Details for: FEN1

Gene ID: 2237

Symbol: FEN1

Ensembl ID: ENSG00000168496

Description: flap structure-specific endonuclease 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.5831
    Cell Significance Index: -10.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 34.4947
    Cell Significance Index: -14.2100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.1841
    Cell Significance Index: -11.4500
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 18.5329
    Cell Significance Index: 8.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.0451
    Cell Significance Index: -11.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.5543
    Cell Significance Index: -11.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6960
    Cell Significance Index: -12.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4870
    Cell Significance Index: -13.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.4430
    Cell Significance Index: 38.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2623
    Cell Significance Index: 79.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1802
    Cell Significance Index: 70.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1522
    Cell Significance Index: 40.0400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1178
    Cell Significance Index: 8.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0521
    Cell Significance Index: 124.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9304
    Cell Significance Index: 101.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.9026
    Cell Significance Index: 15.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8181
    Cell Significance Index: 133.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4769
    Cell Significance Index: 25.0400
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 0.4651
    Cell Significance Index: 0.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4159
    Cell Significance Index: 13.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3370
    Cell Significance Index: 8.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3006
    Cell Significance Index: 164.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2516
    Cell Significance Index: 111.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2277
    Cell Significance Index: 2.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2020
    Cell Significance Index: 182.3900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1733
    Cell Significance Index: 2.7800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1492
    Cell Significance Index: 2.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1349
    Cell Significance Index: 7.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1340
    Cell Significance Index: 15.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1308
    Cell Significance Index: 9.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1228
    Cell Significance Index: 9.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1217
    Cell Significance Index: 7.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1164
    Cell Significance Index: 6.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1039
    Cell Significance Index: 64.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1034
    Cell Significance Index: 13.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0987
    Cell Significance Index: 18.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0859
    Cell Significance Index: 10.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0817
    Cell Significance Index: 8.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0671
    Cell Significance Index: 9.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0667
    Cell Significance Index: 13.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0533
    Cell Significance Index: 3.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0472
    Cell Significance Index: 2.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0357
    Cell Significance Index: 0.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0354
    Cell Significance Index: 1.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0274
    Cell Significance Index: 0.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0267
    Cell Significance Index: 4.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0240
    Cell Significance Index: 0.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0165
    Cell Significance Index: 0.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0121
    Cell Significance Index: 4.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0100
    Cell Significance Index: 0.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0083
    Cell Significance Index: 1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0059
    Cell Significance Index: 4.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0048
    Cell Significance Index: -2.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0052
    Cell Significance Index: -3.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0055
    Cell Significance Index: -3.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0073
    Cell Significance Index: -13.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0098
    Cell Significance Index: -1.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0108
    Cell Significance Index: -7.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0142
    Cell Significance Index: -19.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0152
    Cell Significance Index: -0.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0196
    Cell Significance Index: -12.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0222
    Cell Significance Index: -0.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0230
    Cell Significance Index: -0.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0269
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0331
    Cell Significance Index: -6.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0336
    Cell Significance Index: -9.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0432
    Cell Significance Index: -0.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0507
    Cell Significance Index: -5.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0645
    Cell Significance Index: -12.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0696
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0900
    Cell Significance Index: -10.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0968
    Cell Significance Index: -14.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1228
    Cell Significance Index: -5.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1245
    Cell Significance Index: -3.3900
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1529
    Cell Significance Index: -1.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1547
    Cell Significance Index: -7.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1548
    Cell Significance Index: -9.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1590
    Cell Significance Index: -12.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1646
    Cell Significance Index: -3.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1796
    Cell Significance Index: -2.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1814
    Cell Significance Index: -9.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1857
    Cell Significance Index: -14.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2085
    Cell Significance Index: -14.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2229
    Cell Significance Index: -13.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2330
    Cell Significance Index: -6.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2331
    Cell Significance Index: -3.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2340
    Cell Significance Index: -3.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2438
    Cell Significance Index: -7.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2567
    Cell Significance Index: -3.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3165
    Cell Significance Index: -14.0000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3472
    Cell Significance Index: -3.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3503
    Cell Significance Index: -12.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3537
    Cell Significance Index: -11.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3558
    Cell Significance Index: -13.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3580
    Cell Significance Index: -9.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3694
    Cell Significance Index: -13.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3723
    Cell Significance Index: -5.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3842
    Cell Significance Index: -12.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3891
    Cell Significance Index: -5.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FEN1 is a metalloprotease enzyme that exhibits 5'-3' exonuclease and 5'-flap endonuclease activities. Its catalytic mechanism involves the binding of magnesium ions, which are essential for the enzyme's activity. FEN1 is a member of the flap endonuclease family and shares structural homology with other flap endonucleases, such as FLAP (flap endonuclease-like protein). The enzyme's substrate specificity is characterized by its ability to cleave 5' flaps, which are commonly generated during DNA replication and recombination. **Pathways and Functions:** FEN1 is involved in several DNA repair pathways, including: 1. **Base-excision repair (BER):** FEN1 helps to resolve 5' flaps generated during the processing of abasic sites, which are lesions resulting from the removal of bases from DNA. 2. **Double-strand break repair (DSB):** FEN1 contributes to the resolution of 5' flaps generated during the processing of DSBs, which are breaks in both strands of DNA. 3. **Telomere maintenance:** FEN1 plays a role in the extension of telomeres, which are repetitive DNA sequences that cap the ends of chromosomes. 4. **S-phase DNA synthesis:** FEN1 is involved in the resolution of 5' flaps generated during the synthesis of DNA on the lagging strand. **Clinical Significance:** FEN1 dysregulation has been implicated in several diseases, including: 1. **Cancer:** Mutations in the FEN1 gene have been associated with an increased risk of cancer, particularly in hematopoietic malignancies. 2. **Immunodeficiency disorders:** FEN1 deficiency has been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 3. **Neurological disorders:** FEN1 dysregulation has been implicated in neurological disorders, such as ataxia-telangiectasia. In conclusion, FEN1 is a critical enzyme involved in DNA repair and replication. Its dysregulation has been implicated in several diseases, highlighting the importance of this enzyme in maintaining genome stability. Further research on FEN1 and its role in disease will provide valuable insights into the development of novel therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 1186168352

