Details for: FDPS

Gene ID: 2224

Symbol: FDPS

Ensembl ID: ENSG00000160752

Description: farnesyl diphosphate synthase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.62
    Marker Score: 64267.5
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.95
    Marker Score: 9655
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.63
    Marker Score: 2742.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.62
    Marker Score: 6651
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.49
    Marker Score: 4004
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.37
    Marker Score: 81968
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.3
    Marker Score: 4682
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.24
    Marker Score: 2192
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.23
    Marker Score: 14548
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.17
    Marker Score: 18742
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.14
    Marker Score: 2018
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.13
    Marker Score: 8718.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.11
    Marker Score: 3852
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.03
    Marker Score: 2371
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.99
    Marker Score: 3162
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.96
    Marker Score: 2369
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.96
    Marker Score: 723
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.96
    Marker Score: 7698
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.96
    Marker Score: 15290
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.95
    Marker Score: 12495.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.95
    Marker Score: 4065
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.94
    Marker Score: 1667
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.93
    Marker Score: 950
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.91
    Marker Score: 2058.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.9
    Marker Score: 5980
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.9
    Marker Score: 1695.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.87
    Marker Score: 2013
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.87
    Marker Score: 1762
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.85
    Marker Score: 2231
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.84
    Marker Score: 532
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.83
    Marker Score: 8803
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.83
    Marker Score: 4175.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.81
    Marker Score: 1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.79
    Marker Score: 3035
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.78
    Marker Score: 1879
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.77
    Marker Score: 2286
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.75
    Marker Score: 1765
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.75
    Marker Score: 4746
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.73
    Marker Score: 2298
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.71
    Marker Score: 3414
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.69
    Marker Score: 1131
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.68
    Marker Score: 1399
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.67
    Marker Score: 1789
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.67
    Marker Score: 2458
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.65
    Marker Score: 1201
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.65
    Marker Score: 1476
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.63
    Marker Score: 2891
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.63
    Marker Score: 1104.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.62
    Marker Score: 1014
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.62
    Marker Score: 3845
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.62
    Marker Score: 1816
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.62
    Marker Score: 785
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.6
    Marker Score: 569
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.59
    Marker Score: 16157
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.59
    Marker Score: 5898
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.59
    Marker Score: 666
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.57
    Marker Score: 365
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.57
    Marker Score: 374.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.53
    Marker Score: 1024
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.53
    Marker Score: 513.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.53
    Marker Score: 713
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.52
    Marker Score: 24466.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.52
    Marker Score: 620
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.5
    Marker Score: 2173
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.5
    Marker Score: 1024
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.5
    Marker Score: 711
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.49
    Marker Score: 350
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.49
    Marker Score: 3503
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.49
    Marker Score: 866
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.48
    Marker Score: 1340
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.48
    Marker Score: 8798
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.48
    Marker Score: 643
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.48
    Marker Score: 17191
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.48
    Marker Score: 618
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.47
    Marker Score: 809
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.47
    Marker Score: 4358
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.46
    Marker Score: 9323
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.45
    Marker Score: 913
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.45
    Marker Score: 507
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.45
    Marker Score: 1089.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.45
    Marker Score: 746
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.45
    Marker Score: 12586
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.42
    Marker Score: 6126
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.42
    Marker Score: 1659
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.41
    Marker Score: 1993
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.4
    Marker Score: 5434.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.4
    Marker Score: 1490
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.4
    Marker Score: 10421.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.4
    Marker Score: 2318
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.4
    Marker Score: 7341
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.4
    Marker Score: 1450
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.39
    Marker Score: 2137
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.38
    Marker Score: 862
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.38
    Marker Score: 872
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.38
    Marker Score: 672
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.38
    Marker Score: 549
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.37
    Marker Score: 3660.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.36
    Marker Score: 641.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.35
    Marker Score: 3686
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.35
    Marker Score: 466

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Other Information

**Key characteristics** * The FDPS gene is located on chromosome 15q21.1. * It is a large gene with a molecular weight of approximately 10.5 kb. * The protein is encoded by a single open reading frame. * It is a transmembrane protein with a single transmembrane domain. **Pathways and functions** The FDPS gene is involved in multiple pathways, including: * Activation of gene expression by srebp (SRF-related protein) * Cholesterol biosynthesis * Regulation of cholesterol biosynthesis by srebp * Metabolism of lipids * Metabolism of steroids **Clinical significance** Mutations in the FDPS gene have been linked to several human diseases, including hyperalphalipoproteinemia, which is characterized by high levels of LDL cholesterol in the blood. This is a major risk factor for atherosclerosis and heart disease. **Other relevant information** * The FDPS gene is also known as FPPS. * It is a key regulatory gene in cholesterol metabolism. * It is involved in the regulation of blood cholesterol levels and the development of atherosclerosis.

