Details for: FLT3LG

Gene ID: 2323

Symbol: FLT3LG

Ensembl ID: ENSG00000090554

Description: fms related receptor tyrosine kinase 3 ligand

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 46.3531
    Cell Significance Index: -7.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.5046
    Cell Significance Index: -7.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 19.9850
    Cell Significance Index: -10.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.2046
    Cell Significance Index: -7.6500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 5.0972
    Cell Significance Index: 15.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.6334
    Cell Significance Index: 136.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.4677
    Cell Significance Index: 39.5900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.2320
    Cell Significance Index: 22.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.0837
    Cell Significance Index: -6.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9817
    Cell Significance Index: -7.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0446
    Cell Significance Index: 198.7900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.0004
    Cell Significance Index: 8.7500
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.8337
    Cell Significance Index: 4.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6614
    Cell Significance Index: 14.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6217
    Cell Significance Index: 61.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6039
    Cell Significance Index: 98.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5276
    Cell Significance Index: 476.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3941
    Cell Significance Index: 42.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3853
    Cell Significance Index: 23.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2115
    Cell Significance Index: 14.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1896
    Cell Significance Index: 9.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1779
    Cell Significance Index: 5.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1437
    Cell Significance Index: 18.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1029
    Cell Significance Index: 14.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0971
    Cell Significance Index: 4.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0956
    Cell Significance Index: 3.3600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0595
    Cell Significance Index: 0.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0509
    Cell Significance Index: 9.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0509
    Cell Significance Index: 22.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0391
    Cell Significance Index: 0.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0252
    Cell Significance Index: 0.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0180
    Cell Significance Index: 2.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0161
    Cell Significance Index: 1.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0146
    Cell Significance Index: 2.9300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0116
    Cell Significance Index: 0.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0081
    Cell Significance Index: 2.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0005
    Cell Significance Index: 0.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0067
    Cell Significance Index: -5.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0071
    Cell Significance Index: -9.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0076
    Cell Significance Index: -4.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0101
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0115
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0134
    Cell Significance Index: -7.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0155
    Cell Significance Index: -9.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0170
    Cell Significance Index: -2.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0172
    Cell Significance Index: -0.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0200
    Cell Significance Index: -0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0213
    Cell Significance Index: -9.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0250
    Cell Significance Index: -0.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0294
    Cell Significance Index: -8.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0307
    Cell Significance Index: -2.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0370
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0374
    Cell Significance Index: -6.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0406
    Cell Significance Index: -2.1100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0422
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0464
    Cell Significance Index: -9.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0508
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0554
    Cell Significance Index: -6.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0638
    Cell Significance Index: -9.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0713
    Cell Significance Index: -4.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0754
    Cell Significance Index: -7.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0761
    Cell Significance Index: -5.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0765
    Cell Significance Index: -4.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0771
    Cell Significance Index: -1.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0784
    Cell Significance Index: -3.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0812
    Cell Significance Index: -6.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0836
    Cell Significance Index: -1.2600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0917
    Cell Significance Index: -0.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0937
    Cell Significance Index: -3.0000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1005
    Cell Significance Index: -0.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1080
    Cell Significance Index: -5.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1144
    Cell Significance Index: -6.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1250
    Cell Significance Index: -1.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1258
    Cell Significance Index: -7.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1308
    Cell Significance Index: -10.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1356
    Cell Significance Index: -1.8500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1362
    Cell Significance Index: -0.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1484
    Cell Significance Index: -3.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1534
    Cell Significance Index: -2.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1580
    Cell Significance Index: -6.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1656
    Cell Significance Index: -7.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1677
    Cell Significance Index: -4.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1691
    Cell Significance Index: -4.5300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1728
    Cell Significance Index: -1.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1761
    Cell Significance Index: -6.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1800
    Cell Significance Index: -7.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1973
    Cell Significance Index: -6.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1978
    Cell Significance Index: -6.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1998
    Cell Significance Index: -1.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2098
    Cell Significance Index: -7.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2126
    Cell Significance Index: -5.4300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2155
    Cell Significance Index: -3.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2165
    Cell Significance Index: -8.2000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2292
    Cell Significance Index: -1.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FLT3LG is a ligand for the Fms-related tyrosine kinase 3 (FLT3) receptor, which is a transmembrane receptor tyrosine kinase. FLT3LG is a secreted protein that binds to FLT3, activating its tyrosine kinase activity and triggering a cascade of downstream signaling events. The FLT3LG/FLT3 interaction is essential for the activation of various signaling pathways, including the PI3K/AKT, MAPK, and JAK/STAT pathways. FLT3LG is highly expressed in hematopoietic cells, particularly in T cells, and its expression is regulated by various transcription factors and cytokines. **Pathways and Functions** The FLT3LG/FLT3 interaction activates several signaling pathways that are crucial for the development, differentiation, and function of T cells. The PI3K/AKT pathway is activated through the binding of FLT3LG to FLT3, leading to the phosphorylation and activation of AKT, a key regulator of cell survival and proliferation. The MAPK pathway is also activated, leading to the phosphorylation and activation of MAPK kinases, which regulate various cellular processes, including cell proliferation, differentiation, and apoptosis. Additionally, the JAK/STAT pathway is activated, leading to the phosphorylation and activation of STAT proteins, which regulate gene expression and cytokine production. FLT3LG plays a critical role in the regulation of T cell development and function, particularly in the development of T-helper 22 cells, which are essential for the regulation of immune responses. FLT3LG also regulates the proliferation and differentiation of other immune cells, including mature alpha-beta T cells and gamma-delta T cells. Furthermore, FLT3LG has been implicated in the regulation of other cellular processes, including cell survival, apoptosis, and angiogenesis. **Clinical Significance** Abnormal expression of FLT3LG has been implicated in several diseases, including leukemia. Mutations in the FLT3 gene, which encodes the FLT3 receptor, are commonly found in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). FLT3LG has been shown to contribute to the development and progression of these diseases by activating the FLT3 signaling pathway and promoting the proliferation and survival of leukemic cells. Additionally, FLT3LG has been implicated in other diseases, including autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, where it may contribute to the regulation of immune responses. In summary, FLT3LG is a critical gene involved in the regulation of hematopoiesis, particularly in the development and function of T cells. Its abnormal expression has been implicated in several diseases, including leukemia and autoimmune disorders. Further research is needed to fully understand the mechanisms by which FLT3LG regulates T cell development and function, as well as its role in disease pathogenesis.

