Details for: FGF11

Gene ID: 2256

Symbol: FGF11

Ensembl ID: ENSG00000161958

Description: fibroblast growth factor 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 33.2379
    Cell Significance Index: -5.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.6589
    Cell Significance Index: -5.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.8599
    Cell Significance Index: 46.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.3228
    Cell Significance Index: -5.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1651
    Cell Significance Index: -2.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9880
    Cell Significance Index: 26.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9405
    Cell Significance Index: 11.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6191
    Cell Significance Index: 13.5600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5550
    Cell Significance Index: 4.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4626
    Cell Significance Index: 24.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4623
    Cell Significance Index: 9.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.3609
    Cell Significance Index: 13.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3291
    Cell Significance Index: 62.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2700
    Cell Significance Index: 26.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1774
    Cell Significance Index: 160.1600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1693
    Cell Significance Index: 1.3100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1368
    Cell Significance Index: 2.1700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1287
    Cell Significance Index: 2.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1240
    Cell Significance Index: 20.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1026
    Cell Significance Index: 11.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0865
    Cell Significance Index: 1.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0795
    Cell Significance Index: 4.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0693
    Cell Significance Index: 30.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0663
    Cell Significance Index: 3.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0496
    Cell Significance Index: 1.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0466
    Cell Significance Index: 2.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0432
    Cell Significance Index: 0.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0415
    Cell Significance Index: 0.6300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0400
    Cell Significance Index: 0.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0388
    Cell Significance Index: 1.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0293
    Cell Significance Index: 3.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0287
    Cell Significance Index: 5.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0281
    Cell Significance Index: 1.9500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0281
    Cell Significance Index: 0.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0136
    Cell Significance Index: 1.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0115
    Cell Significance Index: 0.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0100
    Cell Significance Index: 0.5000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0089
    Cell Significance Index: 0.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0065
    Cell Significance Index: 0.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0041
    Cell Significance Index: 2.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0028
    Cell Significance Index: 0.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0011
    Cell Significance Index: -0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -4.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0059
    Cell Significance Index: -3.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0088
    Cell Significance Index: -1.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0164
    Cell Significance Index: -4.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0171
    Cell Significance Index: -1.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0179
    Cell Significance Index: -3.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0223
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0233
    Cell Significance Index: -4.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0237
    Cell Significance Index: -2.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0249
    Cell Significance Index: -0.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0266
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0290
    Cell Significance Index: -4.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0319
    Cell Significance Index: -0.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0320
    Cell Significance Index: -4.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0325
    Cell Significance Index: -2.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0373
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0386
    Cell Significance Index: -4.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0399
    Cell Significance Index: -4.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0409
    Cell Significance Index: -2.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0441
    Cell Significance Index: -2.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0449
    Cell Significance Index: -0.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0500
    Cell Significance Index: -3.9600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0516
    Cell Significance Index: -0.7400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0527
    Cell Significance Index: -0.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0572
    Cell Significance Index: -2.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0631
    Cell Significance Index: -2.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0645
    Cell Significance Index: -4.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0647
    Cell Significance Index: -1.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0666
    Cell Significance Index: -1.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0689
