Details for: FLT3LG

Gene ID: 2323

Symbol: FLT3LG

Ensembl ID: ENSG00000090554

Description: fms related receptor tyrosine kinase 3 ligand

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.85
    Marker Score: 12202
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.78
    Marker Score: 147123
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.27
    Marker Score: 14489
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.92
    Marker Score: 1403
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.77
    Marker Score: 5600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.7
    Marker Score: 16846
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.46
    Marker Score: 3014
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.43
    Marker Score: 2052.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.4
    Marker Score: 1512
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.32
    Marker Score: 2510.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.22
    Marker Score: 880
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.2
    Marker Score: 2055
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4775
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.06
    Marker Score: 940
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.04
    Marker Score: 975
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.04
    Marker Score: 2039
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.03
    Marker Score: 730
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71781
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48006
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.94
    Marker Score: 1296
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.94
    Marker Score: 206
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5250
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.92
    Marker Score: 620
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 359.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.89
    Marker Score: 447
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.89
    Marker Score: 1311
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.89
    Marker Score: 368
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.89
    Marker Score: 545
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13585
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.87
    Marker Score: 558
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.86
    Marker Score: 940
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.85
    Marker Score: 677
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.84
    Marker Score: 326
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.84
    Marker Score: 1492
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.82
    Marker Score: 1857
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.82
    Marker Score: 623
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.79
    Marker Score: 5262
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.78
    Marker Score: 661
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1241
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.76
    Marker Score: 8849
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.74
    Marker Score: 815
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.73
    Marker Score: 285
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.73
    Marker Score: 2043.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 657
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.72
    Marker Score: 523
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.68
    Marker Score: 659
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.67
    Marker Score: 169
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.61
    Marker Score: 185
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.6
    Marker Score: 210
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 360
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 276
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.55
    Marker Score: 452.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 352
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.54
    Marker Score: 766
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.54
    Marker Score: 1489
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.54
    Marker Score: 315
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.52
    Marker Score: 1015
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.52
    Marker Score: 267
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.51
    Marker Score: 311
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.5
    Marker Score: 424
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.49
    Marker Score: 2125
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.49
    Marker Score: 211
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.49
    Marker Score: 211
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.47
    Marker Score: 341
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.46
    Marker Score: 121
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.46
    Marker Score: 2737
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.45
    Marker Score: 141
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.45
    Marker Score: 457
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.45
    Marker Score: 439
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.44
    Marker Score: 253
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.43
    Marker Score: 405
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.43
    Marker Score: 189.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.43
    Marker Score: 132
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.41
    Marker Score: 324
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.41
    Marker Score: 666
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 127
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.4
    Marker Score: 943.5
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.39
    Marker Score: 89
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.39
    Marker Score: 957
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.39
    Marker Score: 285
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.39
    Marker Score: 410.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.39
    Marker Score: 514.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.38
    Marker Score: 386
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.38
    Marker Score: 12853
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 211
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.37
    Marker Score: 217
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.35
    Marker Score: 121

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * FLT3LG is a glycoprotein that is expressed in high levels in T cells and other immune cells. * It is a ligand for the Flt3 receptor, which is a tyrosine kinase that is expressed in high levels on T cells and other immune cells. * Binding of FLT3LG to Flt3 activates the PI3K/AKT pathway, which is a major signaling pathway involved in cell growth, proliferation, and survival. **Pathways and functions:** * FLT3LG is a ligand for the Flt3 receptor, which is a tyrosine kinase that is expressed in high levels on T cells and other immune cells. * Binding of FLT3LG to Flt3 activates the PI3K/AKT pathway, which is a major signaling pathway involved in cell growth, proliferation, and survival. * The PI3K/AKT pathway is involved in a variety of cellular processes, including cell cycle regulation, proliferation, differentiation, and survival. * Dysregulation of the PI3K/AKT pathway has been linked to cancer development and progression. **Clinical significance:** * Mutations in the FLT3LG gene have been linked to the development of several types of cancer, including breast cancer, lung cancer, and leukemia. * Targeting the PI3K/AKT pathway with inhibitors has shown to be effective in treating cancer in preclinical models. * Therefore, FLT3LG is a promising target for the development of novel cancer therapies.

Genular Protein ID: 201836024

Symbol: FLT3L_HUMAN

Name: Fms-related tyrosine kinase 3 ligand

UniProtKB Accession Codes:

P49771 A0AVC2 B9EGH2 Q05C96

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 6 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 10 RefSeq 6 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8145851

Title: Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs.

PubMed ID: 8145851

DOI: 10.1038/368643a0

PubMed ID: 8180375

Title: Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells.

PubMed ID: 8180375

PubMed ID: 7566977

Title: Structural analysis of human and murine flt3 ligand genomic loci.

PubMed ID: 7566977

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10881197

Title: Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.

PubMed ID: 10881197

DOI: 10.1038/75896

Sequence Information:

  • Length: 235
  • Mass: 26416
  • Checksum: 73B95BF693B4CECF
  • Sequence:
    • MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD YLLQDYPVTV 
ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER VNTEIHFVTK CAFQPPPSCL 
RFVQTNISRL LQETSEQLVA LKPWITRQNF SRCLELQCQP DSSTLPPPWS PRPLEATAPT 
APQPPLLLLL LLPVGLLLLA AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH

Genular Protein ID: 468444584

Symbol: B7ZLY4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLY4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 3 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 235
  • Mass: 26416
  • Checksum: 0564EBF693B4CADB
  • Sequence:
    • MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD YLLQDYPVTV 
ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER VNTEIHFVTK CAFQPPPSCL 
RFVQTNISRL LQETSEQLVA LKPWITRQNF SRCLELQCQP DSSTLPPPWS PRPLEATAPT 
APQPPLLLIL LLPVGLLLLA AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.