Details for: FDPS

Gene ID: 2224

Symbol: FDPS

Ensembl ID: ENSG00000160752

Description: farnesyl diphosphate synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 323.3786
    Cell Significance Index: -50.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 212.0103
    Cell Significance Index: -53.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 147.8707
    Cell Significance Index: -60.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 138.1421
    Cell Significance Index: -65.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 131.8623
    Cell Significance Index: -53.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 124.7314
    Cell Significance Index: -64.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 97.3887
    Cell Significance Index: -65.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.4131
    Cell Significance Index: -53.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.3644
    Cell Significance Index: -63.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.2727
    Cell Significance Index: -48.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.7231
    Cell Significance Index: -65.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1187
    Cell Significance Index: -30.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.1106
    Cell Significance Index: -43.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.3203
    Cell Significance Index: 142.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.1315
    Cell Significance Index: 2827.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.8610
    Cell Significance Index: 823.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6924
    Cell Significance Index: 534.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6017
    Cell Significance Index: 136.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3928
    Cell Significance Index: 143.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2510
    Cell Significance Index: 104.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1848
    Cell Significance Index: 1193.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8864
    Cell Significance Index: 55.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8477
    Cell Significance Index: 17.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5295
    Cell Significance Index: 71.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3160
    Cell Significance Index: 237.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2636
    Cell Significance Index: 43.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2474
    Cell Significance Index: 153.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0622
    Cell Significance Index: 68.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0427
    Cell Significance Index: 24.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0138
    Cell Significance Index: 130.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9880
    Cell Significance Index: 26.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9720
    Cell Significance Index: 105.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9300
    Cell Significance Index: 109.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9230
    Cell Significance Index: 24.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8840
    Cell Significance Index: 177.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8726
    Cell Significance Index: 385.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8381
    Cell Significance Index: 7.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8142
    Cell Significance Index: 57.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7983
    Cell Significance Index: 22.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7911
    Cell Significance Index: 16.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7804
    Cell Significance Index: 107.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6844
    Cell Significance Index: 87.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6466
    Cell Significance Index: 33.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6047
    Cell Significance Index: 59.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5051
    Cell Significance Index: 6.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4414
    Cell Significance Index: 32.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3487
    Cell Significance Index: 125.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3431
    Cell Significance Index: 58.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3031
    Cell Significance Index: 229.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2944
    Cell Significance Index: 3.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2778
    Cell Significance Index: 14.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2666
    Cell Significance Index: 14.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2405
    Cell Significance Index: 45.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2260
    Cell Significance Index: 7.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1505
    Cell Significance Index: 24.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1172
    Cell Significance Index: 3.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0949
    Cell Significance Index: 4.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0621
    Cell Significance Index: 1.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0526
    Cell Significance Index: 97.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0494
    Cell Significance Index: 76.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0349
    Cell Significance Index: 65.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0158
    Cell Significance Index: 11.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0061
    Cell Significance Index: -8.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -6.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0157
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0191
    Cell Significance Index: -11.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0526
    Cell Significance Index: -0.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0546
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0734
    Cell Significance Index: -41.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0737
    Cell Significance Index: -33.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0821
    Cell Significance Index: -8.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1209
    Cell Significance Index: -17.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1249
    Cell Significance Index: -7.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1323
    Cell Significance Index: -15.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1547
    Cell Significance Index: -32.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1848
    Cell Significance Index: -11.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2311
    Cell Significance Index: -6.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2752
    Cell Significance Index: -3.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3139
    Cell Significance Index: -8.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3278
    Cell Significance Index: -38.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3905
    Cell Significance Index: -29.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4122
    Cell Significance Index: -8.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4304
    Cell Significance Index: -4.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4633
    Cell Significance Index: -7.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4781
    Cell Significance Index: -54.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4813
    Cell Significance Index: -12.8800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4985
    Cell Significance Index: -3.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5299
    Cell Significance Index: -41.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5428
    Cell Significance Index: -11.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5622
    Cell Significance Index: -37.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5977
    Cell Significance Index: -62.2400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.6369
    Cell Significance Index: -7.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6539
    Cell Significance Index: -11.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8238
    Cell Significance Index: -11.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8536
    Cell Significance Index: -24.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8649
    Cell Significance Index: -12.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9755
    Cell Significance Index: -24.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0545
    Cell Significance Index: -64.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0860
    Cell Significance Index: -48.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1515
    Cell Significance Index: -29.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FDPS is a cytosolic enzyme that exhibits dimethylallyltranstransferase activity, enabling it to transfer dimethylallyl groups to acceptor molecules. This activity is essential for the formation of FPP, which is then utilized in various downstream reactions. FDPS is highly expressed in cells involved in lipid metabolism, such as hepatocytes and adrenal cortical cells. The enzyme's substrate specificity and kinetic parameters have been extensively characterized, revealing a high affinity for isoprenyl pyrophosphate (IPP) and a low affinity for dimethylallyl pyrophosphate (DMAPP). **Pathways and Functions:** FDPS plays a central role in the mevalonate pathway, which is responsible for cholesterol biosynthesis. The enzyme's product, FPP, is then converted into cholesterol by the enzyme HMG-CoA reductase. Beyond cholesterol synthesis, FDPS is involved in the production of other isoprenoids, including geranylgeranyl diphosphate and farnesyl pyrophosphate, which are essential for various cellular processes, such as: 1. Cell signaling: FPP and geranylgeranyl diphosphate are involved in the activation of G-proteins and other signaling molecules. 2. Lipid raft formation: FPP is required for the formation of lipid rafts, which are essential for cell-to-cell communication and signaling. 3. Steroidogenesis: FDPS is involved in the synthesis of cholesterol and other steroids, which are critical for various physiological processes, including hormone production and cell growth. **Clinical Significance:** Dysregulation of FDPS has been implicated in various diseases, including: 1. Hyperlipidemia: Mutations in the FDPS gene have been associated with hyperlipidemia, a condition characterized by elevated levels of cholesterol and triglycerides. 2. Atherosclerosis: The mevalonate pathway, in which FDPS is involved, is also implicated in the development of atherosclerosis, a condition characterized by the accumulation of lipids in the arterial walls. 3. Neurological disorders: Dysregulation of FDPS has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, which are characterized by impaired lipid metabolism and isoprenoid biosynthesis. In conclusion, FDPS is a critical enzyme in the biosynthesis of cholesterol and other isoprenoids, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the molecular mechanisms underlying FDPS's role in lipid metabolism and disease, and to develop novel therapeutic strategies targeting this enzyme.

