Details for: FKBP3

Gene ID: 2287

Symbol: FKBP3

Ensembl ID: ENSG00000100442

Description: FKBP prolyl isomerase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 304.7345
    Cell Significance Index: -47.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 166.6119
    Cell Significance Index: -42.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.0071
    Cell Significance Index: -54.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 126.2172
    Cell Significance Index: -59.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.6380
    Cell Significance Index: -47.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 109.9565
    Cell Significance Index: -56.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.2701
    Cell Significance Index: -48.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.7275
    Cell Significance Index: -56.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.8583
    Cell Significance Index: -47.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.9289
    Cell Significance Index: -58.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.0818
    Cell Significance Index: -40.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3119
    Cell Significance Index: -20.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.1178
    Cell Significance Index: 44.3300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9194
    Cell Significance Index: 15.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.7689
    Cell Significance Index: 61.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6070
    Cell Significance Index: 17.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4958
    Cell Significance Index: 300.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4883
    Cell Significance Index: 40.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.3222
    Cell Significance Index: 69.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2997
    Cell Significance Index: 159.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2878
    Cell Significance Index: 232.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2346
    Cell Significance Index: 674.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1192
    Cell Significance Index: 58.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0875
    Cell Significance Index: 128.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0540
    Cell Significance Index: 27.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0523
    Cell Significance Index: 144.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0248
    Cell Significance Index: 66.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0189
    Cell Significance Index: 64.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9372
    Cell Significance Index: 414.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7775
    Cell Significance Index: 35.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7726
    Cell Significance Index: 20.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7091
    Cell Significance Index: 254.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6842
    Cell Significance Index: 48.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6489
    Cell Significance Index: 83.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6323
    Cell Significance Index: 29.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6130
    Cell Significance Index: 121.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5912
    Cell Significance Index: 17.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5900
    Cell Significance Index: 95.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5673
    Cell Significance Index: 39.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5446
    Cell Significance Index: 5.0200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4896
    Cell Significance Index: 4.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4771
    Cell Significance Index: 24.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4769
    Cell Significance Index: 35.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4030
    Cell Significance Index: 9.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3741
    Cell Significance Index: 4.4600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3516
    Cell Significance Index: 2.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2870
    Cell Significance Index: 37.0800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2615
    Cell Significance Index: 6.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1554
    Cell Significance Index: 15.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1482
    Cell Significance Index: 25.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1202
    Cell Significance Index: 5.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1161
    Cell Significance Index: 80.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1141
    Cell Significance Index: 21.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0688
    Cell Significance Index: 2.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0381
    Cell Significance Index: 1.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0291
    Cell Significance Index: 21.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0276
    Cell Significance Index: 1.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0191
    Cell Significance Index: 0.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0168
    Cell Significance Index: 0.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0080
    Cell Significance Index: 6.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0078
    Cell Significance Index: 14.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0089
    Cell Significance Index: -16.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0194
    Cell Significance Index: -29.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0266
    Cell Significance Index: -36.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0306
    Cell Significance Index: -19.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0346
    Cell Significance Index: -22.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0708
    Cell Significance Index: -7.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0711
    Cell Significance Index: -40.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0737
    Cell Significance Index: -33.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0841
    Cell Significance Index: -6.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1075