    Cell Significance Index: -1.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0748
    Cell Significance Index: -2.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0775
    Cell Significance Index: -4.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0852
    Cell Significance Index: -1.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0888
    Cell Significance Index: -4.1400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0920
    Cell Significance Index: -1.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0930
    Cell Significance Index: -3.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0942
    Cell Significance Index: -1.3900
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0967
    Cell Significance Index: -1.0400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0971
    Cell Significance Index: -1.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1015
    Cell Significance Index: -2.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1045
    Cell Significance Index: -2.6100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1073
    Cell Significance Index: -1.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1099
    Cell Significance Index: -4.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1188
    Cell Significance Index: -1.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1245
    Cell Significance Index: -4.3600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1250
    Cell Significance Index: -3.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1279
    Cell Significance Index: -3.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1314
    Cell Significance Index: -4.9800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1358
    Cell Significance Index: -1.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1382
    Cell Significance Index: -4.0700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1424
    Cell Significance Index: -1.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1428
    Cell Significance Index: -2.3900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1431
    Cell Significance Index: -1.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1435
    Cell Significance Index: -3.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1452
    Cell Significance Index: -3.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FGF11 is a secreted protein that exerts its effects through binding to specific receptors, triggering a cascade of downstream signaling pathways. Its expression is observed in various cell types, including respiratory basal cells, glycinergic neurons, and kidney proximal convoluted tubule epithelial cells. The gene's involvement in cardiac conduction, muscle contraction, and nervous system development highlights its potential role in regulating the function of these complex systems. Furthermore, FGF11's presence in immune cells, such as goblet cells and GABAergic interneurons, suggests its involvement in immune regulation and modulation. **Pathways and Functions:** FGF11's signaling pathways are multifaceted and far-reaching, influencing various cellular processes. Notably, its involvement in: 1. **Cardiac conduction**: FGF11 has been shown to regulate the function of voltage-gated sodium channels, essential for the transmission of electrical impulses in the heart. 2. **Cell-cell signaling**: FGF11 interacts with its receptors, triggering a signaling cascade that modulates cell growth, differentiation, and survival. 3. **Muscle contraction**: FGF11 has been implicated in the regulation of muscle contraction, potentially influencing muscle function and development. 4. **Nervous system development**: FGF11 plays a crucial role in the development of the nervous system, particularly in the formation of GABAergic interneurons. 5. **Immune regulation**: FGF11 is expressed in immune cells, suggesting its involvement in immune modulation and regulation. **Clinical Significance:** The clinical significance of FGF11 is an area of active research, with potential implications for various diseases. Some potential applications include: 1. **Regulation of cardiac conduction disorders**: FGF11's role in regulating cardiac conduction suggests its potential as a therapeutic target for treating cardiac conduction disorders. 2. **Muscle wasting diseases**: FGF11's involvement in muscle contraction and development implies its potential as a therapeutic target for muscle wasting diseases, such as muscular dystrophy. 3. **Neurological disorders**: FGF11's role in nervous system development and immune regulation suggests its potential as a therapeutic target for neurological disorders, such as autism and schizophrenia. 4. **Immunological disorders**: FGF11's expression in immune cells implies its potential as a therapeutic target for immunological disorders, such as autoimmune diseases. In conclusion, FGF11 is a complex gene with far-reaching implications for various cellular processes, from cardiac conduction and muscle contraction to nervous system development and immune regulation. Further research is needed to fully elucidate its role in human disease and to explore its potential as a therapeutic target for various clinical applications.

Genular Protein ID: 1070912529

Symbol: FGF11_HUMAN

Name: Fibroblast growth factor 11

UniProtKB Accession Codes:

Q92914 Q2YDX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8790420

Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

PubMed ID: 8790420

DOI: 10.1073/pnas.93.18.9850

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 225
  • Mass: 25005
  • Checksum: 3176FF22053072DC
  • Sequence:
    • MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV RLCGGRPARP 
DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS FTHFNLIPVG LRVVTIQSAK 
LGHYMAMNAE GLLYSSPHFT AECRFKECVF ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ 
VMKGNRVKKT KAAAHFLPKL LEVAMYQEPS LHSVPEASPS SPPAP

Genular Protein ID: 150778460

Symbol: B7Z1C3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1C3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 166
  • Mass: 18531
  • Checksum: A885497C8AF67512
  • Sequence:
    • MSLSPEPQLK GIVTKLFCRQ GFYLQANPDG SIQGTPEDTS SFTHFNLIPV GLRVVTIQSA 
KLGHYMAMNA EGLLYSSPHF TAECRFKECV FENYYVLYAS ALYRQRRSGR AWYLGLDKEG 
QVMKGNRVKK TKAAAHFLPK LLEVAMYQEP SLHSVPEASP SSPPAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.