Details for: RPL13A

Gene ID: 23521

Symbol: RPL13A

Ensembl ID: ENSG00000142541

Description: ribosomal protein L13a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 806.0491
    Cell Significance Index: -332.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 714.7198
    Cell Significance Index: -290.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 662.4973
    Cell Significance Index: -312.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 620.0606
    Cell Significance Index: -318.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 469.2245
    Cell Significance Index: -314.8600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 27.0739
    Cell Significance Index: 159.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 22.8425
    Cell Significance Index: 583.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.1578
    Cell Significance Index: -54.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 19.0698
    Cell Significance Index: 1947.9700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 17.5549
    Cell Significance Index: 266.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 14.6656
    Cell Significance Index: 509.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.1439
    Cell Significance Index: 378.3400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 12.9832
    Cell Significance Index: 229.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 11.9357
    Cell Significance Index: 1542.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 11.9006
    Cell Significance Index: 312.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 10.4607
    Cell Significance Index: 779.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 9.9800
    Cell Significance Index: 523.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 9.7374
    Cell Significance Index: 203.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.4708
    Cell Significance Index: 1707.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.4657
    Cell Significance Index: 1299.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.3866
    Cell Significance Index: 1154.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.9669
    Cell Significance Index: 418.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.6932
    Cell Significance Index: 1114.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.6570
    Cell Significance Index: 612.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.4096
    Cell Significance Index: 194.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.0587
    Cell Significance Index: 91.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.0549
    Cell Significance Index: 3561.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.9063
    Cell Significance Index: 371.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.6645
    Cell Significance Index: 61.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.1864
    Cell Significance Index: 463.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.1719
    Cell Significance Index: 3916.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.0654
    Cell Significance Index: 76.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 6.4131
    Cell Significance Index: 4854.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 5.8083
    Cell Significance Index: 263.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.5161
    Cell Significance Index: 150.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.4040
    Cell Significance Index: 637.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.1362
    Cell Significance Index: 877.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.7465
    Cell Significance Index: 136.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 4.7074
    Cell Significance Index: 4250.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.1293
    Cell Significance Index: 38.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.4560
    Cell Significance Index: 92.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.8809
    Cell Significance Index: 84.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7596
    Cell Significance Index: 547.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.7130
    Cell Significance Index: 268.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.7145
    Cell Significance Index: 21.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4762
    Cell Significance Index: 160.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4376
    Cell Significance Index: 273.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2416
    Cell Significance Index: 35.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.9973
    Cell Significance Index: 78.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.9507
    Cell Significance Index: 697.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7385
    Cell Significance Index: 41.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4597
    Cell Significance Index: 23.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4158
    Cell Significance Index: 67.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2478
    Cell Significance Index: 4.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0887
    Cell Significance Index: -167.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1243
    Cell Significance Index: -92.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1348
    Cell Significance Index: -248.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1716
    Cell Significance Index: -264.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1880
    Cell Significance Index: -6.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2087
    Cell Significance Index: -74.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2371
    Cell Significance Index: -322.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2787
    Cell Significance Index: -157.1500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3017
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3257
    Cell Significance Index: -203.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3290
    Cell Significance Index: -94.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3974
    Cell Significance Index: -252.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5369
    Cell Significance Index: -18.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6282
    Cell Significance Index: -285.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6396
    Cell Significance Index: -39.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6839
    Cell Significance Index: -144.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.8619
    Cell Significance Index: -172.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0012
    Cell Significance Index: -17.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.3108
    Cell Significance Index: -150.1700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.6235
    Cell Significance Index: -11.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.9007
    Cell Significance Index: -276.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.9558
    Cell Significance Index: -223.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.0202
    Cell Significance Index: -33.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.0310
    Cell Significance Index: -128.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.1068
    Cell Significance Index: -145.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.2774
    Cell Significance Index: -56.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.9873
    Cell Significance Index: -311.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -3.2108
    Cell Significance Index: -19.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.5071
    Cell Significance Index: -52.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.8014
    Cell Significance Index: -291.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -4.1981
    Cell Significance Index: -282.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.2548
    Cell Significance Index: -92.1800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -4.2570
    Cell Significance Index: -25.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.2914
    Cell Significance Index: -263.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.8132
    Cell Significance Index: -65.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.3185
    Cell Significance Index: -63.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -5.5749
    Cell Significance Index: -290.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.7835
    Cell Significance Index: -170.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -5.8907
    Cell Significance Index: -100.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -7.1926
    Cell Significance Index: -318.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -7.4737
    Cell Significance Index: -200.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -7.6621
    Cell Significance Index: -281.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -8.1344
    Cell Significance Index: -158.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -8.1729
    Cell Significance Index: -169.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -8.6029
    Cell Significance Index: -46.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -8.6790
    Cell Significance Index: -328.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPL13A is a highly basic protein, with an estimated molecular weight of 23 kDa. It is a member of the ribosomal protein L13 family, which plays a pivotal role in the regulation of protein synthesis. RPL13A is specifically localized to the large ribosomal subunit, where it interacts with other ribosomal proteins to facilitate the translation process. The protein exhibits a high degree of conservation across species, suggesting its essential function in cellular biology. **Pathways and Functions** RPL13A is involved in various cellular pathways, including: 1. **Translation initiation**: RPL13A plays a crucial role in the recruitment of ribosomal subunits to mRNA, facilitating the initiation of translation. 2. **Translation elongation**: RPL13A interacts with other ribosomal proteins to promote the elongation of peptide chains during translation. 3. **Translation termination**: RPL13A is involved in the regulation of translation termination, ensuring the accurate completion of protein synthesis. 4. **Cellular responses to stress**: RPL13A is activated in response to cellular stress, such as amino acid deficiency, and plays a role in regulating the expression of genes involved in stress response. 5. **Immune response**: RPL13A is expressed in immune cells, including T cells and B cells, and is involved in the regulation of immune response, including the activation of natural T regulatory cells. **Clinical Significance** Dysregulation of RPL13A has been implicated in various diseases, including: 1. **Cancer**: Overexpression of RPL13A has been observed in various types of cancer, including pancreatic cancer, suggesting its potential role as a tumor suppressor. 2. **Neurodegenerative diseases**: Mutations in the RPL13A gene have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: RPL13A has been shown to play a role in the regulation of viral infection pathways, including influenza and HIV. 4. **Metabolic disorders**: RPL13A is involved in the regulation of amino acid metabolism, and dysregulation of the gene has been implicated in metabolic disorders, such as diabetes. In conclusion, RPL13A is a critical component of the large ribosomal subunit, playing a vital role in the regulation of protein synthesis, cell growth, and development. Its dysregulation has been implicated in various diseases, highlighting its importance as a potential therapeutic target. Further research is necessary to fully elucidate the functions and clinical significance of RPL13A.