    Cell Significance Index: -4.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1266
    Cell Significance Index: -26.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1459
    Cell Significance Index: -9.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1647
    Cell Significance Index: -47.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1904
    Cell Significance Index: -5.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2008
    Cell Significance Index: -7.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2091
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2320
    Cell Significance Index: -26.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2384
    Cell Significance Index: -6.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2523
    Cell Significance Index: -36.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2864
    Cell Significance Index: -7.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2994
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3101
    Cell Significance Index: -35.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3227
    Cell Significance Index: -37.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3406
    Cell Significance Index: -10.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3624
    Cell Significance Index: -9.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3861
    Cell Significance Index: -30.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3980
    Cell Significance Index: -24.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5090
    Cell Significance Index: -10.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5175
    Cell Significance Index: -7.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5458
    Cell Significance Index: -56.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5839
    Cell Significance Index: -15.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6479
    Cell Significance Index: -7.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6627
    Cell Significance Index: -18.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6965
    Cell Significance Index: -17.4100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7308
    Cell Significance Index: -10.2500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.8057
    Cell Significance Index: -8.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8441
    Cell Significance Index: -5.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9565
    Cell Significance Index: -58.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FKBP3 exhibits several key characteristics that contribute to its functional significance: 1. **Peptidyl-prolyl cis-trans isomerase activity**: FKBP3 catalyzes the cis-trans isomerization of peptide bonds with a proline residue, a crucial process in protein folding and stability. 2. **FK506 binding**: FKBP3 interacts with FK506 (tacrolimus), a potent immunosuppressive agent, which inhibits its peptidyl-prolyl cis-trans isomerase activity, thereby exerting its immunosuppressive effects. 3. **Cell type specificity**: FKBP3 is significantly expressed in various cell types, including erythroid progenitor cells, GABAergic neurons, and epithelial cells of the nephron, suggesting a specific functional relevance in these tissues. 4. **Multifunctional roles**: FKBP3 is involved in various cellular processes, including protein folding, cell signaling, and transcriptional regulation, highlighting its importance in maintaining cellular homeostasis. **Pathways and Functions** FKBP3 is involved in several pathways and functions, including: 1. **Peptidyl-prolyl cis-trans isomerase activity**: FKBP3 catalyzes the cis-trans isomerization of peptide bonds with a proline residue, which is essential for protein folding and stability. 2. **FK506 signaling**: FKBP3 interacts with FK506, leading to the inhibition of its peptidyl-prolyl cis-trans isomerase activity, thereby exerting immunosuppressive effects. 3. **Cell signaling**: FKBP3 is involved in various cell signaling pathways, including the regulation of calcium channels and the modulation of neurotransmitter release. 4. **Transcriptional regulation**: FKBP3 interacts with transcription factors, influencing gene expression and cellular differentiation. **Clinical Significance** FKBP3 plays a critical role in various diseases and conditions, including: 1. **Immunosuppression**: FKBP3 is targeted by immunosuppressive agents, such as FK506 (tacrolimus), which is used to prevent organ rejection in transplant patients. 2. **Neurological disorders**: FKBP3 is involved in the regulation of calcium channels and neurotransmitter release, making it a potential target for the treatment of neurological disorders, such as epilepsy and Parkinson's disease. 3. **Cancer**: FKBP3 is overexpressed in certain types of cancer, including breast and lung cancer, suggesting its potential as a diagnostic biomarker or therapeutic target. 4. **Endocrine disorders**: FKBP3 is involved in the regulation of hormone secretion, making it a potential target for the treatment of endocrine disorders, such as diabetes and thyroid disease. In conclusion, FKBP3 is a multifunctional protein that plays a critical role in various cellular processes, including protein folding, cell signaling, and transcriptional regulation. Its involvement in immunosuppression, neurological disorders, cancer, and endocrine disorders highlights its importance in maintaining cellular homeostasis and underscores its potential as a therapeutic target for various diseases.

Genular Protein ID: 357364981

Symbol: FKBP3_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP3

UniProtKB Accession Codes:

Q00688 B2R4Q9 Q14317

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1376117

Title: Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein.

PubMed ID: 1376117

DOI: 10.1016/s0006-291x(05)80990-8

PubMed ID: 1374240

Title: cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein.

PubMed ID: 1374240

DOI: 10.1016/0006-291x(92)90651-z

PubMed ID: 1375932

Title: Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25.

PubMed ID: 1375932

DOI: 10.1016/s0021-9258(19)49856-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 224
  • Mass: 25177
  • Checksum: C144C5AAB7EA9522
  • Sequence:
    • MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV 
TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD 
KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL 
TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.