Genular Protein ID: 2680506918

Symbol: FPPS_HUMAN

Name: (2E,6E)-farnesyl diphosphate synthase

UniProtKB Accession Codes:

P14324 D3DV91 E9PCI9 Q96G29

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 DrugCentral 1 EC 2 EMBL 10 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 93 PDBsum 88 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 7 Rhea 2 SABIO-RK 1 SFLD 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1968462

Title: Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester.

PubMed ID: 1968462

DOI: 10.1016/s0021-9258(19)39606-1

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2690933

Title: Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells.

PubMed ID: 2690933

DOI: 10.1021/bi00446a025

PubMed ID: 11773414

Title: Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase.

PubMed ID: 11773414

DOI: 10.1128/jvi.76.3.1400-1414.2002

PubMed ID: 18005724

Title: The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts.

PubMed ID: 18005724

DOI: 10.1016/j.chom.2007.06.009

PubMed ID: 15827605

Title: Farnesyl diphosphate synthase; regulation of product specificity.

PubMed ID: 15827605

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26202976

Title: Genomic variations of the mevalonate pathway in porokeratosis.

PubMed ID: 26202976

DOI: 10.7554/elife.06322

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 16892359

Title: Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.

PubMed ID: 16892359

DOI: 10.1002/cmdc.200500059

PubMed ID: 16684881

Title: The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

PubMed ID: 16684881

DOI: 10.1073/pnas.0601643103

PubMed ID: 19309137

Title: Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.

PubMed ID: 19309137

DOI: 10.1021/ja808285e

Sequence Information:

  • Length: 419
  • Mass: 48275
  • Checksum: 52934B80A808FB67
  • Sequence:
    • MPLSRWLRSV GVFLLPAPYW APRERWLGSL RRPSLVHGYP VLAWHSARCW CQAWTEEPRA 
LCSSLRMNGD QNSDVYAQEK QDFVQHFSQI VRVLTEDEMG HPEIGDAIAR LKEVLEYNAI 
GGKYNRGLTV VVAFRELVEP RKQDADSLQR AWTVGWCVEL LQAFFLVADD IMDSSLTRRG 
QICWYQKPGV GLDAINDANL LEACIYRLLK LYCREQPYYL NLIELFLQSS YQTEIGQTLD 
LLTAPQGNVD LVRFTEKRYK SIVKYKTAFY SFYLPIAAAM YMAGIDGEKE HANAKKILLE 
MGEFFQIQDD YLDLFGDPSV TGKIGTDIQD NKCSWLVVQC LQRATPEQYQ ILKENYGQKE 
AEKVARVKAL YEELDLPAVF LQYEEDSYSH IMALIEQYAA PLPPAVFLGL ARKIYKRRK

Genular Protein ID: 1836028802

Symbol: A0A087X090_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X090

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 EC 2 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 1 Rhea 2 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 248
  • Mass: 28594
  • Checksum: 2E265366B9859027
  • Sequence:
    • MDSSLTRRGQ ICWYQKPGVG LDAINDANLL EACIYRLLKL YCREQPYYLN LIELFLQSSY 
QTEIGQTLDL LTAPQGNVDL VRFTEKRYKS IVKYKTAFYS FYLPIAAAMY MAGIDGEKEH 
ANAKKILLEM GEFFQIQDDY LDLFGDPSVT GKIGTDIQDN KCSWLVVQCL QRATPEQYQI 
LKENYGQKEA EKVARVKALY EELDLPAVFL QYEEDSYSHI MALIEQYAAP LPPAVFLGLA 
RKIYKRRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.