Details for: FGF11

Gene ID: 2256

Symbol: FGF11

Ensembl ID: ENSG00000161958

Description: fibroblast growth factor 11

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.99
    Marker Score: 2855.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.61
    Marker Score: 1940
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.39
    Marker Score: 1315
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.36
    Marker Score: 2762
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.26
    Marker Score: 2603
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 6953
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.93
    Marker Score: 630
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.75
    Marker Score: 2793
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.72
    Marker Score: 227
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2981
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.69
    Marker Score: 219
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 347
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.5
    Marker Score: 10629
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.48
    Marker Score: 203
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.48
    Marker Score: 329
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.45
    Marker Score: 145
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.45
    Marker Score: 778
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.38
    Marker Score: 327
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.37
    Marker Score: 876
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.36
    Marker Score: 105.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.35
    Marker Score: 572
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.34
    Marker Score: 76
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.32
    Marker Score: 84
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.32
    Marker Score: 99
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.3
    Marker Score: 380
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 183
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.27
    Marker Score: 129
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.26
    Marker Score: 108
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.25
    Marker Score: 68
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.23
    Marker Score: 195
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.23
    Marker Score: 2292
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.22
    Marker Score: 2935.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.22
    Marker Score: 143
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.2
    Marker Score: 1568
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.18
    Marker Score: 1327
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.18
    Marker Score: 169.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.17
    Marker Score: 299
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.17
    Marker Score: 121
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.16
    Marker Score: 188
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.16
    Marker Score: 958
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 95
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.16
    Marker Score: 228
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.16
    Marker Score: 79
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.16
    Marker Score: 308
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.16
    Marker Score: 1332
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.15
    Marker Score: 146
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.15
    Marker Score: 75
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.15
    Marker Score: 55
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.15
    Marker Score: 43
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.14
    Marker Score: 353
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.14
    Marker Score: 700.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.14
    Marker Score: 2504
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.14
    Marker Score: 149
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.13
    Marker Score: 90
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.12
    Marker Score: 4144
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.12
    Marker Score: 232
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.12
    Marker Score: 126
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.11
    Marker Score: 403
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.11
    Marker Score: 140
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.11
    Marker Score: 205
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.11
    Marker Score: 45
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 24.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.11
    Marker Score: 109
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.11
    Marker Score: 70
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.1
    Marker Score: 21
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1
    Marker Score: 118
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1
    Marker Score: 62

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * FGF11 is a secreted protein that is produced by various cell types. * It is a potent activator of the intracellular signaling pathway known as the MAPK/ERK pathway. * FGF11 is also a ligand for the cell surface receptor FGFR1, which is expressed in a variety of cell types. * It is a key regulator of cardiac conduction, cell-cell signaling, and muscle contraction. **Pathways and functions:** * FGF11 promotes cardiac conduction by stimulating the proliferation and migration of endothelial cells, leading to the formation of new blood vessels. * It also promotes cell migration and survival in the developing heart. * FGF11 plays a crucial role in cell-cell signaling in various tissues, including the skin, where it promotes the formation of new blood vessels and the growth of skin cells. * It is essential for the development and maintenance of the nervous system, where it promotes the survival and differentiation of neurons and glial cells. * In the kidney, FGF11 is crucial for the regulation of renal function, including the formation of new blood vessels and the regulation of water and electrolyte balance. * It is also involved in the development and maintenance of the gastrointestinal tract, where it promotes the growth and differentiation of enterocytes. **Clinical significance:** * Mutations in FGF11 have been linked to several human diseases, including cardiovascular diseases, cancer, and developmental disorders. * Overexpression of FGF11 has been observed in many cancer cells, where it promotes cell growth, proliferation, and survival. * Inhibition of FGF11 signaling has shown to inhibit cancer growth, suggesting that it may be a potential therapeutic target for cancer treatment.

Genular Protein ID: 1070912529

Symbol: FGF11_HUMAN

Name: Fibroblast growth factor 11

UniProtKB Accession Codes:

Q92914 Q2YDX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8790420

Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

PubMed ID: 8790420

DOI: 10.1073/pnas.93.18.9850

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 225
  • Mass: 25005
  • Checksum: 3176FF22053072DC
  • Sequence:
    • MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV RLCGGRPARP 
DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS FTHFNLIPVG LRVVTIQSAK 
LGHYMAMNAE GLLYSSPHFT AECRFKECVF ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ 
VMKGNRVKKT KAAAHFLPKL LEVAMYQEPS LHSVPEASPS SPPAP

Genular Protein ID: 150778460

Symbol: B7Z1C3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1C3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 166
  • Mass: 18531
  • Checksum: A885497C8AF67512
  • Sequence:
    • MSLSPEPQLK GIVTKLFCRQ GFYLQANPDG SIQGTPEDTS SFTHFNLIPV GLRVVTIQSA 
KLGHYMAMNA EGLLYSSPHF TAECRFKECV FENYYVLYAS ALYRQRRSGR AWYLGLDKEG 
QVMKGNRVKK TKAAAHFLPK LLEVAMYQEP SLHSVPEASP SSPPAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.