Details for: FOXD2

Gene ID: 2306

Symbol: FOXD2

Ensembl ID: ENSG00000186564

Description: forkhead box D2

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 21.1514
    Cell Significance Index: -3.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.0892
    Cell Significance Index: -3.3200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.1701
    Cell Significance Index: 18.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9955
    Cell Significance Index: 90.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.2281
    Cell Significance Index: -3.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1038
    Cell Significance Index: 16.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0486
    Cell Significance Index: 62.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.8363
    Cell Significance Index: -3.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8085
    Cell Significance Index: 131.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5240
    Cell Significance Index: 36.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4061
    Cell Significance Index: 366.6500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3340
    Cell Significance Index: 3.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2264
    Cell Significance Index: 22.4000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2075
    Cell Significance Index: 2.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2065
    Cell Significance Index: 5.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1719
    Cell Significance Index: 1.7800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1506
    Cell Significance Index: 1.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1500
    Cell Significance Index: 3.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1389
    Cell Significance Index: 16.1900
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.1367
    Cell Significance Index: 1.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1365
    Cell Significance Index: 25.9700
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.1309
    Cell Significance Index: 1.0600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1250
    Cell Significance Index: 1.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1200
    Cell Significance Index: 4.1700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0945
    Cell Significance Index: 2.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0901
    Cell Significance Index: 1.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0699
    Cell Significance Index: 2.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0554
    Cell Significance Index: 1.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0539
    Cell Significance Index: 0.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0336
    Cell Significance Index: 0.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0241
    Cell Significance Index: 3.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0188
    Cell Significance Index: 0.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0154
    Cell Significance Index: 0.8000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0126
    Cell Significance Index: 0.2000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0107
    Cell Significance Index: 0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0054
    Cell Significance Index: 2.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0004
    Cell Significance Index: 0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0011
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0022
    Cell Significance Index: -0.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0028
    Cell Significance Index: -0.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0032
    Cell Significance Index: -0.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0033
    Cell Significance Index: -1.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0037
    Cell Significance Index: -2.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0041
    Cell Significance Index: -0.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0044
    Cell Significance Index: -2.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0051
    Cell Significance Index: -3.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0089
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0112
    Cell Significance Index: -1.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0151
    Cell Significance Index: -1.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0153
    Cell Significance Index: -3.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0157
    Cell Significance Index: -3.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0166
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0177
    Cell Significance Index: -3.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0192
    Cell Significance Index: -1.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0201
    Cell Significance Index: -1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0244
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0253
    Cell Significance Index: -0.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0254
    Cell Significance Index: -2.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0265
    Cell Significance Index: -3.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0266
    Cell Significance Index: -3.1400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0268
    Cell Significance Index: -0.3700
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0315
    Cell Significance Index: -0.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0321
    Cell Significance Index: -3.3400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0359
    Cell Significance Index: -0.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0362
    Cell Significance Index: -1.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0362
    Cell Significance Index: -1.5800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0389
    Cell Significance Index: -0.5700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0394
    Cell Significance Index: -0.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0418
    Cell Significance Index: -0.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0423
    Cell Significance Index: -2.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0458
    Cell Significance Index: -3.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0465
    Cell Significance Index: -3.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0498
    Cell Significance Index: -3.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0511
    Cell Significance Index: -1.0700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0568
    Cell Significance Index: -0.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0574
    Cell Significance Index: -3.2200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0596
    Cell Significance Index: -0.3500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0598
    Cell Significance Index: -0.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0640
    Cell Significance Index: -3.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0677
    Cell Significance Index: -1.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0687
    Cell Significance Index: -1.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0699
    Cell Significance Index: -3.0900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0743
    Cell Significance Index: -0.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0759
    Cell Significance Index: -2.0700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0855
    Cell Significance Index: -0.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0855
    Cell Significance Index: -0.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0886
    Cell Significance Index: -2.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0943
    Cell Significance Index: -3.4600
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0961
    Cell Significance Index: -1.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0965
    Cell Significance Index: -3.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0969
    Cell Significance Index: -1.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0969
    Cell Significance Index: -3.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0992
    Cell Significance Index: -1.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0998
    Cell Significance Index: -2.6700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1007
    Cell Significance Index: -1.0700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1066
    Cell Significance Index: -1.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FOXD2 is a transcription factor that belongs to the forkhead box (FOX) family, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is highly expressed in early T lineage precursors, cerebral cortex GABAergic interneurons, and forebrain radial glial cells, suggesting its involvement in the development and maintenance of these cell types. Additionally, FOXD2 is also expressed in various epithelial tissues, including the colon and small intestine, where it may play a role in regulating the differentiation and function of absorptive cells. **Pathways and Functions:** FOXD2 is involved in several key pathways, including: 1. **Anatomical structure morphogenesis**: FOXD2 regulates the development and patterning of various tissues and organs, including the cerebral cortex and forebrain. 2. **Cell differentiation**: FOXD2 is required for the differentiation of early T lineage precursors and GABAergic interneurons, highlighting its role in immune cell development. 3. **Chromatin regulation**: FOXD2 interacts with chromatin-modifying enzymes to regulate gene expression and maintain epigenetic marks. 4. **DNA-binding transcription activator activity**: FOXD2 activates the transcription of target genes by binding to specific DNA sequences and recruiting coactivators. **Clinical Significance:** FOXD2 has been implicated in various diseases, including: 1. **Immune system disorders**: Abnormalities in FOXD2 expression have been linked to immune system disorders, such as autoimmune diseases and immunodeficiency syndromes. 2. **Cancer**: FOXD2 is often downregulated in cancer cells, suggesting its role as a tumor suppressor. 3. **Neurological disorders**: FOXD2 has been implicated in the development of neurological disorders, such as epilepsy and schizophrenia. In conclusion, FOXD2 is a critical transcription factor involved in various biological processes, including cell differentiation, morphogenesis, and regulation of gene expression. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the role of FOXD2 in immunology and its potential therapeutic applications. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which FOXD2 regulates gene expression and its role in immune cell development. 2. The development of FOXD2-specific therapeutic strategies may provide new avenues for treating immune system disorders and cancer. 3. The investigation of FOXD2's role in neurological disorders may lead to the identification of novel therapeutic targets for these conditions. By continuing to explore the complexities of FOXD2, we may uncover new insights into the regulation of gene expression and the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 4079186028

