Details for: FUT7

Gene ID: 2529

Symbol: FUT7

Ensembl ID: ENSG00000180549

Description: fucosyltransferase 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.9
    Marker Score: 3604
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.49
    Marker Score: 1559
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7678
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4812
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5320
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1816
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.89
    Marker Score: 368.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.88
    Marker Score: 598
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.75
    Marker Score: 4826
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 555
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.7
    Marker Score: 479
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.63
    Marker Score: 245
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.61
    Marker Score: 1570
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 363
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8906
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 348
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.48
    Marker Score: 1973
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.48
    Marker Score: 4873
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.38
    Marker Score: 126
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.34
    Marker Score: 117
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 133
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.26
    Marker Score: 1127
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.26
    Marker Score: 321
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.26
    Marker Score: 645
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.26
    Marker Score: 262
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.25
    Marker Score: 161
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.24
    Marker Score: 145
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.23
    Marker Score: 249
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.23
    Marker Score: 159
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 150
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.22
    Marker Score: 163
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.22
    Marker Score: 127
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.21
    Marker Score: 231
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2
    Marker Score: 127
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.19
    Marker Score: 114
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.19
    Marker Score: 110
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 82
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.18
    Marker Score: 49
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.18
    Marker Score: 125
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.18
    Marker Score: 168
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.17
    Marker Score: 162
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.17
    Marker Score: 221
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.17
    Marker Score: 119
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.16
    Marker Score: 99
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.16
    Marker Score: 8968
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.16
    Marker Score: 172
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.16
    Marker Score: 84
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 323
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.16
    Marker Score: 155
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.15
    Marker Score: 67.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.15
    Marker Score: 235
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.15
    Marker Score: 120
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.15
    Marker Score: 61.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 73
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.14
    Marker Score: 131
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.13
    Marker Score: 80
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.13
    Marker Score: 84.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.13
    Marker Score: 93
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 145
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 123
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.12
    Marker Score: 178
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.11
    Marker Score: 83
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.11
    Marker Score: 115

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Other Information

## Summary The FUT7 gene encodes a protein called FUT7, a transmembrane glycoprotein involved in various biological processes. It is responsible for the addition of fucosyl groups to various substrates, including galactose and N-acetylglucosamine. This modification is crucial for the proper functioning of immune cells, blood cells, and other tissues. ## Key characteristics * **Function:** Fucosyltransferase activity * **Ensembl ID:** ENSG00000180549 * **Pathways/Ontology:** * 4-galactosyl-n-acetylglucosaminide 3-alpha-l-fucosyltransferase activity * Alpha-(1->3)-fucosyltransferase activity * Blood group systems biosynthesis * Cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation * Ceramide metabolic process * Fucosyltransferase activity * Inflammatory response * Leukocyte migration involved in immune response * Leukocyte migration involved in inflammatory response * Lewis blood group biosynthesis * Metabolism * Protein binding * Protein glycosylation * **Significantly expressed cells:** * Cardiac endothelial cell * Colon goblet cell * Thymocyte * Goblet cell * Enterocyte of epithelium of small intestine * Cerebral cortex GABAergic interneuron * Forebrain radial glial cell * Absorptive cell * Tuft cell of colon * BEST4+ intestinal epithelial cell ## Pathways and functions * **4-galactosyl-n-acetylglucosaminide 3-alpha-l-fucosyltransferase activity:** This pathway is involved in the biosynthesis of Lewis blood group antigens. * **Alpha-(1->3)-fucosyltransferase activity:** This pathway is involved in the biosynthesis of the Lewis blood group antigen. * **Blood group systems biosynthesis:** FUT7 is expressed in the membranes of red blood cells, where it is responsible for the addition of galactose and N-acetylglucosamine to the sugar molecules of the erythrocyte membrane. * **Ceramide metabolic process:** FUT7 is involved in the ceramide metabolic process, a pathway that is essential for the maintenance of epithelial cell integrity and barrier function. * **Fucosyltransferase activity:** FUT7 is a key enzyme in the fucosylation of various substrates, including galactose, N-acetylglucosamine, and glycoproteins. * **Inflammatory response:** FUT7 is involved in the regulation of inflammatory responses, where it helps to control the production of inflammatory cytokines and chemokines. * **Leukocyte migration involved in immune response:** FUT7 is expressed on various immune cells, including macrophages, neutrophils, and dendritic cells. It is involved in the migration of these cells to sites of inflammation and infection. * **Regulation of type iv hypersensitivity:** FUT7 is involved in the regulation of type IV hypersensitivity, a condition characterized by an exaggerated immune response to allergens.

Genular Protein ID: 2331668559

Symbol: FUT7_HUMAN

Name: Fucosyltransferase 7

UniProtKB Accession Codes:

Q11130 B2R7U7 Q6DK54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 40 ChEMBL 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 16 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8207002

Title: Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant.

PubMed ID: 8207002

DOI: 10.1016/s0021-9258(19)89461-9

PubMed ID: 8051184

Title: Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant.

PubMed ID: 8051184

DOI: 10.1016/s0021-9258(17)32066-5

PubMed ID: 8182079

Title: Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes.

PubMed ID: 8182079

DOI: 10.1016/s0021-9258(17)36686-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8752218

Title: The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis.

PubMed ID: 8752218

DOI: 10.1016/s0092-8674(00)80137-3

PubMed ID: 8666674

Title: The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells.

