Details for: FOXF2

Gene ID: 2295

Symbol: FOXF2

Ensembl ID: ENSG00000137273

Description: forkhead box F2

Associated with

  • Animal organ morphogenesis
    (GO:0009887)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic camera-type eye morphogenesis
    (GO:0048596)
  • Embryonic digestive tract development
    (GO:0048566)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Establishment of planar polarity of embryonic epithelium
    (GO:0042249)
  • Extracellular matrix organization
    (GO:0030198)
  • General transcription initiation factor binding
    (GO:0140296)
  • Genitalia development
    (GO:0048806)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032434)
  • Regulation of protein polyubiquitination
    (GO:1902914)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Roof of mouth development
    (GO:0060021)
  • Sequence-specific dna binding
    (GO:0043565)
  • Tfiib-class transcription factor binding
    (GO:0001093)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.99
    Marker Score: 754
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.72
    Marker Score: 1374
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.41
    Marker Score: 3309
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.05
    Marker Score: 13821
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.01
    Marker Score: 6693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.92
    Marker Score: 1269
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.73
    Marker Score: 838
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.72
    Marker Score: 162
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1267
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.66
    Marker Score: 1459.5
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.65
    Marker Score: 171
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.61
    Marker Score: 387.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 459
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.57
    Marker Score: 547
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.55
    Marker Score: 8570
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1092
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.48
    Marker Score: 596
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 286
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 185
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.38
    Marker Score: 177
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.36
    Marker Score: 492
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.35
    Marker Score: 904
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 161
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.32
    Marker Score: 389
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.31
    Marker Score: 72
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 183.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.28
    Marker Score: 293
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.26
    Marker Score: 149
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.25
    Marker Score: 216
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.24
    Marker Score: 494
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.22
    Marker Score: 343
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.22
    Marker Score: 126
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.22
    Marker Score: 252
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.21
    Marker Score: 87
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2
    Marker Score: 6726
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.2
    Marker Score: 103
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.19
    Marker Score: 123
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.19
    Marker Score: 325
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.16
    Marker Score: 482
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.14
    Marker Score: 206
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.13
    Marker Score: 131
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.12
    Marker Score: 120
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 103
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.11
    Marker Score: 178
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.11
    Marker Score: 292
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.11
    Marker Score: 112
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.11
    Marker Score: 43
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.11
    Marker Score: 120
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.1
    Marker Score: 149
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.09
    Marker Score: 94
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.08
    Marker Score: 69
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.07
    Marker Score: 1007
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 20

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * FOXF2 is a forkhead box protein, a family of transcription factors characterized by a conserved forkhead domain. * It is expressed in a wide range of cell types, including smooth muscle cells, epithelial cells, and neural cells. * FOXF2 proteins are known to regulate gene expression by binding to specific DNA sequences known as Rna polymerase ii cis-regulatory regions. * They are also involved in the regulation of cell differentiation, migration, and survival. **Pathways and functions:** * FOXF2 is a key regulator of organogenesis. It is required for the development of the cardiovascular, digestive, and respiratory systems. * It is involved in the specification of mesodermal cells, which give rise to various tissues and organs. * FOXF2 also plays a role in the development of the eyes, with its expression being highly high in cells of the embryonic eye. * It is also involved in the regulation of tissue remodeling and wound healing. **Clinical significance:** * FOXF2 mutations are associated with a number of human diseases, including Hirschsprung's disease, an intestinal disorder characterized by the absence of smooth muscle cells in the colon. * Understanding the role of FOXF2 in development and disease could lead to the development of new treatments for these disorders. **Additional points:** * FOXF2 is a highly conserved gene, with a similar protein found in other vertebrates. * It is a key regulator of stem cell differentiation. * FOXF2 is a target for cancer therapy.

Genular Protein ID: 2769518266

Symbol: FOXF2_HUMAN

Name: Forkhead box protein F2

UniProtKB Accession Codes:

Q12947 Q5TGJ1 Q9UQ85

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9799607

Title: The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3.

PubMed ID: 9799607

DOI: 10.1006/geno.1998.5451

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8626802

Title: Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.

PubMed ID: 8626802

DOI: 10.1074/jbc.271.8.4482

PubMed ID: 7957066

Title: Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

PubMed ID: 7957066

DOI: 10.1002/j.1460-2075.1994.tb06827.x

PubMed ID: 9722567

Title: The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB.

PubMed ID: 9722567

DOI: 10.1074/jbc.273.36.23335

PubMed ID: 29374064

Title: Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-beta-Catenin Signaling Axis.

PubMed ID: 29374064

DOI: 10.1158/0008-5472.can-17-2403

Sequence Information:

  • Length: 444
  • Mass: 45993
  • Checksum: 32BDC5F373CFB147
  • Sequence:
    • MTTEGGPPPA PLRRACSPVP GALQAALMSP PPAAAAAAAA APETTSSSSS SSSASCASSS 
SSSNSASAPS AACKSAGGGG AGAGSGGAKK ASSGLRRPEK PPYSYIALIV MAIQSSPSKR 
LTLSEIYQFL QARFPFFRGA YQGWKNSVRH NLSLNECFIK LPKGLGRPGK GHYWTIDPAS 
EFMFEEGSFR RRPRGFRRKC QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHSQ 
GGYGGLDMMP AGYDAGAGAP SHAHPHHHHH HHVPHMSPNP GSTYMASCPV PAGPGGVGAA 
GGGGGGDYGP DSSSSPVPSS PAMASAIECH SPYTSPAAHW SSPGASPYLK QPPALTPSSN 
PAASAGLHSS MSSYSLEQSY LHQNAREDLS VGLPRYQHHS TPVCDRKDFV LNFNGISSFH 
PSASGSYYHH HHQSVCQDIK PCVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.