Details for: TP53TG3

Gene ID: 24150

Symbol: TP53TG3

Ensembl ID: ENSG00000183632

Description: TP53 target 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 9.5
    Marker Score: 5,261
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.75
    Marker Score: 3,788
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.4
    Marker Score: 1,263
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.58
    Marker Score: 660
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,584
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,660
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,736
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 742
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.71
    Marker Score: 414
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 425
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 248
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.36
    Marker Score: 2,413
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.31
    Marker Score: 89
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.17
    Marker Score: 296
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.15
    Marker Score: 222
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.11
    Marker Score: 85
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.07
    Marker Score: 255
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.07
    Marker Score: 427
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.06
    Marker Score: 88
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.01
    Marker Score: 150
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: T cell (CL0000084)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0
    Marker Score: 95
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 43
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 5

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TP53 interaction**: TP53TG3 is a direct target of the TP53 protein, a well-established tumor suppressor. The interaction between TP53 and TP53TG3 regulates various cellular processes, including cell cycle arrest, apoptosis, and DNA repair. 2. **Widespread expression**: TP53TG3 is expressed in a variety of cell types, including hematopoietic stem cells, erythrocytes, and neoplastic cells. Its expression is also found in absorptive cells, intestinal crypt stem cells, and transit amplifying cells. 3. **Cytoplasmic and nuclear localization**: TP53TG3 is localized to both the cytoplasm and nucleus, where it interacts with TP53 and other proteins to regulate cellular processes. 4. **Pathway involvement**: TP53TG3 is involved in various cellular pathways, including the cell cycle, apoptosis, and DNA repair. Its dysregulation can lead to the development of cancer. **Pathways and Functions:** 1. **Cell cycle regulation**: TP53TG3 regulates the cell cycle by interacting with TP53 and other proteins to prevent the progression of cells with damaged DNA. 2. **Apoptosis**: TP53TG3 promotes apoptosis, or programmed cell death, in response to DNA damage or other cellular stresses. 3. **DNA repair**: TP53TG3 is involved in DNA repair processes, including nucleotide excision repair and mismatch repair. 4. **Oxidative stress response**: TP53TG3 is also involved in the response to oxidative stress, which can lead to DNA damage and cell death. **Clinical Significance:** 1. **Cancer diagnosis and prognosis**: The dysregulation of TP53TG3 has been implicated in various cancers, including breast, lung, and colon cancer. Its expression can serve as a biomarker for cancer diagnosis and prognosis. 2. **Therapeutic targeting**: TP53TG3 is a potential therapeutic target for cancer treatment. Inhibiting TP53TG3 may lead to the restoration of normal cellular function and the inhibition of tumor growth. 3. **Genetic predisposition**: TP53TG3 mutations have been associated with genetic predisposition to cancer. Understanding the function of TP53TG3 can provide insights into the development of cancer in individuals with genetic mutations. 4. **Gene therapy**: TP53TG3 may be a target for gene therapy, where the gene is modified or replaced to restore normal function and prevent disease. In conclusion, TP53TG3 is a critical gene involved in maintaining genomic stability and preventing tumorigenesis. Its dysregulation has been implicated in various diseases, including cancer. Further research is needed to fully understand the function and clinical significance of TP53TG3, but its potential as a therapeutic target and biomarker for cancer diagnosis and prognosis is significant.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.