Genular Protein ID: 2680506918

Symbol: FPPS_HUMAN

Name: (2E,6E)-farnesyl diphosphate synthase

UniProtKB Accession Codes:

P14324 D3DV91 E9PCI9 Q96G29

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 DrugCentral 1 EC 2 EMBL 10 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 88 PDBsum 88 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 7 Rhea 2 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1968462

Title: Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester.

PubMed ID: 1968462

DOI: 10.1016/s0021-9258(19)39606-1

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2690933

Title: Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells.

PubMed ID: 2690933

DOI: 10.1021/bi00446a025

PubMed ID: 11773414

Title: Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase.

PubMed ID: 11773414

DOI: 10.1128/jvi.76.3.1400-1414.2002

PubMed ID: 18005724

Title: The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts.

PubMed ID: 18005724

DOI: 10.1016/j.chom.2007.06.009

PubMed ID: 15827605

Title: Farnesyl diphosphate synthase; regulation of product specificity.

PubMed ID: 15827605

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26202976

Title: Genomic variations of the mevalonate pathway in porokeratosis.

PubMed ID: 26202976

DOI: 10.7554/elife.06322

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 16892359

Title: Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.

PubMed ID: 16892359

DOI: 10.1002/cmdc.200500059

PubMed ID: 16684881

Title: The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

PubMed ID: 16684881

DOI: 10.1073/pnas.0601643103

PubMed ID: 19309137

Title: Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.

PubMed ID: 19309137

DOI: 10.1021/ja808285e

Sequence Information:

  • Length: 419
  • Mass: 48275
  • Checksum: 52934B80A808FB67
  • Sequence:
    • MPLSRWLRSV GVFLLPAPYW APRERWLGSL RRPSLVHGYP VLAWHSARCW CQAWTEEPRA 
LCSSLRMNGD QNSDVYAQEK QDFVQHFSQI VRVLTEDEMG HPEIGDAIAR LKEVLEYNAI 
GGKYNRGLTV VVAFRELVEP RKQDADSLQR AWTVGWCVEL LQAFFLVADD IMDSSLTRRG 
QICWYQKPGV GLDAINDANL LEACIYRLLK LYCREQPYYL NLIELFLQSS YQTEIGQTLD 
LLTAPQGNVD LVRFTEKRYK SIVKYKTAFY SFYLPIAAAM YMAGIDGEKE HANAKKILLE 
MGEFFQIQDD YLDLFGDPSV TGKIGTDIQD NKCSWLVVQC LQRATPEQYQ ILKENYGQKE 
AEKVARVKAL YEELDLPAVF LQYEEDSYSH IMALIEQYAA PLPPAVFLGL ARKIYKRRK

Genular Protein ID: 1836028802

Symbol: A0A087X090_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X090

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 2 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 248
  • Mass: 28594
  • Checksum: 2E265366B9859027
  • Sequence:
    • MDSSLTRRGQ ICWYQKPGVG LDAINDANLL EACIYRLLKL YCREQPYYLN LIELFLQSSY 
QTEIGQTLDL LTAPQGNVDL VRFTEKRYKS IVKYKTAFYS FYLPIAAAMY MAGIDGEKEH 
ANAKKILLEM GEFFQIQDDY LDLFGDPSVT GKIGTDIQDN KCSWLVVQCL QRATPEQYQI 
LKENYGQKEA EKVARVKALY EELDLPAVFL QYEEDSYSHI MALIEQYAAP LPPAVFLGLA 
RKIYKRRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.