Details for: FGFR4

Gene ID: 2264

Symbol: FGFR4

Ensembl ID: ENSG00000160867

Description: fibroblast growth factor receptor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.3589
    Cell Significance Index: -4.1000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 25.2670
    Cell Significance Index: 156.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.1644
    Cell Significance Index: -4.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.8736
    Cell Significance Index: -5.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.8915
    Cell Significance Index: -4.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.4989
    Cell Significance Index: -5.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.1692
    Cell Significance Index: 111.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.9636
    Cell Significance Index: 43.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.3253
    Cell Significance Index: -4.1000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.0491
    Cell Significance Index: 24.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4145
    Cell Significance Index: 238.8500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.1746
    Cell Significance Index: 16.4900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.7682
    Cell Significance Index: 18.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7435
    Cell Significance Index: 50.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4100
    Cell Significance Index: 153.3600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.3263
    Cell Significance Index: 5.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3246
    Cell Significance Index: 60.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3007
    Cell Significance Index: 211.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2517
    Cell Significance Index: 248.4000
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.2380
    Cell Significance Index: 0.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2355
    Cell Significance Index: 74.1700
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 1.2237
    Cell Significance Index: 8.3600
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1185
    Cell Significance Index: 5.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1143
    Cell Significance Index: 14.2700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.7474
    Cell Significance Index: 7.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7080
    Cell Significance Index: 48.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6781
    Cell Significance Index: 14.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6607
    Cell Significance Index: 14.0700
  • Cell Name: myoblast (CL0000056)
    Fold Change: 0.4987
    Cell Significance Index: 4.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3311
    Cell Significance Index: 10.6100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3243
    Cell Significance Index: 4.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3004
    Cell Significance Index: 3.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2745
    Cell Significance Index: 52.2400
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: 0.1589
    Cell Significance Index: 1.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1468
    Cell Significance Index: 3.6700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0781
    Cell Significance Index: 1.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0753
    Cell Significance Index: 1.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0623
    Cell Significance Index: 34.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0592
    Cell Significance Index: 2.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0591
    Cell Significance Index: 1.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0310
    Cell Significance Index: 0.4700
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0289
    Cell Significance Index: 0.2100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0272
    Cell Significance Index: 0.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0255
    Cell Significance Index: 0.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0206
    Cell Significance Index: 0.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0177
    Cell Significance Index: 3.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0140
    Cell Significance Index: 5.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0056
    Cell Significance Index: 8.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0052
    Cell Significance Index: 0.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0044
    Cell Significance Index: 2.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0027
    Cell Significance Index: 5.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0001
    Cell Significance Index: 0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0065
    Cell Significance Index: -3.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0103
    Cell Significance Index: -4.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0118
    Cell Significance Index: -1.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0122
    Cell Significance Index: -0.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0133
    Cell Significance Index: -0.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0135
    Cell Significance Index: -1.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0138
    Cell Significance Index: -3.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0143
    Cell Significance Index: -0.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0153
    Cell Significance Index: -0.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0156
    Cell Significance Index: -2.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0195
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0195
    Cell Significance Index: -4.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0246
    Cell Significance Index: -3.5800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0256
    Cell Significance Index: -0.1800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0294
    Cell Significance Index: -0.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0316
    Cell Significance Index: -3.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0330
    Cell Significance Index: -4.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0341
    Cell Significance Index: -2.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0354
    Cell Significance Index: -0.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0358
    Cell Significance Index: -4.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0381
    Cell Significance Index: -0.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0386
    Cell Significance Index: -4.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0405
    Cell Significance Index: -2.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0445
    Cell Significance Index: -0.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0486
    Cell Significance Index: -3.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0500
    Cell Significance Index: -3.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0519
    Cell Significance Index: -2.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0533
    Cell Significance Index: -1.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0535
    Cell Significance Index: -3.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0542
    Cell Significance Index: -3.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0573
    Cell Significance Index: -3.0100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0591
    Cell Significance Index: -0.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0622
    Cell Significance Index: -3.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0622
    Cell Significance Index: -3.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0645
    Cell Significance Index: -5.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0724
    Cell Significance Index: -3.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0746
    Cell Significance Index: -4.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0769
    Cell Significance Index: -3.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0780
    Cell Significance Index: -2.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FGFR4 exhibits several key characteristics that distinguish it from other FGFR family members: 1. **Ligand specificity**: FGFR4 is specifically activated by FGFs, particularly FGF2 and FGF3. 2. **Tyrosine kinase activity**: FGFR4 possesses intrinsic tyrosine kinase activity, which allows it to phosphorylate and activate downstream signaling molecules. 3. **Cell surface localization**: FGFR4 is a transmembrane receptor, localized to the cell surface where it can interact with FGFs and other ligands. 4. **Dimerization**: FGFR4 can form dimers with other FGFR family members, modulating its signaling activity. 5. **Regulatory mechanisms**: FGFR4 is subject to negative regulation by various mechanisms, including PI3K/AKT signaling, MAPK/ERK signaling, and B4DVP5-mediated inhibition. **Pathways and Functions** FGFR4 signaling pathways are complex and multifaceted, involving various downstream effectors and regulatory mechanisms. Some of the key pathways and functions associated with FGFR4 include: 1. **Cell proliferation and differentiation**: FGFR4 activation promotes cell proliferation, differentiation, and survival in various cell types, including embryonic development, tissue repair, and cancer. 2. **Angiogenesis**: FGFR4 signaling contributes to angiogenesis, the formation of new blood vessels, which is essential for tumor growth and metastasis. 3. **Fibrosis**: Dysregulation of FGFR4 signaling has been implicated in fibrotic diseases, such as pulmonary fibrosis and liver fibrosis. 4. **Metabolic regulation**: FGFR4 plays a role in glucose homeostasis, insulin signaling, and lipid metabolism. 5. **Cancer**: FGFR4 is overexpressed in various cancers, including breast, lung, and colon cancer, and its aberrant activation can contribute to tumor progression and metastasis. **Clinical Significance** FGFR4 has significant clinical implications in various diseases, including: 1. **Cancer**: FGFR4 mutations or amplifications have been identified in several cancers, including breast, lung, and colon cancer. 2. **Fibrosis**: Dysregulation of FGFR4 signaling has been implicated in fibrotic diseases, such as pulmonary fibrosis and liver fibrosis. 3. **Metabolic disorders**: FGFR4 plays a role in glucose homeostasis, insulin signaling, and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes and obesity. 4. **Neurological disorders**: FGFR4 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FGFR4 is a critical regulator of cell signaling, proliferation, and differentiation, with significant implications in various diseases, including cancer, fibrosis, and metabolic disorders. Further research is needed to fully elucidate the mechanisms of FGFR4 signaling and its clinical significance.

