Details for: FOXF2

Gene ID: 2295

Symbol: FOXF2

Ensembl ID: ENSG00000137273

Description: forkhead box F2

Associated with

  • Animal organ morphogenesis
    (GO:0009887)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic camera-type eye morphogenesis
    (GO:0048596)
  • Embryonic digestive tract development
    (GO:0048566)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Establishment of planar polarity of embryonic epithelium
    (GO:0042249)
  • Extracellular matrix organization
    (GO:0030198)
  • General transcription initiation factor binding
    (GO:0140296)
  • Genitalia development
    (GO:0048806)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032434)
  • Regulation of protein polyubiquitination
    (GO:1902914)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Roof of mouth development
    (GO:0060021)
  • Sequence-specific dna binding
    (GO:0043565)
  • Tfiib-class transcription factor binding
    (GO:0001093)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 11.7766
    Cell Significance Index: -5.5600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.3057
    Cell Significance Index: 14.2700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.5298
    Cell Significance Index: 8.0500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8642
    Cell Significance Index: 13.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5154
    Cell Significance Index: 12.4900
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.3516
    Cell Significance Index: 2.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1794
    Cell Significance Index: 23.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0647
    Cell Significance Index: 40.4100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0605
    Cell Significance Index: 0.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0169
    Cell Significance Index: 7.6900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0144
    Cell Significance Index: 0.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0082
    Cell Significance Index: 0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0045
    Cell Significance Index: -2.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0066
    Cell Significance Index: -1.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0071
    Cell Significance Index: -4.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0093
    Cell Significance Index: -5.0900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0093
    Cell Significance Index: -0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0125
    Cell Significance Index: -2.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0125
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0143
    Cell Significance Index: -2.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0144
    Cell Significance Index: -5.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0169
    Cell Significance Index: -1.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0177
    Cell Significance Index: -5.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0188
    Cell Significance Index: -2.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0189
    Cell Significance Index: -0.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0203
    Cell Significance Index: -2.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0271
    Cell Significance Index: -3.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0274
    Cell Significance Index: -5.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0292
    Cell Significance Index: -4.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0340
    Cell Significance Index: -1.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0376
    Cell Significance Index: -2.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0497
    Cell Significance Index: -2.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0507
    Cell Significance Index: -5.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0518
    Cell Significance Index: -6.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0555
    Cell Significance Index: -5.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0568
    Cell Significance Index: -6.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0643
    Cell Significance Index: -1.7500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0667
    Cell Significance Index: -1.1400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0675
    Cell Significance Index: -0.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0785
    Cell Significance Index: -4.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0827
    Cell Significance Index: -3.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0842
    Cell Significance Index: -5.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0847
    Cell Significance Index: -6.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0851
    Cell Significance Index: -3.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0906
    Cell Significance Index: -5.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0918
    Cell Significance Index: -6.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0943
    Cell Significance Index: -4.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1160
    Cell Significance Index: -6.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1207
    Cell Significance Index: -4.2300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1259
    Cell Significance Index: -3.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1273
    Cell Significance Index: -5.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1275
    Cell Significance Index: -1.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1290
    Cell Significance Index: -2.7000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1301
    Cell Significance Index: -1.4200
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1391
    Cell Significance Index: -1.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1395
    Cell Significance Index: -3.9000
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1403
    Cell Significance Index: -1.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1450
    Cell Significance Index: -2.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1541
    Cell Significance Index: -1.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1567
    Cell Significance Index: -4.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1624
    Cell Significance Index: -6.1500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1636
    Cell Significance Index: -2.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1664
    Cell Significance Index: -2.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1703
    Cell Significance Index: -6.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1719
    Cell Significance Index: -3.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1733
    Cell Significance Index: -6.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1775
    Cell Significance Index: -5.8100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1808
    Cell Significance Index: -1.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1821
    Cell Significance Index: -5.8000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1846
    Cell Significance Index: -1.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1854
    Cell Significance Index: -5.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1859
    Cell Significance Index: -5.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1922
    Cell Significance Index: -5.1500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1941
    Cell Significance Index: -3.9500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1947
    Cell Significance Index: -4.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1970
    Cell Significance Index: -5.2600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2041
    Cell Significance Index: -2.5700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2098
    Cell Significance Index: -1.9700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2154
    Cell Significance Index: -2.9500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2212
    Cell Significance Index: -2.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2236
    Cell Significance Index: -5.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2236
    Cell Significance Index: -2.5400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2246
    Cell Significance Index: -5.6100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2279
    Cell Significance Index: -5.6900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2296
    Cell Significance Index: -2.7700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2312
    Cell Significance Index: -3.1700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2392
    Cell Significance Index: -3.0900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2404
    Cell Significance Index: -1.1100
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.2408
    Cell Significance Index: -2.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2502
    Cell Significance Index: -6.0000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2515
    Cell Significance Index: -3.8200
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: -0.2524
    Cell Significance Index: -1.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2553
    Cell Significance Index: -5.5900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2579
    Cell Significance Index: -4.2500
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.2615
    Cell Significance Index: -2.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2629
    Cell Significance Index: -5.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2640
    Cell Significance Index: -2.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOXF2 is a member of the forkhead box (FOX) family of transcription factors, which are known for their role in regulating gene expression during development and cell differentiation. FOXF2 is specifically expressed in various cell types, including smooth muscle cells, pulmonary interstitial fibroblasts, enteric smooth muscle cells, and goblet cells. Its expression is also observed in the cerebral cortex GABAergic interneuron and forebrain radial glial cells, highlighting its involvement in neural development. **Pathways and Functions** FOXF2 is involved in several signaling pathways, including: 1. **Animal organ morphogenesis**: FOXF2 regulates the development of various organs, such as the digestive tract, genitalia, and eyes, by controlling the expression of target genes involved in cell proliferation, differentiation, and morphogenesis. 2. **Chromatin regulation**: FOXF2 interacts with chromatin to modulate gene expression, influencing the recruitment of transcriptional co-activators and repressors. 3. **RNA polymerase II-specific transcription**: FOXF2 acts as a transcriptional activator, regulating the expression of genes involved in cell growth, differentiation, and survival. 4. **Epithelial-to-mesenchymal transition**: FOXF2 is involved in the regulation of EMT, a process critical for tissue repair, development, and disease progression. FOXF2's functions can be broadly categorized into the following: * **Positive regulation of DNA-templated transcription**: FOXF2 activates transcription by binding to specific DNA sequences and recruiting transcriptional co-activators. * **Negative regulation of DNA-templated transcription**: FOXF2 inhibits transcription by binding to specific DNA sequences and recruiting transcriptional repressors. * **Regulation of proteasomal ubiquitin-dependent protein catabolic process**: FOXF2 modulates protein degradation by interacting with the ubiquitin-proteasome system. **Clinical Significance** FOXF2's dysregulation has been implicated in various diseases, including: 1. **Intestinal disorders**: FOXF2 is involved in the development and maintenance of the intestinal epithelium, and its dysregulation has been linked to conditions such as inflammatory bowel disease (IBD) and colon cancer. 2. **Neurological disorders**: FOXF2's role in neural development and function suggests that its dysregulation may contribute to neurological disorders, such as autism spectrum disorder (ASD) and schizophrenia. 3. **Cancer**: FOXF2's involvement in EMT and chromatin regulation makes it a potential target for cancer therapy, particularly in the development of targeted therapies. In conclusion, FOXF2 is a multifunctional transcription factor that plays a critical role in various developmental processes and disease pathways. Further research is needed to fully elucidate the mechanisms by which FOXF2 regulates gene expression and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2769518266

