Details for: FUT7

Gene ID: 2529

Symbol: FUT7

Ensembl ID: ENSG00000180549

Description: fucosyltransferase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 18.7084
    Cell Significance Index: -2.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 7.1876
    Cell Significance Index: -2.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.3698
    Cell Significance Index: 75.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.3359
    Cell Significance Index: -2.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.9397
    Cell Significance Index: 30.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5908
    Cell Significance Index: 34.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2935
    Cell Significance Index: 37.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.1744
    Cell Significance Index: 72.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0724
    Cell Significance Index: 16.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9230
    Cell Significance Index: -2.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.8635
    Cell Significance Index: 22.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 0.7097
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.5502
    Cell Significance Index: -1.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5202
    Cell Significance Index: 33.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4331
    Cell Significance Index: 19.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4297
    Cell Significance Index: 81.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4037
    Cell Significance Index: 10.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2754
    Cell Significance Index: 27.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2415
    Cell Significance Index: 14.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2070
    Cell Significance Index: 22.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1821
    Cell Significance Index: 164.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1509
    Cell Significance Index: 24.5400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1037
    Cell Significance Index: 1.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0885
    Cell Significance Index: 6.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0839
    Cell Significance Index: 1.7400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.0821
    Cell Significance Index: 1.4100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0497
    Cell Significance Index: 0.6300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0206
    Cell Significance Index: 0.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0122
    Cell Significance Index: 0.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0038
    Cell Significance Index: 0.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0037
    Cell Significance Index: 0.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0017
    Cell Significance Index: -0.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0033
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -3.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0048
    Cell Significance Index: -2.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0053
    Cell Significance Index: -2.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0064
    Cell Significance Index: -0.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0068
    Cell Significance Index: -1.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0086
    Cell Significance Index: -1.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0105
    Cell Significance Index: -0.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0126
    Cell Significance Index: -1.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0128
    Cell Significance Index: -2.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0131
    Cell Significance Index: -1.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0133
    Cell Significance Index: -1.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0135
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0151
    Cell Significance Index: -3.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0185
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0186
    Cell Significance Index: -3.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0207
    Cell Significance Index: -2.8400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0244
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0258
    Cell Significance Index: -2.9600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0330
    Cell Significance Index: -1.4400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0385
    Cell Significance Index: -0.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0412
    Cell Significance Index: -3.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0465
    Cell Significance Index: -3.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0468
    Cell Significance Index: -2.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0470
    Cell Significance Index: -2.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0482
    Cell Significance Index: -2.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0519
    Cell Significance Index: -0.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0574
    Cell Significance Index: -2.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0599
    Cell Significance Index: -3.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0600
    Cell Significance Index: -2.8200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0610
    Cell Significance Index: -0.3300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0634
    Cell Significance Index: -0.8900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0636
    Cell Significance Index: -0.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0648
    Cell Significance Index: -2.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0667
    Cell Significance Index: -0.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0732
    Cell Significance Index: -3.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0790
    Cell Significance Index: -1.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0795
    Cell Significance Index: -2.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0823
    Cell Significance Index: -2.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0831
    Cell Significance Index: -1.7400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0854
    Cell Significance Index: -1.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0862
    Cell Significance Index: -2.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0866
    Cell Significance Index: -3.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0874
    Cell Significance Index: -2.8600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0895
    Cell Significance Index: -2.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0930
    Cell Significance Index: -2.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0934
    Cell Significance Index: -2.6100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0944
    Cell Significance Index: -1.3700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0949
    Cell Significance Index: -1.4200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0955
    Cell Significance Index: -1.2100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0958
    Cell Significance Index: -1.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0976
    Cell Significance Index: -2.8800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0985
    Cell Significance Index: -2.0100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0998
    Cell Significance Index: -1.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1103
    Cell Significance Index: -1.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1106
    Cell Significance Index: -3.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1109
    Cell Significance Index: -2.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1111
    Cell Significance Index: -2.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1112
    Cell Significance Index: -2.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1113
    Cell Significance Index: -3.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1114
    Cell Significance Index: -2.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1124
    Cell Significance Index: -3.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1148
    Cell Significance Index: -2.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1154
    Cell Significance Index: -2.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1185
    Cell Significance Index: -2.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FUT7 is a type II transmembrane glycoprotein that belongs to the fucosyltransferase family. It is characterized by its ability to catalyze the transfer of fucose to specific acceptor molecules, resulting in the formation of fucosylated glycoproteins and glycolipids. The FUT7 protein exhibits: * **Alpha-(1->3)-fucosyltransferase activity**: FUT7 is capable of transferring fucose to specific acceptor molecules through an alpha-1,3-glycosidic bond. * **Blood group systems biosynthesis**: FUT7 plays a crucial role in the synthesis of Lewis blood group antigens, which are essential for blood group compatibility. * **Cell-cell adhesion**: Fucosylated glycoproteins and glycolipids expressed by FUT7 contribute to cell-cell adhesion, a critical process in immune responses and tissue development. * **Regulation of immune responses**: FUT7 is involved in the regulation of immune cell migration, adhesion, and signaling, highlighting its importance in immune system function. **Pathways and Functions** FUT7 is involved in various biological pathways, including: * **Golgi apparatus**: FUT7 is localized to the Golgi apparatus, where it catalyzes the transfer of fucose to specific acceptor molecules. * **Leukocyte migration**: FUT7 regulates leukocyte migration, adhesion, and signaling, highlighting its importance in immune responses. * **Cell-cell adhesion**: Fucosylated glycoproteins and glycolipids expressed by FUT7 contribute to cell-cell adhesion, a critical process in immune responses and tissue development. * **Blood group systems**: FUT7 plays a crucial role in the synthesis of Lewis blood group antigens, which are essential for blood group compatibility. * **Ceramide metabolic process**: FUT7 is involved in the regulation of ceramide metabolism, a critical process in lipid signaling and immune responses. **Clinical Significance** Dysregulation of FUT7 expression has been linked to various diseases, including: * **Inflammatory disorders**: Abnormalities in FUT7 expression have been associated with inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. * **Cancer**: FUT7 expression has been implicated in cancer development and progression, particularly in colorectal and breast cancers. * **Blood group disorders**: Abnormalities in FUT7 expression can lead to blood group disorders, such as hemolytic disease of the newborn. * **Neurological disorders**: FUT7 has been implicated in the regulation of neuronal function and development, highlighting its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, FUT7 is a critical gene involved in various biological processes, including cell-cell adhesion, immune responses, and blood group systems. Its dysregulation has been linked to various diseases, emphasizing the importance of understanding FUT7 function and its role in human health and disease.

