multiple pathways related to phenylalanine synthesis and metabolism. These pathways include: * Atp binding * Cytoplasm, cytosol, and cytosolic tRNA aminoacylation * Magnesium ion binding * Membrane * Metabolism of proteins * Phenylalanine-trna ligase activity * Phenylalanine-trna ligase complex * Protein binding * Protein heterotetramerization * Rna binding * Translation * Trna aminoacylation * Trna binding ## Clinical significance FARSA gene mutations have been linked to several human diseases, including: * Phenylketonuria, a genetic disorder caused by mutations in the FH gene, which encodes for phenylalanine hydroxylase, the enzyme responsible for the final step in phenylalanine biosynthesis. * Pheomelanoderma, a skin disorder characterized by the accumulation of phenylalanine in the skin, which can be caused by mutations in the FARSA gene. * Congenital heart defects, a group of birth defects that can be caused by defects in genes involved in phenylalanine metabolism. FARSA is a promising target for the treatment of phenylketonuria and other disorders caused by mutations in the FARSA gene.

Genular Protein ID: 3613397020

Symbol: SYFA_HUMAN

Name: Phenylalanine--tRNA ligase alpha subunit

UniProtKB Accession Codes:

Q9Y285 B4E363 Q9NSD8 Q9Y4W8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9177188

Title: Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent.

PubMed ID: 9177188

DOI: 10.1073/pnas.94.12.6164

PubMed ID: 10049785

Title: Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells.

PubMed ID: 10049785

DOI: 10.1006/bbrc.1999.0141

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31355908

Title: FARSA mutations mimic phenylalanyl-tRNA synthetase deficiency caused by FARSB defects.

PubMed ID: 31355908

DOI: 10.1111/cge.13614

PubMed ID: 20223217

Title: Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns.

PubMed ID: 20223217

DOI: 10.1016/j.str.2010.01.002

Sequence Information:

  • Length: 508
  • Mass: 57564
  • Checksum: 99BC12E1F3C5FCFD
  • Sequence:
    • MADGQVAELL LRRLEASDGG LDSAELAAEL GMEHQAVVGA VKSLQALGEV IEAELRSTKH 
WELTAEGEEI AREGSHEARV FRSIPPEGLA QSELMRLPSG KVGFSKAMSN KWIRVDKSAA 
DGPRVFRVVD SMEDEVQRRL QLVRGGQAEK LGEKERSELR KRKLLAEVTL KTYWVSKGSA 
FSTSISKQET ELSPEMISSG SWRDRPFKPY NFLAHGVLPD SGHLHPLLKV RSQFRQIFLE 
MGFTEMPTDN FIESSFWNFD ALFQPQQHPA RDQHDTFFLR DPAEALQLPM DYVQRVKRTH 
SQGGYGSQGY KYNWKLDEAR KNLLRTHTTS ASARALYRLA QKKPFTPVKY FSIDRVFRNE 
TLDATHLAEF HQIEGVVADH GLTLGHLMGV LREFFTKLGI TQLRFKPAYN PYTEPSMEVF 
SYHQGLKKWV EVGNSGVFRP EMLLPMGLPE NVSVIAWGLS LERPTMIKYG INNIRELVGH 
KVNLQMVYDS PLCRLDAEPR PPPTQEAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.