Details for: RPL13A

Gene ID: 23521

Symbol: RPL13A

Ensembl ID: ENSG00000142541

Description: ribosomal protein L13a

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 7.88
    Marker Score: 4,442
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.81
    Marker Score: 4,215
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 5.63
    Marker Score: 2,896
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 5.6
    Marker Score: 4,230
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.58
    Marker Score: 11,701
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.52
    Marker Score: 74,188
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.47
    Marker Score: 7,129
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 5.42
    Marker Score: 26,633
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.41
    Marker Score: 4,238
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 5.36
    Marker Score: 1,976
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 5.3
    Marker Score: 3,741
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 5.29
    Marker Score: 3,410
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.26
    Marker Score: 15,352
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.26
    Marker Score: 52,046
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 5.19
    Marker Score: 2,681
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 5.16
    Marker Score: 4,399
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.12
    Marker Score: 3,672
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.06
    Marker Score: 7,792
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 5
    Marker Score: 8,583
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.93
    Marker Score: 4,400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.83
    Marker Score: 2,075
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.73
    Marker Score: 24,878
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.67
    Marker Score: 159,046
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.65
    Marker Score: 1,111
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.61
    Marker Score: 14,538
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.6
    Marker Score: 243,360
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.58
    Marker Score: 1,488
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.48
    Marker Score: 5,411
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.47
    Marker Score: 58,984
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.44
    Marker Score: 4,936
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.4
    Marker Score: 2,679
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.38
    Marker Score: 18,245
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.36
    Marker Score: 27,817
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.34
    Marker Score: 11,985
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.32
    Marker Score: 4,075
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.26
    Marker Score: 25,882
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 4.25
    Marker Score: 989
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.23
    Marker Score: 10,764
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 4.23
    Marker Score: 2,481
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.22
    Marker Score: 49,101
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.21
    Marker Score: 10,286
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.19
    Marker Score: 5,168
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.18
    Marker Score: 11,722
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.17
    Marker Score: 9,497
  • Cell Name: club cell (CL0000158)
    Fold Change: 4.16
    Marker Score: 4,851
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 4.15
    Marker Score: 2,344
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 4.12
    Marker Score: 3,138
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.1
    Marker Score: 229,304
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 4.1
    Marker Score: 939
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 4.09
    Marker Score: 5,950
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.09
    Marker Score: 7,679
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.07
    Marker Score: 3,471
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.06
    Marker Score: 3,921
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.05
    Marker Score: 4,326
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.04
    Marker Score: 17,329
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.02
    Marker Score: 1,809
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4
    Marker Score: 3,940
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.99
    Marker Score: 1,281
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 3.99
    Marker Score: 1,090
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.98
    Marker Score: 3,127
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.97
    Marker Score: 9,900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.96
    Marker Score: 4,255
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.95
    Marker Score: 1,122
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.94
    Marker Score: 25,709
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.94
    Marker Score: 2,103
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.93
    Marker Score: 2,038
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.93
    Marker Score: 4,737
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.93
    Marker Score: 2,033
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.92
    Marker Score: 1,032
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.92
    Marker Score: 1,430
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 3.9
    Marker Score: 947
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.88
    Marker Score: 2,703
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.88
    Marker Score: 1,093
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.85
    Marker Score: 1,758
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.83
    Marker Score: 3,415
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.83
    Marker Score: 1,260
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.82
    Marker Score: 3,371
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.81
    Marker Score: 2,342
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.81
    Marker Score: 1,587
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.81
    Marker Score: 2,101
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.8
    Marker Score: 1,007
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.8
    Marker Score: 3,404
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 3.79
    Marker Score: 2,590
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.79
    Marker Score: 1,082
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.79
    Marker Score: 3,263
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.78
    Marker Score: 941
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.75
    Marker Score: 5,969
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 3.75
    Marker Score: 1,126
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.74
    Marker Score: 4,378
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.73
    Marker Score: 3,606
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.72
    Marker Score: 27,717
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.72
    Marker Score: 2,813
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.72
    Marker Score: 4,111
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.72
    Marker Score: 6,767
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.71
    Marker Score: 1,278
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 3.7
    Marker Score: 1,044
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.7
    Marker Score: 1,658
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 3.7
    Marker Score: 1,009
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.69
    Marker Score: 2,483
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.68
    Marker Score: 13,060