Genular Protein ID: 2331668559

Symbol: FUT7_HUMAN

Name: Fucosyltransferase 7

UniProtKB Accession Codes:

Q11130 B2R7U7 Q6DK54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 40 ChEMBL 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 16 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8207002

Title: Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant.

PubMed ID: 8207002

DOI: 10.1016/s0021-9258(19)89461-9

PubMed ID: 8051184

Title: Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant.

PubMed ID: 8051184

DOI: 10.1016/s0021-9258(17)32066-5

PubMed ID: 8182079

Title: Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes.

PubMed ID: 8182079

DOI: 10.1016/s0021-9258(17)36686-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8752218

Title: The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis.

PubMed ID: 8752218

DOI: 10.1016/s0092-8674(00)80137-3

PubMed ID: 8666674

Title: The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells.

PubMed ID: 8666674

DOI: 10.1083/jcb.133.4.911

PubMed ID: 9299472

Title: Fucosylation of complex glycosphingolipids by recombinant fucosyltransferase-VII.

PubMed ID: 9299472

DOI: 10.1006/bbrc.1997.7254

PubMed ID: 9405391

Title: Enzymatic characterization of human alpha1,3-fucosyltransferase Fuc-TVII synthesized in a B cell lymphoma cell line.

PubMed ID: 9405391

DOI: 10.1074/jbc.272.51.31992

PubMed ID: 9473504

Title: The alpha 1-->3 fucosylation at the penultimate GlcNAc catalyzed by fucosyltransferase VII is blocked by internally fucosylated residue in sialosyl long-chain poly-LacNAc: enzymatic basis for expression of physiological E-selectin epitope.

PubMed ID: 9473504

DOI: 10.1006/bbrc.1998.8080

PubMed ID: 9499379

Title: Acceptor specificity of the human leukocyte alpha3 fucosyltransferase: role of FucT-VII in the generation of selectin ligands.