Genular Protein ID: 1679490345

Symbol: FGFR4_HUMAN

Name: Fibroblast growth factor receptor 4

UniProtKB Accession Codes:

P22455 G3JVM2 G3JVM5 G3JVM7 G3JVM9 O43785 Q14309 Q71TW8 Q8TDA0 Q96KE5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 3 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 2 EMBL 23 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 45 PDBsum 45 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 14 RefSeq 5 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1709094

Title: FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.

PubMed ID: 1709094

DOI: 10.1002/j.1460-2075.1991.tb07654.x

PubMed ID: 7680645

Title: Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor.

PubMed ID: 7680645

DOI: 10.1016/s0021-9258(18)53334-2

PubMed ID: 10631118

Title: Identification of a novel alternative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells.

PubMed ID: 10631118

DOI: 10.1006/bbrc.1999.2010

PubMed ID: 9457674

Title: Genomic structure and complete sequence of the human FGFR4 gene.

PubMed ID: 9457674

DOI: 10.1007/s003359900703

PubMed ID: 21882254

Title: PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma.

PubMed ID: 21882254

DOI: 10.1002/mc.20848

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2247464

Title: Putative tyrosine kinases expressed in K-562 human leukemia cells.

PubMed ID: 2247464

DOI: 10.1073/pnas.87.22.8913

PubMed ID: 11781352

Title: Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis.

PubMed ID: 11781352

DOI: 10.1172/jci14036

PubMed ID: 26237043

Title:

PubMed ID: 26237043

DOI: 10.1172/jci83399

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 7518429

Title: Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.

PubMed ID: 7518429

DOI: 10.1016/s0021-9258(17)32309-8

PubMed ID: 8663044

Title: Receptor specificity of the fibroblast growth factor family.

PubMed ID: 8663044

DOI: 10.1074/jbc.271.25.15292

PubMed ID: 11433297

Title: N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling.

PubMed ID: 11433297

DOI: 10.1038/35083041

PubMed ID: 11830541

Title: Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele.

PubMed ID: 11830541

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 17623664

Title: Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.

PubMed ID: 17623664

DOI: 10.1074/jbc.m704165200

PubMed ID: 17311277

Title: Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus.

PubMed ID: 17311277

DOI: 10.1002/jcp.21014

PubMed ID: 18756523

Title: Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population.

PubMed ID: 18756523

DOI: 10.1002/ijc.23578

PubMed ID: 18480409

Title: Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.

PubMed ID: 18480409

DOI: 10.1091/mbc.e07-12-1219

PubMed ID: 18670643

Title: Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression.

PubMed ID: 18670643

DOI: 10.1593/neo.08450

PubMed ID: 20638838

Title: FGFR4 transmembrane domain polymorphism and cancer risk: a meta-analysis including 8555 subjects.

PubMed ID: 20638838

DOI: 10.1016/j.ejca.2010.06.017

PubMed ID: 20683963

Title: Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1.

PubMed ID: 20683963

DOI: 10.1002/hep.23708

PubMed ID: 20018895

Title: FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

PubMed ID: 20018895

DOI: 10.1074/jbc.m109.068783

PubMed ID: 20798051

Title: FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.

