Details for: FUCA2

Gene ID: 2519

Symbol: FUCA2

Ensembl ID: ENSG00000001036

Description: alpha-L-fucosidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.9407
    Cell Significance Index: -28.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.6922
    Cell Significance Index: -28.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.0665
    Cell Significance Index: -33.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.2511
    Cell Significance Index: -26.9200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.3937
    Cell Significance Index: -31.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.3506
    Cell Significance Index: -27.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.0131
    Cell Significance Index: -30.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4060
    Cell Significance Index: -30.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9142
    Cell Significance Index: -31.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9255
    Cell Significance Index: -18.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.3038
    Cell Significance Index: 501.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0018
    Cell Significance Index: 53.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3688
    Cell Significance Index: 12.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2074
    Cell Significance Index: 196.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0648
    Cell Significance Index: 146.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0189
    Cell Significance Index: 52.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8544
    Cell Significance Index: 18.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8446
    Cell Significance Index: 461.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8127
    Cell Significance Index: 37.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7915
    Cell Significance Index: 142.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6421
    Cell Significance Index: 127.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5437
    Cell Significance Index: 37.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5192
    Cell Significance Index: 63.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5178
    Cell Significance Index: 23.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4812
    Cell Significance Index: 13.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3252
    Cell Significance Index: 55.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3020
    Cell Significance Index: 7.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2959
    Cell Significance Index: 7.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2556
    Cell Significance Index: 51.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2035
    Cell Significance Index: 26.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1966
    Cell Significance Index: 3.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1953
    Cell Significance Index: 10.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1953
    Cell Significance Index: 14.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1799
    Cell Significance Index: 17.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1768
    Cell Significance Index: 122.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1654
    Cell Significance Index: 12.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1531
    Cell Significance Index: 2.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1492
    Cell Significance Index: 28.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1432
    Cell Significance Index: 51.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1352
    Cell Significance Index: 4.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0917
    Cell Significance Index: 2.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0751
    Cell Significance Index: 2.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0565
    Cell Significance Index: 0.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0556
    Cell Significance Index: 50.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0553
    Cell Significance Index: 24.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0487
    Cell Significance Index: 0.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0317
    Cell Significance Index: 4.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0262
    Cell Significance Index: 0.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0238
    Cell Significance Index: 0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0036
    Cell Significance Index: 5.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0029
    Cell Significance Index: 5.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0013
    Cell Significance Index: 0.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0012
    Cell Significance Index: -0.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0026
    Cell Significance Index: -3.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0083
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0086
    Cell Significance Index: -6.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -6.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0182
    Cell Significance Index: -11.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0231
    Cell Significance Index: -14.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0284
    Cell Significance Index: -16.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0378
    Cell Significance Index: -17.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0398
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0530
    Cell Significance Index: -6.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0604
    Cell Significance Index: -12.7300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0714
    Cell Significance Index: -0.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0809
    Cell Significance Index: -23.2700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0869
    Cell Significance Index: -0.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0976
    Cell Significance Index: -11.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0987
    Cell Significance Index: -14.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1106
    Cell Significance Index: -12.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1400
    Cell Significance Index: -2.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1586
    Cell Significance Index: -11.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1754
    Cell Significance Index: -4.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2004
    Cell Significance Index: -10.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2387
    Cell Significance Index: -6.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2393
    Cell Significance Index: -6.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2662
    Cell Significance Index: -16.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2690
    Cell Significance Index: -4.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2748
    Cell Significance Index: -4.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2872
    Cell Significance Index: -29.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3184
    Cell Significance Index: -6.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3400
    Cell Significance Index: -17.7100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3413
    Cell Significance Index: -2.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3504
    Cell Significance Index: -27.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3526
    Cell Significance Index: -22.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3601
    Cell Significance Index: -24.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3745
    Cell Significance Index: -5.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4295
    Cell Significance Index: -26.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4475
    Cell Significance Index: -19.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5290
    Cell Significance Index: -20.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5466
    Cell Significance Index: -28.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5486
    Cell Significance Index: -8.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5536
    Cell Significance Index: -34.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5774
    Cell Significance Index: -6.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5795
    Cell Significance Index: -17.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5906
    Cell Significance Index: -15.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6252
    Cell Significance Index: -18.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6712
    Cell Significance Index: -27.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6745
    Cell Significance Index: -17.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme Function:** FUCA2 is a lysosomal alpha-L-fucosidase, responsible for the hydrolysis of alpha-L-fucosidic linkages in glycoconjugates, such as glycoproteins and glycolipids. 2. **Cellular Distribution:** FUCA2 is expressed in a wide range of cell types, including immune cells (e.g., neutrophils, macrophages), stem cells, epithelial cells, and osteoclasts. 3. **Tissue Distribution:** FUCA2 is found in various tissues, including the ovary, bladder, and lung, where it is involved in the regulation of immune responses and metabolic processes. **Pathways and Functions:** 1. **Immune Response:** FUCA2 plays a critical role in the regulation of immune responses, including neutrophil degranulation, innate immune system activation, and response to bacterial infections. 2. **Metabolic Processes:** FUCA2 is involved in the catabolism of glycoconjugates, which is essential for maintaining cellular homeostasis and regulating metabolic pathways, including protein metabolism and insulin-like growth factor (IGF) transport. 3. **Regulation of Cell Signaling:** FUCA2 modulates the activity of various signaling pathways, including protein phosphorylation, post-translational protein modification, and regulation of entry of bacteria into host cells. 4. **Extracellular Matrix Regulation:** FUCA2 influences the structure and function of the extracellular matrix, which is essential for maintaining tissue integrity and regulating cell migration and adhesion. **Clinical Significance:** 1. **Dysregulation in Disease:** FUCA2 dysregulation has been implicated in various diseases, including cancer (e.g., colorectal cancer, pancreatic cancer), inflammatory disorders (e.g., rheumatoid arthritis, asthma), and metabolic disorders (e.g., diabetes, obesity). 2. **Cancer Metastasis:** FUCA2 is involved in the regulation of metastasis, as it influences the activity of various signaling pathways that control cell migration, invasion, and angiogenesis. 3. **Immunotherapy:** FUCA2 is a potential target for immunotherapy, as its dysregulation can lead to impaired immune responses, making it a promising target for the development of novel therapeutic strategies. In conclusion, FUCA2 is a multifunctional enzyme that plays a critical role in various cellular processes, including immune response, metabolism, and regulation of protein function. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms of FUCA2 and its potential as a therapeutic target.

