Details for: FOXD2

Gene ID: 2306

Symbol: FOXD2

Ensembl ID: ENSG00000186564

Description: forkhead box D2

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.91
    Marker Score: 578.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1463
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.61
    Marker Score: 322
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.61
    Marker Score: 192
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.56
    Marker Score: 561.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.54
    Marker Score: 1014.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 255
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7645
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 147
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.44
    Marker Score: 1366
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.42
    Marker Score: 108
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.39
    Marker Score: 235
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.36
    Marker Score: 276
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.34
    Marker Score: 87
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.34
    Marker Score: 803
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.3
    Marker Score: 212
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 287
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 123
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.28
    Marker Score: 396
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.27
    Marker Score: 330
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 150
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.26
    Marker Score: 79
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.24
    Marker Score: 232
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.24
    Marker Score: 562
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.22
    Marker Score: 474
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.21
    Marker Score: 156
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.2
    Marker Score: 75
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.19
    Marker Score: 44
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.18
    Marker Score: 76
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.18
    Marker Score: 61
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.18
    Marker Score: 138
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.18
    Marker Score: 168
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.17
    Marker Score: 79
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.17
    Marker Score: 349
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.16
    Marker Score: 1083
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.16
    Marker Score: 46
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.13
    Marker Score: 54
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.13
    Marker Score: 146
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.12
    Marker Score: 121
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.12
    Marker Score: 121
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.11
    Marker Score: 211
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.1
    Marker Score: 84
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.1
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.08
    Marker Score: 82
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.08
    Marker Score: 81
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.08
    Marker Score: 118
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 80
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.07
    Marker Score: 198
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.07
    Marker Score: 50
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.07
    Marker Score: 752
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.06
    Marker Score: 29.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.06
    Marker Score: 26

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Other Information

**Key characteristics:** * It is a member of the forkhead box (FOXD) family of transcription factors. * It is expressed in a variety of cell types, including neurons, glial cells, and epithelial cells. * It is a key regulator of transcription, with its expression and activity being modulated by a variety of factors, including growth factors, cytokines, and other transcription factors. * It is a key regulator of neuronal differentiation and survival. * It is also involved in the regulation of intestinal development and function. **Pathways and functions:** * FOXD2 is a key regulator of neuronal differentiation. * It is expressed in early T lineage precursor cells, which give rise to neurons and glial cells. * It is also expressed in adult neurons, where it plays a role in maintaining their survival and preventing their apoptosis. * FOXD2 is also involved in the regulation of glial cell development and function. * It is expressed in a variety of glial cell types, including astrocytes, oligodendrocytes, and microglia. * It plays a role in the development and maintenance of the blood-brain barrier. * It is also involved in the regulation of intestinal development and function. **Clinical significance:** FOXD2 is a promising target for the treatment of a variety of diseases, including cancer, neurodegenerative diseases, and inflammatory diseases. By understanding the role of FOXD2 in cancer development and progression, it may be possible to develop new therapies that can inhibit its activity and improve patient outcomes.

Genular Protein ID: 4079186028

Symbol: FOXD2_HUMAN

Name: Forkhead box protein D2

UniProtKB Accession Codes:

O60548 Q5SVZ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9403061

Title: Cloning and characterization of freac-9 (FKHL17), a novel kidney-expressed human forkhead gene that maps to chromosome 1p32-p34.

PubMed ID: 9403061

DOI: 10.1006/geno.1997.4986

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 495
  • Mass: 48748
  • Checksum: E905950E1FA94565
  • Sequence:
    • MTLGSCCCEI MSSESSPAAL SEADADIDVV GGGSGGGELP ARSGPRAPRD VLPHGHEPPA 
EEAEADLAED EEESGGCSDG EPRALASRGA AAAAGSPGPG AAAARGAAGP GPGPPSGGAA 
TRSPLVKPPY SYIALITMAI LQSPKKRLTL SEICEFISGR FPYYREKFPA WQNSIRHNLS 
LNDCFVKIPR EPGNPGKGNY WTLDPESADM FDNGSFLRRR KRFKRQPLPP PHPHPHPHPE 
LLLRGGAAAA GDPGAFLPGF AAYGAYGYGY GLALPAYGAP PPGPAPHPHP HPHAFAFAAA 
AAAAPCQLSV PPGRAAAPPP GPPTASVFAG AGSAPAPAPA SGSGPGPGPA GLPAFLGAEL 
GCAKAFYAAS LSPPAAGTAA GLPTALLRQG LKTDAGGGAG GGGAGAGQRP SFSIDHIMGH 
GGGGAAPPGA GEGSPGPPFA AAAGPGGQAQ VLAMLTAPAL APVAGHIRLS HPGDALLSSG 
SRFASKVAGL SGCHF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.