Gene FUCA2 - ENSG00000001036 | NCBI Gene ID: 2519

Details for: FUCA2

Gene ID: 2519

Symbol: FUCA2

Ensembl ID: ENSG00000001036

Description: alpha-L-fucosidase 2

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Neutrophil degranulation
(R-HSA-6798695)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Alpha-l-fucosidase activity
(GO:0004560)
Azurophil granule lumen
(GO:0035578)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fucose metabolic process
(GO:0006004)
Glycoside catabolic process
(GO:0016139)
Lysosome
(GO:0005764)
Protein binding
(GO:0005515)
Regulation of entry of bacterium into host cell
(GO:2000535)
Response to bacterium
(GO:0009617)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: decidual cell (CL2000002)
Fold Change: 1.91
Marker Score: 8257
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.41
Marker Score: 777
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.41
Marker Score: 15878
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.39
Marker Score: 2054
Cell Name: germ cell (CL0000586)
Fold Change: 1.39
Marker Score: 2427
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.38
Marker Score: 35339
Cell Name: stem cell (CL0000034)
Fold Change: 1.32
Marker Score: 3138
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.31
Marker Score: 530
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.31
Marker Score: 45213
Cell Name: osteoclast (CL0000092)
Fold Change: 1.29
Marker Score: 644
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.24
Marker Score: 1239.5
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.24
Marker Score: 3888
Cell Name: enterocyte (CL0000584)
Fold Change: 1.24
Marker Score: 5938
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.23
Marker Score: 2045
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.22
Marker Score: 1319
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.2
Marker Score: 756
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.19
Marker Score: 1235
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.17
Marker Score: 330
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.15
Marker Score: 1313
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.14
Marker Score: 4497
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.1
Marker Score: 2783
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.1
Marker Score: 7155
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.09
Marker Score: 2858
Cell Name: kidney cell (CL1000497)
Fold Change: 1.08
Marker Score: 723
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.06
Marker Score: 2415
Cell Name: keratocyte (CL0002363)
Fold Change: 1.06
Marker Score: 243
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.04
Marker Score: 1426
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.03
Marker Score: 2528
Cell Name: peptic cell (CL0000155)
Fold Change: 1.02
Marker Score: 426
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.01
Marker Score: 2753
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.01
Marker Score: 2112
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71679
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47901
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.99
Marker Score: 2261
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.99
Marker Score: 1044
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30386
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.98
Marker Score: 54541
Cell Name: blood cell (CL0000081)
Fold Change: 0.97
Marker Score: 11239
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.96
Marker Score: 528
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.96
Marker Score: 3404
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.95
Marker Score: 1016
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.95
Marker Score: 1848
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2396
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.94
Marker Score: 231
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.93
Marker Score: 481
Cell Name: plasmablast (CL0000980)
Fold Change: 0.93
Marker Score: 1242
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.93
Marker Score: 946
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 480
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.93
Marker Score: 378
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 435
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5214
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.91
Marker Score: 2425.5
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2699
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.9
Marker Score: 513
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.89
Marker Score: 15857
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.88
Marker Score: 30046
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5291
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.87
Marker Score: 801
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.87
Marker Score: 251
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.87
Marker Score: 405
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.87
Marker Score: 864
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.87
Marker Score: 1406
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.86
Marker Score: 13494
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.86
Marker Score: 5209
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.86
Marker Score: 201
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.86
Marker Score: 1058
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.86
Marker Score: 422
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.85
Marker Score: 354
Cell Name: Unknown (CL0002371)
Fold Change: 0.84
Marker Score: 896
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.84
Marker Score: 1183
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.83
Marker Score: 1405
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.82
Marker Score: 873
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.82
Marker Score: 546
Cell Name: reticular cell (CL0000432)
Fold Change: 0.81
Marker Score: 297
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 613
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 321
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.8
Marker Score: 1149
Cell Name: stromal cell (CL0000499)
Fold Change: 0.8
Marker Score: 933
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.79
Marker Score: 1223
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.79
Marker Score: 807
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.79
Marker Score: 5154
Cell Name: paneth cell (CL0000510)
Fold Change: 0.78
Marker Score: 546
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.78
Marker Score: 176
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.78
Marker Score: 1944.5
Cell Name: oocyte (CL0000023)
Fold Change: 0.78
Marker Score: 193
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.78
Marker Score: 250
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.77
Marker Score: 291
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.77
Marker Score: 525
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.77
Marker Score: 4892
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.77
Marker Score: 1616
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.76
Marker Score: 195
Cell Name: neural cell (CL0002319)
Fold Change: 0.76
Marker Score: 367
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.76
Marker Score: 716
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.76
Marker Score: 315
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.76
Marker Score: 309
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.76
Marker Score: 359
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.75
Marker Score: 642
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.75
Marker Score: 16680
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 470

Hover over a box to see details here...

**Key characteristics** * The gene is located on chromosome 17q21.1. * It is a large gene with a size of approximately 1.2 million base pairs. * It contains 13 exons and 12 introns. * It is a member of the alpha-L-fucosidase family of enzymes. **Pathways and functions** * The FUCA2 gene is involved in the alpha-L-fucosylation of proteins, which is a process that is important for the structure and function of many glycoproteins. * This modification is involved in a variety of cellular processes, including cell adhesion, migration, and signaling. * It is also involved in the regulation of inflammation and immune responses. **Clinical significance** * Mutations in the FUCA2 gene have been linked to several human diseases, including breast cancer, ovarian cancer, and rheumatoid arthritis. * These mutations can lead to the loss of fucosylation of glycoproteins, which can disrupt their function and lead to disease. * Therefore, targeting the FUCA2 gene is a potential therapeutic strategy for these diseases. **Additional information** * The protein encoded by the FUCA2 gene is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in high levels in the liver, kidney, and immune cells. * It is also expressed in low levels in the brain and other tissues. * It is a highly conserved protein, with similar sequences found in organisms from yeast to humans.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Plasma alpha-L-fucosidase

Genular Protein ID: 3538186528

Symbol: FUCO2_HUMAN

Name: Plasma alpha-L-fucosidase

UniProtKB Accession Codes:

Q9BTY2 E9PEB6 Q7Z6V1 Q7Z6Y2 Q8NBK4

Database IDs:

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

Length: 467
Mass: 54067
Checksum: A42AA6B369A3AC39
Sequence:

MRPQELPRLA FPLLLLLLLL LPPPPCPAHS ATRFDPTWES LDARQLPAWF DQAKFGIFIH 
WGVFSVPSFG SEWFWWYWQK EKIPKYVEFM KDNYPPSFKY EDFGPLFTAK FFNANQWADI 
FQASGAKYIV LTSKHHEGFT LWGSEYSWNW NAIDEGPKRD IVKELEVAIR NRTDLRFGLY 
YSLFEWFHPL FLEDESSSFH KRQFPVSKTL PELYELVNNY QPEVLWSDGD GGAPDQYWNS 
TGFLAWLYNE SPVRGTVVTN DRWGAGSICK HGGFYTCSDR YNPGHLLPHK WENCMTIDKL 
SWGYRREAGI SDYLTIEELV KQLVETVSCG GNLLMNIGPT LDGTISVVFE ERLRQMGSWL 
KVNGEAIYET HTWRSQNDTV TPDVWYTSKP KEKLVYAIFL KWPTSGQLFL GHPKAILGAT 
EVKLLGHGQP LNWISLEQNG IMVELPQLTI HQMPCKWGWA LALTNVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: FUCA2

Associated with

Cells (max top 100)

Other Information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039