Symbol: FOXD2_HUMAN

Name: Forkhead box protein D2

UniProtKB Accession Codes:

O60548 Q5SVZ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9403061

Title: Cloning and characterization of freac-9 (FKHL17), a novel kidney-expressed human forkhead gene that maps to chromosome 1p32-p34.

PubMed ID: 9403061

DOI: 10.1006/geno.1997.4986

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 495
  • Mass: 48748
  • Checksum: E905950E1FA94565
  • Sequence:
    • MTLGSCCCEI MSSESSPAAL SEADADIDVV GGGSGGGELP ARSGPRAPRD VLPHGHEPPA 
EEAEADLAED EEESGGCSDG EPRALASRGA AAAAGSPGPG AAAARGAAGP GPGPPSGGAA 
TRSPLVKPPY SYIALITMAI LQSPKKRLTL SEICEFISGR FPYYREKFPA WQNSIRHNLS 
LNDCFVKIPR EPGNPGKGNY WTLDPESADM FDNGSFLRRR KRFKRQPLPP PHPHPHPHPE 
LLLRGGAAAA GDPGAFLPGF AAYGAYGYGY GLALPAYGAP PPGPAPHPHP HPHAFAFAAA 
AAAAPCQLSV PPGRAAAPPP GPPTASVFAG AGSAPAPAPA SGSGPGPGPA GLPAFLGAEL 
GCAKAFYAAS LSPPAAGTAA GLPTALLRQG LKTDAGGGAG GGGAGAGQRP SFSIDHIMGH 
GGGGAAPPGA GEGSPGPPFA AAAGPGGQAQ VLAMLTAPAL APVAGHIRLS HPGDALLSSG 
SRFASKVAGL SGCHF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.