PubMed ID: 8666674

DOI: 10.1083/jcb.133.4.911

PubMed ID: 9299472

Title: Fucosylation of complex glycosphingolipids by recombinant fucosyltransferase-VII.

PubMed ID: 9299472

DOI: 10.1006/bbrc.1997.7254

PubMed ID: 9405391

Title: Enzymatic characterization of human alpha1,3-fucosyltransferase Fuc-TVII synthesized in a B cell lymphoma cell line.

PubMed ID: 9405391

DOI: 10.1074/jbc.272.51.31992

PubMed ID: 9473504

Title: The alpha 1-->3 fucosylation at the penultimate GlcNAc catalyzed by fucosyltransferase VII is blocked by internally fucosylated residue in sialosyl long-chain poly-LacNAc: enzymatic basis for expression of physiological E-selectin epitope.

PubMed ID: 9473504

DOI: 10.1006/bbrc.1998.8080

PubMed ID: 9499379

Title: Acceptor specificity of the human leukocyte alpha3 fucosyltransferase: role of FucT-VII in the generation of selectin ligands.

PubMed ID: 9499379

DOI: 10.1093/glycob/8.4.321

PubMed ID: 10386892

Title: Panosialins, inhibitors of an alpha1,3-fucosyltransferase Fuc-TVII, suppress the expression of selectin ligands on U937 cells.

PubMed ID: 10386892

DOI: 10.1023/a:1006953626578

PubMed ID: 9461592

Title: Complementary acceptor and site specificities of Fuc-TIV and Fuc-TVII allow effective biosynthesis of sialyl-TriLex and related polylactosamines present on glycoprotein counterreceptors of selectins.

PubMed ID: 9461592

DOI: 10.1074/jbc.273.7.4021

PubMed ID: 9858509

Title: Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on alpha1, 3-fucosyltransferase VII gene expression.

PubMed ID: 9858509

DOI: 10.1084/jem.188.12.2225

PubMed ID: 9834120

Title: Alpha(1,3)-fucosyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts.

PubMed ID: 9834120

PubMed ID: 10200296

Title: Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA.

PubMed ID: 10200296

DOI: 10.1073/pnas.96.8.4530

PubMed ID: 11425803

Title: Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures.

PubMed ID: 11425803

DOI: 10.1093/glycob/11.5.423

PubMed ID: 15081893

Title: Inhibition of fucosyltransferase VII by gallic acid and its derivatives.

PubMed ID: 15081893

DOI: 10.1016/j.abb.2004.02.039

PubMed ID: 15632313

Title: Development of a sensitive separation and quantification method for sialyl Lewis X and Lewis X involving anion-exchange chromatography: biochemical characterization of alpha1-3 fucosyltransferase-VII.

PubMed ID: 15632313

DOI: 10.1093/jb/mvh179

PubMed ID: 15926890

Title: N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding.

PubMed ID: 15926890

DOI: 10.1042/bj20050344

PubMed ID: 17229154

Title: Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway.

PubMed ID: 17229154

DOI: 10.1111/j.1742-4658.2006.05599.x

PubMed ID: 18553500

Title: FUT7 antisense sequence inhibits the expression of FUT7/sLeX and adhesion between embryonic and uterine cells.

PubMed ID: 18553500

DOI: 10.1002/iub.62

PubMed ID: 18402946

Title: Overexpression of fucosyltransferase VII (FUT7) promotes embryo adhesion and implantation.

PubMed ID: 18402946

DOI: 10.1016/j.fertnstert.2007.12.012

PubMed ID: 19455659

Title: Regulating effect of LIF on the expression of FuT7: Probe into the mechanism of sLe(x) in implantation.

PubMed ID: 19455659

DOI: 10.1002/mrd.21055

PubMed ID: 29593094

Title: Distinct human alpha(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

PubMed ID: 29593094

DOI: 10.1074/jbc.ra117.000775

PubMed ID: 29138114

Title: The alpha1,3-fucosyltransferase FUT7 regulates IL-1beta-induced monocyte-endothelial adhesion via fucosylation of endomucin.

PubMed ID: 29138114

DOI: 10.1016/j.lfs.2017.11.017

PubMed ID: 11404359

Title: Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene.

PubMed ID: 11404359

DOI: 10.1074/jbc.m104165200

Sequence Information:

  • Length: 342
  • Mass: 39239
  • Checksum: D31BFF90DD64DFAB
  • Sequence:
    • MNNAGHGPTR RLRGLGVLAG VALLAALWLL WLLGSAPRGT PAPQPTITIL VWHWPFTDQP 
PELPSDTCTR YGIARCHLSA NRSLLASADA VVFHHRELQT RRSHLPLAQR PRGQPWVWAS 
MESPSHTHGL SHLRGIFNWV LSYRRDSDIF VPYGRLEPHW GPSPPLPAKS RVAAWVVSNF 
QERQLRARLY RQLAPHLRVD VFGRANGRPL CASCLVPTVA QYRFYLSFEN SQHRDYITEK 
FWRNALVAGT VPVVLGPPRA TYEAFVPADA FVHVDDFGSA RELAAFLTGM NESRYQRFFA 
WRDRLRVRLF TDWRERFCAI CDRYPHLPRS QVYEDLEGWF QA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.