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL13A is a highly basic protein, with an estimated molecular weight of 23 kDa. It is a member of the ribosomal protein L13 family, which plays a pivotal role in the regulation of protein synthesis. RPL13A is specifically localized to the large ribosomal subunit, where it interacts with other ribosomal proteins to facilitate the translation process. The protein exhibits a high degree of conservation across species, suggesting its essential function in cellular biology. **Pathways and Functions** RPL13A is involved in various cellular pathways, including: 1. **Translation initiation**: RPL13A plays a crucial role in the recruitment of ribosomal subunits to mRNA, facilitating the initiation of translation. 2. **Translation elongation**: RPL13A interacts with other ribosomal proteins to promote the elongation of peptide chains during translation. 3. **Translation termination**: RPL13A is involved in the regulation of translation termination, ensuring the accurate completion of protein synthesis. 4. **Cellular responses to stress**: RPL13A is activated in response to cellular stress, such as amino acid deficiency, and plays a role in regulating the expression of genes involved in stress response. 5. **Immune response**: RPL13A is expressed in immune cells, including T cells and B cells, and is involved in the regulation of immune response, including the activation of natural T regulatory cells. **Clinical Significance** Dysregulation of RPL13A has been implicated in various diseases, including: 1. **Cancer**: Overexpression of RPL13A has been observed in various types of cancer, including pancreatic cancer, suggesting its potential role as a tumor suppressor. 2. **Neurodegenerative diseases**: Mutations in the RPL13A gene have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: RPL13A has been shown to play a role in the regulation of viral infection pathways, including influenza and HIV. 4. **Metabolic disorders**: RPL13A is involved in the regulation of amino acid metabolism, and dysregulation of the gene has been implicated in metabolic disorders, such as diabetes. In conclusion, RPL13A is a critical component of the large ribosomal subunit, playing a vital role in the regulation of protein synthesis, cell growth, and development. Its dysregulation has been implicated in various diseases, highlighting its importance as a potential therapeutic target. Further research is necessary to fully elucidate the functions and clinical significance of RPL13A.

Genular Protein ID: 1719417308

Symbol: RL13A_HUMAN

Name: 23 kDa highly basic protein

UniProtKB Accession Codes:

P40429 A8K505

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 11 EMDB 68 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 85 PDBsum 81 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1282492

Title: Conservation of a 23-kDa human transplantation antigen in mammalian species.

PubMed ID: 1282492

DOI: 10.1016/s0888-7543(05)80117-x

PubMed ID: 10580157

Title: Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome.

PubMed ID: 10580157

DOI: 10.1016/s0378-1119(99)00429-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14567916

Title: Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.

PubMed ID: 14567916

DOI: 10.1016/s0092-8674(03)00773-6

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 15479637

Title: Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation.

PubMed ID: 15479637

DOI: 10.1016/j.cell.2004.09.030

PubMed ID: 17218275

Title: L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control.

PubMed ID: 17218275

DOI: 10.1016/j.molcel.2006.11.028

PubMed ID: 17921318

Title: Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation.

PubMed ID: 17921318

DOI: 10.1261/rna.694007

PubMed ID: 18995835

Title: DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.

PubMed ID: 18995835

DOI: 10.1016/j.molcel.2008.09.019

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23071094

Title: Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages.

PubMed ID: 23071094

DOI: 10.1128/mcb.01168-12

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 203
  • Mass: 23577
  • Checksum: 3E80D0AB77A0D406
  • Sequence:
    • MAEVQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN KLKYLAFLRK 
RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALD RLKVFDGIPP PYDKKKRMVV 
PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ AVTATLEEKR KEKAKIHYRK KKQLMRLRKQ 
AEKNVEKKID KYTEVLKTHG LLV

Genular Protein ID: 3315893673

Symbol: Q8J015_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8J015

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 142
  • Mass: 16731
  • Checksum: F67CCD5F7D3E9396
  • Sequence:
    • MNTNPSRGPY HFRAPSRIFW RTVRGMLPHK TKRGQAALDR LKVFDGIPPP YDKKKRMVVP 
AALKVVRLKP TRKFAYLGRL AHEVGWKYQA VTATLEEKRK EKAKIHYRKK KQLMRLRKQA 
EKNVEKKIDK YTEVLKTHGL LV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.