PubMed ID: 9499379

DOI: 10.1093/glycob/8.4.321

PubMed ID: 10386892

Title: Panosialins, inhibitors of an alpha1,3-fucosyltransferase Fuc-TVII, suppress the expression of selectin ligands on U937 cells.

PubMed ID: 10386892

DOI: 10.1023/a:1006953626578

PubMed ID: 9461592

Title: Complementary acceptor and site specificities of Fuc-TIV and Fuc-TVII allow effective biosynthesis of sialyl-TriLex and related polylactosamines present on glycoprotein counterreceptors of selectins.

PubMed ID: 9461592

DOI: 10.1074/jbc.273.7.4021

PubMed ID: 9858509

Title: Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on alpha1, 3-fucosyltransferase VII gene expression.

PubMed ID: 9858509

DOI: 10.1084/jem.188.12.2225

PubMed ID: 9834120

Title: Alpha(1,3)-fucosyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts.

PubMed ID: 9834120

PubMed ID: 10200296

Title: Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA.

PubMed ID: 10200296

DOI: 10.1073/pnas.96.8.4530

PubMed ID: 11425803

Title: Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures.

PubMed ID: 11425803

DOI: 10.1093/glycob/11.5.423

PubMed ID: 15081893

Title: Inhibition of fucosyltransferase VII by gallic acid and its derivatives.

PubMed ID: 15081893

DOI: 10.1016/j.abb.2004.02.039

PubMed ID: 15632313

Title: Development of a sensitive separation and quantification method for sialyl Lewis X and Lewis X involving anion-exchange chromatography: biochemical characterization of alpha1-3 fucosyltransferase-VII.

PubMed ID: 15632313

DOI: 10.1093/jb/mvh179

PubMed ID: 15926890

Title: N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding.

PubMed ID: 15926890

DOI: 10.1042/bj20050344

PubMed ID: 17229154

Title: Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway.

PubMed ID: 17229154

DOI: 10.1111/j.1742-4658.2006.05599.x

PubMed ID: 18553500

Title: FUT7 antisense sequence inhibits the expression of FUT7/sLeX and adhesion between embryonic and uterine cells.

PubMed ID: 18553500

DOI: 10.1002/iub.62

PubMed ID: 18402946

Title: Overexpression of fucosyltransferase VII (FUT7) promotes embryo adhesion and implantation.

PubMed ID: 18402946

DOI: 10.1016/j.fertnstert.2007.12.012

PubMed ID: 19455659

Title: Regulating effect of LIF on the expression of FuT7: Probe into the mechanism of sLe(x) in implantation.

PubMed ID: 19455659

DOI: 10.1002/mrd.21055

PubMed ID: 29593094

Title: Distinct human alpha(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

PubMed ID: 29593094

DOI: 10.1074/jbc.ra117.000775

PubMed ID: 29138114

Title: The alpha1,3-fucosyltransferase FUT7 regulates IL-1beta-induced monocyte-endothelial adhesion via fucosylation of endomucin.

PubMed ID: 29138114

DOI: 10.1016/j.lfs.2017.11.017

PubMed ID: 11404359

Title: Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene.

PubMed ID: 11404359

DOI: 10.1074/jbc.m104165200

Sequence Information:

  • Length: 342
  • Mass: 39239
  • Checksum: D31BFF90DD64DFAB
  • Sequence:
    • MNNAGHGPTR RLRGLGVLAG VALLAALWLL WLLGSAPRGT PAPQPTITIL VWHWPFTDQP 
PELPSDTCTR YGIARCHLSA NRSLLASADA VVFHHRELQT RRSHLPLAQR PRGQPWVWAS 
MESPSHTHGL SHLRGIFNWV LSYRRDSDIF VPYGRLEPHW GPSPPLPAKS RVAAWVVSNF 
QERQLRARLY RQLAPHLRVD VFGRANGRPL CASCLVPTVA QYRFYLSFEN SQHRDYITEK 
FWRNALVAGT VPVVLGPPRA TYEAFVPADA FVHVDDFGSA RELAAFLTGM NESRYQRFFA 
WRDRLRVRLF TDWRERFCAI CDRYPHLPRS QVYEDLEGWF QA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.