Genular Protein ID: 3538186528

Symbol: FUCO2_HUMAN

Name: Plasma alpha-L-fucosidase

UniProtKB Accession Codes:

Q9BTY2 E9PEB6 Q7Z6V1 Q7Z6Y2 Q8NBK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 467
  • Mass: 54067
  • Checksum: A42AA6B369A3AC39
  • Sequence:
    • MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF DQAKFGIFIH 
WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY EDFGPLFTAK FFNANQWADI 
FQASGAKYIV LTSKHHEGFT LWGSEYSWNW NAIDEGPKRD IVKELEVAIR NRTDLRFGLY 
YSLFEWFHPL FLEDESSSFH KRQFPVSKTL PELYELVNNY QPEVLWSDGD GGAPDQYWNS 
TGFLAWLYNE SPVRGTVVTN DRWGAGSICK HGGFYTCSDR YNPGHLLPHK WENCMTIDKL 
SWGYRREAGI SDYLTIEELV KQLVETVSCG GNLLMNIGPT LDGTISVVFE ERLRQMGSWL 
KVNGEAIYET HTWRSQNDTV TPDVWYTSKP KEKLVYAIFL KWPTSGQLFL GHPKAILGAT 
EVKLLGHGQP LNWISLEQNG IMVELPQLTI HQMPCKWGWA LALTNVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.