Symbol: FEN1_HUMAN

Name: DNase IV

UniProtKB Accession Codes:

P39748

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 5 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 6 ELM 1 EMBL 5 EMDB 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8007985

Title: Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage.

PubMed ID: 8007985

DOI: 10.1128/mcb.14.7.4878-4888.1994

PubMed ID: 7774922

Title: Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human.

PubMed ID: 7774922

DOI: 10.1016/0888-7543(95)80129-a

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7961795

Title: Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I.

PubMed ID: 7961795

DOI: 10.1016/s0021-9258(19)61935-6

PubMed ID: 8621570

Title: Essential amino acids for substrate binding and catalysis of human flap endonuclease 1.

PubMed ID: 8621570

DOI: 10.1074/jbc.271.16.9173

PubMed ID: 9305916

Title: The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21.

PubMed ID: 9305916

DOI: 10.1074/jbc.272.39.24522

PubMed ID: 10744741

Title: Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1.

PubMed ID: 10744741

DOI: 10.1074/jbc.275.14.10498

PubMed ID: 11430825

Title: Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.

PubMed ID: 11430825

DOI: 10.1016/s1097-2765(01)00272-6

PubMed ID: 11986308

Title: Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination.

PubMed ID: 11986308

DOI: 10.1074/jbc.m111941200

PubMed ID: 18499658

Title: Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1.

PubMed ID: 18499658

DOI: 10.1074/jbc.m802696200

PubMed ID: 18443037

Title: Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.

PubMed ID: 18443037

DOI: 10.1128/mcb.00200-08

PubMed ID: 19336415

Title: Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

PubMed ID: 19336415

DOI: 10.1093/nar/gkp201

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20729856

Title: Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding.

PubMed ID: 20729856

DOI: 10.1038/nchembio.422

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23675412

Title: A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-loop binding properties.

PubMed ID: 23675412

DOI: 10.1371/journal.pone.0062340

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26760506

Title: R152C DNA Pol beta mutation impairs base excision repair and induces cellular transformation.

PubMed ID: 26760506

DOI: 10.18632/oncotarget.6849

PubMed ID: 26751069

Title: Wuho is a new member in maintaining genome stability through its interaction with flap endonuclease 1.

PubMed ID: 26751069

DOI: 10.1371/journal.pbio.1002349

PubMed ID: 15576034

Title: Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.

PubMed ID: 15576034

DOI: 10.1016/j.str.2004.09.018

PubMed ID: 15616578

Title: Structural basis for recruitment of human flap endonuclease 1 to PCNA.

PubMed ID: 15616578

DOI: 10.1038/sj.emboj.7600519

Sequence Information:

  • Length: 380
  • Mass: 42593
  • Checksum: 5154F2F6E57592C5
  • Sequence:
    • MGIQGLAKLI ADVAPSAIRE NDIKSYFGRK VAIDASMSIY QFLIAVRQGG DVLQNEEGET 
TSHLMGMFYR TIRMMENGIK PVYVFDGKPP QLKSGELAKR SERRAEAEKQ LQQAQAAGAE 
QEVEKFTKRL VKVTKQHNDE CKHLLSLMGI PYLDAPSEAE ASCAALVKAG KVYAAATEDM 
DCLTFGSPVL MRHLTASEAK KLPIQEFHLS RILQELGLNQ EQFVDLCILL GSDYCESIRG 
IGPKRAVDLI QKHKSIEEIV RRLDPNKYPV PENWLHKEAH QLFLEPEVLD PESVELKWSE 
PNEEELIKFM CGEKQFSEER IRSGVKRLSK SRQGSTQGRL DDFFKVTGSL SSAKRKEPEP 
KGSTKKKAKT GAAGKFKRGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.