Genular Protein ID: 1719417308

Symbol: RL13A_HUMAN

Name: 23 kDa highly basic protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1282492

Title: Conservation of a 23-kDa human transplantation antigen in mammalian species.

PubMed ID: 1282492

DOI: 10.1016/s0888-7543(05)80117-x

PubMed ID: 10580157

Title: Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome.

PubMed ID: 10580157

DOI: 10.1016/s0378-1119(99)00429-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14567916

Title: Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.

PubMed ID: 14567916

DOI: 10.1016/s0092-8674(03)00773-6

PubMed ID: 12962325

Title: Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing.

PubMed ID: 12962325

DOI: 10.1023/a:1025068419698

PubMed ID: 15479637

Title: Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation.

PubMed ID: 15479637

DOI: 10.1016/j.cell.2004.09.030

PubMed ID: 17218275

Title: L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control.

PubMed ID: 17218275

DOI: 10.1016/j.molcel.2006.11.028

PubMed ID: 17921318

Title: Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation.

PubMed ID: 17921318

DOI: 10.1261/rna.694007

PubMed ID: 18995835

Title: DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.

PubMed ID: 18995835

DOI: 10.1016/j.molcel.2008.09.019

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23071094

Title: Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages.

PubMed ID: 23071094

DOI: 10.1128/mcb.01168-12

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 203
  • Mass: 23577
  • Checksum: 3E80D0AB77A0D406
  • Sequence:
  • MAEVQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN KLKYLAFLRK 
    RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALD RLKVFDGIPP PYDKKKRMVV 
    PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ AVTATLEEKR KEKAKIHYRK KKQLMRLRKQ 
    AEKNVEKKID KYTEVLKTHG LLV

Genular Protein ID: 3315893673

Symbol: Q8J015_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 142
  • Mass: 16731
  • Checksum: F67CCD5F7D3E9396
  • Sequence:
  • MNTNPSRGPY HFRAPSRIFW RTVRGMLPHK TKRGQAALDR LKVFDGIPPP YDKKKRMVVP 
    AALKVVRLKP TRKFAYLGRL AHEVGWKYQA VTATLEEKRK EKAKIHYRKK KQLMRLRKQA 
    EKNVEKKIDK YTEVLKTHGL LV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.