Genular Protein ID: 201836024

Symbol: FLT3L_HUMAN

Name: Fms-related tyrosine kinase 3 ligand

UniProtKB Accession Codes:

P49771 A0AVC2 B9EGH2 Q05C96

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 10 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8145851

Title: Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs.

PubMed ID: 8145851

DOI: 10.1038/368643a0

PubMed ID: 8180375

Title: Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells.

PubMed ID: 8180375

PubMed ID: 7566977

Title: Structural analysis of human and murine flt3 ligand genomic loci.

PubMed ID: 7566977

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10881197

Title: Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.

PubMed ID: 10881197

DOI: 10.1038/75896

Sequence Information:

  • Length: 235
  • Mass: 26416
  • Checksum: 73B95BF693B4CECF
  • Sequence:
    • MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD YLLQDYPVTV 
ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER VNTEIHFVTK CAFQPPPSCL 
RFVQTNISRL LQETSEQLVA LKPWITRQNF SRCLELQCQP DSSTLPPPWS PRPLEATAPT 
APQPPLLLLL LLPVGLLLLA AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH

Genular Protein ID: 468444584

Symbol: B7ZLY4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLY4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 3 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 235
  • Mass: 26416
  • Checksum: 0564EBF693B4CADB
  • Sequence:
    • MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD YLLQDYPVTV 
ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER VNTEIHFVTK CAFQPPPSCL 
RFVQTNISRL LQETSEQLVA LKPWITRQNF SRCLELQCQP DSSTLPPPWS PRPLEATAPT 
APQPPLLLIL LLPVGLLLLA AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.