Details for: FKBP3

Gene ID: 2287

Symbol: FKBP3

Ensembl ID: ENSG00000100442

Description: FKBP prolyl isomerase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.06
    Marker Score: 3194
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.92
    Marker Score: 12193
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.22
    Marker Score: 4634
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.14
    Marker Score: 8758
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.14
    Marker Score: 8398
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.05
    Marker Score: 2305.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.04
    Marker Score: 2930
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.02
    Marker Score: 746
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2
    Marker Score: 17230
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.99
    Marker Score: 2123
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.96
    Marker Score: 3338
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.94
    Marker Score: 1824
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.92
    Marker Score: 2032
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.92
    Marker Score: 1933
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.84
    Marker Score: 1230
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.84
    Marker Score: 24279
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.83
    Marker Score: 2825
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.83
    Marker Score: 3713
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.81
    Marker Score: 4269
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.8
    Marker Score: 6976.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.77
    Marker Score: 7644
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.76
    Marker Score: 60927
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.75
    Marker Score: 2583
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.75
    Marker Score: 575
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.72
    Marker Score: 13455
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.69
    Marker Score: 567
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.67
    Marker Score: 6197
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.67
    Marker Score: 1051
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.66
    Marker Score: 18751
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.65
    Marker Score: 15493
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.64
    Marker Score: 4471
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.62
    Marker Score: 1741
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6
    Marker Score: 98476
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.6
    Marker Score: 3920
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.58
    Marker Score: 1075
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.57
    Marker Score: 4286
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.57
    Marker Score: 4472
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.56
    Marker Score: 15652
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.55
    Marker Score: 4600
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.54
    Marker Score: 3657
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.53
    Marker Score: 724
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.53
    Marker Score: 56283
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.52
    Marker Score: 14483
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.52
    Marker Score: 430
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.51
    Marker Score: 834
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.51
    Marker Score: 1608
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.5
    Marker Score: 748
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.5
    Marker Score: 1813
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.5
    Marker Score: 446.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.5
    Marker Score: 825
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5
    Marker Score: 3412
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.5
    Marker Score: 351
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.49
    Marker Score: 15148
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.49
    Marker Score: 12832
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.49
    Marker Score: 1242
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.48
    Marker Score: 8793
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.48
    Marker Score: 1117
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.46
    Marker Score: 754
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.46
    Marker Score: 767
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.45
    Marker Score: 1371
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.45
    Marker Score: 1927
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.43
    Marker Score: 1350
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.43
    Marker Score: 6879
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.43
    Marker Score: 1488
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.43
    Marker Score: 848.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.42
    Marker Score: 1710
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.41
    Marker Score: 1764
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.4
    Marker Score: 686
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2157
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.39
    Marker Score: 1042
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.39
    Marker Score: 1963
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.38
    Marker Score: 8977
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.37
    Marker Score: 728
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.36
    Marker Score: 2262
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.35
    Marker Score: 388
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.34
    Marker Score: 320
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.34
    Marker Score: 26596
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.34
    Marker Score: 717
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.33
    Marker Score: 460
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.32
    Marker Score: 2125
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.32
    Marker Score: 1816
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.32
    Marker Score: 15328
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.32
    Marker Score: 2096
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.32
    Marker Score: 3213
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.31
    Marker Score: 2463
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.31
    Marker Score: 543
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.31
    Marker Score: 3506
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.3
    Marker Score: 1675
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3
    Marker Score: 5007
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.29
    Marker Score: 5243
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.29
    Marker Score: 3241
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.28
    Marker Score: 411
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.28
    Marker Score: 411
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.28
    Marker Score: 669
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.28
    Marker Score: 516
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.28
    Marker Score: 872
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.28
    Marker Score: 369
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.28
    Marker Score: 1343
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.27
    Marker Score: 48404
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.27
    Marker Score: 849

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Other Information

**Key characteristics:** * FKBP3 is a transmembrane protein with a molecular weight of approximately 150 kDa. * It is expressed in high levels in proliferating and differentiating cells. * It is also expressed in cells that are in contact with the extracellular matrix. **Pathways and functions:** FKBP3 is involved in multiple pathways, including the Fk506 signaling pathway, the nucleus, and cell adhesion. * In the Fk506 pathway, FKBP3 binds to the Fk506 protein and activates it. * FKBP3 is also involved in the regulation of cell cycle progression and apoptosis. * It interacts with various transcription factors, including NF-κB and STAT3. * FKBP3 is also involved in the regulation of cell migration and adhesion. **Clinical significance:** Mutations in FKBP3 have been linked to several human diseases, including cancer and cardiovascular disease. * In cancer, FKBP3 mutations can lead to the activation of oncogenes and the development of tumors. * FKBP3 mutations can also lead to the development of heart disease, stroke, and other cardiovascular disorders. **Additional information:** * FKBP3 is a conserved protein with similar sequences in other organisms. * It is expressed in all tissues of the human body. * It is a ubiquitin-dependent protein, meaning that it is targeted for degradation by the proteasome when it is no longer needed.

Genular Protein ID: 357364981

Symbol: FKBP3_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP3

UniProtKB Accession Codes:

Q00688 B2R4Q9 Q14317

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1376117

Title: Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein.

PubMed ID: 1376117

DOI: 10.1016/s0006-291x(05)80990-8

PubMed ID: 1374240

Title: cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein.

PubMed ID: 1374240

DOI: 10.1016/0006-291x(92)90651-z

PubMed ID: 1375932

Title: Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25.

PubMed ID: 1375932

DOI: 10.1016/s0021-9258(19)49856-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 224
  • Mass: 25177
  • Checksum: C144C5AAB7EA9522
  • Sequence:
    • MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV 
TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD 
KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL 
TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.