PubMed ID: 20798051

DOI: 10.1073/pnas.0914459107

PubMed ID: 21349172

Title: FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: a meta-analysis of 2618 cases and 2305 controls.

PubMed ID: 21349172

DOI: 10.1186/1471-2407-11-84

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21412156

Title: Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor.

PubMed ID: 21412156

DOI: 10.1097/cej.0b013e3283457274

PubMed ID: 21653700

Title: Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho.

PubMed ID: 21653700

DOI: 10.1074/jbc.m111.251140

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26675719

Title: Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site.

PubMed ID: 26675719

DOI: 10.1038/nature16449

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 15863030

Title: Cellular signaling by fibroblast growth factor receptors.

PubMed ID: 15863030

DOI: 10.1016/j.cytogfr.2005.01.001

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 20876804

Title: Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.

PubMed ID: 20876804

DOI: 10.1158/0008-5472.can-10-1223

Sequence Information:

  • Length: 802
  • Mass: 87954
  • Checksum: B22B259831BB889F
  • Sequence:
    • MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA 
ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARGSMIVL QNLTLITGDS 
LTSSNDDEDP KSHRDPSNRH SYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP 
TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENAV GSIRYNYLLD 
VLERSPHRPI LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDPTWTA 
AAPEARYTDI ILYASGSLAL AVLLLLAGLY RGQALHGRHP RPPATVQKLS RFPLARQFSL 
ESGSSGKSSS SLVRGVRLSS SGPALLAGLV SLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ 
VVRAEAFGMD PARPDQASTV AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC 
TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPVLV SCAYQVARGM 
QYLESRKCIH RDLAARNVLV TEDNVMKIAD FGLARGVHHI DYYKKTSNGR LPVKWMAPEA 
LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS LLREGHRMDR PPHCPPELYG 
LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT FGPYSPSGGD ASSTCSSSDS 
VFSHDPLPLG SSSFPFGSGV QT

Genular Protein ID: 3274659060

Symbol: J3KPQ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KPQ0

Database IDs:

ARBA 23 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneTree 1 HGNC 1 InterPro 14 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 SAM 2 SMART 3 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 734
  • Mass: 80466
  • Checksum: 33FE53DD99570C52
  • Sequence:
    • MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA 
ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARGSMIVL QNLTLITGDS 
LTSSNDDEDP KSHRDPSNRH SYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP 
TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENAV GSIRYNYLLD 
VLERSPHRPI LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDPTWTA 
AAPEASSPWS QALPASQAHP WYEACVSPPA APPCSPASLV LGKPLGEGCF GQVVRAEAFG 
MDPARPDQAS TVAVKMLKDN ASDKDLADLV SEMEVMKLIG RHKNIINLLG VCTQEGPLYV 
IVECAAKGNL REFLRARRPP GPDLSPDGPR SSEGPLSFPV LVSCAYQVAR GMQYLESRKC 
IHRDLAARNV LVTEDNVMKI ADFGLARGVH HIDYYKKTSN GRLPVKWMAP EALFDRVYTH 
QSDVWSFGIL LWEIFTLGGS PYPGIPVEEL FSLLREGHRM DRPPHCPPEL YGLMRECWHA 
APSQRPTFKQ LVEALDKVLL AVSEEYLDLR LTFGPYSPSG GDASSTCSSS DSVFSHDPLP 
LGSSSFPFGS GVQT

Genular Protein ID: 2723869101

Symbol: B4DVP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DVP5

Database IDs:

ARBA 23 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 11 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 10 Gene3D 2 InterPro 14 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 Rhea 3 SAM 2 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 734
  • Mass: 80447
  • Checksum: D20EC792AEEF3E57
  • Sequence:
    • MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA 
ERGGHWYKEG SRLAPAGRVR GWRGHLEIAS FLPEDAGRYL CLARGSMIVL QNLTLITGDS 
LTSSNDDEDP KSHRDPSNRH SYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP 
TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENAV GSIRYNYLLD 
VLERSPHRPI LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDPTWTA 
AAPEASSPWS QALPASQAHP WYEACVSPPA APPCSPASLV LGKPLGEGCF GQVVRAEAFG 
MDPARPDQAS TVAVKMLKDN ASDKDLADLV SEMEVMKLIG RHKNIINLLG VCTQEGPLYV 
IVECAAKGNL REFLRARRPP GPDLSPDGPR SSEGPLSFPV LVSCAYQVAR GMQYLESRKC 
IHRDLAARNV LVTEDNVMKI ADFGLARGVH HIDYYKKTSN GRLPVKWMAP EALFDRVYTH 
QSDVWSFGIL LWEIFTLGGS PYPGIPVEEL FSLLREGHRM DRPPHCPPEL YGLMRECWHA 
APSQRPTFKQ LVEALDKVLL AVSEEYLDLR LTFGPYSPSG GDASSTCSSS DSVFSHDPLP 
LGSSSFPFGS GVQT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.