Symbol: FOXF2_HUMAN

Name: Forkhead box protein F2

UniProtKB Accession Codes:

Q12947 Q5TGJ1 Q9UQ85

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9799607

Title: The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3.

PubMed ID: 9799607

DOI: 10.1006/geno.1998.5451

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8626802

Title: Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.

PubMed ID: 8626802

DOI: 10.1074/jbc.271.8.4482

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 9722567

Title: The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB.

PubMed ID: 9722567

DOI: 10.1074/jbc.273.36.23335

PubMed ID: 29374064

Title: Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-beta-Catenin Signaling Axis.

PubMed ID: 29374064

DOI: 10.1158/0008-5472.can-17-2403

Sequence Information:

  • Length: 444
  • Mass: 45993
  • Checksum: 32BDC5F373CFB147
  • Sequence:
    • MTTEGGPPPA PLRRACSPVP GALQAALMSP PPAAAAAAAA APETTSSSSS SSSASCASSS 
SSSNSASAPS AACKSAGGGG AGAGSGGAKK ASSGLRRPEK PPYSYIALIV MAIQSSPSKR 
LTLSEIYQFL QARFPFFRGA YQGWKNSVRH NLSLNECFIK LPKGLGRPGK GHYWTIDPAS 
EFMFEEGSFR RRPRGFRRKC QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHSQ 
GGYGGLDMMP AGYDAGAGAP SHAHPHHHHH HHVPHMSPNP GSTYMASCPV PAGPGGVGAA 
GGGGGGDYGP DSSSSPVPSS PAMASAIECH SPYTSPAAHW SSPGASPYLK QPPALTPSSN 
PAASAGLHSS MSSYSLEQSY LHQNAREDLS VGLPRYQHHS TPVCDRKDFV LNFNGISSFH 
PSASGSYYHH HHQSVCQDIK PCVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.